C Difficile

The latest market intelligence report published by WMR with the title Global Fecal Transplant Therapy Market 2024 Growth Opportunities and Forecast provides actionable insights on Healthcare and Pharmaceuticals industry The report provides demand analysis industry insights competitive intelligence and customer ...

Preparing fecal microbiota transplants immediately after donation is resource-intensive, and a proportion are destroyed following abnormal screening results. We retrospectively compared two processes, frozen fecal preparation (FFP) and fresh native frozen preparation (FNFP), for clinical efficacy in …

The presence of DKA significantly elevates hospital burden and CDI complications in diabetic patients. These findings underscore the need for close monitoring and aggressive management of DKA in patients with concurrent CDI to improve outcomes.

The importance of recognition of comorbidities: Diabetic ketoacidosis and Clostridioides difficile infection

Selenium is a trace element that plays critical roles in redox biology; it is typically incorporated into "selenoproteins" as the 21st amino acid selenocysteine. Additionally, selenium exists as a labile non-selenocysteine cofactor in a small subset of selenoproteins known as selenium-dependent moly …

Ulcerative colitis (UC) is a chronic colonic mucosal inflammation characterized by reduced gut microbial diversity. UC patients at pregnancy are prone to suf...

Launching the Clostridioides difficile collection

Antimicrobial resistance poses a significant threat to humanity, and the development of new antibiotics is urgently needed. Our research has focused on thiopeptide antibiotics such as micrococcin P2 (MP2) and derivatives thereof as new anti-infective agents. Thiopeptides are sulfur-rich, structurall …

391 hospitals in the U.S. have a Clostridioides difficile infection rate of zero according to CMS data

Scientists discover how C. diff rapidly evolves resistance to vancomycin, a crucial antibiotic, posing a significant threat to global health.

Among ventilated ICU patients with suspected infection, the length of antibiotic use went down after respiratory viral panel testing was adopted, according to results published in Annals of the American Thoracic Society.“These results suggest that [respiratory viral panel] testing is a valuable tool to guide antibiotic use in patients with suspected infection,” Jacqueline Dinh, MD,

Antimicrobial susceptibility testing techniques and results were found to be diverse and heterogeneous. There is no evidence of an exclusive antimicrobial resistance pattern in any animal species. Despite the phenotypic and genomic data collected over the years, further interdisciplinary studies are …

The guideline panel reviewed the impact of decolonization, targeted PAP, and combined interventions (e.g., decolonization and targeted PAP) on the risk of SSIs and other outcomes in MDR-GPB carriers, according to the type of bacteria and type of surgery. We recommend screening for S. aureus (SA) bef …

Oxygen tolerance of anaerobes is a virulence factor, but can also be a beneficial property. Many species have evolved to tolerate or take advantage of the presence of low, especially nanaerobic (≤0.14%) oxygen concentrations. Oxygen tolerance is genus-, species- and strain-dependent according to the …

This chapter emphasizes on comparisons between the Clostridium perfringens and Clostridium difficile antibiotic resistance determinants and transposon…

At DDW 2024, Jessica Allegretti, MD, MPH, described new treatments for recurrent emC. difficile/em and how she incorporates them into her practice.

We developed ML models to predict 28-day all-cause mortality in HF patients associated with CDI in the ICU, which are more effective than the conventional logistic regression model. The RF model has the best performance among all the ML models employed. It may be useful to help clinicians identify h …

Antibiotic resistance is increasingly becoming one of the most pressing concerns within healthcare systems worldwide. This issue affects not only individual patients…

Clostridioides difficile is an important human pathogen, for which there are very limited treatment options, primarily the glycopeptide antibiotic vancomycin. In recent years, vancomycin resistance has emerged as a serious problem in several gram-positive pathogens, but high-level resistance has yet …

Most bacteria are surrounded by a cell wall that contains peptidoglycan (PG), a large polymer composed of glycan strands held together by short peptide cross-links. There are two major types of cross-links, termed 4-3 and 3-3 based on the amino acids involved. 4-3 cross-links are created by penicill …

Concurrent cytomegalovirus infection in patients with inflammatory bowel disease presents a significant clinical challenge due to its associated morbidity and mortality. Diagnosing and managing this condition is particularly difficult, especially regarding the initiation or continuation of immunosup …

The study confirmed the multifaceted nature to infection prevention and emphasized the importance of interdepartmental collaboration to improve patient safety.

Due to envelope differences between Gram-positive and Gram-negative bacteria, engineering precision bactericidal contractile nanomachines requires atomic-level understanding of their structures; however, only those killing Gram-negative bacteria are currently known. Here, we report the atomic struct …

An Indiana grandma killed off a devastating superbug with a homemade fecal transplant and then embarked on a crusade to win over the FDA.

The use of clindamycin or metronidazole prescribed in an outpatient setting was associated with a statistically significant increased risk of CDI in patients with IBD. Although the association between clindamycin and CDI is a well-established and common finding, the association between metronidazole …

Fecal microbial transplantation (FMT) for inflammatory diseases or refractory immune checkpoint inhibitor therapy is less effective than for preventing recurrent Clostridioides difficile infection. This commentary outlines strategies to use biomarkers of successful FMT to guide newer approaches to r …

Clostridioides difficile is an important human pathogen, for which there are very limited treatment options, primarily the glycopeptide antibiotic vancomycin. In recent years, vancomycin resistance has emerged as a serious problem in several gram-positive pathogens, but high-level resistance has yet …

The global burden of CDI has continuously increased for the past 30 years, especially in high to middle-SDI regions. World antibiotic consumption showed a strong positive correlation with CDI with different risk stratification. More effective prevention and control measures should be implemented in …

Researchers have discovered how the hospital superbug Clostridioides difficile (C. diff), rapidly evolves resistance to the frontline drug vancomycin, which is used for treatment in the UK. C. diff is […]

Most bacteria are surrounded by a cell wall that contains peptidoglycan (PG), a large polymer composed of glycan strands held together by short peptide cross-links. There are two major types of cross-links, termed 4-3 and 3-3 based on the amino acids involved. 4-3 cross-links are created by penicill …