Microbiome and Metabolome Restoration After Administration of Fecal Microbiota, Live-jslm (REBYOTA®) for Preventing Recurrent Clostridioides difficile Infection - PubMed
NCT03244644.
C Difficile
FMT
Clostridium Difficile Diagnostics And Treatment Market Advancements Highlighted by Demand, Business Growing Strategies and Forecast 2031 | Merck & Co., Pfizer, Inc.
The latest market intelligence report published by CMI with the title Global Clostridium Difficile Diagnostics And Treatment Market 2024 Growth Opportunities and Forecast provides actionable insights on Medical Devices industry The report provides demand analysis industry insights competitive intelligence and ...
C Diff DiagnosisClostridioides difficile exploits xanthine and uric acid as nutrients by utilizing a selenium-dependent catabolic pathway - PubMed
Selenium is a trace element that plays critical roles in redox biology; it is typically incorporated into "selenoproteins" as the 21st amino acid selenocysteine. Additionally, selenium exists as a labile non-selenocysteine cofactor in a small subset of selenoproteins known as selenium-dependent moly …
C Diff Molecular
Fecal Transplant Therapy Market Company Share, Major Competitors, Regional Segments, Strategies, And Forecast Until 2031 | Rebiotix, Inc, Microbiotica, Second Genome Inc.
The latest market intelligence report published by WMR with the title Global Fecal Transplant Therapy Market 2024 Growth Opportunities and Forecast provides actionable insights on Healthcare and Pharmaceuticals industry The report provides demand analysis industry insights competitive intelligence and customer ...
Use of frozen native feces for fecal microbiota transplantation in recurrent Clostridioides difficile infection: a simple way to improve the efficiency of donor feces preparation - PubMed
Preparing fecal microbiota transplants immediately after donation is resource-intensive, and a proportion are destroyed following abnormal screening results. We retrospectively compared two processes, frozen fecal preparation (FFP) and fresh native frozen preparation (FNFP), for clinical efficacy in …
Impact of diabetic ketoacidosis on outcomes in hospitalized diabetic patients with Clostridioides difficile infection: a national inpatient analysis - PubMed
The presence of DKA significantly elevates hospital burden and CDI complications in diabetic patients. These findings underscore the need for close monitoring and aggressive management of DKA in patients with concurrent CDI to improve outcomes.
C Diff TreatmentThe importance of recognition of comorbidities: Diabetic ketoacidosis and Clostridioides difficile infection - PubMed
The importance of recognition of comorbidities: Diabetic ketoacidosis and Clostridioides difficile infection
Clostridioides difficile exploits xanthine and uric acid as nutrients by utilizing a selenium-dependent catabolic pathway - PubMed
Selenium is a trace element that plays critical roles in redox biology; it is typically incorporated into "selenoproteins" as the 21st amino acid selenocysteine. Additionally, selenium exists as a labile non-selenocysteine cofactor in a small subset of selenoproteins known as selenium-dependent moly …
Frontiers | Fecal Microbiota Transplant for Clostridium difficile Infection in a Pregnant Patient with Acute Severe Ulcerative Colitis
Ulcerative colitis (UC) is a chronic colonic mucosal inflammation characterized by reduced gut microbial diversity. UC patients at pregnancy are prone to suf...
Launching the Clostridioides difficile collection - PubMed
Launching the Clostridioides difficile collection
Chemical optimization and derivatization of micrococcin p2 to target multiple bacterial infections: new antibiotics from thiopeptides - PubMed
Antimicrobial resistance poses a significant threat to humanity, and the development of new antibiotics is urgently needed. Our research has focused on thiopeptide antibiotics such as micrococcin P2 (MP2) and derivatives thereof as new anti-infective agents. Thiopeptides are sulfur-rich, structurall …
C Diff Drug Development
391 hospitals with the lowest C. diff rates
391 hospitals in the U.S. have a Clostridioides difficile infection rate of zero according to CMS data
Scientists Uncover Rapid Evolution of Antibiotic Resistance in Hospital Superbug C. diff
Scientists discover how C. diff rapidly evolves resistance to vancomycin, a crucial antibiotic, posing a significant threat to global health.
Respiratory viral panel lowers antibiotic use duration in ventilated patients
Among ventilated ICU patients with suspected infection, the length of antibiotic use went down after respiratory viral panel testing was adopted, according to results published in Annals of the American Thoracic Society.“These results suggest that [respiratory viral panel] testing is a valuable tool to guide antibiotic use in patients with suspected infection,” Jacqueline Dinh, MD,
Antimicrobial resistance of Clostridioides difficile in veterinary medicine around the world: A scoping review of minimum inhibitory concentrations - PubMed
Antimicrobial susceptibility testing techniques and results were found to be diverse and heterogeneous. There is no evidence of an exclusive antimicrobial resistance pattern in any animal species. Despite the phenotypic and genomic data collected over the years, further interdisciplinary studies are …
ESCMID/EUCIC clinical guidelines on preoperative decolonization and targeted prophylaxis in patients colonized by multidrug-resistant Gram-positive bacteria before surgery - PubMed
The guideline panel reviewed the impact of decolonization, targeted PAP, and combined interventions (e.g., decolonization and targeted PAP) on the risk of SSIs and other outcomes in MDR-GPB carriers, according to the type of bacteria and type of surgery. We recommend screening for S. aureus (SA) bef …
C Diff PreventionOxygen tolerance in anaerobes as a virulence factor and a health-beneficial property - PubMed
Oxygen tolerance of anaerobes is a virulence factor, but can also be a beneficial property. Many species have evolved to tolerate or take advantage of the presence of low, especially nanaerobic (≤0.14%) oxygen concentrations. Oxygen tolerance is genus-, species- and strain-dependent according to the …
Transposable Genetic Elements and Antibiotic Resistance Determinants from Clostridium perfringens and Clostridium difficile
This chapter emphasizes on comparisons between the Clostridium perfringens and Clostridium difficile antibiotic resistance determinants and transposon…
microbiome therapeutics Rebyota Vowst fecal microbiota transplant
At DDW 2024, Jessica Allegretti, MD, MPH, described new treatments for recurrent emC. difficile/em and how she incorporates them into her practice.
Prediction of 28-day all-cause mortality in heart failure patients with Clostridioides difficile infection using machine learning models: evidence from the MIMIC-IV database - PubMed
We developed ML models to predict 28-day all-cause mortality in HF patients associated with CDI in the ICU, which are more effective than the conventional logistic regression model. The RF model has the best performance among all the ML models employed. It may be useful to help clinicians identify h …
Rising Threat Of Antibiotic Resistance Demands Urgent Action
Antibiotic resistance is increasingly becoming one of the most pressing concerns within healthcare systems worldwide. This issue affects not only individual patients…
Identification of pathways to high-level vancomycin resistance in Clostridioides difficile that incur high fitness costs in key pathogenicity traits - PubMed
Clostridioides difficile is an important human pathogen, for which there are very limited treatment options, primarily the glycopeptide antibiotic vancomycin. In recent years, vancomycin resistance has emerged as a serious problem in several gram-positive pathogens, but high-level resistance has yet …
Identification of a family of peptidoglycan transpeptidases reveals that Clostridioides difficile requires noncanonical cross-links for viability - PubMed
Most bacteria are surrounded by a cell wall that contains peptidoglycan (PG), a large polymer composed of glycan strands held together by short peptide cross-links. There are two major types of cross-links, termed 4-3 and 3-3 based on the amino acids involved. 4-3 cross-links are created by penicill …
A diagnostic dilemma: cytomegalovirus colitis as an uncommon comorbidity in inflammatory bowel disease: a case report - PubMed
Concurrent cytomegalovirus infection in patients with inflammatory bowel disease presents a significant clinical challenge due to its associated morbidity and mortality. Diagnosing and managing this condition is particularly difficult, especially regarding the initiation or continuation of immunosup …
Organizational and Infrastructural Risk Factors for Healthcare-associated Clostridioides difficile Infections or Methicillin-resistant Staphylococcus aureus in Hospitals - PubMed
The study confirmed the multifaceted nature to infection prevention and emphasized the importance of interdepartmental collaboration to improve patient safety.
Atomic structures of a bacteriocin targeting Gram-positive bacteria - PubMed
Due to envelope differences between Gram-positive and Gram-negative bacteria, engineering precision bactericidal contractile nanomachines requires atomic-level understanding of their structures; however, only those killing Gram-negative bacteria are currently known. Here, we report the atomic struct …
The Magic Poop Potion
An Indiana grandma killed off a devastating superbug with a homemade fecal transplant and then embarked on a crusade to win over the FDA.
Antibiotic use and risk of Clostridioides difficile infection in patients with inflammatory bowel disease - PubMed
The use of clindamycin or metronidazole prescribed in an outpatient setting was associated with a statistically significant increased risk of CDI in patients with IBD. Although the association between clindamycin and CDI is a well-established and common finding, the association between metronidazole …
Microbiome modification for personalized treatment of dysbiotic diseases - PubMed
Fecal microbial transplantation (FMT) for inflammatory diseases or refractory immune checkpoint inhibitor therapy is less effective than for preventing recurrent Clostridioides difficile infection. This commentary outlines strategies to use biomarkers of successful FMT to guide newer approaches to r …
Identification of pathways to high-level vancomycin resistance in Clostridioides difficile that incur high fitness costs in key pathogenicity traits - PubMed
Clostridioides difficile is an important human pathogen, for which there are very limited treatment options, primarily the glycopeptide antibiotic vancomycin. In recent years, vancomycin resistance has emerged as a serious problem in several gram-positive pathogens, but high-level resistance has yet …