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Proton pump inhibitors for gastrointestinal bleeding prophylaxis in critically ill patients: A systematic review protocol - PubMed
Proton pump inhibitors for gastrointestinal bleeding prophylaxis in critically ill patients: A systematic review protocol - PubMed
This systematic review will provide the most up-to-date evidence regarding the merits and limitations of stress ulcer prophylaxis with PPIs in critically ill patients in contemporary practice.
·pubmed.ncbi.nlm.nih.gov·
Proton pump inhibitors for gastrointestinal bleeding prophylaxis in critically ill patients: A systematic review protocol - PubMed
Characteristics of Patients With Initial Clostridioides difficile Infection (CDI) That Are Associated With Increased Risk of Multiple CDI Recurrences - PubMed
Characteristics of Patients With Initial Clostridioides difficile Infection (CDI) That Are Associated With Increased Risk of Multiple CDI Recurrences - PubMed
Patients with iCDI who are older, on hemodialysis, or had recent hospitalization or nitrofurantoin use had increased risk of mrCDI and may benefit from early use of adjunctive therapy to prevent mrCDI. If confirmed, these findings could aid in clinical decision making and interventional study design …
·pubmed.ncbi.nlm.nih.gov·
Characteristics of Patients With Initial Clostridioides difficile Infection (CDI) That Are Associated With Increased Risk of Multiple CDI Recurrences - PubMed
Novel insights into phage biology of the pathogen Clostridioides difficile based on the active virome - PubMed
Novel insights into phage biology of the pathogen Clostridioides difficile based on the active virome - PubMed
The global pathogen Clostridioides difficile is a well-studied organism, and researchers work on unraveling its fundamental virulence mechanisms and biology. Prophages have been demonstrated to influence C. difficile toxin expression and contribute to the distribution of advantageous g …
·pubmed.ncbi.nlm.nih.gov·
Novel insights into phage biology of the pathogen Clostridioides difficile based on the active virome - PubMed
Intestinal Colonization by Campylobacter jejuni, Clostridium difficile, and Clostridium perfringens among Commensal Rattus norvegicus in the Urban Areas of Tehran, Iran - PubMed
Intestinal Colonization by Campylobacter jejuni, Clostridium difficile, and Clostridium perfringens among Commensal Rattus norvegicus in the Urban Areas of Tehran, Iran - PubMed
According to the findings, rats are the main reservoirs for diseases. Therefore, rodent control coupled with the implementation of surveillance systems should be prioritized for urban health.
·pubmed.ncbi.nlm.nih.gov·
Intestinal Colonization by Campylobacter jejuni, Clostridium difficile, and Clostridium perfringens among Commensal Rattus norvegicus in the Urban Areas of Tehran, Iran - PubMed
Evaluation of a surveillance system for Clostridioides difficile infections for Swiss hospitals - PubMed
Evaluation of a surveillance system for Clostridioides difficile infections for Swiss hospitals - PubMed
This study underscores the importance of a joint effort towards standardized surveillance practices in providing comprehensive insights into C. difficile infection epidemiology and effective prevention strategies in Swiss healthcare settings. The patient-related approach remains the gold standard fo …
·pubmed.ncbi.nlm.nih.gov·
Evaluation of a surveillance system for Clostridioides difficile infections for Swiss hospitals - PubMed
Effects of fecal microbiota transfer on blood pressure in animal models: A systematic review and meta-analysis - PubMed
Effects of fecal microbiota transfer on blood pressure in animal models: A systematic review and meta-analysis - PubMed
This meta-analysis suggests a relationship between gut microbiota dysbiosis and increased blood pressure, where transplantation of fecal bacteria from the hypertensive model can cause a significant increase in systolic pressure and diastolic pressure in animal models.
·pubmed.ncbi.nlm.nih.gov·
Effects of fecal microbiota transfer on blood pressure in animal models: A systematic review and meta-analysis - PubMed
[A case of disseminated tuberculosis presenting as a metastasizing tumor, complicated by toxic megacolon caused by Clostridium difficile: Difficulties in diagnosis] - PubMed
[A case of disseminated tuberculosis presenting as a metastasizing tumor, complicated by toxic megacolon caused by Clostridium difficile: Difficulties in diagnosis] - PubMed
A mára ritkán előforduló tuberkulózis (tbc) extrapulmonális manifesztációi előrehaladott rosszindulatú daganatok képét utánozhatják, jelentős diagnosztikus dilemmákat okozva. A tbc igazolása gyakorta bonyolult, komplex vizsgálatokat igényel. Egy fiatal vietnámi nőbeteg esetét ismertetjük, aki idült …
·pubmed.ncbi.nlm.nih.gov·
[A case of disseminated tuberculosis presenting as a metastasizing tumor, complicated by toxic megacolon caused by Clostridium difficile: Difficulties in diagnosis] - PubMed
A new toxin toolkit for C. diff
A new toxin toolkit for C. diff
Clostridioides difficile (C. diff) is a leading cause of diarrhea and healthcare-associated infections in the United States and recognized as an urgent threat by the Centers for Disease Control. Virulence of C. diff infections is believed to rely primarily on the production of two toxins: TcdA and TcdB. TcdA and TcdB are large homologous proteins...
·news.google.com·
A new toxin toolkit for C. diff
A commensal protozoan attenuates Clostridioides difficile pathogenesis in mice via arginine-ornithine metabolism and host intestinal immune response
A commensal protozoan attenuates Clostridioides difficile pathogenesis in mice via arginine-ornithine metabolism and host intestinal immune response
Nature Communications - Faecal microbiome transplant has been shown to be able to reduce Clostridioides difficile infection. Here the authors show that an intestinal commensal protozoan reduces C....
·news.google.com·
A commensal protozoan attenuates Clostridioides difficile pathogenesis in mice via arginine-ornithine metabolism and host intestinal immune response
Multifunctional host-defense peptides isolated from skin secretions of the banana tree dwelling frog Boana platanera (Hylidae; Hylinae) - PubMed
Multifunctional host-defense peptides isolated from skin secretions of the banana tree dwelling frog Boana platanera (Hylidae; Hylinae) - PubMed
Five host-defense peptides (figainin 2PL, hylin PL, raniseptin PL, plasticin PL, and peptide YL) were isolated from norepinephrine-stimulated skin secretions of the banana tree dwelling frog Boana platanera (Hylidae; Hylinae) collected in Trinidad. Raniseptin PL (GVFDTVKKIGKAVGKFALGVAKNYLNS.NH2 …
·pubmed.ncbi.nlm.nih.gov·
Multifunctional host-defense peptides isolated from skin secretions of the banana tree dwelling frog Boana platanera (Hylidae; Hylinae) - PubMed
The impact of existing total anti-toxin B IgG immunity in outcomes of recurrent Clostridioides difficile infection - PubMed
The impact of existing total anti-toxin B IgG immunity in outcomes of recurrent Clostridioides difficile infection - PubMed
Late anti-toxin-B humoral immunity acquired after treatment is important for preventing recurrent Clostridioides difficile infection. We prospectively-measured anti-toxin-B IgG and neutralization titers at diagnosis as potential early predictors of recurrence. High anti-toxin-B-IgG/neutralizing anti …
·pubmed.ncbi.nlm.nih.gov·
The impact of existing total anti-toxin B IgG immunity in outcomes of recurrent Clostridioides difficile infection - PubMed
Approaching toxigenic Clostridia from a one health perspective - PubMed
Approaching toxigenic Clostridia from a one health perspective - PubMed
Spore-forming pathogens have a unique capacity to thrive in diverse environments, and with temporal persistence afforded through their ability to sporulate. Their prevalence in diverse ecosystems requires a One Health approach to identify critical reservoirs and outbreak-associated transmission chai …
·pubmed.ncbi.nlm.nih.gov·
Approaching toxigenic Clostridia from a one health perspective - PubMed
Cefepime Versus Piperacillin-Tazobactam for the Treatment of Intra-Abdominal Infections Secondary to Potential AmpC Beta-Lactamase-Producing Organisms - PubMed
Cefepime Versus Piperacillin-Tazobactam for the Treatment of Intra-Abdominal Infections Secondary to Potential AmpC Beta-Lactamase-Producing Organisms - PubMed
Background: Recent studies have established cefepime as an effective treatment option for AmpC beta-lactamase (AmpC) Enterobacterales; however, the efficacy of beta-lactam/beta-lactamase inhibitors is unclear. Objective: The objective of this study was to determine if piperacillintazob …
·pubmed.ncbi.nlm.nih.gov·
Cefepime Versus Piperacillin-Tazobactam for the Treatment of Intra-Abdominal Infections Secondary to Potential AmpC Beta-Lactamase-Producing Organisms - PubMed
Identification of a new family of peptidoglycan transpeptidases reveals atypical crosslinking is essential for viability in Clostridioides difficile - PubMed
Identification of a new family of peptidoglycan transpeptidases reveals atypical crosslinking is essential for viability in Clostridioides difficile - PubMed
Clostridioides difficile , the leading cause of antibiotic-associated diarrhea, relies primarily on 3-3 crosslinks created by L,D-transpeptidases (LDTs) to fortify its peptidoglycan (PG) cell wall. This is unusual, as in most bacteria the vast majority of PG crosslinks are 4-3 crosslinks, whi …
·pubmed.ncbi.nlm.nih.gov·
Identification of a new family of peptidoglycan transpeptidases reveals atypical crosslinking is essential for viability in Clostridioides difficile - PubMed
Clinical Efficacy of Therapeutic Agents for Clostridioides difficile Infection Based on Four Severity Classifications - PubMed
Clinical Efficacy of Therapeutic Agents for Clostridioides difficile Infection Based on Four Severity Classifications - PubMed
The Japanese guidelines for the management of Clostridioides difficile infection (CDI) recommend metronidazole (MNZ) for non-severe cases and vancomycin (VCM) for severe cases. Here, we investigated the use of CDI antimicrobials and evaluated their clinical efficacy in four severity classifications …
·pubmed.ncbi.nlm.nih.gov·
Clinical Efficacy of Therapeutic Agents for Clostridioides difficile Infection Based on Four Severity Classifications - PubMed
Fecal Microbiota Transplantation Repairs Radiation Enteritis Through Modulating the Gut Microbiota-Mediated Tryptophan Metabolism - PubMed
Fecal Microbiota Transplantation Repairs Radiation Enteritis Through Modulating the Gut Microbiota-Mediated Tryptophan Metabolism - PubMed
Radiation enteritis is a common complication of abdominal and pelvic radiotherapy. Several previous studies showed that fecal microbiota transplantation (FMT) could alleviate radiation enteritis. In this study, we investigated the efficacy of FMT in alleviating radiation enteritis and explored the m …
·pubmed.ncbi.nlm.nih.gov·
Fecal Microbiota Transplantation Repairs Radiation Enteritis Through Modulating the Gut Microbiota-Mediated Tryptophan Metabolism - PubMed
Microplastics dampen the self-renewal of hematopoietic stem cells by disrupting the gut microbiota-hypoxanthine-Wnt axis - PubMed
Microplastics dampen the self-renewal of hematopoietic stem cells by disrupting the gut microbiota-hypoxanthine-Wnt axis - PubMed
Microplastics (MPs) are contaminants ubiquitously found in the global biosphere that enter the body through inhalation or ingestion, posing significant risks to human health. Recent studies emerge that MPs are present in the bone marrow and damage the hematopoietic system. However, it remains largel …
·pubmed.ncbi.nlm.nih.gov·
Microplastics dampen the self-renewal of hematopoietic stem cells by disrupting the gut microbiota-hypoxanthine-Wnt axis - PubMed
Microbiome bacterial influencers of host immunity and response to immunotherapy - PubMed
Microbiome bacterial influencers of host immunity and response to immunotherapy - PubMed
The gut microbiota influences anti-tumor immunity and can induce or inhibit response to immune checkpoint inhibitors (ICIs). Therefore, microbiome features are being studied as predictive/prognostic biomarkers of patient response to ICIs, and microbiome-based interventions are attractive adjuvant tr …
·pubmed.ncbi.nlm.nih.gov·
Microbiome bacterial influencers of host immunity and response to immunotherapy - PubMed
Ginsenoside Rg5 Activates the LKB1/AMPK/mTOR Signaling Pathway and Modifies the Gut Microbiota to Alleviate Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet - PubMed
Ginsenoside Rg5 Activates the LKB1/AMPK/mTOR Signaling Pathway and Modifies the Gut Microbiota to Alleviate Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet - PubMed
The primary objective of this investigation was to elucidate the manner in which ginsenoside Rg5 (Rg5) ameliorates nonalcoholic fatty liver disease (NAFLD) via the modulation of the gut microbiota milieu. We administered either a standard diet (ND) or a high-fat diet (HFD), cou …
·pubmed.ncbi.nlm.nih.gov·
Ginsenoside Rg5 Activates the LKB1/AMPK/mTOR Signaling Pathway and Modifies the Gut Microbiota to Alleviate Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet - PubMed
Antimicrobial effects of cannabidiol on select agriculturally important Clostridia - PubMed
Antimicrobial effects of cannabidiol on select agriculturally important Clostridia - PubMed
Amino acid-fermenting Clostridia have undesirable effects in agricultural systems, which can be mitigated by antibiotics, but resistance necessitates alternatives. Here, we demonstrate the efficacy of cannabidiol on growth and ammonia inhibition of five agriculturally relevant Clostridia: Clostridiu …
·pubmed.ncbi.nlm.nih.gov·
Antimicrobial effects of cannabidiol on select agriculturally important Clostridia - PubMed
Epidemiological and clinical burden of Clostridioides difficile infections and recurrences between 2015 - 2019: the RECUR Germany study - PubMed
Epidemiological and clinical burden of Clostridioides difficile infections and recurrences between 2015 - 2019: the RECUR Germany study - PubMed
CDI remains a public health concern in Germany despite a decline in the incidence over recent years. A substantial proportion of CDI patients experience rCDIs, which increase the risk of severe clinical complications. The results highlight an increasing need of improved therapeutic management of CDI …
·pubmed.ncbi.nlm.nih.gov·
Epidemiological and clinical burden of Clostridioides difficile infections and recurrences between 2015 - 2019: the RECUR Germany study - PubMed
Gut Microbiome-Colorectal Cancer Relationship - PubMed
Gut Microbiome-Colorectal Cancer Relationship - PubMed
Traditionally, the role of gut dysbiosis was thought to be limited to pathologies like Clostridioides difficile infection, but studies have shown its role in other intestinal and extraintestinal pathologies. Similarly, recent studies have surfaced showing the strong potential role of the gut …
·pubmed.ncbi.nlm.nih.gov·
Gut Microbiome-Colorectal Cancer Relationship - PubMed
Assessment of Faecal Microbiota Transplant Stability in Deep-Freeze Conditions: A 12-Month Ex Vivo Viability Analysis - PubMed
Assessment of Faecal Microbiota Transplant Stability in Deep-Freeze Conditions: A 12-Month Ex Vivo Viability Analysis - PubMed
The study confirmed that faecal microbiota can be preserved with high viability in deep-freeze storage for up to a year, making allogenic FMT from biobanked samples a viable and safer option for patients. However, a multidonor approach may be beneficial to mitigate the risk of viability loss in any …
·pubmed.ncbi.nlm.nih.gov·
Assessment of Faecal Microbiota Transplant Stability in Deep-Freeze Conditions: A 12-Month Ex Vivo Viability Analysis - PubMed