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The presence of Clostridioides difficile in faeces before and after faecal microbiota transplantation and its relation with recurrent C. difficile infection and the gut microbiota in a Dutch cohort - PubMed
The presence of Clostridioides difficile in faeces before and after faecal microbiota transplantation and its relation with recurrent C. difficile infection and the gut microbiota in a Dutch cohort - PubMed
While eradication of C. difficile is not required for clinical cure of rCDI by FMT, it is associated with reduced prevalence of early CDI recurrence, as are the full completion of pre-FMT vancomycin (at least 10 days) and avoiding post-FMT antibiotics.
·pubmed.ncbi.nlm.nih.gov·
The presence of Clostridioides difficile in faeces before and after faecal microbiota transplantation and its relation with recurrent C. difficile infection and the gut microbiota in a Dutch cohort - PubMed
Gastrointestinal bacteria growth inhibition by a toilet sanitary good for disaster shelter - PubMed
Gastrointestinal bacteria growth inhibition by a toilet sanitary good for disaster shelter - PubMed
Japan has experienced several large earthquakes in the past 30 years. Emergency evacuation shelters become overcrowded immediately after disasters. Deteriorating sanitary conditions in toilets are associated with a higher risk of infectious pathogen transmission. "Ho!Toilet" is a toilet sanitary goo …
·pubmed.ncbi.nlm.nih.gov·
Gastrointestinal bacteria growth inhibition by a toilet sanitary good for disaster shelter - PubMed
Cervicovaginal and gastrointestinal microbiomes in gynecological cancers and their roles in therapeutic intervention - PubMed
Cervicovaginal and gastrointestinal microbiomes in gynecological cancers and their roles in therapeutic intervention - PubMed
Cancer remains a significant global health concern, and understanding factors that regulate cancer development is important. The microbiome, with its potential role in cancer development, progression, and treatment, has garnered increasing attention in recent years. The cervicovaginal and gastrointe …
·pubmed.ncbi.nlm.nih.gov·
Cervicovaginal and gastrointestinal microbiomes in gynecological cancers and their roles in therapeutic intervention - PubMed
Clinical significance of toxin EIA positivity in patients with suspected Clostridioides difficile infection: systematic review and meta-analysis - PubMed
Clinical significance of toxin EIA positivity in patients with suspected Clostridioides difficile infection: systematic review and meta-analysis - PubMed
The laboratory diagnosis of iClostridioides difficile/i infection (CDI) is controversial. Nucleic acid amplification tests (NAAT) and toxin enzyme immunoassays (EIA) are most widely used, often in combination. However, the interpretation of a positive NAAT and negative toxin immunoassay (NAAT+/E …
·pubmed.ncbi.nlm.nih.gov·
Clinical significance of toxin EIA positivity in patients with suspected Clostridioides difficile infection: systematic review and meta-analysis - PubMed
Atractylodes macrocephala Koidz polysaccharide ameliorates DSS-induced colitis in mice by regulating the gut microbiota and tryptophan metabolism - PubMed
Atractylodes macrocephala Koidz polysaccharide ameliorates DSS-induced colitis in mice by regulating the gut microbiota and tryptophan metabolism - PubMed
Based on our findings, we elucidate a novel mechanism by which PAMK alleviates DSS-induced colitis and thus provides evidence to support the potential development of PAMK as a new clinical drug against UC.
·pubmed.ncbi.nlm.nih.gov·
Atractylodes macrocephala Koidz polysaccharide ameliorates DSS-induced colitis in mice by regulating the gut microbiota and tryptophan metabolism - PubMed
Maternal gut microbiota influence stem cell function in offspring - PubMed
Maternal gut microbiota influence stem cell function in offspring - PubMed
The maternal microbiome influences child health. However, its impact on a given offspring's stem cells, which regulate development, remains poorly understood. To investigate the role of the maternal microbiome in conditioning the offspring's stem cells, we manipulated maternal microbiota using Akker …
·pubmed.ncbi.nlm.nih.gov·
Maternal gut microbiota influence stem cell function in offspring - PubMed
Dr. Kirk Hevener Awarded $3.7 Million for Groundbreaking Research on Bacterial Gut Infection Treatment - UTHSC News
Dr. Kirk Hevener Awarded $3.7 Million for Groundbreaking Research on Bacterial Gut Infection Treatment - UTHSC News
The National Institute of Allergy and Infectious Diseases has awarded $3.7 million to Kirk Hevener, PharmD, PhD, associate professor in the Department of Pharmaceutical Sciences at the University of Tennessee Health Science Center College of Pharmacy, for a project to develop new treatments for Clostridioides difficile (C. diff) infection, a serious and often deadly bacterial infection of the colon.
·news.uthsc.edu·
Dr. Kirk Hevener Awarded $3.7 Million for Groundbreaking Research on Bacterial Gut Infection Treatment - UTHSC News
Modulating gut microbiota for treating antibiotic-associated diarrhea from Clostridium difficile infection: insights from Lizhong decoction and its polysaccharide component - PubMed
Modulating gut microbiota for treating antibiotic-associated diarrhea from Clostridium difficile infection: insights from Lizhong decoction and its polysaccharide component - PubMed
To investigate whether the polysaccharide component of the Traditional Chinese Medicine (TCM) formula Lizhong decoction (LZD) has therapeutic effects and regulates gut microbiota in antibiotic-associated diarrhea (AAD) related to Clostridium difficile infection, a polysaccharide was extracted from L …
·pubmed.ncbi.nlm.nih.gov·
Modulating gut microbiota for treating antibiotic-associated diarrhea from Clostridium difficile infection: insights from Lizhong decoction and its polysaccharide component - PubMed
Impact of type 2 diabetes mellitus on mortality and recurrence of clostridioides difficile infection - PubMed
Impact of type 2 diabetes mellitus on mortality and recurrence of clostridioides difficile infection - PubMed
Diabetes is associated with a worse prognosis in patients with CDI. Prevention efforts should be optimized in patients with diabetes by reducing CDI transmission and avoiding nonessential medications, such as PPIs or antibiotics when they are not necessary.
·pubmed.ncbi.nlm.nih.gov·
Impact of type 2 diabetes mellitus on mortality and recurrence of clostridioides difficile infection - PubMed
Gut microbiome and NAFLD: impact and therapeutic potential - PubMed
Gut microbiome and NAFLD: impact and therapeutic potential - PubMed
Non-Alcoholic Fatty Liver Disease (NAFLD) affects approximately 32.4% of the global population and poses a significant health concern. Emerging evidence underscores the pivotal role of the gut microbiota-including bacteria, viruses, fungi, and parasites-in the development and progression of NAFLD. D …
·pubmed.ncbi.nlm.nih.gov·
Gut microbiome and NAFLD: impact and therapeutic potential - PubMed
The role of the microbiota-gut-brain axis in methamphetamine-induced neurotoxicity: Disruption of microbial composition and short-chain fatty acid metabolism - PubMed
The role of the microbiota-gut-brain axis in methamphetamine-induced neurotoxicity: Disruption of microbial composition and short-chain fatty acid metabolism - PubMed
Methamphetamine (METH) abuse is associated with significant neurotoxicity, high addiction potential, and behavioral abnormalities. Recent studies have identified a connection between the gut microbiota and METH-induced neurotoxicity and behavioral disorders. However, the underlying causal mechanisms …
·pubmed.ncbi.nlm.nih.gov·
The role of the microbiota-gut-brain axis in methamphetamine-induced neurotoxicity: Disruption of microbial composition and short-chain fatty acid metabolism - PubMed
Antibiotic-perturbed microbiota and the role of probiotics - PubMed
Antibiotic-perturbed microbiota and the role of probiotics - PubMed
The disruptive effect of antibiotics on the composition and function of the human microbiota is well established. However, the hypothesis that probiotics can help restore the antibiotic-disrupted microbiota has been advanced, with little consideration of the strength of evidence supporting it. Some …
·pubmed.ncbi.nlm.nih.gov·
Antibiotic-perturbed microbiota and the role of probiotics - PubMed
A quantitative PCR to detect non-toxigenic Clostridioides difficile - PubMed
A quantitative PCR to detect non-toxigenic Clostridioides difficile - PubMed
spaniClostridioides difficile/i species lacking toxin genes (non-toxigenic iC. difficile/i or NTCD) may confer protection against CDI. However, current diagnostic tests detect either toxin proteins or toxin genes and cannot detect NTCD. This study developed a molecular testing method that unique/span …
·pubmed.ncbi.nlm.nih.gov·
A quantitative PCR to detect non-toxigenic Clostridioides difficile - PubMed
The gut-brain-metabolic axis: exploring the role of microbiota in insulin resistance and cognitive function - PubMed
The gut-brain-metabolic axis: exploring the role of microbiota in insulin resistance and cognitive function - PubMed
The gut-brain-metabolic axis has emerged as a critical area of research, highlighting the intricate connections between the gut microbiome, metabolic processes, and cognitive function. This review article delves into the complex interplay between these interconnected systems, exploring their role in …
·pubmed.ncbi.nlm.nih.gov·
The gut-brain-metabolic axis: exploring the role of microbiota in insulin resistance and cognitive function - PubMed
Updated outcomes and exploratory analysis of RENMIN-215: tislelizumab plus fruquintinib and fecal microbiota transplantation in refractory microsatellite stable metastatic colorectal cancer - PubMed
Updated outcomes and exploratory analysis of RENMIN-215: tislelizumab plus fruquintinib and fecal microbiota transplantation in refractory microsatellite stable metastatic colorectal cancer - PubMed
Primary analysis of the open-label, single-arm, phase II RENMIN-215 trial (primary data cutoff date: July 10, 2023) showed promising efficacy and tolerable safety with tislelizumab plus fruquintinib and fecal microbiota transplantation (FMT) in patients with refractory microsatellite stable (MSS) me …
·pubmed.ncbi.nlm.nih.gov·
Updated outcomes and exploratory analysis of RENMIN-215: tislelizumab plus fruquintinib and fecal microbiota transplantation in refractory microsatellite stable metastatic colorectal cancer - PubMed
Detection, characterization and antimicrobial susceptibility of Clostridioides difficile from seafood of Marmara Sea, Turkey - PubMed
Detection, characterization and antimicrobial susceptibility of Clostridioides difficile from seafood of Marmara Sea, Turkey - PubMed
The objective of this study was to determine the presence of C. difficile in seafood, to identify the ribotype of isolates, to reveal the distribution of their toxinogenic genes and to evaluate the antibiotic susceptibility of C. difficile strains. For this purpose, a total of 755 seafood samples we …
·pubmed.ncbi.nlm.nih.gov·
Detection, characterization and antimicrobial susceptibility of Clostridioides difficile from seafood of Marmara Sea, Turkey - PubMed
FMT Restores Colonic Protein Biosynthesis and Cell Proliferation in Patients with Recurrent Clostridioides difficile Disease - PubMed
FMT Restores Colonic Protein Biosynthesis and Cell Proliferation in Patients with Recurrent Clostridioides difficile Disease - PubMed
Recurrent C. difficile infection (CDI) is a major health threat with significant mortality and financial costs. Fecal Microbiota Transplantation (FMT) is an effective therapy, however the mechanisms by which it acts, particularly on the host, are poorly understood. Here we enrolled a prospect …
·pubmed.ncbi.nlm.nih.gov·
FMT Restores Colonic Protein Biosynthesis and Cell Proliferation in Patients with Recurrent Clostridioides difficile Disease - PubMed
Draft genome sequences of two distinct Clostridioides difficile isolates coinfecting a patient - PubMed
Draft genome sequences of two distinct Clostridioides difficile isolates coinfecting a patient - PubMed
Clostridioides difficile is a spore-forming anaerobic Gram-positive bacillus. In this study, two distinct strains of C. difficile causing coinfection were isolated from the same fecal sample. Whole-genome sequencing was performed on these two strains to elucidate their genomic characte …
·pubmed.ncbi.nlm.nih.gov·
Draft genome sequences of two distinct Clostridioides difficile isolates coinfecting a patient - PubMed
Updated outcomes and exploratory analysis of RENMIN-215: tislelizumab plus fruquintinib and fecal microbiota transplantation in refractory microsatellite stable metastatic colorectal cancer - PubMed
Updated outcomes and exploratory analysis of RENMIN-215: tislelizumab plus fruquintinib and fecal microbiota transplantation in refractory microsatellite stable metastatic colorectal cancer - PubMed
Primary analysis of the open-label, single-arm, phase II RENMIN-215 trial (primary data cutoff date: July 10, 2023) showed promising efficacy and tolerable safety with tislelizumab plus fruquintinib and fecal microbiota transplantation (FMT) in patients with refractory microsatellite stable (MSS) me …
·pubmed.ncbi.nlm.nih.gov·
Updated outcomes and exploratory analysis of RENMIN-215: tislelizumab plus fruquintinib and fecal microbiota transplantation in refractory microsatellite stable metastatic colorectal cancer - PubMed
Gut Microbiome and Its Role in Parkinson's Disease - PubMed
Gut Microbiome and Its Role in Parkinson's Disease - PubMed
Parkinson's disease (PD) afflicted more than 8.5 million people globally in 2019, as the prevalence of the condition more than doubled during the preceding 25 years. Both non-motor symptoms, such as mood disorders and cognitive impairment, and motor symptoms, such as tremors and rigidity, are indica …
·pubmed.ncbi.nlm.nih.gov·
Gut Microbiome and Its Role in Parkinson's Disease - PubMed
Gut Microbiota: A Modulator and Therapeutic Target for Chronic Pain - PubMed
Gut Microbiota: A Modulator and Therapeutic Target for Chronic Pain - PubMed
Chronic pain is a prevalent condition, impacting nearly one-fifth of the global population. Despite the availability of various clinical treatments, each comes with inherent limitations, and few offer a complete cure, resulting in a significant social and economic burden. Therefore, it is important …
·pubmed.ncbi.nlm.nih.gov·
Gut Microbiota: A Modulator and Therapeutic Target for Chronic Pain - PubMed
Sex Differences in Gut Microbiota, Hypertension, and Cardiovascular Risk - PubMed
Sex Differences in Gut Microbiota, Hypertension, and Cardiovascular Risk - PubMed
The intricate ecosystem of the gut microbiome exhibits sex-specific differences, influencing the susceptibility to cardiovascular diseases (CVD). Imbalance within the gut microbiome compromises the gut barrier, activates inflammatory pathways, and alters the production of metabolites, all of which i …
·pubmed.ncbi.nlm.nih.gov·
Sex Differences in Gut Microbiota, Hypertension, and Cardiovascular Risk - PubMed
Astragalus polysaccharide alleviates mastitis disrupted by Staphylococcus aureus infection by regulating gut microbiota and SCFAs metabolism - PubMed
Astragalus polysaccharide alleviates mastitis disrupted by Staphylococcus aureus infection by regulating gut microbiota and SCFAs metabolism - PubMed
Polysaccharides, key bioactive compounds derived from Chinese herbs, are increasingly recognized for their therapeutic potential in modulating gut microbiota to treat various diseases. However, their efficacy in alleviating mammary inflammation and oxidative stress and protecting the blood-milk barr …
·pubmed.ncbi.nlm.nih.gov·
Astragalus polysaccharide alleviates mastitis disrupted by Staphylococcus aureus infection by regulating gut microbiota and SCFAs metabolism - PubMed
Investigation of the protective mechanism of paeoniflorin against hyperlipidemia by an integrated metabolomics and gut microbiota strategy - PubMed
Investigation of the protective mechanism of paeoniflorin against hyperlipidemia by an integrated metabolomics and gut microbiota strategy - PubMed
The prevalence of hyperlipidemia is gradually increasing globally, posing a serious threat to public health. Previous studies have shown that paeoniflorin (PF) effectively improved abnormal lipid metabolism in atherosclerotic mice. However, the anti-hyperlipidemia effect and potential mechanism of p …
·pubmed.ncbi.nlm.nih.gov·
Investigation of the protective mechanism of paeoniflorin against hyperlipidemia by an integrated metabolomics and gut microbiota strategy - PubMed
Dietary inulin ameliorates obesity-induced severe acute pancreatitis via gut-pancreas axis - PubMed
Dietary inulin ameliorates obesity-induced severe acute pancreatitis via gut-pancreas axis - PubMed
Obesity is a definitive factor of severity and mortality of acute pancreatitis (AP), and gut microbiota dysbiosis is involved in its pathogenesis. However, the effect of gut microbiota modulation by dietary components on high fat diet (HFD)-induced severe AP remains unclear. Here, we found that the …
·pubmed.ncbi.nlm.nih.gov·
Dietary inulin ameliorates obesity-induced severe acute pancreatitis via gut-pancreas axis - PubMed
Gut Microbiota-Immune System Interactions in Health and Neurodegenerative Diseases: Insights into Molecular Mechanisms and Therapeutic Applications - PubMed
Gut Microbiota-Immune System Interactions in Health and Neurodegenerative Diseases: Insights into Molecular Mechanisms and Therapeutic Applications - PubMed
The human body contains approximately 100 trillion microorganisms, predominantly within the gastrointestinal tract, collectively called the gut microbiota. Investigations have revealed the bidirectional communication between the gut microbiota and the brain, characterized as the "microbiota-gut-brai …
·pubmed.ncbi.nlm.nih.gov·
Gut Microbiota-Immune System Interactions in Health and Neurodegenerative Diseases: Insights into Molecular Mechanisms and Therapeutic Applications - PubMed