C Difficile

Certain ribotypes, including RT 027, were the sole independent risk factors for reduced VAN susceptibility. Increased clinical surveillance of these strains, especially RT 027, and their antibiotic susceptibly is warranted to inform prescribing practices.

MGPP testing is most useful when administered as an outpatient and of little benefit for inpatients with hospital-onset diarrhea. Since MGPP is sensitive and does not distinguish between colonization and causes of diarrhea, caution is needed in interpretation of results, especially for toxin-negativ …

CDI prevalence increased with the number of antimicrobial classes used in combination. Certain types or combinations of antimicrobials may increase the OR for CDI.

Prolonged hospital stay after birth is associated with infant gut dysbiosis.

The diagnosis, pharmacologic management, and surgical options for Clostridioides difficile infection (CDI) are rapidly evolving, which presents a challenge for the busy surgeon to remain up to date on the latest clinical guidelines. This review provides an evidence-based practical guide for CDI mana …

EriB ameliorated in mice with EAP, the gut microbiota mediates vitamin D3 alterations to modulate macrophage phenotype polarizing from M1 to M2.

As patients increasingly turn to at-home food sensitivity and microbiome tests, gastroenterologists are navigating a landscape fraught with scientific uncertainty ...

The country’s largest fecal distributor, OpenBiome, could be prevented from offering the product next year if the FDA does not approve the product used for fecal microbiota transplants to treat fulminant C difficile.

At Mayo Clinic’s Center for Individualized Medicine, scientists are investigating stool samples to uncover new insights into cancer treatment.

A dive into microbiome-focused skincare

According to a new CDC progress report, rates of healthcare-associated infections (HAIs) at U.S. hospitals decreased in 2023 after increasing significantly during the COVID-19 pandemic. However, even with progress being made, experts say that more work is needed to sustain the improvements.

Colitis is associated with many diseases, and treatment depends on the exact cause.

Healthcare

Dr David Johnson highlights studies on increasing disease rates, the surprising effects of palliative care consultations, and drugs on the verge of approval.

A randomized controlled trial finds no clear benefit of adding bezlotoxumab to FMT in patients with IBD and recurrent C difficile infection.

The certification is for products used in hematology instruments manufactured globally, including instruments from Abbott, Beckman Coulter, and Siemens Healthineers.

George Sakoulas, MD, offered clinical considerations for treatment selection.

Taking probiotics with antibiotics can help protect the gut from the negative effects of antibiotics. But some people may benefit from it more than others.

PHILADELPHIA — Rebyota was safe and effective at 8 weeks and up to 6 months in patients with recurrent Clostridioides difficile infection, many of whom had other gastrointestinal comorbidities and risk factors, according to data presented. “We showed a significant decrease in recurrence rates of Clostridioides difficile in a real-world population,” Timothy E. Ritter, MD, a

Clostridium difficile is the most common cause of nosocomial infectious diarrhea. The incidence of C difficile infection (CDI) is increasing in both inpatients and outpatients, and outbreaks caused by a hypervirulent strain of C difficile are ...

RBL is the first FDA-approved microbiota-based live biotherapeutic product for adults.

PHILADELPHIA — Bezlotoxumab in combination with fecal microbiota transplantation did not further reduce recurrence of Clostridioides difficile infection in patients with inflammatory bowel disease, according to data presented here. “This was the first clinical trial to assess the clinical effect of FMT in combination with bezlotoxumab in patients with IBD and recurrent C. diff,”

The global antimicrobial resistance diagnostics market was valued at USD 4.4 billion in 2023 and is estimated to grow at a CAGR of over 6.3% from 2024 to 2032 driven by increasing incidence of drug-resistant infection.

Migracytosis is a recently described cellular process that generates and releases membrane-bound pomegranate-like organelles called migrasomes. Migracytosis normally occurs during cell migration, participating in various intercellular biological functions. Here, we report a new type of migracytosis …

In a new study, researchers at the University of Copenhagen have been cultivating ‘good viruses’ from feces. The goal is to replace fecal capsules now being used in so-called fecal transplants. Their new technique has shown potential in studies with mice and the hope is that it will improve this life-saving treatment through standardization and pave its way toward mainstream medicine.

The role of the gut microbiota in the association between high-fat diet and cognition is not clear. We hypothesized that a high-fat diet may influence cognition by altering the intestinal microbiota. Fecal microbiota isolated from male C57BL/6J mice feeding on various high-fat diets and a control ba …

Fidaxomicin (FDX), an RNA polymerase (RNAP) inhibitor antibiotic, is a guideline-recommended therapy for Clostridioides difficile infection. Mutations associated with reduced FDX minimum inhibitory concentrations (MICs) have been identified. However, the molecular characterization of these mu …

In a novel study that identified male chromosome genetic material in the intestines of female patients undergoing fecal transplants, researchers at