Risk factors for Recurrent Clostridioides Difficile Infection in Children - PubMed
Findings from this study demonstrate the importance of underlying chronic conditions in the development of recurrent C. difficile disease and the shortcomings of current treatment options for recurrent cases. Additionally, our findings indicate that initial treatment selection may impact the likelih …
VIDEO: ‘Future is now here’ for recurrent C. difficile, thanks to live biotherapeutics
VANCOUVER, British Columbia — In this Healio video exclusive, Paul Feuerstadt, MD, FACG, AGAF, discusses the evolution of treatment for Clostridioides difficile infection, from antimicrobials to recently FDA-approved live biotherapeutics. “It’s so important for us to understand that C. diff has a major impact on our society,” Feuerstadt, assistant clinical professor of
Oral teicoplanin administration suppresses recurrence of Clostridioides difficile infection: Proof of concept - PubMed
The results obtained from the present basic experiments could suggest that teicoplanin is a potential antibiotic for the treatment of severe CDI with recurrence-prevention activity.
Paul Feuerstadt, MD: Preventing Recurrent C Difficile in Older Adults with Comorbidities
Feuerstadt reviews ACG 2023 data showing live microbiota therapy provides consistent protection against rCDI in one of the most vulnerable patient populations.
Dysregulated Immunity to Clostridioides difficile in IBD Patients Without a History of Recognized Infection - PubMed
These data suggest that IBD patients, potentially due to underlying intestinal dysbiosis, experience undiagnosed C. difficile infections that result in impaired toxin-specific immunity. This may contribute to the development of inflammatory T cell responses toward commensal bacteria and provide a ra …
Risk factors for Recurrent Clostridioides Difficile Infection in Children - PubMed
Findings from this study demonstrate the importance of underlying chronic conditions in the development of recurrent C. difficile disease and the shortcomings of current treatment options for recurrent cases. Additionally, our findings indicate that initial treatment selection may impact the likelih …
Host fecal DNA specific methylation signatures mark gut dysbiosis and inflammation in children affected by autism spectrum disorder
Scientific Reports - Host fecal DNA specific methylation signatures mark gut dysbiosis and inflammation in children affected by autism spectrum disorder
Recent trends and risk factors associated with Clostridioides difficile infections in hospitalized patients with inflammatory bowel disease - PubMed
Rates of CDI among hospitalized patients with IBD had initially increased, but have declined since 2015. Increased comorbidity, large hospital size, public insurance, and urban teaching hospitals were associated with higher rates of CDI. CDI was associated with increased mortality in hospitalized pa …
Linda Stein Gold, MD: Nonsteroidal Topical Treatment for Psoriasis, Atopic Dermatitis
Linda Stein Gold, MD, discusses the notable transition in topical therapies for both psoriasis and atopic dermatitis, with the introduction of effective FDA-approved nonsteroidal treatments.
Nanobodies against C. difficile TcdA and TcdB reveal unexpected neutralizing epitopes and provide a toolkit for toxin quantitation in vivo - PubMed
Clostridioides difficile is a leading cause of antibiotic-associated diarrhea and nosocomial infection in the United States. The symptoms of C. difficile infection (CDI) are associated with the production of two homologous protein toxins, TcdA and TcdB. The toxins are considered bona fide targets fo …
Gut Microbiota Regulates Epigenetic Remodelling in the Amygdala: A Role in Repeated Mild Traumatic Brain Injury (rMTBI)-Induced Anxiety - PubMed
Gut microbiota serves in the development and maintenance of phenotype. However, the underlying mechanisms are still in its infancy. The current study shows epigenetic remodelling in the brain as a causal mechanism in the gut microbiota-brain axis. Like in trauma patients, gut dysbiosis and anxiety w …
Core genome multilocus sequence typing of Clostridioides difficile to investigate transmission in the hospital setting - PubMed
Among clusters determined by cgMLST analysis, roughly 40% included unexplained HA-CDI acquisitions, which may be explained by unidentified epidemiological links, asymptomatic colonization, and/or shared common community reservoirs. The use of DLST, followed by whole genome sequencing analysis, is a …
VIDEO: Rebyota ‘not only shuts down recurrence,’ also affects quality of life in C. diff
VANCOUVER, British Columbia — In this Healio video, Paul Feuerstadt, MD, FACG, AGAF, discusses data that link health-related quality of life and microbiome composition among patients with recurrent Clostridioides difficile infection. “C. difficile is a major problem in the United States; in fact, it’s estimated that upwards of a half million individuals are diagnosed with this
Colonic distribution of FMT by different enema procedures compared to colonoscopy – proof of concept study using contrast fluid - BMC Gastroenterology
Background Fecal microbiota transplantation (FMT) has become an important treatment method in recurrent Clostridioides difficile infections and is under investigation as a treatment for several other diseases. FMT’s mechanism of action is assumed to be through alterations of the colon microbiota. FMT can be delivered by several methods, but few studies have directly compared how FMT is distributed in the colon by different methods. Specifically, the proximal distribution of FMT delivered by enema is unknown. Methods In eight participants, we administered contrast fluid (CF) with viscosity similar to an FMT in a crossover study design. First, CF was administered by colonoscopy, followed by an abdominal X-ray to visualize the CF distribution. Next, after four to eight weeks, participants were given CF, but as an enema, followed by a positioning procedure. X-rays were obtained before (enema ÷) and after (enema +) the positioning procedure. Conclusion Proportion of participants with CF in cecum were 100% after colonoscopy, 50% after enema + and 38% after enema ÷. In the transverse colon, proportions were 100% (colonoscopy), 88% (enema +) and 63% (enema ÷). There were no adverse events. Interpretation This study shows proof of concept for the distribution of FMT to proximal colon when delivered by enema. A positioning procedure after the enema slightly improves the proximal distribution. However, colonoscopy is the only method that ensures delivery to the cecum. Studies are needed to see if FMT colon distribution correlates with treatment effectiveness. Trial registration The study was retrospectively registered at ClinicalTrials.gov (NCT05121285) (16/11/2021).
Gut microbiota and traumatic central nervous system injuries: Insights into pathophysiology and therapeutic approaches - PubMed
Traumatic brain injury and spinal cord injury are two distinct but fundamentally similar types of acute insults to the central nervous system (CNS) that often culminate in death or cognitive and motor impairment. Over the past decade, researchers have tapped into research to discover the potential r …
Fecal microbiota transplant for treatment of diarrhea in adult hospitalized horses-111 cases (2013-2018) - PubMed
There were no significant advantages of performing FMTs in horses with diarrhea in this retrospective study. This highlights the need for prospective, randomized studies to evaluate the efficacy of FMT, as well as different formulations, in horses with colitis before this can become standard practic …
Gut Microbiome (Bacteria, Fungi, and Viruses) and HIV Infection: Revealing Novel Treatment Strategies - PubMed
Plenty of research on microbial-viral interactions has revealed that some commensal microorganisms in the gut, including bacteria, fungi, and viruses, can resist or promote viral infection, whereas other microorganisms are involved in pathogenicity. Therefore, the balance between commensal microorga …
Global Microbiome Therapeutics for Clostridium Difficile Infection Market is projected to reach the value of USD 3.75 billion by 2030
According to the report published by Virtue Market Research in Global Microbiome Therapeutics for Clostridium Difficile Infection Market was valued at USD 1 2 billion and is projected to reach a market size of USD 3 75 billion by the ...
Re: 'the effect of antibiotic therapy for Clostridioides difficile infection on mortality and other patient-relevant outcomes' by Stabholz et al - PubMed
Re: 'the effect of antibiotic therapy for Clostridioides difficile infection on mortality and other patient-relevant outcomes' by Stabholz et al
C difficile and antibiotics . . . and other stories
A case-control study from the US quantified the risk of Clostridioides difficile infection following a recent antibiotic prescription. It found a 20-fold variation across antibiotic classes and only slightly less variation across individual antibiotics within classes. Clindamycin and later generation cephalosporins carried the greatest risk for C difficile infection, while tetracyclines hardly increased risk at all ( Open Forum Infect Dis doi:10.1093/ofid/ofad413). People who said they were lonely at the time of recruitment into the UK Biobank study were more likely to develop incident Parkinson disease over 15 years of observation. The association was only slightly diminished after adjustment …