C Difficile

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Healthcare-associated infections and antimicrobial resistance in Canadian acute care hospitals, 2018-2022 - PubMed
Healthcare-associated infections and antimicrobial resistance in Canadian acute care hospitals, 2018-2022 - PubMed
From 2018 to 2022, the incidence of MRSA BSIs and CDIs decreased and VRE BSI and CPE infections increased in the Canadian acute care hospitals participating in a national sentinel network (CNISP). Few C. auris isolates were identified from 2012 to 2022. Reporting standardized surveillance dat …
C Diff TransmissionC Diff Transmission
·pubmed.ncbi.nlm.nih.gov·
Healthcare-associated infections and antimicrobial resistance in Canadian acute care hospitals, 2018-2022 - PubMed
Symbiotic biofilms formed by Clostridioides difficile and bacteroides thetaiotaomicron in the presence of vancomycin - PubMed
Symbiotic biofilms formed by Clostridioides difficile and bacteroides thetaiotaomicron in the presence of vancomycin - PubMed
Vancomycin (VAN) treatment in Clostridioides difficile infection (CDI) suffers from a relatively high rate of recurrence, with a variety of reasons behind this, including biofilm-induced recurrent infections. C. difficile can form monophyletic or symbiotic biofilms with other microbes …
C Diff MolecularC Diff Molecular
·pubmed.ncbi.nlm.nih.gov·
Symbiotic biofilms formed by Clostridioides difficile and bacteroides thetaiotaomicron in the presence of vancomycin - PubMed
Healing from Within: How Gut Microbiota Predicts IBD Treatment Success-A Systematic Review - PubMed
Healing from Within: How Gut Microbiota Predicts IBD Treatment Success-A Systematic Review - PubMed
Recent research indicates that the microbiome has a significant impact on the progression of inflammatory bowel disease (IBD) and that creating therapies that change its composition could positively impact the outcomes of IBD treatment. This review summarizes the results of extensive studies that ex …
C Diff MolecularC Diff Molecular
·pubmed.ncbi.nlm.nih.gov·
Healing from Within: How Gut Microbiota Predicts IBD Treatment Success-A Systematic Review - PubMed
MicroRNA miR-27a-5p reduces intestinal inflammation induced by Clostridioides difficile flagella by regulating the NF-κB signaling pathway - PubMed
MicroRNA miR-27a-5p reduces intestinal inflammation induced by Clostridioides difficile flagella by regulating the NF-κB signaling pathway - PubMed
miR-27a-5p plays a crucial role in regulating C. difficile-induced inflammation, suggesting its potential as a therapeutic target for controlling severe infection. These findings offer valuable insights into potential therapeutic strategies for managing C. difficile infection and associated inflamma …
C Diff MolecularC Diff Molecular
·pubmed.ncbi.nlm.nih.gov·
MicroRNA miR-27a-5p reduces intestinal inflammation induced by Clostridioides difficile flagella by regulating the NF-κB signaling pathway - PubMed
Development of two recombinant vaccines against Clostridioides difficile infection and immunogenicity in pregnant sows and neonatal piglets - PubMed
Development of two recombinant vaccines against Clostridioides difficile infection and immunogenicity in pregnant sows and neonatal piglets - PubMed
The synthesized recombinant proteins were capable of inducing antibody titers against C. difficile toxins A and B in sows, and were passively transferred to piglets through colostrum.
C Diff Drug DevelopmentC Diff Drug Development
·pubmed.ncbi.nlm.nih.gov·
Development of two recombinant vaccines against Clostridioides difficile infection and immunogenicity in pregnant sows and neonatal piglets - PubMed
Use of extracorporeal hemoperfusion therapy in an adult horse with Clostridioides difficile colitis and severe systemic inflammatory response syndrome - PubMed
Use of extracorporeal hemoperfusion therapy in an adult horse with Clostridioides difficile colitis and severe systemic inflammatory response syndrome - PubMed
An 8-year-old American Quarter Horse gelding was treated with extracorporeal hemoperfusion (HP) therapy for treatment of Clostridioides difficile (C. difficile) colitis-induced systemic inflammatory response syndrome (SIRS). The gelding developed C. difficile associated peracute colitis and severe S …
C Diff TreatmentC Diff Treatment
·pubmed.ncbi.nlm.nih.gov·
Use of extracorporeal hemoperfusion therapy in an adult horse with Clostridioides difficile colitis and severe systemic inflammatory response syndrome - PubMed
The impact of 30-day antecedent antibiotic exposure on C. difficile ribotype patterns and the relationship with clinical outcomes: A single center study - PubMed
The impact of 30-day antecedent antibiotic exposure on C. difficile ribotype patterns and the relationship with clinical outcomes: A single center study - PubMed
These findings suggest that fluoroquinolone and macrolide exposure were significantly associated with isolating a resistant strain, but we did not find significant differences in clinical outcomes based on the presence of antimicrobial resistance.
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·pubmed.ncbi.nlm.nih.gov·
The impact of 30-day antecedent antibiotic exposure on C. difficile ribotype patterns and the relationship with clinical outcomes: A single center study - PubMed
#VisualAbstract: Ridinilazole reduces recurrent Clostridioides difficile infection and preserves gut microbi-ome diversity versus vancomycin | 2 Minute Medicine
#VisualAbstract: Ridinilazole reduces recurrent Clostridioides difficile infection and preserves gut microbi-ome diversity versus vancomycin | 2 Minute Medicine
Click here to read this study in CID. ©2024 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.
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·2minutemedicine.com·
#VisualAbstract: Ridinilazole reduces recurrent Clostridioides difficile infection and preserves gut microbi-ome diversity versus vancomycin | 2 Minute Medicine
Efficacy of fidaxomicin versus vancomycin in the treatment of Clostridium difficile infection: A systematic meta-analysis - PubMed
Efficacy of fidaxomicin versus vancomycin in the treatment of Clostridium difficile infection: A systematic meta-analysis - PubMed
There were no significant differences between fidaxomicin and vancomycin in the treatment of CDI in therapeutic effectiveness and adverse reactions, while fidaxomicin was superior to vancomycin in terms of recurrence rate and long-term mortality, and vancomycin is more effective in treating severe C …
C Diff TreatmentC Diff Treatment
·pubmed.ncbi.nlm.nih.gov·
Efficacy of fidaxomicin versus vancomycin in the treatment of Clostridium difficile infection: A systematic meta-analysis - PubMed
Vaccines and monoclonal antibodies to prevent healthcare-associated bacterial infections - PubMed
Vaccines and monoclonal antibodies to prevent healthcare-associated bacterial infections - PubMed
SUMMARYHealthcare-associated infections (HAIs) represent a burden for public health with a high prevalence and high death rates associated with them. Pathogens with a high potential for antimicrobial resistance, such as ESKAPE pathogens (Enterococcus faecium, S …
C Diff PreventionC Diff Prevention
·pubmed.ncbi.nlm.nih.gov·
Vaccines and monoclonal antibodies to prevent healthcare-associated bacterial infections - PubMed
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Importance of underlying mechanisms for interpreting relative risk of Clostridioides difficile infection among antibiotic-exposed patients in healthcare facilities - PubMed
Importance of underlying mechanisms for interpreting relative risk of Clostridioides difficile infection among antibiotic-exposed patients in healthcare facilities - PubMed
Clostridioides difficile infection (CDI) is a significant public health threat, associated with antibiotic-induced disruption of the normally protective gastrointestinal microbiota. CDI is thought to occur in two stages: acquisition of asymptomatic colonization from ingesting C. difficile bacteria f …
C Diff Drug StewardshipC Diff Drug Stewardship
·pubmed.ncbi.nlm.nih.gov·
Importance of underlying mechanisms for interpreting relative risk of Clostridioides difficile infection among antibiotic-exposed patients in healthcare facilities - PubMed
Importance of underlying mechanisms for interpreting relative risk of Clostridioides difficile infection among antibiotic-exposed patients in healthcare facilities - PubMed
Importance of underlying mechanisms for interpreting relative risk of Clostridioides difficile infection among antibiotic-exposed patients in healthcare facilities - PubMed
Clostridioides difficile infection (CDI) is a significant public health threat, associated with antibiotic-induced disruption of the normally protective gastrointestinal microbiota. CDI is thought to occur in two stages: acquisition of asymptomatic colonization from ingesting C. difficile bacteria f …
C Diff Drug StewardshipC Diff Drug Stewardship
·pubmed.ncbi.nlm.nih.gov·
Importance of underlying mechanisms for interpreting relative risk of Clostridioides difficile infection among antibiotic-exposed patients in healthcare facilities - PubMed
Disturbances of the gut microbiota-derived tryptophan metabolites as key actors in vagotomy-induced mastitis in mice - PubMed
Disturbances of the gut microbiota-derived tryptophan metabolites as key actors in vagotomy-induced mastitis in mice - PubMed
Previous studies have demonstrated that gut microbiota dysbiosis promotes the development of mastitis. The interaction of the vagus nerve and gut microbiota endows host homeostasis and regulates disease development, but whether the vagus nerve participates in the pathogenesis of mastitis is unclear. …
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·pubmed.ncbi.nlm.nih.gov·
Disturbances of the gut microbiota-derived tryptophan metabolites as key actors in vagotomy-induced mastitis in mice - PubMed
Mouse adaptation of human inflammatory bowel diseases microbiota enhances colonization efficiency and alters microbiome aggressiveness depending on the recipient colonic inflammatory environment - PubMed
Mouse adaptation of human inflammatory bowel diseases microbiota enhances colonization efficiency and alters microbiome aggressiveness depending on the recipient colonic inflammatory environment - PubMed
Our findings support a model of IBD pathogenesis in which host inflammation promotes aggressive resident bacteria, which further drives a feed-forward process of dysbiosis exacerbated by gut inflammation. This model implies that effective management of IBD requires treating both the dysregulated hos …
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·pubmed.ncbi.nlm.nih.gov·
Mouse adaptation of human inflammatory bowel diseases microbiota enhances colonization efficiency and alters microbiome aggressiveness depending on the recipient colonic inflammatory environment - PubMed
Multi-omics analysis reveals a feedback loop amplifying immune responses in acute graft-versus-host disease due to imbalanced gut microbiota and bile acid metabolism - PubMed
Multi-omics analysis reveals a feedback loop amplifying immune responses in acute graft-versus-host disease due to imbalanced gut microbiota and bile acid metabolism - PubMed
Acute graft-versus-host disease (aGVHD) is primarily driven by allogeneic donor T cells associated with an altered composition of the host gut microbiome and its metabolites. The severity of aGVHD after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is not solely determined by the ho …
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·pubmed.ncbi.nlm.nih.gov·
Multi-omics analysis reveals a feedback loop amplifying immune responses in acute graft-versus-host disease due to imbalanced gut microbiota and bile acid metabolism - PubMed
The Effects of Opioid Administration on Clostridioides Difficile Infection: A Retrospective Cohort Study - PubMed
The Effects of Opioid Administration on Clostridioides Difficile Infection: A Retrospective Cohort Study - PubMed
Background: Clostridioides difficile (C. difficile) is a leading cause of healthcare-associated infections. Using opioids while infected with C. difficile may hypothetically lead to reduced clearance of the organism and higher risk of progressing to severe or fulminant in …
C Diff Drug StewardshipC Diff Drug Stewardship
·pubmed.ncbi.nlm.nih.gov·
The Effects of Opioid Administration on Clostridioides Difficile Infection: A Retrospective Cohort Study - PubMed
NASDAQAnnounces New Data on NRX-101 Demonstrating No Damage to Intestinal and Vaginal Flora in Validated Rodent Models Compared to Standard Antibiotics: Potential Implications for Avoidance of C. Difficile infections
NASDAQAnnounces New Data on NRX-101 Demonstrating No Damage to Intestinal and Vaginal Flora in Validated Rodent Models Compared to Standard Antibiotics: Potential Implications for Avoidance of C. Difficile infections
/PRNewswire/ -- NRx Pharmaceuticals, Inc. (Nasdaq:NRXP) ("NRx Pharmaceuticals", "NRx", the "Company"), a clinical-stage biopharmaceutical company, today...
C Diff Drug DevelopmentC Diff Drug Development
·prnewswire.com·
NASDAQAnnounces New Data on NRX-101 Demonstrating No Damage to Intestinal and Vaginal Flora in Validated Rodent Models Compared to Standard Antibiotics: Potential Implications for Avoidance of C. Difficile infections
The Impact of Microbiome Dysbiosis on Hematopoietic Stem Cell Transplantation Outcomes: A Review Article - PubMed
The Impact of Microbiome Dysbiosis on Hematopoietic Stem Cell Transplantation Outcomes: A Review Article - PubMed
Microbiome dysbiosis has emerged as a critical factor influencing the outcomes of hematopoietic stem cell transplantation (HSCT). This comprehensive review delves into the intricate relationship between microbiome composition and HSCT outcomes, highlighting the mechanisms through which dysbiosis imp …
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·pubmed.ncbi.nlm.nih.gov·
The Impact of Microbiome Dysbiosis on Hematopoietic Stem Cell Transplantation Outcomes: A Review Article - PubMed
Polystyrene microplastics aggravate radiation-induced intestinal injury in mice - PubMed
Polystyrene microplastics aggravate radiation-induced intestinal injury in mice - PubMed
Radiotherapy is a common treatment for abdominal and pelvic tumors, while the radiation-induced intestinal injury (RIII) is one of the major side-effects of radiotherapy, which reduces the life quality and impedes the treatment completion of cancer patients. Previous studies have demonstrated that e …
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·pubmed.ncbi.nlm.nih.gov·
Polystyrene microplastics aggravate radiation-induced intestinal injury in mice - PubMed
When can we cure Crohn's? - PubMed
When can we cure Crohn's? - PubMed
Crohn's disease is a life-long idiopathic inflammatory disease which affects the entire gastrointestinal tract and occasionally extra-intestinal organs. CD is thought to result from complex interactions between environmental factors, the gut microbes, and the genetic background and the immune system …
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·pubmed.ncbi.nlm.nih.gov·
When can we cure Crohn's? - PubMed
Higher alpha diversity and Lactobacillus blooms are associated with better engraftment after fecal microbiota transplant in inflammatory bowel disease - PubMed
Higher alpha diversity and Lactobacillus blooms are associated with better engraftment after fecal microbiota transplant in inflammatory bowel disease - PubMed
Fecal Microbiota Transplant (FMT) has shown some success in treating inflammatory bowel diseases (IBD). There is emerging evidence that host engraftment of donor taxa is a tenet of successful FMT. We undertook a double-blind, randomized, placebo-controlled pilot study to characterize the response to …
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·pubmed.ncbi.nlm.nih.gov·
Higher alpha diversity and Lactobacillus blooms are associated with better engraftment after fecal microbiota transplant in inflammatory bowel disease - PubMed
Q&A: Biologic drugs are reinvented to treat infectious diseases
Q&A: Biologic drugs are reinvented to treat infectious diseases
Lumen scientists were the first to crack that long-standing barrier. Once that was done, we started looking around for useful applications. To our surprise, we discovered that there is actually a very robust literature on orally delivered therapeutic proteins, although most people are unaware of it.
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·digitaljournal.com·
Q&A: Biologic drugs are reinvented to treat infectious diseases
Therapeutic interventions for gut dysbiosis and related disorders in the elderly: antibiotics, probiotics or faecal microbiota transplantation? - PubMed
Therapeutic interventions for gut dysbiosis and related disorders in the elderly: antibiotics, probiotics or faecal microbiota transplantation? - PubMed
Ageing and physiological functions of the human body are inversely proportional to each other. The gut microbiota and host immune system co-evolve from infants to the elderly. Ageing is accompanied by a decline in gut microbial diversity, immunity and metabolism, which increases susceptibility to in …
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·pubmed.ncbi.nlm.nih.gov·
Therapeutic interventions for gut dysbiosis and related disorders in the elderly: antibiotics, probiotics or faecal microbiota transplantation? - PubMed
Link between gut microbiota dysbiosis and childhood asthma: Insights from a systematic review - PubMed
Link between gut microbiota dysbiosis and childhood asthma: Insights from a systematic review - PubMed
Asthma, a chronic inflammatory disorder of the airways, is a prevalent childhood chronic disease with a substantial global health burden. The complex etiology and pathogenesis of asthma involve genetic and environmental factors, posing challenges in diagnosis, severity prediction, and therapeutic st …
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·pubmed.ncbi.nlm.nih.gov·
Link between gut microbiota dysbiosis and childhood asthma: Insights from a systematic review - PubMed