C Difficile

Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide and seriously affects the quality of life of elderly patients. PD is characterized by the loss of dopaminergic neurons in the substantia nigra as well as abnormal accumulation of α-synuclein in neurons. Recent res …

In this letter, we commented on the article by Wu et al. We examined the interactions between mesenteric adipose tissue, creeping fat, and gut microbiota in Crohn's disease (CD), a condition marked by chronic gastrointestinal inflammation with a rising global incidence. The pathogenesis of CD …

Gut microbiota has a symbiotic relationship with the host and is closely linked to the development of type 2 diabetes mellitus (T2DM). Polysaccharides are natural bioactive compounds with beneficial effects on T2DM; however, the mechanisms underlying their effects remain unclear. This study investig …

There is a significant association between AUD and increased risk of C. diff, with that risk increasing in patients actively withdrawing. This information can be used to guide earlier interventions.

Enhancing understanding and treatment of post-infectious IBS following Clostridioides difficile Infection

Guava Health explains the complex post-pandemic relationship between Long COVID and postural orthostatic tachycardia syndrome.

The Journal of Antibiotics - Differential gene expression analysis shows that cephalosporin resistance is intrinsic to Clostridioides difficile strain 630

This research is the first to demonstrate that WOA prevents PE by enriching Bifidobacterium bifidum, strengthening the gut-placenta barrier, and inhibiting placental ferroptosis. Our findings provide compelling evidence for the vital involvement of the gut-placental axis in the protection of AVL on …

An imbalance in the microbiota-gut-brain axis exerts an essential effect on the pathophysiology of depressive and anxiety disorders. Our previous research revealed that the timing of inulin administration altered its effects on chronic unpredictable mild stress (CUMS)-induced anxiety and depression. …

The gut microbiome plays a key role in bile acid (BA) metabolism, where a diversity of metabolic products contribute to human health and disease. In particular, Inflammatory Bowel Disease (IBD) is characterized by a low concentration of secondary bile acids (SBAs), whose transformation from primary …

Bacterial noncoding RNAs fulfill a variety of cellular functions as catalysts, as scaffolds in protein complexes or as regulators of gene expression. They often exhibit complex tertiary structures that are a key determinant of their biochemical function. Here, we characterize the structured "raiA mo …

Clostridioides difficile is a major cause of nosocomial infections, often associated with individuals who have gut dysbiosis from previous antibiotic therapies. C. difficile infections (CDI) have a high recurrence rate and impose significant financial and mortality burdens on the healthcare system. …

(a) Clostridioides difficile (C. difficile) bacterium can cause severe diarrhea and its over-colonization in the host's intestinal tract lead to the development of pseudomembranous colitis, generally due to antibiotic usage. The primary exotoxins involved are toxin A (TcdA) and toxin B (TcdB), the l …

Long-term-stool-storage enhances FMT accessibility without compromising its success, despite taxonomic changes after 24 months.

Although immune-checkpoint inhibitors (ICIs) have significantly improved cancer treatment, their effectiveness is limited by primary or acquired resistance in many patients. The gut microbiota, through its production of metabolites and regulation of immune cell functions, plays a vital role in maint …

Broad-spectrum antibiotics were related to an increased risk for adverse drug events among adults with CAP who were treated in the outpatient setting.

OROVILLE — In a nonprofit’s report released this week grading hospitals across the nation on overall performance in keeping patients safe from preventable harm and medical errors, Oroville Hospital received a D. The Leapfrog Group, an independent national nonprofit health care watchdog organization established in 2000, annually grades health care facilities on a scale from A to F, with A ...

Bacterial non-coding RNAs influence various cellular functions and often have complex tertiary structures. This study characterizes ModT, a conserved ncRNA found in 2,500 bacterial species, found to regulate growth transition and sporulation in Clostridioides difficile via changes in c-di-GMP.

OpenBiome has voluntarily suspended distribution of fecal transplantation preparations for the treatment of recurrent emC. difficile/em infections.

While eradication of C. difficile is not required for clinical cure of rCDI by FMT, it is associated with reduced prevalence of early CDI recurrence, as are the full completion of pre-FMT vancomycin (at least 10 days) and avoiding post-FMT antibiotics.

Japan has experienced several large earthquakes in the past 30 years. Emergency evacuation shelters become overcrowded immediately after disasters. Deteriorating sanitary conditions in toilets are associated with a higher risk of infectious pathogen transmission. "Ho!Toilet" is a toilet sanitary goo …

This rapid review identified and summarised evidence of the accuracy of new diagnostic tests for Clostridioides difficile (C. difficile).

Cancer remains a significant global health concern, and understanding factors that regulate cancer development is important. The microbiome, with its potential role in cancer development, progression, and treatment, has garnered increasing attention in recent years. The cervicovaginal and gastrointe …

The laboratory diagnosis of iClostridioides difficile/i infection (CDI) is controversial. Nucleic acid amplification tests (NAAT) and toxin enzyme immunoassays (EIA) are most widely used, often in combination. However, the interpretation of a positive NAAT and negative toxin immunoassay (NAAT+/E …

Based on our findings, we elucidate a novel mechanism by which PAMK alleviates DSS-induced colitis and thus provides evidence to support the potential development of PAMK as a new clinical drug against UC.

The maternal microbiome influences child health. However, its impact on a given offspring's stem cells, which regulate development, remains poorly understood. To investigate the role of the maternal microbiome in conditioning the offspring's stem cells, we manipulated maternal microbiota using Akker …

The National Institute of Allergy and Infectious Diseases has awarded $3.7 million to Kirk Hevener, PharmD, PhD, associate professor in the Department of Pharmaceutical Sciences at the University of Tennessee Health Science Center College of Pharmacy, for a project to develop new treatments for Clostridioides difficile (C. diff) infection, a serious and often deadly bacterial infection of the colon.

To investigate whether the polysaccharide component of the Traditional Chinese Medicine (TCM) formula Lizhong decoction (LZD) has therapeutic effects and regulates gut microbiota in antibiotic-associated diarrhea (AAD) related to Clostridium difficile infection, a polysaccharide was extracted from L …

Diabetes is associated with a worse prognosis in patients with CDI. Prevention efforts should be optimized in patients with diabetes by reducing CDI transmission and avoiding nonessential medications, such as PPIs or antibiotics when they are not necessary.