C Difficile

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Poria cocos polysaccharides alleviate dextran sulphate sodium-induced ulcerative colitis in mice by modulating intestinal inflammatory responses and microbial dysbiosis - PubMed
Poria cocos polysaccharides alleviate dextran sulphate sodium-induced ulcerative colitis in mice by modulating intestinal inflammatory responses and microbial dysbiosis - PubMed
Poria cocos polysaccharide (PCP), one of the main active components of P. cocos, is extensively used worldwide and exhibits strong pharmacological effects. However, whether PCP can attenuate inflammatory bowel disease remains unclear. In this study, we assessed the effects of PCP supplementation on …
·pubmed.ncbi.nlm.nih.gov·
Poria cocos polysaccharides alleviate dextran sulphate sodium-induced ulcerative colitis in mice by modulating intestinal inflammatory responses and microbial dysbiosis - PubMed
Maidong Dishao Decoction mitigates submandibular gland injury in NOD mice through modulation of gut microbiota and restoration of Th17/Treg immune balance - PubMed
Maidong Dishao Decoction mitigates submandibular gland injury in NOD mice through modulation of gut microbiota and restoration of Th17/Treg immune balance - PubMed
In summary, MDDST demonstrates protective effects against pSS by restoring the balance between Th17 and Treg cells. The therapeutic effects can be partially attributed to its regulation of gut microbiota and SCFAs. Our finding provides a new option for treating pSS.
·pubmed.ncbi.nlm.nih.gov·
Maidong Dishao Decoction mitigates submandibular gland injury in NOD mice through modulation of gut microbiota and restoration of Th17/Treg immune balance - PubMed
Probiotics and their metabolite spermidine enhance IFN-γ+CD4+ T cell immunity to inhibit hepatitis B virus - PubMed
Probiotics and their metabolite spermidine enhance IFN-γ+CD4+ T cell immunity to inhibit hepatitis B virus - PubMed
The therapeutic potential of commensal microbes and their metabolites is promising in the functional cure of chronic hepatitis B virus (HBV) infection, which is defined as hepatitis B surface antigen (HBsAg) loss. Here, using both specific-pathogen-free and germ-free mice, we report that probiotics …
·pubmed.ncbi.nlm.nih.gov·
Probiotics and their metabolite spermidine enhance IFN-γ+CD4+ T cell immunity to inhibit hepatitis B virus - PubMed
The always evolving diagnosis and management of Clostridioides difficile colitis: What you need to know - PubMed
The always evolving diagnosis and management of Clostridioides difficile colitis: What you need to know - PubMed
The diagnosis, pharmacologic management, and surgical options for Clostridioides difficile infection (CDI) are rapidly evolving, which presents a challenge for the busy surgeon to remain up to date on the latest clinical guidelines. This review provides an evidence-based practical guide for CDI mana …
·pubmed.ncbi.nlm.nih.gov·
The always evolving diagnosis and management of Clostridioides difficile colitis: What you need to know - PubMed
Adenosine regulates depressive behavior in mice with chronic social defeat stress through gut microbiota - PubMed
Adenosine regulates depressive behavior in mice with chronic social defeat stress through gut microbiota - PubMed
Major depressive disorder (MDD) is recognized as the most prevalent affective disorder worldwide. Metagenomic studies increasingly support a critical role for dysbiosis of gut microbiota in the development of depression. Previous studies have demonstrated that adenosine alleviates gut dysbiosis, sug …
·pubmed.ncbi.nlm.nih.gov·
Adenosine regulates depressive behavior in mice with chronic social defeat stress through gut microbiota - PubMed
Gut-brain axis and neurodegeneration: mechanisms and therapeutic potentials - PubMed
Gut-brain axis and neurodegeneration: mechanisms and therapeutic potentials - PubMed
This paper reviews the effects of gut microbiota in regulating neurodegenerative diseases through controlling gut-brain axis. Specific microbial populations and their metabolites (short-chain fatty acids and tryptophan derivatives) regulate neuroinflammation, neurogenesis and neural barrier integrit …
·pubmed.ncbi.nlm.nih.gov·
Gut-brain axis and neurodegeneration: mechanisms and therapeutic potentials - PubMed
Interaction between young fecal transplantation and perfluorobutanesulfonate endocrine disrupting toxicity in aged recipients: An estrobolome perspective - PubMed
Interaction between young fecal transplantation and perfluorobutanesulfonate endocrine disrupting toxicity in aged recipients: An estrobolome perspective - PubMed
Transplanting young feces into the aged was found to effectively counteract the endocrine disrupting effects of perfluorobutanesulfonate (PFBS) pollutant, showing promise in the maintenance of healthy aging. However, the interactive mechanisms between young fecal transplantation and PFBS endocrine d …
·pubmed.ncbi.nlm.nih.gov·
Interaction between young fecal transplantation and perfluorobutanesulfonate endocrine disrupting toxicity in aged recipients: An estrobolome perspective - PubMed
EmeritusDX Launches GI Detect™: A Comprehensive Diagnostic Test for Gastrointestinal Health with Rapid 24-Hour Turnaround
EmeritusDX Launches GI Detect™: A Comprehensive Diagnostic Test for Gastrointestinal Health with Rapid 24-Hour Turnaround
New Test Detects 26 Bacteria, Viruses, and Parasites in a Single, Simple Stool Swab LAKE FOREST, Calif., Nov. 14, 2024 /PRNewswire-PRWeb/ -- EmeritusDX, a rapidly growing diagnostics and information company, today...
·streetinsider.com·
EmeritusDX Launches GI Detect™: A Comprehensive Diagnostic Test for Gastrointestinal Health with Rapid 24-Hour Turnaround
Medication-related burden among Iraqi patients with ulcerative colitis: a cross-sectional study - PubMed
Medication-related burden among Iraqi patients with ulcerative colitis: a cross-sectional study - PubMed
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by recurring periods of inflammation and remission, primarily affecting the colon. The concept of medication-related burden, which refers to the adverse effects experienced by patients due to conventional medical treatment …
·pubmed.ncbi.nlm.nih.gov·
Medication-related burden among Iraqi patients with ulcerative colitis: a cross-sectional study - PubMed
Association of gut microbiota with allograft injury in kidney transplant recipients: a comparative profiling through 16S metagenomics and quantitative PCR - PubMed
Association of gut microbiota with allograft injury in kidney transplant recipients: a comparative profiling through 16S metagenomics and quantitative PCR - PubMed
Introduction. The existence of a mutual relationship between gut microbiota and immune homeostasis highlights its importance in the context of kidney transplantation.Gap statement. The translational utility of gut microbiota as a biomarker for allograft injury has not been assessed bef …
·pubmed.ncbi.nlm.nih.gov·
Association of gut microbiota with allograft injury in kidney transplant recipients: a comparative profiling through 16S metagenomics and quantitative PCR - PubMed
Clostridioides difficile infection increases in-hospital mortality, length of stay, and hospital cost but not 30-day mortality in cirrhotic patients - PubMed
Clostridioides difficile infection increases in-hospital mortality, length of stay, and hospital cost but not 30-day mortality in cirrhotic patients - PubMed
CDI is associated with increased in-hospital mortality, length of stay, and hospital costs, but not with 30-day mortality in cirrhotic patients.
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile infection increases in-hospital mortality, length of stay, and hospital cost but not 30-day mortality in cirrhotic patients - PubMed
Spatiotemporal dynamics during niche remodeling by super-colonizing microbiota in the mammalian gut - PubMed
Spatiotemporal dynamics during niche remodeling by super-colonizing microbiota in the mammalian gut - PubMed
While fecal microbiota transplantation (FMT) has been shown to be effective in reversing gut dysbiosis, we lack an understanding of the fundamental processes underlying microbial engraftment in the mammalian gut. Here, we explored a murine gut colonization model leveraging natural inter-individual v …
·pubmed.ncbi.nlm.nih.gov·
Spatiotemporal dynamics during niche remodeling by super-colonizing microbiota in the mammalian gut - PubMed
Freeze-dried fecal microorganisms as an effective biomaterial for the treatment of calves suffering from diarrhea - PubMed
Freeze-dried fecal microorganisms as an effective biomaterial for the treatment of calves suffering from diarrhea - PubMed
Fecal microbiota transplantation (FMT) is a therapeutic modality for treating neonatal calf diarrhea. Several practical barriers, including donor selection, fecal collection, and a limited timeframe for FMT, are the main constraints to using fresh feces for implementing on-farm FMT. We report the ut …
·pubmed.ncbi.nlm.nih.gov·
Freeze-dried fecal microorganisms as an effective biomaterial for the treatment of calves suffering from diarrhea - PubMed
Safety comparison of single-donor and pooled fecal microbiota transfer product preparation in ulcerative colitis: systematic review and meta-analysis - PubMed
Safety comparison of single-donor and pooled fecal microbiota transfer product preparation in ulcerative colitis: systematic review and meta-analysis - PubMed
Similar safety profiles were observed for MDN and SDN strategies. Alongside previously described superior efficacy, treatment with MDN has greater benefit-risk ratio than SDN in patients with UC. Further development of MDN FMT treatment for UC should be considered.
·pubmed.ncbi.nlm.nih.gov·
Safety comparison of single-donor and pooled fecal microbiota transfer product preparation in ulcerative colitis: systematic review and meta-analysis - PubMed
The landscape of new therapeutic opportunities for IBD - PubMed
The landscape of new therapeutic opportunities for IBD - PubMed
This chapter presents an overview of the emerging strategies to address the unmet needs in the management of inflammatory bowel diseases (IBD). IBD poses significant challenges, as over half of patients experience disease progression despite interventions, leading to irreversible complications, and …
·pubmed.ncbi.nlm.nih.gov·
The landscape of new therapeutic opportunities for IBD - PubMed
Understanding the relationship between breast cancer, immune checkpoint inhibitors, and gut microbiota: a narrative review - PubMed
Understanding the relationship between breast cancer, immune checkpoint inhibitors, and gut microbiota: a narrative review - PubMed
The composition of gut microbiota could help predict the chance of response to immunotherapy, and modulating gut microbiota has the potential to enhance the efficacy of chemo-immunotherapy in breast cancer. However, the available data relating to breast cancer are limited. Larger prospective studies …
·pubmed.ncbi.nlm.nih.gov·
Understanding the relationship between breast cancer, immune checkpoint inhibitors, and gut microbiota: a narrative review - PubMed
Contribution of gut microbiota to the development of Crohn's disease: Insights gained from fecal microbiota transplantation studies in mice - PubMed
Contribution of gut microbiota to the development of Crohn's disease: Insights gained from fecal microbiota transplantation studies in mice - PubMed
We would like to present some new thoughts on the publication in the journal published in August 2024 in iWorld Journal of Gastroenterology/i. We specifically focused on the alterations in the intestinal tract, mesenteric adipose tissue (MAT), and systemic inflammatory changes in mice following …
·pubmed.ncbi.nlm.nih.gov·
Contribution of gut microbiota to the development of Crohn's disease: Insights gained from fecal microbiota transplantation studies in mice - PubMed
Clinical outcomes and associated bacterial and fungal microbiota changes after high dose probiotic therapy for severe alcohol-associated hepatitis: An observational study - PubMed
Clinical outcomes and associated bacterial and fungal microbiota changes after high dose probiotic therapy for severe alcohol-associated hepatitis: An observational study - PubMed
Alcohol-associated hepatitis (AH) is a critical condition with high mortality rates and is worsened by infections. Organ failure is strongly associated with intestinal dysbiosis. Emerging research suggests that gut microbiota modulation with probiotics can improve AH outcomes. This study investigate …
·pubmed.ncbi.nlm.nih.gov·
Clinical outcomes and associated bacterial and fungal microbiota changes after high dose probiotic therapy for severe alcohol-associated hepatitis: An observational study - PubMed
[The role and features of the gut microbiota in Alzheimer's disease] - PubMed
[The role and features of the gut microbiota in Alzheimer's disease] - PubMed
Alzheimer's disease causes gradual, persistent deterioration of cognitive function in the elderly, causing social and economic damage to society. Over the past decades, mankind has made significant progress in the study of Alzheimer's disease, but there are no methods to fully control the disease. T …
·pubmed.ncbi.nlm.nih.gov·
[The role and features of the gut microbiota in Alzheimer's disease] - PubMed
Investigating surface area and recovery efficiency of healthcare-associated pathogens to optimize composite environmental sampling - PubMed
Investigating surface area and recovery efficiency of healthcare-associated pathogens to optimize composite environmental sampling - PubMed
Hospital surfaces are known to contribute to the spread of healthcare-associated antimicrobial pathogens. Environmental sampling can help locate reservoirs and determine intervention strategies, although sampling and detection can be labor intensive. Composite approaches may help reduce time and cos …
·pubmed.ncbi.nlm.nih.gov·
Investigating surface area and recovery efficiency of healthcare-associated pathogens to optimize composite environmental sampling - PubMed
From Chaos to Clarity? The Quest for Effective Probiotics in Antibiotic-Associated Diarrhea - PubMed
From Chaos to Clarity? The Quest for Effective Probiotics in Antibiotic-Associated Diarrhea - PubMed
Antibiotic-associated diarrhea (AAD) frequently complicates treatment of infections. A recent randomized, double-blind, placebo-controlled trial tested a proprietary probiotic mixture and found that it reduced the incidence of AAD by 16%. This is encouraging for patients, but future progress on prob …
·pubmed.ncbi.nlm.nih.gov·
From Chaos to Clarity? The Quest for Effective Probiotics in Antibiotic-Associated Diarrhea - PubMed
Distribution of Clostridioides difficile ribotypes and sequence types across humans, animals and food in thirteen European countries - PubMed
Distribution of Clostridioides difficile ribotypes and sequence types across humans, animals and food in thirteen European countries - PubMed
spaniClostridioides difficile/i is a One Health pathogen found in humans, animals, and environment, with food representing a potential transmission route. One Health studies are often limited to single country or selected reservoirs and ribotypes. This study provides a varied and accessible collecti/span …
·pubmed.ncbi.nlm.nih.gov·
Distribution of Clostridioides difficile ribotypes and sequence types across humans, animals and food in thirteen European countries - PubMed
Bioengineered Probiotics for Clostridioides difficile Infection: An Overview of the Challenges and Potential for This New Treatment Approach - PubMed
Bioengineered Probiotics for Clostridioides difficile Infection: An Overview of the Challenges and Potential for This New Treatment Approach - PubMed
The rapid increase in microbial antibiotic resistance in Clostridioides difficile (C. difficile) strains and the formation of hypervirulent strains have been associated with a global increase in the incidence of C. difficile infection (CDI) and subsequently, an increase in the rate of recurrence. Th …
·pubmed.ncbi.nlm.nih.gov·
Bioengineered Probiotics for Clostridioides difficile Infection: An Overview of the Challenges and Potential for This New Treatment Approach - PubMed
Clostridioides difficile infections caused by hypervirulent strains: a single-centre real-life study - PubMed
Clostridioides difficile infections caused by hypervirulent strains: a single-centre real-life study - PubMed
Our epidemiological data, while suggesting a potential resurgence in CDI transmission during COVID-19 pandemic, are derived from a single-center experience with limited generalizability to the broader population. Nonetheless, they highlight the need for strengthened antimicrobial stewardship and nat …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile infections caused by hypervirulent strains: a single-centre real-life study - PubMed
Transmission of MRSA, ESBL E. coli, and C. difficile within a tertiary care hospital and across surrounding facilities in Japan: a molecular epidemiological study with the PCR-based Open-reading frame typing - PubMed
Transmission of MRSA, ESBL E. coli, and C. difficile within a tertiary care hospital and across surrounding facilities in Japan: a molecular epidemiological study with the PCR-based Open-reading frame typing - PubMed
MDROs/C. difficile transmission is prevalent within a tertiary care hospital and further complicated by its inter-facility transmission across surrounding LTCFs and hospitals in Japan.
·pubmed.ncbi.nlm.nih.gov·
Transmission of MRSA, ESBL E. coli, and C. difficile within a tertiary care hospital and across surrounding facilities in Japan: a molecular epidemiological study with the PCR-based Open-reading frame typing - PubMed
Regulatory Networks: Linking Toxin Production and Sporulation in Clostridioides difficile - PubMed
Regulatory Networks: Linking Toxin Production and Sporulation in Clostridioides difficile - PubMed
Clostridioides difficile has been recognized as an important nosocomial pathogen that causes diarrheal disease as a consequence of antibiotic exposure and costs the healthcare system billions of dollars every year. C. difficile enters the host gut as dormant spores, germinates into vegetative cells, …
·pubmed.ncbi.nlm.nih.gov·
Regulatory Networks: Linking Toxin Production and Sporulation in Clostridioides difficile - PubMed
Assessing the Risk of Spreading Clostridioides difficile and Its Toxins Within the Dairy Farm - PubMed
Assessing the Risk of Spreading Clostridioides difficile and Its Toxins Within the Dairy Farm - PubMed
Clostridioides difficile currently constitutes a major pathogen of the gastrointestinal tract, which poses a significant growing burden on medicine and veterinary medicine in many regions. A farm was assessed (feed table, silage pit, and feces (healthy animals, emaciated animals, and animals …
·pubmed.ncbi.nlm.nih.gov·
Assessing the Risk of Spreading Clostridioides difficile and Its Toxins Within the Dairy Farm - PubMed