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The impact of 30-day antecedent antibiotic exposure on C. difficile ribotype patterns and the relationship with clinical outcomes: A single center study - PubMed
The impact of 30-day antecedent antibiotic exposure on C. difficile ribotype patterns and the relationship with clinical outcomes: A single center study - PubMed
These findings suggest that fluoroquinolone and macrolide exposure were significantly associated with isolating a resistant strain, but we did not find significant differences in clinical outcomes based on the presence of antimicrobial resistance.
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·pubmed.ncbi.nlm.nih.gov·
The impact of 30-day antecedent antibiotic exposure on C. difficile ribotype patterns and the relationship with clinical outcomes: A single center study - PubMed
#VisualAbstract: Ridinilazole reduces recurrent Clostridioides difficile infection and preserves gut microbi-ome diversity versus vancomycin | 2 Minute Medicine
#VisualAbstract: Ridinilazole reduces recurrent Clostridioides difficile infection and preserves gut microbi-ome diversity versus vancomycin | 2 Minute Medicine
Click here to read this study in CID. ©2024 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.
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·2minutemedicine.com·
#VisualAbstract: Ridinilazole reduces recurrent Clostridioides difficile infection and preserves gut microbi-ome diversity versus vancomycin | 2 Minute Medicine
Efficacy of fidaxomicin versus vancomycin in the treatment of Clostridium difficile infection: A systematic meta-analysis - PubMed
Efficacy of fidaxomicin versus vancomycin in the treatment of Clostridium difficile infection: A systematic meta-analysis - PubMed
There were no significant differences between fidaxomicin and vancomycin in the treatment of CDI in therapeutic effectiveness and adverse reactions, while fidaxomicin was superior to vancomycin in terms of recurrence rate and long-term mortality, and vancomycin is more effective in treating severe C …
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·pubmed.ncbi.nlm.nih.gov·
Efficacy of fidaxomicin versus vancomycin in the treatment of Clostridium difficile infection: A systematic meta-analysis - PubMed
Vaccines and monoclonal antibodies to prevent healthcare-associated bacterial infections - PubMed
Vaccines and monoclonal antibodies to prevent healthcare-associated bacterial infections - PubMed
SUMMARYHealthcare-associated infections (HAIs) represent a burden for public health with a high prevalence and high death rates associated with them. Pathogens with a high potential for antimicrobial resistance, such as ESKAPE pathogens (Enterococcus faecium, S …
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·pubmed.ncbi.nlm.nih.gov·
Vaccines and monoclonal antibodies to prevent healthcare-associated bacterial infections - PubMed
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·l.facebook.com·
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Importance of underlying mechanisms for interpreting relative risk of Clostridioides difficile infection among antibiotic-exposed patients in healthcare facilities - PubMed
Importance of underlying mechanisms for interpreting relative risk of Clostridioides difficile infection among antibiotic-exposed patients in healthcare facilities - PubMed
Clostridioides difficile infection (CDI) is a significant public health threat, associated with antibiotic-induced disruption of the normally protective gastrointestinal microbiota. CDI is thought to occur in two stages: acquisition of asymptomatic colonization from ingesting C. difficile bacteria f …
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·pubmed.ncbi.nlm.nih.gov·
Importance of underlying mechanisms for interpreting relative risk of Clostridioides difficile infection among antibiotic-exposed patients in healthcare facilities - PubMed
Importance of underlying mechanisms for interpreting relative risk of Clostridioides difficile infection among antibiotic-exposed patients in healthcare facilities - PubMed
Importance of underlying mechanisms for interpreting relative risk of Clostridioides difficile infection among antibiotic-exposed patients in healthcare facilities - PubMed
Clostridioides difficile infection (CDI) is a significant public health threat, associated with antibiotic-induced disruption of the normally protective gastrointestinal microbiota. CDI is thought to occur in two stages: acquisition of asymptomatic colonization from ingesting C. difficile bacteria f …
C Diff Drug StewardshipC Diff Drug Stewardship
·pubmed.ncbi.nlm.nih.gov·
Importance of underlying mechanisms for interpreting relative risk of Clostridioides difficile infection among antibiotic-exposed patients in healthcare facilities - PubMed
Disturbances of the gut microbiota-derived tryptophan metabolites as key actors in vagotomy-induced mastitis in mice - PubMed
Disturbances of the gut microbiota-derived tryptophan metabolites as key actors in vagotomy-induced mastitis in mice - PubMed
Previous studies have demonstrated that gut microbiota dysbiosis promotes the development of mastitis. The interaction of the vagus nerve and gut microbiota endows host homeostasis and regulates disease development, but whether the vagus nerve participates in the pathogenesis of mastitis is unclear. …
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·pubmed.ncbi.nlm.nih.gov·
Disturbances of the gut microbiota-derived tryptophan metabolites as key actors in vagotomy-induced mastitis in mice - PubMed
Mouse adaptation of human inflammatory bowel diseases microbiota enhances colonization efficiency and alters microbiome aggressiveness depending on the recipient colonic inflammatory environment - PubMed
Mouse adaptation of human inflammatory bowel diseases microbiota enhances colonization efficiency and alters microbiome aggressiveness depending on the recipient colonic inflammatory environment - PubMed
Our findings support a model of IBD pathogenesis in which host inflammation promotes aggressive resident bacteria, which further drives a feed-forward process of dysbiosis exacerbated by gut inflammation. This model implies that effective management of IBD requires treating both the dysregulated hos …
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·pubmed.ncbi.nlm.nih.gov·
Mouse adaptation of human inflammatory bowel diseases microbiota enhances colonization efficiency and alters microbiome aggressiveness depending on the recipient colonic inflammatory environment - PubMed
Multi-omics analysis reveals a feedback loop amplifying immune responses in acute graft-versus-host disease due to imbalanced gut microbiota and bile acid metabolism - PubMed
Multi-omics analysis reveals a feedback loop amplifying immune responses in acute graft-versus-host disease due to imbalanced gut microbiota and bile acid metabolism - PubMed
Acute graft-versus-host disease (aGVHD) is primarily driven by allogeneic donor T cells associated with an altered composition of the host gut microbiome and its metabolites. The severity of aGVHD after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is not solely determined by the ho …
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·pubmed.ncbi.nlm.nih.gov·
Multi-omics analysis reveals a feedback loop amplifying immune responses in acute graft-versus-host disease due to imbalanced gut microbiota and bile acid metabolism - PubMed
The Effects of Opioid Administration on Clostridioides Difficile Infection: A Retrospective Cohort Study - PubMed
The Effects of Opioid Administration on Clostridioides Difficile Infection: A Retrospective Cohort Study - PubMed
Background: Clostridioides difficile (C. difficile) is a leading cause of healthcare-associated infections. Using opioids while infected with C. difficile may hypothetically lead to reduced clearance of the organism and higher risk of progressing to severe or fulminant in …
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·pubmed.ncbi.nlm.nih.gov·
The Effects of Opioid Administration on Clostridioides Difficile Infection: A Retrospective Cohort Study - PubMed
NASDAQAnnounces New Data on NRX-101 Demonstrating No Damage to Intestinal and Vaginal Flora in Validated Rodent Models Compared to Standard Antibiotics: Potential Implications for Avoidance of C. Difficile infections
NASDAQAnnounces New Data on NRX-101 Demonstrating No Damage to Intestinal and Vaginal Flora in Validated Rodent Models Compared to Standard Antibiotics: Potential Implications for Avoidance of C. Difficile infections
/PRNewswire/ -- NRx Pharmaceuticals, Inc. (Nasdaq:NRXP) ("NRx Pharmaceuticals", "NRx", the "Company"), a clinical-stage biopharmaceutical company, today...
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·prnewswire.com·
NASDAQAnnounces New Data on NRX-101 Demonstrating No Damage to Intestinal and Vaginal Flora in Validated Rodent Models Compared to Standard Antibiotics: Potential Implications for Avoidance of C. Difficile infections
The Impact of Microbiome Dysbiosis on Hematopoietic Stem Cell Transplantation Outcomes: A Review Article - PubMed
The Impact of Microbiome Dysbiosis on Hematopoietic Stem Cell Transplantation Outcomes: A Review Article - PubMed
Microbiome dysbiosis has emerged as a critical factor influencing the outcomes of hematopoietic stem cell transplantation (HSCT). This comprehensive review delves into the intricate relationship between microbiome composition and HSCT outcomes, highlighting the mechanisms through which dysbiosis imp …
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·pubmed.ncbi.nlm.nih.gov·
The Impact of Microbiome Dysbiosis on Hematopoietic Stem Cell Transplantation Outcomes: A Review Article - PubMed
Polystyrene microplastics aggravate radiation-induced intestinal injury in mice - PubMed
Polystyrene microplastics aggravate radiation-induced intestinal injury in mice - PubMed
Radiotherapy is a common treatment for abdominal and pelvic tumors, while the radiation-induced intestinal injury (RIII) is one of the major side-effects of radiotherapy, which reduces the life quality and impedes the treatment completion of cancer patients. Previous studies have demonstrated that e …
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·pubmed.ncbi.nlm.nih.gov·
Polystyrene microplastics aggravate radiation-induced intestinal injury in mice - PubMed
When can we cure Crohn's? - PubMed
When can we cure Crohn's? - PubMed
Crohn's disease is a life-long idiopathic inflammatory disease which affects the entire gastrointestinal tract and occasionally extra-intestinal organs. CD is thought to result from complex interactions between environmental factors, the gut microbes, and the genetic background and the immune system …
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·pubmed.ncbi.nlm.nih.gov·
When can we cure Crohn's? - PubMed
Higher alpha diversity and Lactobacillus blooms are associated with better engraftment after fecal microbiota transplant in inflammatory bowel disease - PubMed
Higher alpha diversity and Lactobacillus blooms are associated with better engraftment after fecal microbiota transplant in inflammatory bowel disease - PubMed
Fecal Microbiota Transplant (FMT) has shown some success in treating inflammatory bowel diseases (IBD). There is emerging evidence that host engraftment of donor taxa is a tenet of successful FMT. We undertook a double-blind, randomized, placebo-controlled pilot study to characterize the response to …
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·pubmed.ncbi.nlm.nih.gov·
Higher alpha diversity and Lactobacillus blooms are associated with better engraftment after fecal microbiota transplant in inflammatory bowel disease - PubMed
Q&A: Biologic drugs are reinvented to treat infectious diseases
Q&A: Biologic drugs are reinvented to treat infectious diseases
Lumen scientists were the first to crack that long-standing barrier. Once that was done, we started looking around for useful applications. To our surprise, we discovered that there is actually a very robust literature on orally delivered therapeutic proteins, although most people are unaware of it.
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·digitaljournal.com·
Q&A: Biologic drugs are reinvented to treat infectious diseases
Therapeutic interventions for gut dysbiosis and related disorders in the elderly: antibiotics, probiotics or faecal microbiota transplantation? - PubMed
Therapeutic interventions for gut dysbiosis and related disorders in the elderly: antibiotics, probiotics or faecal microbiota transplantation? - PubMed
Ageing and physiological functions of the human body are inversely proportional to each other. The gut microbiota and host immune system co-evolve from infants to the elderly. Ageing is accompanied by a decline in gut microbial diversity, immunity and metabolism, which increases susceptibility to in …
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·pubmed.ncbi.nlm.nih.gov·
Therapeutic interventions for gut dysbiosis and related disorders in the elderly: antibiotics, probiotics or faecal microbiota transplantation? - PubMed
Link between gut microbiota dysbiosis and childhood asthma: Insights from a systematic review - PubMed
Link between gut microbiota dysbiosis and childhood asthma: Insights from a systematic review - PubMed
Asthma, a chronic inflammatory disorder of the airways, is a prevalent childhood chronic disease with a substantial global health burden. The complex etiology and pathogenesis of asthma involve genetic and environmental factors, posing challenges in diagnosis, severity prediction, and therapeutic st …
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·pubmed.ncbi.nlm.nih.gov·
Link between gut microbiota dysbiosis and childhood asthma: Insights from a systematic review - PubMed
Reproducible chemostat cultures to minimize eukaryotic viruses from fecal transplant material - PubMed
Reproducible chemostat cultures to minimize eukaryotic viruses from fecal transplant material - PubMed
Recent studies indicate an important role of bacteriophages for successful fecal microbiota transplantation (FMT). However, wider clinical applications of FMT are hampered by to donor variability and concerns of infection risks by bacteria and human viruses. To overcome these challenges, mouse cecal …
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·pubmed.ncbi.nlm.nih.gov·
Reproducible chemostat cultures to minimize eukaryotic viruses from fecal transplant material - PubMed
The fecal microbiota of patients with primary biliary cholangitis (PBC) causes PBC-like liver lesions in mice and exacerbates liver damage in a mouse model of PBC - PubMed
The fecal microbiota of patients with primary biliary cholangitis (PBC) causes PBC-like liver lesions in mice and exacerbates liver damage in a mouse model of PBC - PubMed
The role of the gut microbiota in the occurrence and progression of primary biliary cholangitis (PBC) is not fully understood. First, the fecal microbiota of patients with PBC (n = 4) (PBC-FMT) or healthy individuals (n = 3) (HC-FMT) was transplanted into pseudo germ-free mice or 2OA-B …
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·pubmed.ncbi.nlm.nih.gov·
The fecal microbiota of patients with primary biliary cholangitis (PBC) causes PBC-like liver lesions in mice and exacerbates liver damage in a mouse model of PBC - PubMed
Frontiers | Potential effectiveness of parenteral nemonoxacin in the treatment of Clostridioides difficile infections: in vitro, ex vivo, and mouse studies
Frontiers | Potential effectiveness of parenteral nemonoxacin in the treatment of Clostridioides difficile infections: in vitro, ex vivo, and mouse studies
Antimicrobial therapy plays a crucial role in the management of CDI patients. However, the standard agent for treating CDIs is limited to oral fidaxomicin or...
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·frontiersin.org·
Frontiers | Potential effectiveness of parenteral nemonoxacin in the treatment of Clostridioides difficile infections: in vitro, ex vivo, and mouse studies
Clostridium septicum manifests a bile salt germinant response mediated by Clostridioides difficile csp gene orthologs - PubMed
Clostridium septicum manifests a bile salt germinant response mediated by Clostridioides difficile csp gene orthologs - PubMed
Clostridium septicum infections are highly predictive of certain malignancies in human patients. To initiate infections, C. septicum spores must first germinate and regain vegetative growth. Yet, what triggers the germination of C. septicum spores is still unknown. Here, we observe that C. septicum …
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·pubmed.ncbi.nlm.nih.gov·
Clostridium septicum manifests a bile salt germinant response mediated by Clostridioides difficile csp gene orthologs - PubMed
High Prevalence of Multistep Algorithms in Diagnostic Clostridioides difficile Laboratory Testing - PubMed
High Prevalence of Multistep Algorithms in Diagnostic Clostridioides difficile Laboratory Testing - PubMed
Multistep algorithms for CDI diagnosis are widely used in line with published recommendations. Most respondents reported rejection of formed stool for CDI testing, but few reported rejection of testing in infants and patients taking laxatives, suggesting these may be areas of opportunity for laborat …
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·pubmed.ncbi.nlm.nih.gov·
High Prevalence of Multistep Algorithms in Diagnostic Clostridioides difficile Laboratory Testing - PubMed
Clostridioides difficile infection following COVID-19: A nationwide analysis using routine surveillance data in Wales - PubMed
Clostridioides difficile infection following COVID-19: A nationwide analysis using routine surveillance data in Wales - PubMed
Findings suggest a relationship between COVID-19 and CDI. However, incidence of CDI following COVID-19 was a rare outcome generally, suggesting other factors are likely contributing to the increased rates of CDI observed since 2020.
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·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile infection following COVID-19: A nationwide analysis using routine surveillance data in Wales - PubMed
Comparing treatment effects on dogs with acute hemorrhagic diarrhea syndrome: fecal microbiota transplantation, symptomatic therapy, or antibiotic treatment - PubMed
Comparing treatment effects on dogs with acute hemorrhagic diarrhea syndrome: fecal microbiota transplantation, symptomatic therapy, or antibiotic treatment - PubMed
Overall, in dogs with AHDS, neither FMT nor AT resulted in faster clinical improvement. In addition, C perfringens strains are self-limiting and do not require antibiotic therapy.
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·pubmed.ncbi.nlm.nih.gov·
Comparing treatment effects on dogs with acute hemorrhagic diarrhea syndrome: fecal microbiota transplantation, symptomatic therapy, or antibiotic treatment - PubMed