C Difficile

9590 bookmarks
Newest
Ganoderic Acid A Mitigates Inflammatory Bowel Disease through Modulation of AhR Activity by Microbial Tryptophan Metabolism - PubMed
Ganoderic Acid A Mitigates Inflammatory Bowel Disease through Modulation of AhR Activity by Microbial Tryptophan Metabolism - PubMed
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a complex gastrointestinal condition influenced by genetic, microbial, and environmental factors, among which the gut microbiota plays a crucial role and has emerged as a potential therapeutic target. Ganoderic ac …
·pubmed.ncbi.nlm.nih.gov·
Ganoderic Acid A Mitigates Inflammatory Bowel Disease through Modulation of AhR Activity by Microbial Tryptophan Metabolism - PubMed
MS-20 enhances the gut microbiota-associated antitumor effects of anti-PD1 antibody - PubMed
MS-20 enhances the gut microbiota-associated antitumor effects of anti-PD1 antibody - PubMed
Cancer immunotherapy has been regarded as a promising strategy for cancer therapy by blocking immune checkpoints and evoking immunity to fight cancer, but its efficacy seems to be heterogeneous among patients. Manipulating the gut microbiota is a potential strategy for enhancing the efficacy of immu …
·pubmed.ncbi.nlm.nih.gov·
MS-20 enhances the gut microbiota-associated antitumor effects of anti-PD1 antibody - PubMed
Escape Velocity-the Launch of Microbiome Therapies - PubMed
Escape Velocity-the Launch of Microbiome Therapies - PubMed
Food and Drug Administration approval of the first microbiome therapies represents a true expansion the treatment paradigm for Clostridioides difficile but raises new questions about the future role of fecal microbiota transplantation. The authors outline the advances in microbiome therapeutic devel …
·pubmed.ncbi.nlm.nih.gov·
Escape Velocity-the Launch of Microbiome Therapies - PubMed
Washed microbiota transplantation via colonic transendoscopic enteral tube rescues severe acute pancreatitis: A case series - PubMed
Washed microbiota transplantation via colonic transendoscopic enteral tube rescues severe acute pancreatitis: A case series - PubMed
WMT via colonic TET played a critical therapeutic role in rescuing severe AP cases. This is the first report providing direct evidence for the clinical value of targeting microbiota through colonic TET in rescuing severe AP.
·pubmed.ncbi.nlm.nih.gov·
Washed microbiota transplantation via colonic transendoscopic enteral tube rescues severe acute pancreatitis: A case series - PubMed
Efficacy and safety of fecal microbiota transplantation for treatment of ulcerative colitis: A post-consensus systematic review and meta-analysis - PubMed
Efficacy and safety of fecal microbiota transplantation for treatment of ulcerative colitis: A post-consensus systematic review and meta-analysis - PubMed
FMT demonstrates favorable performance and safety; however, well-designed randomized clinical trials are still needed before the widespread use of FMT can be recommended. Furthermore, standardizing the FMT process is urgently needed for improved safety and efficacy.
·pubmed.ncbi.nlm.nih.gov·
Efficacy and safety of fecal microbiota transplantation for treatment of ulcerative colitis: A post-consensus systematic review and meta-analysis - PubMed
Human gut microbiota interactions shape the long-term growth dynamics and evolutionary adaptations of Clostridioides difficile - PubMed
Human gut microbiota interactions shape the long-term growth dynamics and evolutionary adaptations of Clostridioides difficile - PubMed
Clostridioides difficile can transiently or persistently colonize the human gut, posing a risk factor for infections. This colonization is influenced by complex molecular and ecological interactions with human gut microbiota. By investigating C. difficile dynamics in human gut communit …
·pubmed.ncbi.nlm.nih.gov·
Human gut microbiota interactions shape the long-term growth dynamics and evolutionary adaptations of Clostridioides difficile - PubMed
Clostridioides difficile colonization is not mediated by bile salts and requires Stickland fermentation of proline in an in vitro model of infection - PubMed
Clostridioides difficile colonization is not mediated by bile salts and requires Stickland fermentation of proline in an in vitro model of infection - PubMed
C. difficile is one of the leading causes of hospital-acquired infections and antibiotic-associated diarrhea. Several potential mechanisms through which the microbiota can limit C. difficile infection have been identified and are potential targets for new therapeutics. However, it is u …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile colonization is not mediated by bile salts and requires Stickland fermentation of proline in an in vitro model of infection - PubMed
A case of community-acquired Clostridioides difficile infection causing intussusception, severe pneumonia, and severe hypokalemia - PubMed
A case of community-acquired Clostridioides difficile infection causing intussusception, severe pneumonia, and severe hypokalemia - PubMed
This case report highlights a binary toxin-producing C. difficile that caused intussusception. The consideration of community-acquired C. difficile in the differential diagnosis of severe enteritis is necessary, even in Japan.
·pubmed.ncbi.nlm.nih.gov·
A case of community-acquired Clostridioides difficile infection causing intussusception, severe pneumonia, and severe hypokalemia - PubMed
Fecal microbiota transplantation improves anti-PD-1 inhibitor efficacy in unresectable or metastatic solid cancers refractory to anti-PD-1 inhibitor - PubMed
Fecal microbiota transplantation improves anti-PD-1 inhibitor efficacy in unresectable or metastatic solid cancers refractory to anti-PD-1 inhibitor - PubMed
The gut microbiome significantly influences immune responses and the efficacy of immune checkpoint inhibitors. We conducted a clinical trial (NCT04264975) combining an anti-programmed death-1 (PD-1) inhibitor with fecal microbiota transplantation (FMT) from anti-PD-1 responder in 13 patients with an …
·pubmed.ncbi.nlm.nih.gov·
Fecal microbiota transplantation improves anti-PD-1 inhibitor efficacy in unresectable or metastatic solid cancers refractory to anti-PD-1 inhibitor - PubMed
Exploring Fecal Microbiota Transplantation for Modulating Inflammation in Parkinson's Disease: A Review of Inflammatory Markers and Potential Effects - PubMed
Exploring Fecal Microbiota Transplantation for Modulating Inflammation in Parkinson's Disease: A Review of Inflammatory Markers and Potential Effects - PubMed
Parkinson's disease (PD) is a complex neurodegenerative disorder characterized by numerous motor and non-motor symptoms. Recent data highlight a potential interplay between the gut microbiota and the pathophysiology of PD. The degeneration of dopaminergic neurons in PD leads to motor symptoms (tremo …
·pubmed.ncbi.nlm.nih.gov·
Exploring Fecal Microbiota Transplantation for Modulating Inflammation in Parkinson's Disease: A Review of Inflammatory Markers and Potential Effects - PubMed
Time-Dependent Shifts in Intestinal Bacteriome, Klebsiella Colonization and Incidence of Antibiotic-Resistance Genes after Allogeneic Hematopoietic Stem Cell Transplantation - PubMed
Time-Dependent Shifts in Intestinal Bacteriome, Klebsiella Colonization and Incidence of Antibiotic-Resistance Genes after Allogeneic Hematopoietic Stem Cell Transplantation - PubMed
Dose-intensive cytostatic therapy and antibiotic treatment in allogeneic hematopoietic stem cell transplantation (allo-HSCT) cause severe abnormalities in a composition of gut microbiota as well as the emergence of antibiotic resistance. The data on the longitudinal recovery of major bacterial phyla …
·pubmed.ncbi.nlm.nih.gov·
Time-Dependent Shifts in Intestinal Bacteriome, Klebsiella Colonization and Incidence of Antibiotic-Resistance Genes after Allogeneic Hematopoietic Stem Cell Transplantation - PubMed
Comparative Efficacy of Fecal Microbiota Transplantation in Treating Refractory or Recurrent Clostridioides difficile Infection among Patients with and without Inflammatory Bowel Disease: A Retrospective Cohort Study - PubMed
Comparative Efficacy of Fecal Microbiota Transplantation in Treating Refractory or Recurrent Clostridioides difficile Infection among Patients with and without Inflammatory Bowel Disease: A Retrospective Cohort Study - PubMed
Clostridioides difficile infection (CDI) worsens inflammatory bowel disease (IBD) prognosis. While fecal microbiota transplantation (FMT) is effective for refractory or recurrent CDI (rrCDI), comparative success rates between IBD and non-IBD patients are scarce. This study addresses this gap. …
·pubmed.ncbi.nlm.nih.gov·
Comparative Efficacy of Fecal Microbiota Transplantation in Treating Refractory or Recurrent Clostridioides difficile Infection among Patients with and without Inflammatory Bowel Disease: A Retrospective Cohort Study - PubMed
Gut microbiota regulates gut homeostasis, mucosal immunity and influences immune-related diseases - PubMed
Gut microbiota regulates gut homeostasis, mucosal immunity and influences immune-related diseases - PubMed
The intestinal microbiome constitutes a sophisticated and massive ecosystem pivotal for maintaining gastrointestinal equilibrium and mucosal immunity via diverse pathways. The gut microbiota is continuously reshaped by multiple environmental factors, thereby influencing overall wellbeing or predispo …
·pubmed.ncbi.nlm.nih.gov·
Gut microbiota regulates gut homeostasis, mucosal immunity and influences immune-related diseases - PubMed
The Relationship between Canine Behavioral Disorders and Gut Microbiome and Future Therapeutic Perspectives - PubMed
The Relationship between Canine Behavioral Disorders and Gut Microbiome and Future Therapeutic Perspectives - PubMed
Canine behavioral disorders have become one of the most common concerns and challenging issues among dog owners. Thus, there is a great demand for knowledge about various factors affecting dogs' emotions and well-being. Among them, the gut-brain axis seems to be particularly interesting, especially …
·pubmed.ncbi.nlm.nih.gov·
The Relationship between Canine Behavioral Disorders and Gut Microbiome and Future Therapeutic Perspectives - PubMed
Clostridioides difficile Infections: Prevention and Treatment Strategies - PubMed
Clostridioides difficile Infections: Prevention and Treatment Strategies - PubMed
Clostridioides difficile is the most common causative agent of antibiotic-associated diarrhea. This spore forming, obligate anaerobic, gram-positive bacillus is becoming responsible for an increasing number of infections worldwide, both in community and in hospital settings, whose severity can vary …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile Infections: Prevention and Treatment Strategies - PubMed
Nutritional Interventions, Probiotics, Synbiotics and Fecal Microbiota Transplantation in Steatotic Liver Disease : Pediatric Fatty Liver and Probiotics - PubMed
Nutritional Interventions, Probiotics, Synbiotics and Fecal Microbiota Transplantation in Steatotic Liver Disease : Pediatric Fatty Liver and Probiotics - PubMed
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major health problem worldwide, and the strongest determinant of liver disease in children. The possible influence of high-fat/low-fiber dietary patterns with microbiota (e.g., increased Firmicutes/Bacteroidetes ratio), and ultima …
·pubmed.ncbi.nlm.nih.gov·
Nutritional Interventions, Probiotics, Synbiotics and Fecal Microbiota Transplantation in Steatotic Liver Disease : Pediatric Fatty Liver and Probiotics - PubMed
Correlation between Alzheimer's Disease and Gastrointestinal Tract Disorders - PubMed
Correlation between Alzheimer's Disease and Gastrointestinal Tract Disorders - PubMed
Alzheimer's disease is the most common cause of dementia globally. The pathogenesis is multifactorial and includes deposition of amyloid-β in the central nervous system, presence of intraneuronal neurofibrillary tangles and a decreased amount of synapses. It remains uncertain what causes the progres …
·pubmed.ncbi.nlm.nih.gov·
Correlation between Alzheimer's Disease and Gastrointestinal Tract Disorders - PubMed
Ramulus Mori (Sangzhi) Alkaloids Alleviate Diabetic Nephropathy through Improving Gut Microbiota Disorder - PubMed
Ramulus Mori (Sangzhi) Alkaloids Alleviate Diabetic Nephropathy through Improving Gut Microbiota Disorder - PubMed
Diabetic nephropathy (DN), one of the leading causes of end-stage kidney failure worldwide, is closely associated with high mortality in diabetic patients. However, therapeutic drugs for DN are still lacking. Ramulus Mori alkaloids (SZ-A), an effective component of alkaloids extracted from …
·pubmed.ncbi.nlm.nih.gov·
Ramulus Mori (Sangzhi) Alkaloids Alleviate Diabetic Nephropathy through Improving Gut Microbiota Disorder - PubMed
The Contrasting Effects of Two Distinct Exercise Training Modalities on Exhaustive Exercise-Induced Muscle Damage in Mice May Be Associated with Alterations in the Gut Microbiota - PubMed
The Contrasting Effects of Two Distinct Exercise Training Modalities on Exhaustive Exercise-Induced Muscle Damage in Mice May Be Associated with Alterations in the Gut Microbiota - PubMed
Exhaustive exercise is known to induce muscle damage characterized by inflammation and oxidative stress. Although "regular" and "weekend warrior" exercise regimens have been shown to confer comparable health benefits in human studies, such as reduced risks of all-cause, cardiovascular disease (CVD), …
·pubmed.ncbi.nlm.nih.gov·
The Contrasting Effects of Two Distinct Exercise Training Modalities on Exhaustive Exercise-Induced Muscle Damage in Mice May Be Associated with Alterations in the Gut Microbiota - PubMed
Prospective Audit and Feedback for Antimicrobial Treatment of Patients Receiving Renal Replacement Therapy in Community-Based University Hospitals: A before-and-after Study - PubMed
Prospective Audit and Feedback for Antimicrobial Treatment of Patients Receiving Renal Replacement Therapy in Community-Based University Hospitals: A before-and-after Study - PubMed
In South Korea, because of manpower and budgetary limitations, antimicrobial stewardship programs have relied on preauthorization. This study analyzed the impact of a prospective audit and feedback (PAF) program targeting inpatients undergoing intermittent hemodialysis or continuous renal replacemen …
·pubmed.ncbi.nlm.nih.gov·
Prospective Audit and Feedback for Antimicrobial Treatment of Patients Receiving Renal Replacement Therapy in Community-Based University Hospitals: A before-and-after Study - PubMed
Comparative Efficacy of Fecal Microbiota Transplantation in Treating Refractory or Recurrent Clostridioides difficile Infection among Patients with and without Inflammatory Bowel Disease: A Retrospective Cohort Study - PubMed
Comparative Efficacy of Fecal Microbiota Transplantation in Treating Refractory or Recurrent Clostridioides difficile Infection among Patients with and without Inflammatory Bowel Disease: A Retrospective Cohort Study - PubMed
Clostridioides difficile infection (CDI) worsens inflammatory bowel disease (IBD) prognosis. While fecal microbiota transplantation (FMT) is effective for refractory or recurrent CDI (rrCDI), comparative success rates between IBD and non-IBD patients are scarce. This study addresses this gap. …
·pubmed.ncbi.nlm.nih.gov·
Comparative Efficacy of Fecal Microbiota Transplantation in Treating Refractory or Recurrent Clostridioides difficile Infection among Patients with and without Inflammatory Bowel Disease: A Retrospective Cohort Study - PubMed
Characterization of Clostridioides difficile Persister Cells and Their Role in Antibiotic Tolerance - PubMed
Characterization of Clostridioides difficile Persister Cells and Their Role in Antibiotic Tolerance - PubMed
Clostridioides difficile is a Gram-positive pathogen known for its toxin production and spore formation. It is primarily responsible for most cases of antibiotic-associated diarrhea. Bacterial persisters are a small subset of the population that exhibits transient tolerance to bactericidal su …
·pubmed.ncbi.nlm.nih.gov·
Characterization of Clostridioides difficile Persister Cells and Their Role in Antibiotic Tolerance - PubMed
Evaluation of Bacterial Viability for Fecal Microbiota Transplantation: Impact of Thawing Temperature and Storage Time - PubMed
Evaluation of Bacterial Viability for Fecal Microbiota Transplantation: Impact of Thawing Temperature and Storage Time - PubMed
Fecal Microbiota Transplantation (FMT) represents a promising therapeutic tool under study for several purposes and is currently applied to the treatment of recurrent Clostridioides difficile infection. However, since the use of fresh stool was affected by several issues linked to donor scree …
·pubmed.ncbi.nlm.nih.gov·
Evaluation of Bacterial Viability for Fecal Microbiota Transplantation: Impact of Thawing Temperature and Storage Time - PubMed
Clinical Characteristics and Risk Factors for Clostridioides difficile Infection in the Hematopoietic Cell Transplantation Population - PubMed
Clinical Characteristics and Risk Factors for Clostridioides difficile Infection in the Hematopoietic Cell Transplantation Population - PubMed
CDI presents an early complication after HCT, particularly in allogenic recipients who experience higher incidence rates and severe complications. Early recognition and management of these risk factors are essential to prevent these adverse outcomes.
·pubmed.ncbi.nlm.nih.gov·
Clinical Characteristics and Risk Factors for Clostridioides difficile Infection in the Hematopoietic Cell Transplantation Population - PubMed
Clostridioides difficile Infections: Prevention and Treatment Strategies - PubMed
Clostridioides difficile Infections: Prevention and Treatment Strategies - PubMed
Clostridioides difficile is the most common causative agent of antibiotic-associated diarrhea. This spore forming, obligate anaerobic, gram-positive bacillus is becoming responsible for an increasing number of infections worldwide, both in community and in hospital settings, whose severity can vary …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile Infections: Prevention and Treatment Strategies - PubMed
Clorox wipes receive EPA registration for C. diff
Clorox wipes receive EPA registration for C. diff
BALTIMORE — The Clorox Company has announced that the U.S. Environmental Protection Agency (EPA) accepted the registration of Clorox Commercial Solutions” Germicidal Wipes to kill Clostridium difficile (C. diff) spores in five minutes, according to a press release. The bleach wipe used by the most U.S. hospitals, Clorox Germicidal Wipes are ready-to-use, hospital-grade disinfectant wipes […]
·cmmonline.com·
Clorox wipes receive EPA registration for C. diff
Genomic study of European Clostridioides difficile ribotype 002/sequence type 8 - PubMed
Genomic study of European Clostridioides difficile ribotype 002/sequence type 8 - PubMed
Clostridioides difficile has significant clinical importance as a leading cause of healthcare-associated infections, with symptoms ranging from mild diarrhoea to severe colitis, and possible life-threatening complications. C. difficile ribotype (RT) 002, mainly associated with MLST seq …
·pubmed.ncbi.nlm.nih.gov·
Genomic study of European Clostridioides difficile ribotype 002/sequence type 8 - PubMed
Antimicrobial susceptibilities, resistance mechanisms and molecular characteristics of toxigenic Clostridioides difficile isolates in a large teaching hospital in Chongqing, China - PubMed
Antimicrobial susceptibilities, resistance mechanisms and molecular characteristics of toxigenic Clostridioides difficile isolates in a large teaching hospital in Chongqing, China - PubMed
In contrast to prior studies, we found higher proportions of ST3 isolates with decreased tigecycline sensitivity, sharing similar resistance patterns and resistance genes. In the resistance process of tigecycline and tetracycline, the tetA(P) and tetB(P) genes may play a weak role.
·pubmed.ncbi.nlm.nih.gov·
Antimicrobial susceptibilities, resistance mechanisms and molecular characteristics of toxigenic Clostridioides difficile isolates in a large teaching hospital in Chongqing, China - PubMed