Scientific Reports - Genetic variation in the human leukocyte antigen region confers susceptibility to Clostridioides difficile infection

Colitis induced by treatment with immune checkpoint inhibitors (ICI), termed irColitis, is a substantial cause of morbidity complicating cancer treatment. We hypothesized that abnormal fecal microbiome features would be present at the time of irColitis onset, and that restoring the microbiome with f …

Nature Medicine - A cluster randomized trial in Tanzania showed that the implementation of a decision support algorithm decreased antibiotic prescriptions to children considerably, without...

This review summarizes mechanisms underlying microbiota-gut-brain axis and novel therapeutic opportunities for neurological sequelae in preterm infants. Optimizing the initial colonization and microbiota development in preterm infants may represent a novel therapy to promote brain development and re …

Objective The novel coronavirus disease 2019 (COVID-19) pandemic has spread worldwide, and hospitals in Japan have been forced to respond to the situation. This study evaluated the broad-spectrum antimicrobial use before and during the COVID-19 pandemic in an acute tertiary-care hospital. Methods Th …

Clostridioides difficile infection (CDI) is a major cause of healthcare-associated diarrhea, despite the widespread implementation of contact precautions for patients with CDI. Here, we investigate strain contamination in a hospital setting and genomic determinants of disease outcomes. Across …

Make sure to disinfect beds properly after they are used by someone with Clostridioides difficile, or C. diff. According to a new study, staying in a bed previously used by a person with C. diff raises the risk that they’ll get the infection.

Stool-derived products and bacterial consortia need to be clearly distinguished in terms of product characterization and their associated risks with specific long-term post-marketing evaluation similar to registries used for FMT. Their place in the therapeutic strategy for patients with rCDI require …

Therefore, B. acidifaciens and its derived EVs can alleviate DSS-induced colitis by reducing mucosal damage to colon tissue, reducing inflammatory response, promoting mucosal barrier repair, restoring gut microbiota diversity, and restoring gut microbiota balance in mice. The results of this …

Vowst's FDA approval is a boon for the prevention of recurrent Clostridioides difficile infection

Here, we show that levels of fecal short-chain fatty acids (SCFAs), particularly butyrate, are reduced, and normal colon structure is damaged in patients with CDI compared with those in healthy individuals. Bile acid (BA) metabolic disorder in patients ...

In Greece, the stark increase in Clostridioides difficile (C. diff) incidence cannot be explained by a rise of antimicrobial use during the pandemic.

The FDA approved VOWST to prevent recurrence of C. difficile infection. The approval is based on a trial in which UC Davis Health’s Stuart Cohen served as principal investigator.

Intestinal bile acids play an essential role in the Clostridioides difficile lifecycle having been shown in vitro to modulate various aspects of pa...

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A team of investigators from Mass General Brigham’s founding members, Brigham and Women’s Hospital and Massachusetts General Hospital, has identified metabolic strategies used by Clostridioides difficile to rapidly colonize the gut and new treatments for it.

Off-target effects of NSAIDs enhance damage done by the important nosocomial pathogen, C. difficile.

Scientific Reports - Clostridioides difficile infection in thoroughbred horses in Japan from 2010 to 2021

Scientific Reports - Modulation of colonic immunometabolic responses during Clostridioides difficile infection ameliorates disease severity and inflammation

Clostridioides difficile infection (CDI) induces intense acute inflammatory responses through toxin release. A combination of antibiotic and anti-infl…

Clostridioides difficile is an anaerobic, Gram-positive, spore-forming gastrointestinal pathogen that causes severe diarrheal disease which can lead to death (1). To cause disease, C. difficile spores must be ingested and germinate in the intestine upon exposure to bile salts and glycine (2). Upon the outgrowth of spores into vegetative cells, C. difficile colonizes the colon, using the available nutrients to replicate within the host. As the population increases and nutrients become scarce, C. difficile produces toxins (TcdA and TcdB), releasing additional nutrients and further altering the metabolic environment (3). In turn, host inflammation is induced, resulting in the release of immune effectors and the characteristic pathologies associated with C. difficile infections (4).

Scientific Reports - An integrated pipeline for prediction of Clostridioides difficile infection

Leveraging systems biology approaches, we illustrate how metabolically distinct species of Clostridia protect against or worsen Clostridioides diffici…

The overuse of antibiotics has resulted in Clostridium difficile infection (CDI) as a significant global public health concern. Studies have shown tha…

A study of more than 25,000 hospitals encounters found that staying in a hospital bed that previously had a patient with C diff was associated with an increased risk of hospital-onset CDI.

Feldman details her experience with C. diff, how the COVID-19 pandemic slowed the timeline of care, and how her surgical history and the use of antibiotics played into the disease’s onset.

Feldman, who previously had C. diff, urges individuals to begin having conversations to help remove the stigma of the disease and raise awareness of its prevalence.

The Business Research Company's Difficile-Associated Diarrhea Treatment Global Market Report 2024 – Market Size, Trends, And Global Forecast 2024-2033