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Efficacy of fecal microbiota transplantation in patients with Parkinson's disease: clinical trial results from a randomized, placebo-controlled design - PubMed
Efficacy of fecal microbiota transplantation in patients with Parkinson's disease: clinical trial results from a randomized, placebo-controlled design - PubMed
The occurrence and development of Parkinson's disease (PD) have been demonstrated to be related to gut dysbiosis, however, the impact of fecal microbiota transplantation (FMT) on microbiota engraftment in PD patients is uncertain. We performed a randomized, placebo-controlled trial at the Department …
·pubmed.ncbi.nlm.nih.gov·
Efficacy of fecal microbiota transplantation in patients with Parkinson's disease: clinical trial results from a randomized, placebo-controlled design - PubMed
Review Article: Safety of Live Biotherapeutic Products Used for the Prevention of Clostridioides difficile Infection Recurrence - PubMed
Review Article: Safety of Live Biotherapeutic Products Used for the Prevention of Clostridioides difficile Infection Recurrence - PubMed
Live biotherapeutic products (LBPs) represent a new class of therapeutics indicated to prevent the recurrence of Clostridioides difficile infection (CDI) in adults. However, microbiota-based therapies have been used in CDI management before the Food and Drug Administration (FDA) designated this new …
·pubmed.ncbi.nlm.nih.gov·
Review Article: Safety of Live Biotherapeutic Products Used for the Prevention of Clostridioides difficile Infection Recurrence - PubMed
Periodontitis salivary microbiota exacerbates colitis-induced anxiety-like behavior via gut microbiota - PubMed
Periodontitis salivary microbiota exacerbates colitis-induced anxiety-like behavior via gut microbiota - PubMed
The gut-brain axis is a bidirectional communication system between the gut and central nervous system. Many host-related factors can affect gut microbiota, including oral bacteria, making the brain a vulnerable target via the gut-brain axis. Saliva contains a large number of oral bacteria, and perio …
·pubmed.ncbi.nlm.nih.gov·
Periodontitis salivary microbiota exacerbates colitis-induced anxiety-like behavior via gut microbiota - PubMed
Early diagnosis of monomicrobial Clostridioides difficile bacteremia in a patient without colitis - PubMed
Early diagnosis of monomicrobial Clostridioides difficile bacteremia in a patient without colitis - PubMed
Bacteremia is a rare finding among Clostridioides difficile infections. We describe a case of a 67-year-old man with resected colorectal cancer with colostomy who presented with small bowel obstruction and was admitted for lysis of adhesions. On day 8 of admission, he developed leukocytosis a …
·pubmed.ncbi.nlm.nih.gov·
Early diagnosis of monomicrobial Clostridioides difficile bacteremia in a patient without colitis - PubMed
Analysis of healthcare facility-onset Clostridioides difficile Infection (CDI) in a hematopoietic cell transplant (HCT) unit: A Call for Diagnostic Stewardship in a Complex Patient Population - PubMed
Analysis of healthcare facility-onset Clostridioides difficile Infection (CDI) in a hematopoietic cell transplant (HCT) unit: A Call for Diagnostic Stewardship in a Complex Patient Population - PubMed
Nearly half the patients identified as having healthcare facility-onset Clostridioides difficile infections (HO-CDI) on a hematopoietic cell transplant (HCT) unit had an alternative clinical explanation for diarrhea, including conditioning regimen toxicity or other medications. Our study supports th …
·pubmed.ncbi.nlm.nih.gov·
Analysis of healthcare facility-onset Clostridioides difficile Infection (CDI) in a hematopoietic cell transplant (HCT) unit: A Call for Diagnostic Stewardship in a Complex Patient Population - PubMed
Associations of motility and auto-aggregation with biofilm-formation capacity levels in Clostridioidesdifficile - PubMed
Associations of motility and auto-aggregation with biofilm-formation capacity levels in Clostridioidesdifficile - PubMed
Clostridioides difficile (C. difficile) is responsible for one of the most common nosocomial infections worldwide. This work assessed associations between biofilm-formation capacity levels of C. difficile and cell viability, motility, flagella, motility and auto-aggregation in 118 clinical isolates. …
·pubmed.ncbi.nlm.nih.gov·
Associations of motility and auto-aggregation with biofilm-formation capacity levels in Clostridioidesdifficile - PubMed
Gut liver brain axis in diseases: the implications for therapeutic interventions - PubMed
Gut liver brain axis in diseases: the implications for therapeutic interventions - PubMed
Gut-liver-brain axis is a three-way highway of information interaction system among the gastrointestinal tract, liver, and nervous systems. In the past few decades, breakthrough progress has been made in the gut liver brain axis, mainly through understanding its formation mechanism and increasing tr …
·pubmed.ncbi.nlm.nih.gov·
Gut liver brain axis in diseases: the implications for therapeutic interventions - PubMed
Multi-omics analysis of fecal microbiota transplantation's impact on functional constipation and comorbid depression and anxiety - PubMed
Multi-omics analysis of fecal microbiota transplantation's impact on functional constipation and comorbid depression and anxiety - PubMed
FMT can relieve patients' constipation, depression, and anxiety symptoms by reshaping gut microbiota. The 5-HT level was associated with an altered abundance of specific bacteria or metabolites. This study provides specific evidence for FMT intervention in constipation patients with psychiatric symp …
·pubmed.ncbi.nlm.nih.gov·
Multi-omics analysis of fecal microbiota transplantation's impact on functional constipation and comorbid depression and anxiety - PubMed
Longitudinal dynamics of gut microbiota in the pathogenesis of acute graft-versus-host disease - PubMed
Longitudinal dynamics of gut microbiota in the pathogenesis of acute graft-versus-host disease - PubMed
Dynamic changes in gut microbiota composition and related cytokines were found to be related to aGvHD, including pathogenic or protective changes. These findings suggested that manipulation of gut microbiota at different timepoints might be a promising avenue for preventing or treating this common c …
·pubmed.ncbi.nlm.nih.gov·
Longitudinal dynamics of gut microbiota in the pathogenesis of acute graft-versus-host disease - PubMed
Dissecting the role of the gut microbiome and fecal microbiota transplantation in radio- and immunotherapy treatment of colorectal cancer - PubMed
Dissecting the role of the gut microbiome and fecal microbiota transplantation in radio- and immunotherapy treatment of colorectal cancer - PubMed
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers and poses a major burden on the human health worldwide. At the moment, treatment of CRC consists of surgery in combination with (neo)adjuvant chemotherapy and/or radiotherapy. More recently, immune checkpoint blockers (ICBs) have …
·pubmed.ncbi.nlm.nih.gov·
Dissecting the role of the gut microbiome and fecal microbiota transplantation in radio- and immunotherapy treatment of colorectal cancer - PubMed
Fecal microbiota transplantation: a novel strategy for treating Alzheimer's disease - PubMed
Fecal microbiota transplantation: a novel strategy for treating Alzheimer's disease - PubMed
Alzheimer's disease is a common neurological disorder, which has become one of the major factors affecting human health due to its serious impact on individuals, families and society. It has been confirmed that gut microbiota can affect the occurrence and development of Alzheimer's disease. Especial …
·pubmed.ncbi.nlm.nih.gov·
Fecal microbiota transplantation: a novel strategy for treating Alzheimer's disease - PubMed
Fecal microbiota transplanted from old mice promotes more colonic inflammation, proliferation, and tumor formation in azoxymethane-treated A/J mice than microbiota originating from young mice - PubMed
Fecal microbiota transplanted from old mice promotes more colonic inflammation, proliferation, and tumor formation in azoxymethane-treated A/J mice than microbiota originating from young mice - PubMed
Aging is a strong risk factor for colorectal cancer (CRC). It is well established that gut microbial dysbiosis can play a role in the etiology of CRC. Although the composition of the gut microbial community changes with age and is reported to become more pro-inflammatory, it is unclear whether such …
·pubmed.ncbi.nlm.nih.gov·
Fecal microbiota transplanted from old mice promotes more colonic inflammation, proliferation, and tumor formation in azoxymethane-treated A/J mice than microbiota originating from young mice - PubMed
Engraftment of essential functions through multiple fecal microbiota transplants in chronic antibiotic-resistant pouchitis-a case study using metatranscriptomics - PubMed
Engraftment of essential functions through multiple fecal microbiota transplants in chronic antibiotic-resistant pouchitis-a case study using metatranscriptomics - PubMed
Our study demonstrates the clear but short-lived activity engraftment of donor microbiota, particularly the butyrate biosynthesis after each FMT. The data suggest that FMT triggers shifts in the activity of patient microbiota towards health which need to be repeated to reach critical thresholds. As …
·pubmed.ncbi.nlm.nih.gov·
Engraftment of essential functions through multiple fecal microbiota transplants in chronic antibiotic-resistant pouchitis-a case study using metatranscriptomics - PubMed
Gut microbiome-associated predictors as biomarkers of response to advanced therapies in inflammatory bowel disease: a systematic review - PubMed
Gut microbiome-associated predictors as biomarkers of response to advanced therapies in inflammatory bowel disease: a systematic review - PubMed
Loss of response to therapy in inflammatory bowel disease (IBD) has led to a surge in research focusing on precision medicine. Three systematic reviews have been published investigating the associations between gut microbiota and disease activity or IBD therapy. We performed a systematic review to i …
·pubmed.ncbi.nlm.nih.gov·
Gut microbiome-associated predictors as biomarkers of response to advanced therapies in inflammatory bowel disease: a systematic review - PubMed
The Relationship Between the Microbiome and Antimicrobial Resistance - PubMed
The Relationship Between the Microbiome and Antimicrobial Resistance - PubMed
Antibiotics have benefitted human health since their introduction nearly a century ago. However, the rise of antibiotic resistance may portend the dawn of the "post-antibiotic age." With the narrow pipeline for novel antimicrobials, we need new approaches to deal with the rise of multidrug resistant …
·pubmed.ncbi.nlm.nih.gov·
The Relationship Between the Microbiome and Antimicrobial Resistance - PubMed
Review Article: Gastroenterology and Clostridium difficile Infection: Past, Present, and Future - PubMed
Review Article: Gastroenterology and Clostridium difficile Infection: Past, Present, and Future - PubMed
Research and innovation around Clostridium difficile infection (CDI) has been a multidisciplinary endeavor since discovery of the organism in 1978. The field of gastroenterology has contributed to our understanding of CDI as a disease caused by disruptions in the gut microbiome and led to advances i …
·pubmed.ncbi.nlm.nih.gov·
Review Article: Gastroenterology and Clostridium difficile Infection: Past, Present, and Future - PubMed
Infectious Inequity: How the Gut Microbiome and Social Determinants of Health May Contribute to Clostridioides difficile Infection Among Racial and Ethnic Minorities - PubMed
Infectious Inequity: How the Gut Microbiome and Social Determinants of Health May Contribute to Clostridioides difficile Infection Among Racial and Ethnic Minorities - PubMed
Infectious diseases are a leading contributor to death in the United States, and racial differences in clinical outcomes have been increasingly reported. Clostridioides difficile infection (CDI) is a growing public health concern, as it causes nearly half a million infections per year and considerab …
·pubmed.ncbi.nlm.nih.gov·
Infectious Inequity: How the Gut Microbiome and Social Determinants of Health May Contribute to Clostridioides difficile Infection Among Racial and Ethnic Minorities - PubMed
The Role of the Gut Microbiome in Cancer: A Review, With Special Focus on Colorectal Neoplasia and Clostridioides difficile - PubMed
The Role of the Gut Microbiome in Cancer: A Review, With Special Focus on Colorectal Neoplasia and Clostridioides difficile - PubMed
The gut microbiome has coevolved with humans to aid in physiologic functions and prevent disease. An increasing prevalence of gut dysbiosis in modern society exists and has strong linkages to multiple disease processes common in the developed world. Mechanisms for microbiome-human interactions that …
·pubmed.ncbi.nlm.nih.gov·
The Role of the Gut Microbiome in Cancer: A Review, With Special Focus on Colorectal Neoplasia and Clostridioides difficile - PubMed
Review Article: Safety of Live Biotherapeutic Products Used for the Prevention of Clostridioides difficile Infection Recurrence - PubMed
Review Article: Safety of Live Biotherapeutic Products Used for the Prevention of Clostridioides difficile Infection Recurrence - PubMed
Live biotherapeutic products (LBPs) represent a new class of therapeutics indicated to prevent the recurrence of Clostridioides difficile infection (CDI) in adults. However, microbiota-based therapies have been used in CDI management before the Food and Drug Administration (FDA) designated this new …
·pubmed.ncbi.nlm.nih.gov·
Review Article: Safety of Live Biotherapeutic Products Used for the Prevention of Clostridioides difficile Infection Recurrence - PubMed
Advancements in Novel Live Biotherapeutic Products for Clostridioides difficile Infection Prevention - PubMed
Advancements in Novel Live Biotherapeutic Products for Clostridioides difficile Infection Prevention - PubMed
The profound impact of the human microbiome on health and disease has captivated the interest of clinical and scientific communities. The human body hosts a vast array of microorganisms collectively forming the human microbiome, which significantly influences various physiological processes and prof …
·pubmed.ncbi.nlm.nih.gov·
Advancements in Novel Live Biotherapeutic Products for Clostridioides difficile Infection Prevention - PubMed
Fecal Pharmacokinetics and Gut Microbiome Effects of Oral Omadacycline versus Vancomycin in Healthy Volunteers - PubMed
Fecal Pharmacokinetics and Gut Microbiome Effects of Oral Omadacycline versus Vancomycin in Healthy Volunteers - PubMed
Subjects given omadacycline had high fecal concentrations with a distinct microbiome profile compared to vancomycin. These pharmacokinetic and microbiome properties may help explain its low risk to cause Clostridioides difficile infection and warrant further research into its development as an antib …
·pubmed.ncbi.nlm.nih.gov·
Fecal Pharmacokinetics and Gut Microbiome Effects of Oral Omadacycline versus Vancomycin in Healthy Volunteers - PubMed