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Reduction of product composition variability using pooled microbiome ecosystem therapy and consequence in two infectious murine models - PubMed
Reduction of product composition variability using pooled microbiome ecosystem therapy and consequence in two infectious murine models - PubMed
Growing evidence demonstrates the key role of the gut microbiota in human health and disease. The recent success of microbiotherapy products to treat recurrent Clostridioides difficile infection has shed light on its potential in conditions associated with gut dysbiosis, such as acute graft-v …
·pubmed.ncbi.nlm.nih.gov·
Reduction of product composition variability using pooled microbiome ecosystem therapy and consequence in two infectious murine models - PubMed
COVID-19 and Clostridioides difficile Coinfection Analysis in the Intensive Care Unit - PubMed
COVID-19 and Clostridioides difficile Coinfection Analysis in the Intensive Care Unit - PubMed
Since the emergence of SARS-CoV-2 in late 2019, the global mortality attributable to COVID-19 has reached 6,972,152 deaths according to the World Health Organization (WHO). The association between coinfection with Clostridioides difficile (CDI) and SARS-CoV-2 has limited data in the literatur …
·pubmed.ncbi.nlm.nih.gov·
COVID-19 and Clostridioides difficile Coinfection Analysis in the Intensive Care Unit - PubMed
Efficacy Assessment of the Co-Administration of Vancomycin and Metronidazole in Clostridioides difficile-Infected Mice Based on Changes in Intestinal Ecology - PubMed
Efficacy Assessment of the Co-Administration of Vancomycin and Metronidazole in Clostridioides difficile-Infected Mice Based on Changes in Intestinal Ecology - PubMed
Vancomycin (VAN) and metronidazole (MTR) remain the current drugs of choice for the treatment of non-severe Clostridioides difficile infection (CDI); however, while their co-administration has appeared in clinical treatment, the efficacy varies greatly and the mechanism is unknown. In this st …
·pubmed.ncbi.nlm.nih.gov·
Efficacy Assessment of the Co-Administration of Vancomycin and Metronidazole in Clostridioides difficile-Infected Mice Based on Changes in Intestinal Ecology - PubMed
Clostridioides difficile Colitis - PubMed
Clostridioides difficile Colitis - PubMed
Clostridioides difficile colitis is an important source of hospital-acquired diarrhea associated with antibiotic use. Symptoms are profuse watery diarrhea, typically following a course of antibiotics; however, some cases of fulminant disease may manifest with shock, ileus, or megacolon. Nonfulminant …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile Colitis - PubMed
Colorectal Disease and the Gut Microbiome: What a Surgeon Needs to Know - PubMed
Colorectal Disease and the Gut Microbiome: What a Surgeon Needs to Know - PubMed
The gut microbiome is defined as the microorganisms that reside within the gastrointestinal tract and produce a variety of metabolites that impact human health. These microbes play an intricate role in human health, and an imbalance in the gut microbiome, termed gut dysbiosis, has been implicated in …
·pubmed.ncbi.nlm.nih.gov·
Colorectal Disease and the Gut Microbiome: What a Surgeon Needs to Know - PubMed
Donor screening for fecal microbiota transplantation with a direct stool testing-based strategy: a prospective cohort study - PubMed
Donor screening for fecal microbiota transplantation with a direct stool testing-based strategy: a prospective cohort study - PubMed
Fecal microbiota transplantation (FMT) is effective against recurrent Clostridioides difficile infection (rCDI), but its safety is jeopardized by the potential transmission of pathogens, so international guidelines recommend either a quarantine or a direct stool testing. Whereas reports of the quara …
·pubmed.ncbi.nlm.nih.gov·
Donor screening for fecal microbiota transplantation with a direct stool testing-based strategy: a prospective cohort study - PubMed
Guideline for the management of Clostridioides difficile infection in pediatric patients with cancer and hematopoietic cell transplantation recipients: 2024 update - PubMed
Guideline for the management of Clostridioides difficile infection in pediatric patients with cancer and hematopoietic cell transplantation recipients: 2024 update - PubMed
Our objective was to update a clinical practice guideline for the prevention and treatment of Clostridioides difficile infection (CDI) in pediatric patients with cancer and hematopoietic cell transplantation recipients. We reconvened an international multi-disciplinary panel. A systematic rev …
·pubmed.ncbi.nlm.nih.gov·
Guideline for the management of Clostridioides difficile infection in pediatric patients with cancer and hematopoietic cell transplantation recipients: 2024 update - PubMed
An ultrasensitive genosensor for detection of toxigenic and non-toxigenic Clostridioides difficile based on a conserved sequence in surface layer protein coding gene - PubMed
An ultrasensitive genosensor for detection of toxigenic and non-toxigenic Clostridioides difficile based on a conserved sequence in surface layer protein coding gene - PubMed
Clostridioides difficile (C. difficile) is the most common agent of antibiotic-associated diarrhea, leading to intestinal infection through the secretion of two major toxins. Not all strains of this bacterium are toxigenic, but some of them cause infection via their accessory virulence factors, such …
·pubmed.ncbi.nlm.nih.gov·
An ultrasensitive genosensor for detection of toxigenic and non-toxigenic Clostridioides difficile based on a conserved sequence in surface layer protein coding gene - PubMed
Identifying Contact Time Required for Secondary Transmission of Clostridioides difficile Infections by Using Real-Time Locating System - PubMed
Identifying Contact Time Required for Secondary Transmission of Clostridioides difficile Infections by Using Real-Time Locating System - PubMed
Considering patient room shortages and prevalence of other communicable diseases, reassessing the isolation of patients with Clostridioides difficile infection (CDI) is imperative. We conducted a retrospective study to investigate the secondary CDI transmission rate in a hospital in South Korea, whe …
·pubmed.ncbi.nlm.nih.gov·
Identifying Contact Time Required for Secondary Transmission of Clostridioides difficile Infections by Using Real-Time Locating System - PubMed
Clinical outcomes and treatment necessity in patients with toxin-negative Clostridioides difficile stool samples - PubMed
Clinical outcomes and treatment necessity in patients with toxin-negative Clostridioides difficile stool samples - PubMed
Our study demonstrates that toxin EIA-negative patients had milder laboratory findings and no complications, despite not receiving treatment. Prolonged hospitalisation and exposure to high-risk antibiotics could potentially serve as markers for the development of toxin EIA-positive CDI.
·pubmed.ncbi.nlm.nih.gov·
Clinical outcomes and treatment necessity in patients with toxin-negative Clostridioides difficile stool samples - PubMed
Environmental and Nutritional Parameters Modulating Genetic Expression for Virulence Factors of Clostridioides difficile - PubMed
Environmental and Nutritional Parameters Modulating Genetic Expression for Virulence Factors of Clostridioides difficile - PubMed
Clostridioides difficile infections (CDIs) continue to be a persistent healthcare concern despite newer antibiotic treatments, enhanced infection control practices, and preventive strategies focused on restoring the protective intestinal microbial barrier. Recent strides in gene sequencing re …
·pubmed.ncbi.nlm.nih.gov·
Environmental and Nutritional Parameters Modulating Genetic Expression for Virulence Factors of Clostridioides difficile - PubMed
Genotypic and phenotypic antimicrobial resistance of Irish Clostridioides difficile isolates, 2022 - PubMed
Genotypic and phenotypic antimicrobial resistance of Irish Clostridioides difficile isolates, 2022 - PubMed
Our results suggest that for moxifloxacin, tetracycline and clindamycin, phenotypic resistance in C. difficile can be predicted by genetic indicators and used for public health purposes. However, for the other five antibiotics, the model is not accurate and further development is necessary.
·pubmed.ncbi.nlm.nih.gov·
Genotypic and phenotypic antimicrobial resistance of Irish Clostridioides difficile isolates, 2022 - PubMed
Antimicrobial Effects of Some Natural Products on Adhesion and Biofilm Inhibition of Clostridioides difficile - PubMed
Antimicrobial Effects of Some Natural Products on Adhesion and Biofilm Inhibition of Clostridioides difficile - PubMed
Understanding the potential antimicrobial properties of natural compounds and their impacts on Clostridioides difficile virulence factors may aid in developing alternative strategies for preventing and treating C. difficile infections (CDI). In this study, we investigated the bacterici …
·pubmed.ncbi.nlm.nih.gov·
Antimicrobial Effects of Some Natural Products on Adhesion and Biofilm Inhibition of Clostridioides difficile - PubMed
Perioperative Cefazolin for Total Joint Arthroplasty Patients Who Have a Penicillin Allergy: Is it Safe? - PubMed
Perioperative Cefazolin for Total Joint Arthroplasty Patients Who Have a Penicillin Allergy: Is it Safe? - PubMed
In this series of over 5,500 patients who had a rPCNA undergoing primary TJA, perioperative prophylaxis with cefazolin resulted in a 0.1% incidence of allergic reactions that were clinically indolent. Cefazolin can be safely administered to most patients, independent of rPCNA severity.
·pubmed.ncbi.nlm.nih.gov·
Perioperative Cefazolin for Total Joint Arthroplasty Patients Who Have a Penicillin Allergy: Is it Safe? - PubMed
Fecal microbiota transplantation for recurrent C. difficile infection can be the best therapeutic option in severely immunocompromised patients depending on a case-by-case assessment of the benefit/risk ratio - PubMed
Fecal microbiota transplantation for recurrent C. difficile infection can be the best therapeutic option in severely immunocompromised patients depending on a case-by-case assessment of the benefit/risk ratio - PubMed
Fecal microbiota transplantation for recurrent C. difficile infection can be the best therapeutic option in severely immunocompromised patients depending on a case-by-case assessment of the benefit/risk ratio
·pubmed.ncbi.nlm.nih.gov·
Fecal microbiota transplantation for recurrent C. difficile infection can be the best therapeutic option in severely immunocompromised patients depending on a case-by-case assessment of the benefit/risk ratio - PubMed
Clostridioides difficile infection is associated with differences in transcriptionally active microbial communities - PubMed
Clostridioides difficile infection is associated with differences in transcriptionally active microbial communities - PubMed
Clostridioides difficile infection (CDI) is responsible for around 300,000 hospitalizations yearly in the United States, with the associated monetary cost being billions of dollars. Gut microbiome dysbiosis is known to be important to CDI. To the best of our knowledge, metatranscriptomics (MT …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile infection is associated with differences in transcriptionally active microbial communities - PubMed
E-cadherin of IECs interacts with increasing C. difficile spores in...
E-cadherin of IECs interacts with increasing C. difficile spores in...
Download scientific diagram | E-cadherin of IECs interacts with increasing C. difficile spores in TcdA- and TcdB-intoxicated cells. Differentiated Caco-2 cells were intoxicated with TcdA and TcdB for 8 h at 37°C in DMEM without serum. As a control, cells were incubated with DMEM without serum. Then, cells were infected with C. difficile spores for 1 h at 37°C. Nonpermeabilized cells were stained for accessible E-cadherin (shown as acc Ecad; green), spores (red), and nuclei (blue). (A) Representative 3D projection confocal micrograph of healthy cells infected with C. difficile spores (Ctrl). (A, Right) Magnifications of representative C. difficile spores associated or not with E-cadherin. (B and C) Plot profiles of fluorescence intensity of C. difficile spores (red line) and accessible E-cadherin (shown as Ecad, green line) performed in the white line of panel A. (D) Representative 3D projection confocal micrograph of TcdA- and TcdB-intoxicated cells infected with C. difficile spores. (D, Right) Magnifications of representative C. difficile spores associated or not with E-cadherin. (E and F) Plot profiles of fluorescence intensity of C. difficile spores (red) and accessible E-cadherin (shown as Ecad, in green) performed in the white line of panel D. Repartition of spores that were positive (Ecad+) or negative (Ecad−) associated with fluorescence signal for accessible E-cadherin was shown as the average associated/nonassociated spores with E-cadherin for each field; a total of ~500 spores were analyzed. Fluorophores were digitally reassigned for a better representation. Micrographs are representative of 6 independent fields of 3 different experiments. Error bars indicate mean ± SEM. Statistical analysis was performed by two-tailed unpaired Student’s t test. P ≤ 0.01; ***, P ≤ 0.001. Bars, 10 μm. from publication: Redistribution of the Novel Clostridioides difficile Spore Adherence Receptor E-Cadherin by TcdA and TcdB Increases Spore Binding to Adherens Junctions | Clostridioides difficile causes antibiotic-associated diseases in humans, ranging from mild diarrhea to severe pseudomembranous colitis and death. A major clinical challenge is the prevention of disease recurrence, which affects nearly ~20 to 30% of the patients with a... | Spores, Cadherins and Adherens Junctions | ResearchGate, the professional network for scientists.
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E-cadherin of IECs interacts with increasing C. difficile spores in...
Effects of Prevotella copri on insulin, gut microbiota and bile acids - PubMed
Effects of Prevotella copri on insulin, gut microbiota and bile acids - PubMed
Obesity is becoming a major global health problem in children that can cause diseases such as type 2 diabetes and metabolic disorders, which are closely related to the gut microbiota. However, the underlying mechanism remains unclear. In this study, a significant positive correlation was observed be …
·pubmed.ncbi.nlm.nih.gov·
Effects of Prevotella copri on insulin, gut microbiota and bile acids - PubMed
Short-chain fatty acid-producing bacterial strains attenuate experimental ulcerative colitis by promoting M2 macrophage polarization via JAK/STAT3/FOXO3 axis inactivation - PubMed
Short-chain fatty acid-producing bacterial strains attenuate experimental ulcerative colitis by promoting M2 macrophage polarization via JAK/STAT3/FOXO3 axis inactivation - PubMed
Our approach provides new opportunities to rationally harness live gut probiotic strains and metabolites to reduce intestinal inflammation, restore gut microbial composition, and expedite the development of safe and effective treatments for IBD.
·pubmed.ncbi.nlm.nih.gov·
Short-chain fatty acid-producing bacterial strains attenuate experimental ulcerative colitis by promoting M2 macrophage polarization via JAK/STAT3/FOXO3 axis inactivation - PubMed
The gut commensal Blautia maintains colonic mucus function under low-fiber consumption through secretion of short-chain fatty acids - PubMed
The gut commensal Blautia maintains colonic mucus function under low-fiber consumption through secretion of short-chain fatty acids - PubMed
Beneficial gut bacteria are indispensable for developing colonic mucus and fully establishing its protective function against intestinal microorganisms. Low-fiber diet consumption alters the gut bacterial configuration and disturbs this microbe-mucus interaction, but the specific bacteria and microb …
·pubmed.ncbi.nlm.nih.gov·
The gut commensal Blautia maintains colonic mucus function under low-fiber consumption through secretion of short-chain fatty acids - PubMed
Washed microbiota transplantation for Crohn's disease: A metagenomic, metatranscriptomic, and metabolomic-based study - PubMed
Washed microbiota transplantation for Crohn's disease: A metagenomic, metatranscriptomic, and metabolomic-based study - PubMed
WMT demonstrated therapeutic efficacy in CD treatment, likely due to the effective reconstruction of the patient's microbiome. Multi-omics techniques can effectively help decipher the potential mechanisms of WMT in treating CD.
·pubmed.ncbi.nlm.nih.gov·
Washed microbiota transplantation for Crohn's disease: A metagenomic, metatranscriptomic, and metabolomic-based study - PubMed
Influence of Microbiota on Tumor Immunotherapy - PubMed
Influence of Microbiota on Tumor Immunotherapy - PubMed
The role of the microbiome in immunotherapy has recently garnered substantial attention, with molecular studies and clinical trials providing emerging evidence on the pivotal influence of the microbiota in enhancing therapeutic outcomes via immune response modulation. However, the impact of microbia …
·pubmed.ncbi.nlm.nih.gov·
Influence of Microbiota on Tumor Immunotherapy - PubMed
Gut microbiota and female health - PubMed
Gut microbiota and female health - PubMed
The gut microbiota is recognized as an endocrine organ with the capacity to influence distant organs and associated biological pathways. Recent advancements underscore the critical role of gut microbial homeostasis in female health; with dysbiosis potentially leading to diseases among women such as …
·pubmed.ncbi.nlm.nih.gov·
Gut microbiota and female health - PubMed
[Chinese expert consensus on the clinical diagnosis and treatment of gut microecology in chronic constipation (2024 edition)] - PubMed
[Chinese expert consensus on the clinical diagnosis and treatment of gut microecology in chronic constipation (2024 edition)] - PubMed
Chronic constipation is one of the common gastrointestinal disorders, with an incidence rate that is gradually increasing yearly and becoming an important chronic disease that affects people's health and quality of life. In recent years, significant progress has been made in the basic and clinical r …
·pubmed.ncbi.nlm.nih.gov·
[Chinese expert consensus on the clinical diagnosis and treatment of gut microecology in chronic constipation (2024 edition)] - PubMed
Role of the gut microbiota in tumorigenesis and treatment - PubMed
Role of the gut microbiota in tumorigenesis and treatment - PubMed
The gut microbiota is a crucial component of the intricate microecosystem within the human body that engages in interactions with the host and influences various physiological processes and pathological conditions. In recent years, the association between dysbiosis of the gut microbiota and tumorige …
·pubmed.ncbi.nlm.nih.gov·
Role of the gut microbiota in tumorigenesis and treatment - PubMed