Sean Brown’s 2024 Disease Prevention Summit presentation emphasized leveraging technology, prioritizing high-risk patients, and environmental surveillance to enhance infection prevention and control strategies.

An experimental vaccine failed to prevent Clostridioides difficile infection in a phase 3 trial but successfully reduced the duration of symptoms, infections requiring medical attention and antibiotic treatments, researchers reported.

The following is a summary of “Interventional antibiotic treatment replacing antibiotic prophylaxis during allogeneic hematopoietic stem cell transplantation is safe and leads to a reduction of antibiotic administration,” published in the September 2024 issue of Hematology by Toenges et al. Patients undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT) suffer a higher risk of infection-related death,

The benefits, challenges, and prospects of wastewater data in enhancing public health strategies against AMR.

C diff remains a major healthcare burden globally, with over 225,000 hospitalizations in the US alone. Over half of these cases had recent antibiotic exposure, underlining the significant relationship between antibiotic use and the risk of the healthcare-associated infection.

Cefotaxime and ceftriaxone are two prominent third-generation cephalosporin antibiotics, which are a class of antimicrobial agents with overlapping antibacterial spectra and therapeutic indicati...

YabG is a sporulation-specific protease that is conserved among sporulating bacteria. Clostridioides difficile YabG processes the cortex destined proteins preproSleC into proSleC and CspBA to CspB and CspA. YabG also affects synthesis of spore coat/exosporium proteins CotA and CdeM. In prior work th …

Crestone’s novel therapy, CRS3123, demonstrated 97% clinical cure rate in small phase 2 study.

For the first time in the organization's history, all of the honourees are women. Each honouree is dedicated to creating positive change in the fight against ‘C. diff’.

Crestone Pharmaceuticals recently shared topline results from a phase 2 trial of its investigational drug treatment for Clostridioides difficile infection.

Scientific Reports - Alpha-1 antitrypsin inhibits Clostridium botulinum C2 toxin, Corynebacterium diphtheriae diphtheria toxin and B. anthracis fusion toxin

COVID fatigue describes brain fog, mental, and physical weakness after infection. This article covers ways to improve fatigue and feel less exhausted.

Scientific Reports - Symptom burden, coagulopathy and heart disease after acute SARS-CoV-2 infection in primary practice

Recent data and conversations with experts highlighted the increasing concern of Long COVID’s impact on the brain in patients who have been previously infected with the virus.

Clostridioides difficile is a bacterium that causes life-threatening intestinal infections. Infection symptoms are mediated by a toxin secreted by the bacterium. Toxin pathogenesis is modulated by the intracellular molecule, inositol-hexakisphosphate (IP6). IP6 binds to a cysteine protease do …

The small-molecule protein synthesis inhibitor CRS3121 met its primary endpoints, with high rates of clinical cure at day 12 and low rates of CDI recurrence.

Hospital-acquired pneumonia (HAP) is a significant infection prevention concern, leading to high patient mortality, increased health care costs, and ICU usage. Oral hygiene is an effective preventive measure.

Diverse gut microorganisms present in humans and mice are essential for the prevention of microbial pathogen colonization. However, antibiotic-induced dysbiosis of the gut microbiome reduces microbial diversity and allows C. difficile to colonize the intestine. The Oligo Mouse Microbiota 19.1 …

Where the trial court struck a plaintiff’s standard of care expert in a nursing home wrongful death case, it erred. She had relevant experience, and her uncontradicted testimony demonstrated she had knowledge of the relevant standards of care for the nursing staff. Background Barbara H. Clements qualified as administrator of the estate of Fred Hodnett,

Debra Goff, PharmD, discusses her advocacy around this topic and bringing the stewardship message to dentists about how antibiotic prescribing practices have changed and getting them to recalibrate their thinking and actions in their field.

Toxin inhibition plays a key role in successful management of patients with infections due to toxin-producing organisms. Adjunctive therapy with a tetracycline could be considered in severe, fulminant CDI, but the associated benefit is variable. The benefit of antitoxin treatment for necrotizing S. …

This study demonstrates the potential utility of metagenomic studies of the gut microbial community as a biomarker for prognosis prediction in AAD patients.

PDF | Purpose Diverting Loop Ileostomy (DLI) with intraoperative colonic lavage has emerged as a potential alternative to Total Abdominal Colectomy... | Find, read and cite all the research you need on ResearchGate

The Royal Liverpool Hospital failed to hit C.difficile targets on eight consecutive months.

DLI shows a lower postoperative mortality rate and higher ostomy reversal rate than TAC, suggesting it as a potential organ-preserving, minimally invasive alternative. Further high-quality studies and trials are needed to confirm these findings.

Take 5 minutes to catch up on Infection Control Today’s highlights for the week ending September 6, 2024.

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A whistleblower who raised concerns about infection control at a...

Polyphenols have been reported to inhibit C. difficile growth and toxin production by several mechanisms in preclinical studies. However, more clinical studies are needed to investigate their safety in humans.