C Difficile

Antibiotic-associated diarrhea (AAD) frequently complicates treatment of infections. A recent randomized, double-blind, placebo-controlled trial tested a proprietary probiotic mixture and found that it reduced the incidence of AAD by 16%. This is encouraging for patients, but future progress on prob …

spaniClostridioides difficile/i is a One Health pathogen found in humans, animals, and environment, with food representing a potential transmission route. One Health studies are often limited to single country or selected reservoirs and ribotypes. This study provides a varied and accessible collecti/span …

The rapid increase in microbial antibiotic resistance in Clostridioides difficile (C. difficile) strains and the formation of hypervirulent strains have been associated with a global increase in the incidence of C. difficile infection (CDI) and subsequently, an increase in the rate of recurrence. Th …

Our epidemiological data, while suggesting a potential resurgence in CDI transmission during COVID-19 pandemic, are derived from a single-center experience with limited generalizability to the broader population. Nonetheless, they highlight the need for strengthened antimicrobial stewardship and nat …

MDROs/C. difficile transmission is prevalent within a tertiary care hospital and further complicated by its inter-facility transmission across surrounding LTCFs and hospitals in Japan.

Clostridioides difficile has been recognized as an important nosocomial pathogen that causes diarrheal disease as a consequence of antibiotic exposure and costs the healthcare system billions of dollars every year. C. difficile enters the host gut as dormant spores, germinates into vegetative cells, …

Clostridioides difficile currently constitutes a major pathogen of the gastrointestinal tract, which poses a significant growing burden on medicine and veterinary medicine in many regions. A farm was assessed (feed table, silage pit, and feces (healthy animals, emaciated animals, and animals …

UV-C emitter configuration impacts efficacy in attenuating C. difficile.

Certain ribotypes, including RT 027, were the sole independent risk factors for reduced VAN susceptibility. Increased clinical surveillance of these strains, especially RT 027, and their antibiotic susceptibly is warranted to inform prescribing practices.

MGPP testing is most useful when administered as an outpatient and of little benefit for inpatients with hospital-onset diarrhea. Since MGPP is sensitive and does not distinguish between colonization and causes of diarrhea, caution is needed in interpretation of results, especially for toxin-negativ …

CDI prevalence increased with the number of antimicrobial classes used in combination. Certain types or combinations of antimicrobials may increase the OR for CDI.

Prolonged hospital stay after birth is associated with infant gut dysbiosis.

The diagnosis, pharmacologic management, and surgical options for Clostridioides difficile infection (CDI) are rapidly evolving, which presents a challenge for the busy surgeon to remain up to date on the latest clinical guidelines. This review provides an evidence-based practical guide for CDI mana …

EriB ameliorated in mice with EAP, the gut microbiota mediates vitamin D3 alterations to modulate macrophage phenotype polarizing from M1 to M2.

As patients increasingly turn to at-home food sensitivity and microbiome tests, gastroenterologists are navigating a landscape fraught with scientific uncertainty ...

The country’s largest fecal distributor, OpenBiome, could be prevented from offering the product next year if the FDA does not approve the product used for fecal microbiota transplants to treat fulminant C difficile.

At Mayo Clinic’s Center for Individualized Medicine, scientists are investigating stool samples to uncover new insights into cancer treatment.

A dive into microbiome-focused skincare

According to a new CDC progress report, rates of healthcare-associated infections (HAIs) at U.S. hospitals decreased in 2023 after increasing significantly during the COVID-19 pandemic. However, even with progress being made, experts say that more work is needed to sustain the improvements.

Colitis is associated with many diseases, and treatment depends on the exact cause.

Healthcare

Dr David Johnson highlights studies on increasing disease rates, the surprising effects of palliative care consultations, and drugs on the verge of approval.

A randomized controlled trial finds no clear benefit of adding bezlotoxumab to FMT in patients with IBD and recurrent C difficile infection.

The certification is for products used in hematology instruments manufactured globally, including instruments from Abbott, Beckman Coulter, and Siemens Healthineers.

George Sakoulas, MD, offered clinical considerations for treatment selection.

Taking probiotics with antibiotics can help protect the gut from the negative effects of antibiotics. But some people may benefit from it more than others.

PHILADELPHIA — Rebyota was safe and effective at 8 weeks and up to 6 months in patients with recurrent Clostridioides difficile infection, many of whom had other gastrointestinal comorbidities and risk factors, according to data presented. “We showed a significant decrease in recurrence rates of Clostridioides difficile in a real-world population,” Timothy E. Ritter, MD, a

Clostridium difficile is the most common cause of nosocomial infectious diarrhea. The incidence of C difficile infection (CDI) is increasing in both inpatients and outpatients, and outbreaks caused by a hypervirulent strain of C difficile are ...