Antibiotic for Treating Deadly Superbug C. difficile May No Longer Be Effective
Vancomycin, the first line of treatment for C. difficile infection, is becoming less effective.
C Diff Treatment
Comparison of rectal swabs and fecal samples for the detection of Clostridioides difficile infections with a new in-house PCR assay - PubMed
Clostridioides difficile infection (CDI) is the leading cause of healthcare-associated diarrhea, resulting in high morbidity, mortality, and economic burden. In clinical laboratories, CDI testing is currently performed on stool samples collected from patients with diarrhea. However, the diagn …
C Diff DiagnosisEffect of Leptin Receptor Q223R Polymorphism on Clostridioides difficile Infection-Induced Macrophage Migration Inhibitory Factor Production - PubMed
Proinflammatory cytokine levels and host genetic makeup are key determinants of Clostridioides difficile infection (CDI) outcomes. We previously reported that blocking the inflammatory cytokine macrophage migration inhibitory factor (MIF) ameliorates CDI. Here, we determined kinetics of MIF producti …
C Diff MolecularCorrection to: A review of fecal microbiota, live-jslm for the prevention of recurrent Clostridioides difficile infection - PubMed
Correction to: A review of fecal microbiota, live-jslm for the prevention of recurrent Clostridioides difficile infection
FMTDeficiency of IL-22-binding protein enhances the ability of the gut microbiota to protect against enteric pathogens - PubMed
Interleukin 22 (IL-22) promotes intestinal barrier integrity, stimulating epithelial cells to enact defense mechanisms against enteric infections, including the production of antimicrobial peptides. IL-22 binding protein (IL-22BP) is a soluble decoy encoded by the Il22ra2 gene that decreases …
X-ray structure and mutagenesis analyses of Clostridioides difficile endolysin Ecd09610 glucosaminidase domain - PubMed
Clostridioides difficile endolysin (Ecd09610) consists of an unknown domain at its N terminus, followed by two catalytic domains, a glucosaminidase domain and endopeptidase domain. X-ray structure and mutagenesis analyses of the Ecd09610 catalytic domain with glucosaminidase activity (Ecd09610CD53) …
Fecal microbiota transplantation for irritable bowel syndrome: Current evidence and perspectives - PubMed
In this editorial we comment on the article published in the recent issue of the World journal of Gastroenterology. We focus specifically on the mechanisms un-derlying the effects of fecal microbiota transplantation (FMT) for irritable bowel syndrome (IBS), the factors which affect the outcom …
Histidine kinase-mediated cross-regulation of the vancomycin-resistance operon in Clostridioides difficile - PubMed
The dipeptide D-Ala-D-Ala is an essential component of peptidoglycan and the target of vancomycin. Most Clostridioides difficile strains possess the vanG operon responsible for the synthesis of D-Ala-D-Ser, which can replace D-Ala-D-Ala in peptidoglycan. The C. difficile vanG operon is regulated by …
Post-infectious ibs following Clostridioides difficile infection; role of microbiota and implications for treatment - PubMed
Up to 25% of patients recovering from antibiotic-treated Clostridioides difficile infection (CDI) develop functional symptoms reminiscent of Post-Infectious Irritable Bowel Syndrome (PI-IBS). For patients with persistent symptoms following infection, a clinical dilemma arises as to whether to provid …
Clostridiodes difficile infection in inflammatory bowel disease: a clinical review - PubMed
Available studies show that the prevalence of CDI-IBD is not optimistic. Currently, potential treatment options for CDI-IBD include a number of probiotics and novel antibiotics. This review updates the knowledge on the management of CDI in IBD patients, which is timely and important for GI doctors a …
Theophylline-based control of repA on a Clostridioides difficile plasmid for use in allelic exchange - PubMed
Historically, mutagenesis in the non-model enteropathogenic bacterium Clostridioides difficile has been challenging. Developing a versatile and reliable method of generating targeted mutations in C. difficile is important to further our understanding of its pathogenesis. Some of the most common targ …
Scutellaria baicalensis Georgi alleviates Clostridium difficile associated diarrhea and its modulatory effects on the gut microbiota - PubMed
The growing incidence of Clostridium difficile associated diarrhea (CDAD) underscores the urgency for potent treatments. This research delves into the therapeutic potential of Scutellaria baicalensis Georgi (Lamiaceae) root (SR) in addressing CDAD and its influence on gut microbiota. Using a CDAD mo …
Management and Outcomes of Patients at a Specialty Clinic for Clostridioides difficile Infection - PubMed
Vancomycin and fidaxomicin taper regimens were the most common treatment strategies employed but nearly half of patients (40/83) referred to our Clostridioides difficile infection (CDI) clinic did not require further treatment. The overall 60-day CDI recurrence rate was 16.9% (11/65). CDI man …
Deficiency of IL-22-binding protein enhances the ability of the gut microbiota to protect against enteric pathogens - PubMed
Interleukin 22 (IL-22) promotes intestinal barrier integrity, stimulating epithelial cells to enact defense mechanisms against enteric infections, including the production of antimicrobial peptides. IL-22 binding protein (IL-22BP) is a soluble decoy encoded by the Il22ra2 gene that decreases …
Impact of including productivity costs in economic analyses of vaccines for C. difficile infections and infant respiratory syncytial virus, in a UK setting - PubMed
Considering productivity costs in future cost-effectiveness analyses of vaccines for C. difficile and RSV will contribute to better-informed reimbursement decisions from a societal perspective.
C Diff Drug DevelopmentComparison of rectal swabs and fecal samples for the detection of Clostridioides difficile infections with a new in-house PCR assay - PubMed
Clostridioides difficile infection (CDI) is the leading cause of healthcare-associated diarrhea, resulting in high morbidity, mortality, and economic burden. In clinical laboratories, CDI testing is currently performed on stool samples collected from patients with diarrhea. However, the diagn …
Effect of Leptin Receptor Q223R Polymorphism on Clostridioides difficile Infection-Induced Macrophage Migration Inhibitory Factor Production - PubMed
Proinflammatory cytokine levels and host genetic makeup are key determinants of Clostridioides difficile infection (CDI) outcomes. We previously reported that blocking the inflammatory cytokine macrophage migration inhibitory factor (MIF) ameliorates CDI. Here, we determined kinetics of MIF producti …
Histidine kinase-mediated cross-regulation of the vancomycin-resistance operon in Clostridioides difficile - PubMed
The dipeptide D-Ala-D-Ala is an essential component of peptidoglycan and the target of vancomycin. Most Clostridioides difficile strains possess the vanG operon responsible for the synthesis of D-Ala-D-Ser, which can replace D-Ala-D-Ala in peptidoglycan. The C. difficile vanG operon is regulated by …
Enhancing Clostridium difficile Treatment and Prevention Efforts
Insights from Dr. Md Zahidul Alam on treatments and prevention strategies for C difficile infection (CDI), supported by the CDC's recent study on CDI management in healthcare settings.
Microbial Symphony: Exploring the Role of the Gut in Osteoarthritis-Related Pain. A Narrative Review - PubMed
One of the most common musculoskeletal disorders, osteoarthritis (OA), causes worldwide disability, morbidity, and poor quality of life by degenerating articular cartilage, modifying subchondral bone, and inflaming synovial membranes. OA pathogenesis pathways must be understood to generate new preve …
Rejuvenating fecal microbiota transplant enhances peripheral nerve repair in aged mice by modulating endoneurial inflammation - PubMed
Peripheral nerve injury (PNI) resulting from trauma or neuropathies can cause significant disability, and its prognosis deteriorates with age. Emerging evidence suggests that gut dysbiosis and reduced fecal short-chain fatty acids (SCFAs) contribute to an age-related systemic hyperinflammation (infl …
Fecal microbiota transplantation for recurrent C. difficile infection can be the best therapeutic option in severely immunocompromised patients depending on a case-by-case assessment of the benefit/risk ratio - PubMed
Fecal microbiota transplantation for recurrent C. difficile infection can be the best therapeutic option in severely immunocompromised patients depending on a case-by-case assessment of the benefit/risk ratio
Metastasis and the Microbiome: The Impact of Bacteria in Disseminated Colorectal Cancer - PubMed
Metastasis remains a leading cause of mortality for patients with solid tumors. An expanding body of literature suggests interplay between the host, gut, and tumoral microbiomes may play a role in cancer initiation and distant dissemination. These associations have been particularly well-studied in …
Safety and efficacy of faecal microbiota transplantation in patients with mild to moderate Parkinson's disease (GUT-PARFECT): a double-blind, placebo-controlled, randomised, phase 2 trial - PubMed
Flemish PD patient organizations (VPL and Parkili), Research Foundation Flanders (FWO), Biocodex Microbiota Foundation.
FMT Therapy Effective Preventing C. Difficile
Treatment with FMT is effective for preventing recurrent Clostridioides difficile infection in adults with robust immune systems, for whom standard antibiotics do ...
C. diff Update: Tips to Treat a Stubborn Infection
Managing emClostridioides difficile/em infection is a challenge that requires a multipronged approach.
Fecal Microbiota Products
Use of the new fecal microbiota products following antibiotics in the treatment of recurrent Clostridioides difficile infection resulted in low rates of CDI ...
C. diff in 2024: New Treatments For a Stubborn Problem
The key to understanding and effectively treating Clostridioides difficile infection is noting its two phases: the vegetative state that releases toxins and causes ...
FMT Therapy Effective Preventing C. Difficile
Treatment with FMT is effective for preventing recurrent C. diff infection in adults with robust immune systems, for whom standard antibiotics do not eliminate the ...
Hospital Acquired Infections and C. diff. Is My Hospital Safe?
There isn’t a hospital in the country that isn’t battling against C. diff. infection. We are not winning the war against this crafty and cunning ...
C Diff Prevention