C Difficile

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Multi-omics analysis reveals a feedback loop amplifying immune responses in acute graft-versus-host disease due to imbalanced gut microbiota and bile acid metabolism - PubMed
Multi-omics analysis reveals a feedback loop amplifying immune responses in acute graft-versus-host disease due to imbalanced gut microbiota and bile acid metabolism - PubMed
Acute graft-versus-host disease (aGVHD) is primarily driven by allogeneic donor T cells associated with an altered composition of the host gut microbiome and its metabolites. The severity of aGVHD after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is not solely determined by the ho …
·pubmed.ncbi.nlm.nih.gov·
Multi-omics analysis reveals a feedback loop amplifying immune responses in acute graft-versus-host disease due to imbalanced gut microbiota and bile acid metabolism - PubMed
The Effects of Opioid Administration on Clostridioides Difficile Infection: A Retrospective Cohort Study - PubMed
The Effects of Opioid Administration on Clostridioides Difficile Infection: A Retrospective Cohort Study - PubMed
Background: Clostridioides difficile (C. difficile) is a leading cause of healthcare-associated infections. Using opioids while infected with C. difficile may hypothetically lead to reduced clearance of the organism and higher risk of progressing to severe or fulminant in …
·pubmed.ncbi.nlm.nih.gov·
The Effects of Opioid Administration on Clostridioides Difficile Infection: A Retrospective Cohort Study - PubMed
NASDAQAnnounces New Data on NRX-101 Demonstrating No Damage to Intestinal and Vaginal Flora in Validated Rodent Models Compared to Standard Antibiotics: Potential Implications for Avoidance of C. Difficile infections
NASDAQAnnounces New Data on NRX-101 Demonstrating No Damage to Intestinal and Vaginal Flora in Validated Rodent Models Compared to Standard Antibiotics: Potential Implications for Avoidance of C. Difficile infections
/PRNewswire/ -- NRx Pharmaceuticals, Inc. (Nasdaq:NRXP) ("NRx Pharmaceuticals", "NRx", the "Company"), a clinical-stage biopharmaceutical company, today...
·prnewswire.com·
NASDAQAnnounces New Data on NRX-101 Demonstrating No Damage to Intestinal and Vaginal Flora in Validated Rodent Models Compared to Standard Antibiotics: Potential Implications for Avoidance of C. Difficile infections
The Impact of Microbiome Dysbiosis on Hematopoietic Stem Cell Transplantation Outcomes: A Review Article - PubMed
The Impact of Microbiome Dysbiosis on Hematopoietic Stem Cell Transplantation Outcomes: A Review Article - PubMed
Microbiome dysbiosis has emerged as a critical factor influencing the outcomes of hematopoietic stem cell transplantation (HSCT). This comprehensive review delves into the intricate relationship between microbiome composition and HSCT outcomes, highlighting the mechanisms through which dysbiosis imp …
·pubmed.ncbi.nlm.nih.gov·
The Impact of Microbiome Dysbiosis on Hematopoietic Stem Cell Transplantation Outcomes: A Review Article - PubMed
Polystyrene microplastics aggravate radiation-induced intestinal injury in mice - PubMed
Polystyrene microplastics aggravate radiation-induced intestinal injury in mice - PubMed
Radiotherapy is a common treatment for abdominal and pelvic tumors, while the radiation-induced intestinal injury (RIII) is one of the major side-effects of radiotherapy, which reduces the life quality and impedes the treatment completion of cancer patients. Previous studies have demonstrated that e …
·pubmed.ncbi.nlm.nih.gov·
Polystyrene microplastics aggravate radiation-induced intestinal injury in mice - PubMed
When can we cure Crohn's? - PubMed
When can we cure Crohn's? - PubMed
Crohn's disease is a life-long idiopathic inflammatory disease which affects the entire gastrointestinal tract and occasionally extra-intestinal organs. CD is thought to result from complex interactions between environmental factors, the gut microbes, and the genetic background and the immune system …
·pubmed.ncbi.nlm.nih.gov·
When can we cure Crohn's? - PubMed
Higher alpha diversity and Lactobacillus blooms are associated with better engraftment after fecal microbiota transplant in inflammatory bowel disease - PubMed
Higher alpha diversity and Lactobacillus blooms are associated with better engraftment after fecal microbiota transplant in inflammatory bowel disease - PubMed
Fecal Microbiota Transplant (FMT) has shown some success in treating inflammatory bowel diseases (IBD). There is emerging evidence that host engraftment of donor taxa is a tenet of successful FMT. We undertook a double-blind, randomized, placebo-controlled pilot study to characterize the response to …
·pubmed.ncbi.nlm.nih.gov·
Higher alpha diversity and Lactobacillus blooms are associated with better engraftment after fecal microbiota transplant in inflammatory bowel disease - PubMed
Q&A: Biologic drugs are reinvented to treat infectious diseases
Q&A: Biologic drugs are reinvented to treat infectious diseases
Lumen scientists were the first to crack that long-standing barrier. Once that was done, we started looking around for useful applications. To our surprise, we discovered that there is actually a very robust literature on orally delivered therapeutic proteins, although most people are unaware of it.
·digitaljournal.com·
Q&A: Biologic drugs are reinvented to treat infectious diseases
Therapeutic interventions for gut dysbiosis and related disorders in the elderly: antibiotics, probiotics or faecal microbiota transplantation? - PubMed
Therapeutic interventions for gut dysbiosis and related disorders in the elderly: antibiotics, probiotics or faecal microbiota transplantation? - PubMed
Ageing and physiological functions of the human body are inversely proportional to each other. The gut microbiota and host immune system co-evolve from infants to the elderly. Ageing is accompanied by a decline in gut microbial diversity, immunity and metabolism, which increases susceptibility to in …
·pubmed.ncbi.nlm.nih.gov·
Therapeutic interventions for gut dysbiosis and related disorders in the elderly: antibiotics, probiotics or faecal microbiota transplantation? - PubMed
Link between gut microbiota dysbiosis and childhood asthma: Insights from a systematic review - PubMed
Link between gut microbiota dysbiosis and childhood asthma: Insights from a systematic review - PubMed
Asthma, a chronic inflammatory disorder of the airways, is a prevalent childhood chronic disease with a substantial global health burden. The complex etiology and pathogenesis of asthma involve genetic and environmental factors, posing challenges in diagnosis, severity prediction, and therapeutic st …
·pubmed.ncbi.nlm.nih.gov·
Link between gut microbiota dysbiosis and childhood asthma: Insights from a systematic review - PubMed
Reproducible chemostat cultures to minimize eukaryotic viruses from fecal transplant material - PubMed
Reproducible chemostat cultures to minimize eukaryotic viruses from fecal transplant material - PubMed
Recent studies indicate an important role of bacteriophages for successful fecal microbiota transplantation (FMT). However, wider clinical applications of FMT are hampered by to donor variability and concerns of infection risks by bacteria and human viruses. To overcome these challenges, mouse cecal …
·pubmed.ncbi.nlm.nih.gov·
Reproducible chemostat cultures to minimize eukaryotic viruses from fecal transplant material - PubMed
The fecal microbiota of patients with primary biliary cholangitis (PBC) causes PBC-like liver lesions in mice and exacerbates liver damage in a mouse model of PBC - PubMed
The fecal microbiota of patients with primary biliary cholangitis (PBC) causes PBC-like liver lesions in mice and exacerbates liver damage in a mouse model of PBC - PubMed
The role of the gut microbiota in the occurrence and progression of primary biliary cholangitis (PBC) is not fully understood. First, the fecal microbiota of patients with PBC (n = 4) (PBC-FMT) or healthy individuals (n = 3) (HC-FMT) was transplanted into pseudo germ-free mice or 2OA-B …
·pubmed.ncbi.nlm.nih.gov·
The fecal microbiota of patients with primary biliary cholangitis (PBC) causes PBC-like liver lesions in mice and exacerbates liver damage in a mouse model of PBC - PubMed
Frontiers | Potential effectiveness of parenteral nemonoxacin in the treatment of Clostridioides difficile infections: in vitro, ex vivo, and mouse studies
Frontiers | Potential effectiveness of parenteral nemonoxacin in the treatment of Clostridioides difficile infections: in vitro, ex vivo, and mouse studies
Antimicrobial therapy plays a crucial role in the management of CDI patients. However, the standard agent for treating CDIs is limited to oral fidaxomicin or...
·frontiersin.org·
Frontiers | Potential effectiveness of parenteral nemonoxacin in the treatment of Clostridioides difficile infections: in vitro, ex vivo, and mouse studies
Clostridium septicum manifests a bile salt germinant response mediated by Clostridioides difficile csp gene orthologs - PubMed
Clostridium septicum manifests a bile salt germinant response mediated by Clostridioides difficile csp gene orthologs - PubMed
Clostridium septicum infections are highly predictive of certain malignancies in human patients. To initiate infections, C. septicum spores must first germinate and regain vegetative growth. Yet, what triggers the germination of C. septicum spores is still unknown. Here, we observe that C. septicum …
·pubmed.ncbi.nlm.nih.gov·
Clostridium septicum manifests a bile salt germinant response mediated by Clostridioides difficile csp gene orthologs - PubMed
High Prevalence of Multistep Algorithms in Diagnostic Clostridioides difficile Laboratory Testing - PubMed
High Prevalence of Multistep Algorithms in Diagnostic Clostridioides difficile Laboratory Testing - PubMed
Multistep algorithms for CDI diagnosis are widely used in line with published recommendations. Most respondents reported rejection of formed stool for CDI testing, but few reported rejection of testing in infants and patients taking laxatives, suggesting these may be areas of opportunity for laborat …
·pubmed.ncbi.nlm.nih.gov·
High Prevalence of Multistep Algorithms in Diagnostic Clostridioides difficile Laboratory Testing - PubMed
Clostridioides difficile infection following COVID-19: A nationwide analysis using routine surveillance data in Wales - PubMed
Clostridioides difficile infection following COVID-19: A nationwide analysis using routine surveillance data in Wales - PubMed
Findings suggest a relationship between COVID-19 and CDI. However, incidence of CDI following COVID-19 was a rare outcome generally, suggesting other factors are likely contributing to the increased rates of CDI observed since 2020.
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile infection following COVID-19: A nationwide analysis using routine surveillance data in Wales - PubMed
Comparing treatment effects on dogs with acute hemorrhagic diarrhea syndrome: fecal microbiota transplantation, symptomatic therapy, or antibiotic treatment - PubMed
Comparing treatment effects on dogs with acute hemorrhagic diarrhea syndrome: fecal microbiota transplantation, symptomatic therapy, or antibiotic treatment - PubMed
Overall, in dogs with AHDS, neither FMT nor AT resulted in faster clinical improvement. In addition, C perfringens strains are self-limiting and do not require antibiotic therapy.
·pubmed.ncbi.nlm.nih.gov·
Comparing treatment effects on dogs with acute hemorrhagic diarrhea syndrome: fecal microbiota transplantation, symptomatic therapy, or antibiotic treatment - PubMed
The gut microbiome and dietary metabolites in the treatment of renal cell carcinoma - PubMed
The gut microbiome and dietary metabolites in the treatment of renal cell carcinoma - PubMed
The gut microbiome is interlinked with renal cell carcinoma (RCC) and its response to systemic treatment. Mounting data suggests that certain elements of the gut microbiome may correlate with improved outcomes. New generation sequencing techniques and advanced bioinformatic data curation are acceler …
·pubmed.ncbi.nlm.nih.gov·
The gut microbiome and dietary metabolites in the treatment of renal cell carcinoma - PubMed
β-resorcylic acid released by Limosilactobacillusreuteri protects against cisplatin-induced ovarian toxicity and infertility - PubMed
β-resorcylic acid released by Limosilactobacillusreuteri protects against cisplatin-induced ovarian toxicity and infertility - PubMed
Chemotherapy-induced premature ovarian insufficiency (CIPOI) triggers gonadotoxicity in women undergoing cancer treatment, leading to loss of ovarian reserves and subfertility, with no effective therapies available. In our study, fecal microbiota transplantation in a cisplatin-induced POI mouse mode …
·pubmed.ncbi.nlm.nih.gov·
β-resorcylic acid released by Limosilactobacillusreuteri protects against cisplatin-induced ovarian toxicity and infertility - PubMed
The influence of Akkermansia muciniphila on intestinal barrier function - PubMed
The influence of Akkermansia muciniphila on intestinal barrier function - PubMed
Intestinal barriers play a crucial role in human physiology, both in homeostatic and pathological conditions. Disruption of the intestinal barrier is a significant factor in the pathogenesis of gastrointestinal inflammatory diseases, such as inflammatory bowel disease. The profound influence of the …
·pubmed.ncbi.nlm.nih.gov·
The influence of Akkermansia muciniphila on intestinal barrier function - PubMed
Vonoprazan-associated Clostridioides difficile infection: an analysis of the Japanese Adverse Drug Event Report and the FDA Adverse Event Reporting System - PubMed
Vonoprazan-associated Clostridioides difficile infection: an analysis of the Japanese Adverse Drug Event Report and the FDA Adverse Event Reporting System - PubMed
While signal detection analysis based on the JADER and FAERS databases could not establish causality, our study demonstrated that both vonoprazan and PPIs were significantly associated with CDI. Vonoprazan showed a stronger association with CDI in both databases.
·pubmed.ncbi.nlm.nih.gov·
Vonoprazan-associated Clostridioides difficile infection: an analysis of the Japanese Adverse Drug Event Report and the FDA Adverse Event Reporting System - PubMed
Public health case for microbiome-sparing antibiotics and new opportunities for drug development - PubMed
Public health case for microbiome-sparing antibiotics and new opportunities for drug development - PubMed
Although antibiotics remain a cornerstone of modern medicine, the issues of widespread antibiotic resistance and collateral damage to the microbiome from antibiotic use are driving a need for drug developers to consider more tailored, patient-directed products to avoid antibiotic-induced perturbatio …
·pubmed.ncbi.nlm.nih.gov·
Public health case for microbiome-sparing antibiotics and new opportunities for drug development - PubMed
[Update in diagnosis and management of Clostridioides difficile] - PubMed
[Update in diagnosis and management of Clostridioides difficile] - PubMed
Clostridioides difficile (C. difficile) is one of the leading causes of infection associated with health care with high morbidity and mortality, especially among hospitalized older adults. The increase in the use of antibiotics has been associated with a higher number of cases and greater virulence. …
·pubmed.ncbi.nlm.nih.gov·
[Update in diagnosis and management of Clostridioides difficile] - PubMed
Clostridioides difficile Infection Risk Following Different Antibiotics: Insights from Multi-source Medical Data - PubMed
Clostridioides difficile Infection Risk Following Different Antibiotics: Insights from Multi-source Medical Data - PubMed
Our findings unveiled substantial diversity in CDI risk, both within and among antibiotic classes, providing valuable guidance for clinicians in antibiotic prescription decisions and for initiatives aimed at antibiotic stewardship.
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile Infection Risk Following Different Antibiotics: Insights from Multi-source Medical Data - PubMed
Treatment and Management of Gastrointestinal Disorders - PubMed
Treatment and Management of Gastrointestinal Disorders - PubMed
This article reviews the evaluation and management of several gastrointestinal disorders that are commonly encountered by gastroenterologists and primary care physicians. With a focus on newer therapies, we discuss the management of chronic constipation, irritable bowel syndrome, Clostridioides diff …
·pubmed.ncbi.nlm.nih.gov·
Treatment and Management of Gastrointestinal Disorders - PubMed