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Increased Prevalence of Clostridioides difficile Infection Among Pediatric Oncology Patients: Risk Factors for Infection and Complications - PubMed
Increased Prevalence of Clostridioides difficile Infection Among Pediatric Oncology Patients: Risk Factors for Infection and Complications - PubMed
This is the largest study of CDI in pediatric oncology patients to date. The study identifies specific oncologic diagnoses with increased CDI risk and factors predictive of poor outcomes. As CDI treatment guidelines are developed for this population, these data will be useful for risk stratification …
·pubmed.ncbi.nlm.nih.gov·
Increased Prevalence of Clostridioides difficile Infection Among Pediatric Oncology Patients: Risk Factors for Infection and Complications - PubMed
Gut microbiota in cancer: insights on microbial metabolites and therapeutic strategies - PubMed
Gut microbiota in cancer: insights on microbial metabolites and therapeutic strategies - PubMed
In recent years, the role of gut microbiota in cancer treatment has attracted substantial attention. It is now well established that gut microbiota and its metabolites significantly contribute to the incidence, treatment, and prognosis of various cancers. This review provides a comprehensive review …
·pubmed.ncbi.nlm.nih.gov·
Gut microbiota in cancer: insights on microbial metabolites and therapeutic strategies - PubMed
Effects of fecal microbiota transplantation and fecal virome transplantation on LPS-induced intestinal injury in broilers - PubMed
Effects of fecal microbiota transplantation and fecal virome transplantation on LPS-induced intestinal injury in broilers - PubMed
The interesting roles and efficiencies of fecal microbiota transplantation (FMT) have attracted considerable attention and have been gradually evidenced in specific animal models. While the growing evidence that bacteriophages play roles in FMT efficacy has attracted considerable interest. In this s …
·pubmed.ncbi.nlm.nih.gov·
Effects of fecal microbiota transplantation and fecal virome transplantation on LPS-induced intestinal injury in broilers - PubMed
The gut-brain axis in Parkinson's disease - PubMed
The gut-brain axis in Parkinson's disease - PubMed
There is a bi-directional communication between the gut, including the microbiota, and the brain through the autonomic nervous system. Accumulating evidence has suggested a bidirectional link between gastrointestinal inflammation and neurodegeneration, in accordance with the concept of the gut-rain …
·pubmed.ncbi.nlm.nih.gov·
The gut-brain axis in Parkinson's disease - PubMed
Analysis of risk factors for community-acquired Clostridioides difficile diarrhea in children: a case-control study in Chenzhou, China - PubMed
Analysis of risk factors for community-acquired Clostridioides difficile diarrhea in children: a case-control study in Chenzhou, China - PubMed
Children who had been treated with antibiotics and not breastfed were more susceptible to CDI. Therefore, in order to prevent and to control the spread of CD infection, being prudent to the aforementioned high-risk factors is strongly advocated in clinical practice.
·pubmed.ncbi.nlm.nih.gov·
Analysis of risk factors for community-acquired Clostridioides difficile diarrhea in children: a case-control study in Chenzhou, China - PubMed
Inter-Hospital Transfer Is an Independent Risk Factor for Hospital-Associated Infection - PubMed
Inter-Hospital Transfer Is an Independent Risk Factor for Hospital-Associated Infection - PubMed
Background: Regionalization of surgical care shifts higher acuity patients to larger centers. Hospital-associated infections (HAIs) are important quality measures with financial implications. In our ongoing efforts to eliminate HAIs, we examined the potential role for inter-hospital tr …
·pubmed.ncbi.nlm.nih.gov·
Inter-Hospital Transfer Is an Independent Risk Factor for Hospital-Associated Infection - PubMed
Appropriate antibiotic use in dentistry: a review of the literature and clinical recommendations - PubMed
Appropriate antibiotic use in dentistry: a review of the literature and clinical recommendations - PubMed
This article reviews the latest evidence on the use of antibiotics in dentistry, beginning with the risks of antibiotic use, which include Clostridioides difficile infection and antimicrobial resistance. The article then reviews the clinical practice guidelines for antibiotic prophylaxis for patient …
·pubmed.ncbi.nlm.nih.gov·
Appropriate antibiotic use in dentistry: a review of the literature and clinical recommendations - PubMed
The many faces of microbiota-gut-brain axis in autism spectrum disorder - PubMed
The many faces of microbiota-gut-brain axis in autism spectrum disorder - PubMed
The gut-brain axis is gaining more attention in neurodevelopmental disorders, especially autism spectrum disorder (ASD). Many factors can influence microbiota in early life, including host genetics and perinatal events (infections, mode of birth/delivery, medications, nutritional supply, and environ …
·pubmed.ncbi.nlm.nih.gov·
The many faces of microbiota-gut-brain axis in autism spectrum disorder - PubMed
The impact of gut microbiome enterotypes on ulcerative colitis: identifying key bacterial species and revealing species co-occurrence networks using machine learning - PubMed
The impact of gut microbiome enterotypes on ulcerative colitis: identifying key bacterial species and revealing species co-occurrence networks using machine learning - PubMed
Ulcerative colitis (UC) is a chronic inflammatory intestinal disease affecting the colon and rectum, with its pathogenesis attributed to genetic background, environmental factors, and gut microbes. This study aimed to investigate the role of enterotypes in UC by conducting a hierarchical analysis, d …
·pubmed.ncbi.nlm.nih.gov·
The impact of gut microbiome enterotypes on ulcerative colitis: identifying key bacterial species and revealing species co-occurrence networks using machine learning - PubMed
Faecal microbiota and fatty acids in feline chronic enteropathy - PubMed
Faecal microbiota and fatty acids in feline chronic enteropathy - PubMed
The study revealed alterations in microbiota compositions and short-chain fatty acid concentration in cats suffering from chronic enteropathy, which is an important finding both for research on the pathogenesis of the disease and for potential therapeutic interventions in the form of faecal microbio …
·pubmed.ncbi.nlm.nih.gov·
Faecal microbiota and fatty acids in feline chronic enteropathy - PubMed
Gut microbiota modification by diosgenin mediates antiepileptic effects in a mouse model of epilepsy - PubMed
Gut microbiota modification by diosgenin mediates antiepileptic effects in a mouse model of epilepsy - PubMed
Diosgenin, a natural steroid saponin, holds promise as a multitarget therapeutic for various diseases, including neurodegenerative conditions. Its efficacy in slowing Alzheimer's disease, Parkinson's disease, multiple sclerosis, and stroke progression has been demonstrated. However, the role of dios …
·pubmed.ncbi.nlm.nih.gov·
Gut microbiota modification by diosgenin mediates antiepileptic effects in a mouse model of epilepsy - PubMed
Blocking MyD88 signaling with MyD88 inhibitor prevents colitis-associated colorectal cancer development by maintaining colonic microbiota homeostasis - PubMed
Blocking MyD88 signaling with MyD88 inhibitor prevents colitis-associated colorectal cancer development by maintaining colonic microbiota homeostasis - PubMed
Certain intestinal microbiota alterations appear to positively correlate with tumorigenesis of CAC due to the disruption of the balance between the host and microorganisms. It is proven that blocking MyD88 signaling can prevent colitis-associated colorectal cancer (CAC) development in mice. We are a …
·pubmed.ncbi.nlm.nih.gov·
Blocking MyD88 signaling with MyD88 inhibitor prevents colitis-associated colorectal cancer development by maintaining colonic microbiota homeostasis - PubMed
Effect of Fecal Microbiota Transplantation on Early Intestinal Immune Function and Histomorphology of Immune Organs in Chicks - PubMed
Effect of Fecal Microbiota Transplantation on Early Intestinal Immune Function and Histomorphology of Immune Organs in Chicks - PubMed
The intestinal microbiota drives the maturation of the immune system, which is essential for maintaining lifetime homeostasis. Whether fecal microbiota transplantation can promote the development of the immune system in chicks? On days 1, 3, and 5, the post-hatch Hy-line Brown chicks were treated wi …
·pubmed.ncbi.nlm.nih.gov·
Effect of Fecal Microbiota Transplantation on Early Intestinal Immune Function and Histomorphology of Immune Organs in Chicks - PubMed
‘The future is here’: New products join armamentarium for C. difficile
‘The future is here’: New products join armamentarium for C. difficile
Clostridioides difficile infection presents a unique treatment paradox for clinicians: Antibiotics are often both its cause and its cure.Broad-spectrum antibiotics used to treat infections radically alter the composition of a patient’s microbiota, wiping out a significant portion of the bacterial community and upsetting the natural balance of gut flora. Without competition from healthy
·news.google.com·
‘The future is here’: New products join armamentarium for C. difficile
Design, Synthesis, and Evaluation of Cephamycin-Based Antisporulation Agents targeting Clostridioides difficile - PubMed
Design, Synthesis, and Evaluation of Cephamycin-Based Antisporulation Agents targeting Clostridioides difficile - PubMed
With the aim of discovering small molecule inhibitors of the sporulation process in Clostridioides difficile, we prepared a series of C-7 α-(4-substituted-1H-1,2,3-triazol-1-yl)acetamide analogues of cefotetan, a known inhibitor of the C. difficile sporulation-specific protein t …
·pubmed.ncbi.nlm.nih.gov·
Design, Synthesis, and Evaluation of Cephamycin-Based Antisporulation Agents targeting Clostridioides difficile - PubMed
Microbiome-preserving antibiotics for the treatment of Clostridioides difficile infection: a systematic review and meta-analysis - PubMed
Microbiome-preserving antibiotics for the treatment of Clostridioides difficile infection: a systematic review and meta-analysis - PubMed
Fidaxomicin (in seven studies) demonstrated significant improvement in achieving sustained clinical cure. A limitation of this study may that more studies are needed to compare fidaxomicin with other antibiotics.
·pubmed.ncbi.nlm.nih.gov·
Microbiome-preserving antibiotics for the treatment of Clostridioides difficile infection: a systematic review and meta-analysis - PubMed
Prevalence of toxigenic Clostridium difficile in hospitalized patients in the southwestern province of Saudi Arabia: Confirmation using the GeneXpert analysis - PubMed
Prevalence of toxigenic Clostridium difficile in hospitalized patients in the southwestern province of Saudi Arabia: Confirmation using the GeneXpert analysis - PubMed
Clostridium difficile (Clostridioides difficile) is a leading cause of nosocomial infections in hospitalized patients worldwide. Stool samples were collected from 112 inpatients admitted to different hospitals and were screened for C. difficile GDH + toxin A + B by immunoassay, …
·pubmed.ncbi.nlm.nih.gov·
Prevalence of toxigenic Clostridium difficile in hospitalized patients in the southwestern province of Saudi Arabia: Confirmation using the GeneXpert analysis - PubMed
Immune-related colitis is associated with fecal microbial dysbiosis and can be mitigated by fecal microbiota transplantation - PubMed
Immune-related colitis is associated with fecal microbial dysbiosis and can be mitigated by fecal microbiota transplantation - PubMed
Colitis induced by treatment with immune checkpoint inhibitors (ICI), termed irColitis, is a substantial cause of morbidity complicating cancer treatment. We hypothesized that abnormal fecal microbiome features would be present at the time of irColitis onset, and that restoring the microbiome with f …
·pubmed.ncbi.nlm.nih.gov·
Immune-related colitis is associated with fecal microbial dysbiosis and can be mitigated by fecal microbiota transplantation - PubMed
Treatment of preterm brain injury via gut-microbiota-metabolite-brain axis - PubMed
Treatment of preterm brain injury via gut-microbiota-metabolite-brain axis - PubMed
This review summarizes mechanisms underlying microbiota-gut-brain axis and novel therapeutic opportunities for neurological sequelae in preterm infants. Optimizing the initial colonization and microbiota development in preterm infants may represent a novel therapy to promote brain development and re …
·pubmed.ncbi.nlm.nih.gov·
Treatment of preterm brain injury via gut-microbiota-metabolite-brain axis - PubMed
The Changes in Broad-spectrum Antimicrobial Consumption during the COVID-19 Pandemic in a Japanese Acute Tertiary-care Hospital: An Interrupted Time-series Analysis - PubMed
The Changes in Broad-spectrum Antimicrobial Consumption during the COVID-19 Pandemic in a Japanese Acute Tertiary-care Hospital: An Interrupted Time-series Analysis - PubMed
Objective The novel coronavirus disease 2019 (COVID-19) pandemic has spread worldwide, and hospitals in Japan have been forced to respond to the situation. This study evaluated the broad-spectrum antimicrobial use before and during the COVID-19 pandemic in an acute tertiary-care hospital. Methods Th …
·pubmed.ncbi.nlm.nih.gov·
The Changes in Broad-spectrum Antimicrobial Consumption during the COVID-19 Pandemic in a Japanese Acute Tertiary-care Hospital: An Interrupted Time-series Analysis - PubMed
Genomic surveillance of Clostridioides difficile transmission and virulence in a healthcare setting - PubMed
Genomic surveillance of Clostridioides difficile transmission and virulence in a healthcare setting - PubMed
Clostridioides difficile infection (CDI) is a major cause of healthcare-associated diarrhea, despite the widespread implementation of contact precautions for patients with CDI. Here, we investigate strain contamination in a hospital setting and genomic determinants of disease outcomes. Across …
·pubmed.ncbi.nlm.nih.gov·
Genomic surveillance of Clostridioides difficile transmission and virulence in a healthcare setting - PubMed
C. diff linked to contaminated hospital beds, study finds
C. diff linked to contaminated hospital beds, study finds
Make sure to disinfect beds properly after they are used by someone with Clostridioides difficile, or C. diff. According to a new study, staying in a bed previously used by a person with C. diff raises the risk that they’ll get the infection.
·news.google.com·
C. diff linked to contaminated hospital beds, study finds