Pathogenic Bacillus and clostridial (i.e., Clostridium and Clostridioides) bacteria express a diverse repertoire of effector proteins to promote disease. This includes production of binary toxins, which enter host epithelial cells and seriously damage the intestinal tracts of in …

The goal of this article is to summarize common methods of antibiotic operationalization used in clinical research and demonstrate methods for exposure variable selection. We demonstrate three methods for modeling exposure, using data from a case-control study on Clostridioides difficile infection i …

There is increasing evidence about the influence the changes in microbiota and its metabolism has on numerous diseases and infections such as Clostridioides difficile infection (CDI). The knowledge of these changes at local and systemic levels can help us manage this infection to avoid recurr …

Glycogen plays a vital role as an energy reserve in various bacterial and fungal species. Clostridioides difficile possesses a glycogen metabolism operon that contains genes for both glycogen synthesis and utilization. In our investigation, we focused on understanding the significance of glyc …

We sought to better understand how intestinal microbiota confer protection against Clostridioides difficile (C. difficile) infection (CDI). We utilized gnotobiotic altered Schaedler flora (ASF) mice, which lack the abnormalities of germfree (GF) mice as well as the complexity and heter …

If you’re going into a public restroom, you may want to take a quick step back after flushing, as the swirling water creates an invisible aerosol that will carry whatever pathogen may be residing in the toilet bowl up and into your nostrils. A study by a team from the University of Colorado Boulder, published […]

The Phase 3 CLOVER trial still showed safety and potential benefits by reducing C difficile infection duration, medical attention needs, and antibiotic use.

The gastrointestinal tract is a hypoxic environment, with the existence of two gradients of O2 along the gut, one longitudinal anteroposterior decreasing gradient and one proximodistal increasing from the lumen to the epithelial cells. O2 is a major source of stress for an obli …

New research uncovers how COVID-19 may cause neuroinflammation, leading to persistent neurological symptoms even after recovery.

Live biotherapeutic products (LBPs) such as fecal microbiota, live-jslm (RBL) are becoming more frequently administered in gastroentintestinal (GI) care settings. As a result, GI nurses must be knowledgeable about and skilled in their administration of LBPs. RBL is a single-dose, rectally-administer …

Nestlé aims to increase the global availability of Vowst, an FDA-approved therapy for preventing recurrent C difficile infection, while also seeking new opportunities for the product worldwide.

Clostridioides difficile infection (CDI) is a major cause of antibiotic-associated diarrhea and colitis. It is recognized as one of the most significant hospital-acquired infections. Although CDI can develop severe complications and spores of Clostridioides difficile can be transmitted by the fecal- …

The gut pathogen Clostridioides difficile utilizes a wide range of carbon sources. Microbial communities can be rationally designed to combat C. difficile by depleting its preferred nutrients in the gut. However, C. difficile is genetically diverse with hundreds of identified ri …

In the second part of our interview with Christian Lillis, cofounder and CEO of the Peggy Lillis Foundation, he discusses what the passage of the Peggy Lillis Clostridioides difficile Inclusion Act would do for reporting of the infection as well as the potential ancillary effects around antibiotic development and antimicrobial resistance.

The vaccine didn't reduce C difficile infections in at-risk adults, but it did show the potential to reduce infection severity and limit need for medical attention.

EXCLUSIVE: A mother of three, 46, was healthy and energetic but was left periodically bedbound after battling symptoms of long Covid for almost two years - 'it became debilitating'

The Clostridia produce and secrete Large Clostridial Glucosylating Toxins (LCGTs) responsible for disease symptoms, but the secretion mechanism is largely unknown. Recently, a holin-like protein was shown to be essential for toxin secretion. Holins, typically bacteriophage-specific proteins, are par …

npj Digital Medicine - Deep learning-based prediction of Clostridioides difficile infection caused by antibiotics using longitudinal electronic health records

Three PF-06425090 doses were safe and well-tolerated. Although the primary endpoint was not met, PF-06425090 reduced symptom duration, CDI requiring medical attention, and CDI-directed antibiotic treatment, highlighting its potential to reduce CDI-associated healthcare burden. NCT03090191.

The study is registered at ClinicalTrials.gov (NCT03931941).

Communications Biology - Identification of an N-acetylmuramoyl-l-alanine amidase in the ribotype 027 C. difficile strain M7404, involved in the active secretion of the large clostridial...

The end of toxoid vaccine development for preventing Clostridioides difficile infections?

Pseudomembranous colitis (PC) is an inflammation of the colon primarily caused by the bacterium Clostridium difficile (C. difficile), often following antibiotic use. This case report describes the intricate clinical course of a 48-year-old male farmer with a history of chronic alcoholism, tobacco us …

The study found that vancomycin is more effective than metronidazole in achieving event-free survival for C difficile infections across all infection severity levels.

Antimicrobial resistance is a growing threat exacerbated by overuse of antibiotics – as well as poor waste management and climate change.

The analysis suggests administration of Rebyota is associated with significant restoration of microbiota and bile acid composition.

The study will collect and analyze data on war wounds linked to the conflict in Ukraine.

Dublin, Aug. 22, 2024 (GLOBE NEWSWIRE) — The “2024 Microbiome Market Trend” report has been added to ResearchAndMarkets.com’s offering. In the microbiome therapeutics market, some microbiome drugs have succeeded in commercialization. The microbiome market is growing not only in therapeutics but also in food-related markets. For example, consumers recognize probiotics as good for the body, […]