C Difficile

PDF | Introduction Inflammatory bowel disease (IBD) has historically been seen as predominantly affecting non-Hispanic Whites (NHW). Hispanics are the... | Find, read and cite all the research you need on ResearchGate

Download Citation | Delayed Corticosteroid Treatment for Patients Requiring Hospitalization for Acute Inflammatory Bowel Disease Exacerbations Increases Length of Stay and Risk for Surgery in Crohn’s Disease | Background While corticosteroids are not recommended for maintenance of remission in inflammatory bowel disease (IBD), they are quite effective... | Find, read and cite all the research you need on ResearchGate

Prevention beats treatment for everyone — patients, payers and investors.

Findings from the VIVID-2 open-label extension study of mirikizumab-mrkz (Omvoh) in patients with moderately to severely active Crohn's disease (CD) are shed...

The crucial drugs can have unintended consequences. Innovative therapies could shield the microbiome from their effects.

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Among common empiric antibiotics, parenteral vancomycin and cefepime appeared to increase risk of hospital-onset CDI. Causal inference observational study designs can be used to estimate patient-level harms of interventions such as empiric antimicrobials.

Composed of an elaborate ecosystem of bacteria, fungi, viruses and protozoa residing in the human digestive tract, the gut microbiome influences metabolism, immune modulation, bile acid homeostasis and host defence. Through observational and preclinical data, the gut microbiome has been implicated i …

UVL disinfection technologies have demonstrated potential in reducing HAIs, particularly when integrated into a comprehensive infection prevention strategy. Their effectiveness, however, varies by application, pathogen type, and healthcare setting. Further research is needed to optimize UVL implemen …

spaniClostridioides difficile/i (iC. difficile/i) infections (CDIs) are typically intestinal but can also present extraintestinally, a rare occurrence with limited literature. This case describes a woman with cirrhosis who developed spontaneous bacterial peritonitis (SBP) caused by monomicrobial/span …

Anti-IL5 therapy significantly reduces adverse events categorized as serious bacterial infections, pneumonia, influenza, non-serious lower respiratory tract infections and C.difficile infection. In the population of patients receiving anti-IL5 therapy, these effects may translate into substantial de …

A CDI prior to TKA is an independent risk factor for PJI. Closer proximity of CDI to surgery is associated with a "dose-dependent" increased PJI risk. Surgeons should consider delaying TKA until a minimum of one year after a diagnosis of CDI.

We demonstrated favorable clinical and safety outcomes with our COpAT program and substantial cost savings using existing infrastructure. COpAT allows efficient use of healthcare resources including decongestion of hospitals.

IBD significantly increases the risk of CDI among patients treated with biologic therapy; although such treatments do not seem to individually increase the risk, the number of biologics received may be a new predictor of CDI.

Faecal microbiota transplantation (FMT) is increasingly used for diseases associated with a disrupted intestinal microbiome, mainly iClostridioides difficile/i infection. Encapsulated FMT is a patient-friendly application method that improves accessibility and convenience. Capsule processing may …

Citrulline exerts anti-inflammatory effects in the intestines against C. difficile toxins and inhibits CDI recurrence in mice and hamsters.

Bacterial spores formed upon metabolic stress have minimal metabolic activity and can remain dormant for years. Nevertheless, they can sense the environment and germinate quickly upon exposure to various germinants. Germinated spores can then outgrow into vegetative cells. Germination of spores of s …

The monitoring of gut colonization by MDR microorganisms in a single LTCF for 1 year demonstrated the predominance of ESBL-producing iE. coli/i. Almost half of the residents were resistant to its colonization, whereas in 15.5% of them gut colonization was stable. Incidence of infectious episodes …

Our work provides, for the first time, genomic insights into C. difficile strains present in Mexico. In our hospital setting, the predominant strains were primarily NAP1/RT027 and exhibited resistance to linezolid, a pattern observed in both pediatric and adult populations. This unique combination o …

A shocking outbreak of Clostridium difficile at Margaret Hospital has resulted in the tragic death of one of the hospital's oncologists, raising alarms about food…

Learn more about the facts and figures surrounding the state of healthcare-associated infections in the US today.

Clostridioides difficile (C. difficile) is a leading cause of hospital-associated diarrhea, primarily due to gut dysbiosis following antibiotic use. Probioti...

Dietary intervention with the exclusion of potential allergens from poultry meat and egg sources can be an effective approach for the management of canine atopic dermatitis.

CDI recurrence rates among cancer patients remain significant. Nonetheless, fidaxomicin and other preventive strategies are seldom used. We identified several factors that could inform the implementation of these strategies in cancer patients.

The DASC score within 30 days before CDI diagnosis appears to be a predictive risk factor for CDI recurrence.

Clostridioides difficile infection (CDI) is an urgent public health threat with a high rate of recurrence and limited treatment options. In vivo models have been indispensable in understanding CDI pathophysiology and establishing treatment protocols and continue to be essential in pre- …

This retrospective cohort study evaluated the proportion of inpatients initiated and successfully discharged on fidaxomicin for Clostridioides difficile infection. Nearly, all patients (96.4%; 27/28) were able to obtain fidaxomicin to complete their treatment course, although there was variab …

Bioaerosols, a subset of aerosols released from the biosphere, can carry pathogens, and include particles with diameters from nanometres to a few micrometres. They can remain suspended indoors and travel significant distances. Bioaerosol studies play a vital role in public health, as bioaerosols are …