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Incorporating patient, nursing and environmental factors into antimicrobial stewardship: effects of simplifying treatment from cefuroxime to ceftriaxone - PubMed
Incorporating patient, nursing and environmental factors into antimicrobial stewardship: effects of simplifying treatment from cefuroxime to ceftriaxone - PubMed
This simplification of our AG from a three-times-daily to a once-daily antibiotic resulted in considerable savings for our hospital (roughly 1.7 full-time equivalent nurses and over a tonne of waste yearly), with no significant increases in CDI or 3GCR-E. The impact of dosing schedules on non-antibi …
·pubmed.ncbi.nlm.nih.gov·
Incorporating patient, nursing and environmental factors into antimicrobial stewardship: effects of simplifying treatment from cefuroxime to ceftriaxone - PubMed
Impact of time to treatment in first occurrence, non-severe Clostridioides difficile infection for elderly patients: are we waiting too long to treat? - PubMed
Impact of time to treatment in first occurrence, non-severe Clostridioides difficile infection for elderly patients: are we waiting too long to treat? - PubMed
Delayed CDI treatment was associated with disease progression and could represent an important antimicrobial stewardship measure with future evaluation.
·pubmed.ncbi.nlm.nih.gov·
Impact of time to treatment in first occurrence, non-severe Clostridioides difficile infection for elderly patients: are we waiting too long to treat? - PubMed
Incidence, Clinical Characteristics, and Outcomes of Clostridium difficile Infection in a Tertiary Care Center in Bahrain - PubMed
Incidence, Clinical Characteristics, and Outcomes of Clostridium difficile Infection in a Tertiary Care Center in Bahrain - PubMed
Background Clostridioides difficile infection (CDI) represents a significant healthcare challenge associated with antibiotic use and healthcare settings. While healthcare facility-onset CDI (HO-CDI) rates have been extensively studied, the incidence and risk factors of CDI in various settings …
·pubmed.ncbi.nlm.nih.gov·
Incidence, Clinical Characteristics, and Outcomes of Clostridium difficile Infection in a Tertiary Care Center in Bahrain - PubMed
Derivation and internal validation of the multivariate toxigenic C. difficile diarrhea model and risk score for emergency room and hospitalized patients with diarrhea - PubMed
Derivation and internal validation of the multivariate toxigenic C. difficile diarrhea model and risk score for emergency room and hospitalized patients with diarrhea - PubMed
TCdD risk can be predicted using readily available clinical risk factors with modest accuracy.
·pubmed.ncbi.nlm.nih.gov·
Derivation and internal validation of the multivariate toxigenic C. difficile diarrhea model and risk score for emergency room and hospitalized patients with diarrhea - PubMed
Clostridioides difficile infection, recurrence and the associated healthcare consumption in Sweden between 2006 and 2019: a population-based cohort study - BMC Infectious Diseases
Clostridioides difficile infection, recurrence and the associated healthcare consumption in Sweden between 2006 and 2019: a population-based cohort study - BMC Infectious Diseases
Background Clostridioides difficile infection (CDI) causes a major burden to individuals and society, yet the impact may vary depending on age, sex, underlying comorbidities and where CDI was acquired (hospital or community). Methods This Swedish nationwide population-based cohort study (2006–2019) compared all 43,150 individuals with CDI to their 355,172 matched controls (first year and entire follow-up). Negative binomial regression models compared the cumulated length of stay, number of in-hospital admissions, outpatient visits and prescriptions after the first CDI episode expressed as incidence rate ratios (IRR) and 95% confidence intervals for the entire follow-up. Results Overall, 91.6% of CDI cases were hospital acquired, and 16.8% presented with recurrence(s); 74.8%of cases were ≥ 65 years and 54.2% were women. Compared to individuals without CDI, in-hospital stay rates were 18.01 times higher after CDI (95% CI 17.40–18.63, first-year: 27.4 versus 1.6 days), 9.45 times higher in-hospital admission (95% CI 9.16–9.76, first-year: 2.6 versus 1.3 hospitalisations), 3.94 times higher outpatient visit (95% CI 3.84–4.05, first-year: 4.0 versus 1.9 visits) and 3.39 times higher dispensed prescriptions rates (95% CI 3.31–3.48, first-year: 25.5 versus 13.7 prescriptions). For all outcomes, relative risks were higher among the younger (
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Clostridioides difficile infection, recurrence and the associated healthcare consumption in Sweden between 2006 and 2019: a population-based cohort study - BMC Infectious Diseases
Microbiota Therapeutics Could Become Strong Ally in IBD Treatment
Microbiota Therapeutics Could Become Strong Ally in IBD Treatment
Novel therapeutics could offer clinicians an additional tool in developing their patient treatment plans, particularly for those with no response or resistance to existing therapies.
·news.google.com·
Microbiota Therapeutics Could Become Strong Ally in IBD Treatment
Gut-lung axis and asthma: A historical review on mechanism and future perspective - PubMed
Gut-lung axis and asthma: A historical review on mechanism and future perspective - PubMed
The gut-lung axis has a bidirectional effect on asthma. Gut microecology imbalance contributes to asthma through bacterial structural components and metabolites. Asthma, in turn, can also cause intestinal damage through inflammation throughout the body. The manipulation of gut microbiota through pro …
·pubmed.ncbi.nlm.nih.gov·
Gut-lung axis and asthma: A historical review on mechanism and future perspective - PubMed
Unlocking the gut-heart axis: exploring the role of gut microbiota in cardiovascular health and disease - PubMed
Unlocking the gut-heart axis: exploring the role of gut microbiota in cardiovascular health and disease - PubMed
The gut microbiota is emerging as a potential therapeutic target for CVD prevention and management. However, current research has limitations, including the need for larger and more diverse studies, the challenges of establishing causality, and concerns regarding the long-term consequences and safet …
·pubmed.ncbi.nlm.nih.gov·
Unlocking the gut-heart axis: exploring the role of gut microbiota in cardiovascular health and disease - PubMed
Buty and the beast: the complex role of butyrate in Parkinson's disease - PubMed
Buty and the beast: the complex role of butyrate in Parkinson's disease - PubMed
Parkinson's disease (PD) is a complex neurodegenerative disease which is often associated with gastrointestinal (GI) dysfunction. The GI tract is home to a wide range of microorganisms, among which bacteria, that can influence the host through various mechanisms. Products produced by these bacteria …
·pubmed.ncbi.nlm.nih.gov·
Buty and the beast: the complex role of butyrate in Parkinson's disease - PubMed
The Many Faces of Metabolic Dysfunction-Associated Fatty Liver Disease Treatment: From the Mediterranean Diet to Fecal Microbiota Transplantation - PubMed
The Many Faces of Metabolic Dysfunction-Associated Fatty Liver Disease Treatment: From the Mediterranean Diet to Fecal Microbiota Transplantation - PubMed
The gastrointestinal tract is inhabited by the gut microbiota. The main phyla are Firmicutes and Bacteroidetes. In non-alcoholic fatty liver disease, now renamed metabolic dysfunction-associated fatty liver disease (MAFLD), an alteration in Firmicutes and Bacteroidetes abundance promotes its pathoge …
·pubmed.ncbi.nlm.nih.gov·
The Many Faces of Metabolic Dysfunction-Associated Fatty Liver Disease Treatment: From the Mediterranean Diet to Fecal Microbiota Transplantation - PubMed
Dysbiosis in Inflammatory Bowel Disease and Spondyloarthritis: Still a Long Way to Go? - PubMed
Dysbiosis in Inflammatory Bowel Disease and Spondyloarthritis: Still a Long Way to Go? - PubMed
The association between Inflammatory Bowel Disease (IBD) and Spondyloarthritis (SpA) has been known for years, as has the concept that IBD is associated with an altered intestinal bacterial composition, a condition known as "dysbiosis". Recently, a state of intestinal dysbiosis has also been found i …
·pubmed.ncbi.nlm.nih.gov·
Dysbiosis in Inflammatory Bowel Disease and Spondyloarthritis: Still a Long Way to Go? - PubMed
Complementary Therapeutic Effect of Fecal Microbiota Transplantation in Ulcerative Colitis after the Response to Anti-Tumor Necrosis Factor Alpha Agent Was Lost: A Case Report - PubMed
Complementary Therapeutic Effect of Fecal Microbiota Transplantation in Ulcerative Colitis after the Response to Anti-Tumor Necrosis Factor Alpha Agent Was Lost: A Case Report - PubMed
In patients with ulcerative colitis (UC), the development of an antidrug antibody (ADA) to anti-tumor necrosis factor (TNF)α agent is a crucial problem which aggravates the clinical course of the disease, being cited as one of the most common causes for discontinuing anti-TNFα treatment. This is due …
·pubmed.ncbi.nlm.nih.gov·
Complementary Therapeutic Effect of Fecal Microbiota Transplantation in Ulcerative Colitis after the Response to Anti-Tumor Necrosis Factor Alpha Agent Was Lost: A Case Report - PubMed
Modulating gut microbiome in cancer immunotherapy: Harnessing microbes to enhance treatment efficacy - PubMed
Modulating gut microbiome in cancer immunotherapy: Harnessing microbes to enhance treatment efficacy - PubMed
Immunotherapy has emerged as a robust approach against cancer, yet its efficacy has varied among individuals, accompanied by the occurrence of immune-related adverse events. As a result, the efficacy of immunotherapy is far from satisfactory, and enormous efforts have been invested to develop strate …
·pubmed.ncbi.nlm.nih.gov·
Modulating gut microbiome in cancer immunotherapy: Harnessing microbes to enhance treatment efficacy - PubMed
Phlorizin Limits Bovine Viral Diarrhea Virus Infection in Mice via Regulating Gut Microbiota Composition - PubMed
Phlorizin Limits Bovine Viral Diarrhea Virus Infection in Mice via Regulating Gut Microbiota Composition - PubMed
Phlorizin (PHZ) is one of the main pharmacologically active ingredients in Lithocarpus polystachyus. We have previously shown that PHZ inhibits the replication of bovine viral diarrhea virus (BVDV), but the exact antiviral mechanism, especially in vivo, is still unknown. Here, we furth …
·pubmed.ncbi.nlm.nih.gov·
Phlorizin Limits Bovine Viral Diarrhea Virus Infection in Mice via Regulating Gut Microbiota Composition - PubMed
Microbial perspective on the skin-gut axis and atopic dermatitis - PubMed
Microbial perspective on the skin-gut axis and atopic dermatitis - PubMed
Atopic dermatitis (AD) is a relapsing inflammatory skin condition that has become a global health issue with complex etiology and mounting prevalence. The association of AD with skin and gut microbiota has been revealed by virtue of the continuous development of sequencing technology and genomics an …
·pubmed.ncbi.nlm.nih.gov·
Microbial perspective on the skin-gut axis and atopic dermatitis - PubMed
[Buzhong Yiqi Decoction ameliorates spleen deficiency syndrome by regulating gut microbiota] - PubMed
[Buzhong Yiqi Decoction ameliorates spleen deficiency syndrome by regulating gut microbiota] - PubMed
This study aims to decipher the mechanism of Buzhong Yiqi Decoction(BZYQD) in the treatment of spleen deficiency syndrome via gut microbiota. The mouse models of spleen deficiency syndrome were established by fecal microbiota transplantation(FMT, from patients with spleen deficiency syndrome) and ad …
·pubmed.ncbi.nlm.nih.gov·
[Buzhong Yiqi Decoction ameliorates spleen deficiency syndrome by regulating gut microbiota] - PubMed
Microbiota therapeutics for inflammatory bowel disease: the way forward - PubMed
Microbiota therapeutics for inflammatory bowel disease: the way forward - PubMed
Microbiota therapeutics that transplant faecal material from healthy donors to people with mild-to-moderate ulcerative colitis have shown the potential to induce remission in about 30% of participants in small, phase 2 clinical trials. Despite this substantial achievement, the field needs to leverag …
·pubmed.ncbi.nlm.nih.gov·
Microbiota therapeutics for inflammatory bowel disease: the way forward - PubMed
Safety profile and effects on the peripheral immune response of fecal microbiota transplantation in clinically healthy dogs - PubMed
Safety profile and effects on the peripheral immune response of fecal microbiota transplantation in clinically healthy dogs - PubMed
Fecal microbiota transplantation did not significantly alter the evaluated variables and recipients experienced minimal adverse events associated with FMT administration. Fecal microbiota transplantation was not associated with serious adverse events, changes in peripheral immunologic variables, or …
·pubmed.ncbi.nlm.nih.gov·
Safety profile and effects on the peripheral immune response of fecal microbiota transplantation in clinically healthy dogs - PubMed
Gut-Liver Axis Dysregulation in Portal Hypertension: Emerging Frontiers - PubMed
Gut-Liver Axis Dysregulation in Portal Hypertension: Emerging Frontiers - PubMed
Portal hypertension (PH) is a complex clinical challenge with severe complications, including variceal bleeding, ascites, hepatic encephalopathy, and hepatorenal syndrome. The gut microbiota (GM) and its interconnectedness with human health have emerged as a captivating field of research. This revie …
·pubmed.ncbi.nlm.nih.gov·
Gut-Liver Axis Dysregulation in Portal Hypertension: Emerging Frontiers - PubMed
Alterations in gut microbiota contribute to cognitive deficits induced by chronic infection of Toxoplasma gondii - PubMed
Alterations in gut microbiota contribute to cognitive deficits induced by chronic infection of Toxoplasma gondii - PubMed
Chronic infection with Toxoplasma gondii (T. gondii) emerges as a risk factor for neurodegenerative diseases in animals and humans. However, the underlying mechanisms are largely unknown. We aimed to investigate whether gut microbiota and its metabolites play a role in T. gondii-induced cognitive de …
·pubmed.ncbi.nlm.nih.gov·
Alterations in gut microbiota contribute to cognitive deficits induced by chronic infection of Toxoplasma gondii - PubMed
Comparison of rectal swabs and fecal samples for the detection of Clostridioides difficile infections with a new in-house PCR assay - PubMed
Comparison of rectal swabs and fecal samples for the detection of Clostridioides difficile infections with a new in-house PCR assay - PubMed
Clostridioides difficile infection (CDI) is the leading cause of healthcare-associated diarrhea, resulting in high morbidity, mortality, and economic burden. In clinical laboratories, CDI testing is currently performed on stool samples collected from patients with diarrhea. However, the diagn …
·pubmed.ncbi.nlm.nih.gov·
Comparison of rectal swabs and fecal samples for the detection of Clostridioides difficile infections with a new in-house PCR assay - PubMed
Effect of Leptin Receptor Q223R Polymorphism on Clostridioides difficile Infection-Induced Macrophage Migration Inhibitory Factor Production - PubMed
Effect of Leptin Receptor Q223R Polymorphism on Clostridioides difficile Infection-Induced Macrophage Migration Inhibitory Factor Production - PubMed
Proinflammatory cytokine levels and host genetic makeup are key determinants of Clostridioides difficile infection (CDI) outcomes. We previously reported that blocking the inflammatory cytokine macrophage migration inhibitory factor (MIF) ameliorates CDI. Here, we determined kinetics of MIF producti …
·pubmed.ncbi.nlm.nih.gov·
Effect of Leptin Receptor Q223R Polymorphism on Clostridioides difficile Infection-Induced Macrophage Migration Inhibitory Factor Production - PubMed
Deficiency of IL-22-binding protein enhances the ability of the gut microbiota to protect against enteric pathogens - PubMed
Deficiency of IL-22-binding protein enhances the ability of the gut microbiota to protect against enteric pathogens - PubMed
Interleukin 22 (IL-22) promotes intestinal barrier integrity, stimulating epithelial cells to enact defense mechanisms against enteric infections, including the production of antimicrobial peptides. IL-22 binding protein (IL-22BP) is a soluble decoy encoded by the Il22ra2 gene that decreases …
·pubmed.ncbi.nlm.nih.gov·
Deficiency of IL-22-binding protein enhances the ability of the gut microbiota to protect against enteric pathogens - PubMed
X-ray structure and mutagenesis analyses of Clostridioides difficile endolysin Ecd09610 glucosaminidase domain - PubMed
X-ray structure and mutagenesis analyses of Clostridioides difficile endolysin Ecd09610 glucosaminidase domain - PubMed
Clostridioides difficile endolysin (Ecd09610) consists of an unknown domain at its N terminus, followed by two catalytic domains, a glucosaminidase domain and endopeptidase domain. X-ray structure and mutagenesis analyses of the Ecd09610 catalytic domain with glucosaminidase activity (Ecd09610CD53) …
·pubmed.ncbi.nlm.nih.gov·
X-ray structure and mutagenesis analyses of Clostridioides difficile endolysin Ecd09610 glucosaminidase domain - PubMed
Fecal microbiota transplantation for irritable bowel syndrome: Current evidence and perspectives - PubMed
Fecal microbiota transplantation for irritable bowel syndrome: Current evidence and perspectives - PubMed
In this editorial we comment on the article published in the recent issue of the World journal of Gastroenterology. We focus specifically on the mechanisms un-derlying the effects of fecal microbiota transplantation (FMT) for irritable bowel syndrome (IBS), the factors which affect the outcom …
·pubmed.ncbi.nlm.nih.gov·
Fecal microbiota transplantation for irritable bowel syndrome: Current evidence and perspectives - PubMed
Histidine kinase-mediated cross-regulation of the vancomycin-resistance operon in Clostridioides difficile - PubMed
Histidine kinase-mediated cross-regulation of the vancomycin-resistance operon in Clostridioides difficile - PubMed
The dipeptide D-Ala-D-Ala is an essential component of peptidoglycan and the target of vancomycin. Most Clostridioides difficile strains possess the vanG operon responsible for the synthesis of D-Ala-D-Ser, which can replace D-Ala-D-Ala in peptidoglycan. The C. difficile vanG operon is regulated by …
·pubmed.ncbi.nlm.nih.gov·
Histidine kinase-mediated cross-regulation of the vancomycin-resistance operon in Clostridioides difficile - PubMed