Clostridium Difficile Infections Pipeline Analysis 2024: FDA Approvals and Emerging Therapies by DelveInsight| Novartis AG, Astellas Pharma, Eli Lilly & Company AstraZeneca, Actelion Pharmaceuticals Ltd., Merck & Co. Inc., Baxter International Inc., Sanof
Las Vegas Nevada United States As per DelveInsight s assessment globally Clostridium Difficile Infections pipeline constitutes 20 key companies continuously working towards developing 22 Clostridium Difficile Infections treatment therapies analysis of Clinical Trials Therapies Mechanism of Action Route of Administration ...
Frontiers | Recent Advances in Fecal Microbiota Transplantation for Clostridium difficile Infection-Associated Diarrhea after Kidney Transplantation
Following the introduction of kidney transplantation in the 1950s, it has become the most developed and widely-used type of solid organ transplantation world...
The impact of YabG mutations on C. difficile spore germination and processing of spore substrates - PubMed
YabG is a sporulation-specific protease that is conserved among sporulating bacteria. C. difficile YabG processes cortex destined proteins preproSleC into proSleC and CspBA to CspB and CspA. YabG also affects synthesis of spore coat/exosporium proteins CotA and CdeM. In prior work that identi …
Intestinal microbiota imbalance resulted by anti-Toxoplasma gondii immune responses aggravate gut and brain injury - PubMed
Our study revealed that host immune responses against T. gondii infection severely disrupted the balance of gut microbiota, resulting in intestinal and brain damage. Lactobacillus spp. play a crucial role in immune regulation, and the metabolite ILA is a promising therapeutic compound for efficient …
Epidemiology of Clostridioides difficile infection at one hospital 10 years after an outbreak of the epidemic C. difficile strain BI/027: changing strain prevalence, antimicrobial susceptibilities, and patient antibiotic exposures - PubMed
In contrast to the epidemiology 10 years earlier at our hospital when the epidemic restriction endonuclease analysis (REA) group strain BI accounted for 72% of Clostridioides difficile isolates recovered from first-episode C. difficile infection (CDI) cases, BI represented 19% of first …
Clostridioides difficile causes a serious diarrheal disease and is a common healthcare-associated bacterial pathogen. Although it has a major impact on human health, the mechanistic details of C. difficile intestinal colonization remain undefined. C. difficile is highly sensitiv …
Insoluble polysaccharides produced in plant cell cultures protect from Clostridioides difficile colitis - PubMed
Clostridioides difficile infection (CDI) poses a significant health threat due to high recurrence rates. Antimicrobial agents are commonly used to manage CDI-related diarrhoea; however, by aggravating intestinal dysbiosis, antibiotics enable C. difficile spores germination and production of toxins, …
Clostridioides difficile causes a serious diarrheal disease and is a common healthcare-associated bacterial pathogen. Although it has a major impact on human health, the mechanistic details of C. difficile intestinal colonization remain undefined. C. difficile is highly sensitiv …
Epidemiology of Clostridioides difficile infection at one hospital 10 years after an outbreak of the epidemic C. difficile strain BI/027: changing strain prevalence, antimicrobial susceptibilities, and patient antibiotic exposures - PubMed
In contrast to the epidemiology 10 years earlier at our hospital when the epidemic restriction endonuclease analysis (REA) group strain BI accounted for 72% of Clostridioides difficile isolates recovered from first-episode C. difficile infection (CDI) cases, BI represented 19% of first …
Overcoming donor variability and risks associated with fecal microbiota transplants through bacteriophage-mediated treatments - PubMed
This proof-of-concept study shows that specific modifications of FVT hold promise in addressing challenges related to donor variability and infection risks. Two strategies lead to treatments significantly limiting C. difficile colonization in mice, with solvent/detergent treatment and chemostat prop …
Frontiers | Clostridioides difficile infection is associated with differences in transcriptionally active microbial communities
Clostridioides difficile infection (CDI) is responsible for around 300,000 hospitalizations yearly in the United States, with the associated monetary cost be...
Molecular Clostridium Difficile Diagnostic Equipment Market Expected to Reach XX Billion by 2032 due to Rising Global Awareness of Infections
Dataintelo recently unveiled its latest report detailing the global Molecular Clostridium Difficile Diagnostic Equipment market which was valued at USD XX Billion in 2023 This exhaustively researched study projects that the market will go on to reach a striking USD ...
Immuron requests pre-IND meeting for IMM-529 with FDA filing
MELBOURNE, Australia, July 02, 2024 (GLOBE NEWSWIRE) -- Immuron Limited (ASX: IMC; NASDAQ: IMRN), an Australian based and globally integrated biopharmaceutical company, is pleased to announce that it has filed a pre-IND (investigational new...
Overcoming donor variability and risks associated with fecal microbiota transplants through bacteriophage-mediated treatments - PubMed
This proof-of-concept study shows that specific modifications of FVT hold promise in addressing challenges related to donor variability and infection risks. Two strategies lead to treatments significantly limiting C. difficile colonization in mice, with solvent/detergent treatment and chemostat prop …
#VisualAbstract: Ridinilazole reduces recurrent Clostridioides difficile infection and preserves gut microbi-ome diversity versus vancomycin | 2 Minute Medicine
Frontiers | Isolation, molecular typing and antimicrobial resistance of Clostridium difficile in dogs and cats in Lanzhou city of Northwest China
Clostridium difficile infection (CDI) in human and animals belonged usually to antibiotic-associated diarrhea, ranging in severity from mild to life-threaten...
Antibiotic resistance of enteropathogenic bacteria in a teaching hospital in North Khuzestan during a three-year period - PubMed
Susceptibility to antibiotics was different among the isolates, which shows that the early identification of the infection agent and the selection of the correct antibiotic treatment are effective in improving the gastrointestinal infection and preventing the spread of the infection.
Sleep deprivation causes gut dysbiosis impacting on systemic metabolomics leading to premature ovarian insufficiency in adolescent mice - PubMed
Rationale: Currently, there are occasional reports of health problems caused by sleep deprivation (SD). However, to date, there remains a lack of in-depth research regarding the effects of SD on the growth and development of oocytes in females. The present work aimed to investigate whether SD …
Frontiers | Role of probiotics in preventing Clostridioides difficile infection in older adults: an integrative review
Clostridioides difficile infection (CDI) is the leading cause of healthcare-associated diarrhea. This infection can particularly affect older adults, the mos...
Frontiers | High Prevalence of Multidrug-Resistant Clostridioides difficile Following Extensive Use of Antimicrobials in Hospitalized Patients in Kenya
IntroductionClostridioides difficile is a neglected pathogen in many African countries as it is generally not regarded as one of the major contributors towar...
Frontiers | Characterization of the gut microbiome of patients with Clostridioides difficile infection, patients with non–C. difficile diarrhea, and C. difficile–colonized patients
IntroductionClostridioides difficile infection (CDI) is the main cause of nosocomial diarrhea in developed countries. A key challenge in CDI is the lack of o...
Differences in enteric pathogens and intestinal microbiota between diarrheic weaned piglets and healthy penmates - PubMed
Postweaning diarrhea (PWD) is a multifactorial disease caused by different aetiological agents, like viruses or bacteria and where the role of the microbiota remains unclear. The aim of this study was to assess differences between healthy and diarrheic weaned pigs concerning the prevalence of pathog …
Potent and specific antibiotic combination therapy against Clostridioides difficile - PubMed
Keratinicyclins and keratinimicins are recently discovered glycopeptide antibiotics. Keratinimicins show broad-spectrum activity against Gram-positive bacteria, while keratinicyclins form a new chemotype by virtue of an unusual oxazolidinone moiety and exhibit specific antibiosis against Clostridioi …
Exploring novel microbial metabolites and drugs for inhibiting Clostridioides difficile - PubMed
The most frequent infection associated with hospital settings is Clostridioides difficile, which can cause fatal diarrhea and severe colitis, toxic megacolon, sepsis, and leaky gut. Those who have taken antibiotics for other illnesses that affect the gut's healthy microbiota are more suscepti …
Frontiers | Microbiome profile and calprotectin levels as markers of risk of recurrent Clostridioides difficile infection
IntroductionClostridioides difficile infection (CDI) is the main cause of nosocomial diarrhoea in developed countries. Recurrent CDI (R-CDI), which affects 2...
Frontiers | Global and Historical Distribution of Clostridioides difficile in the Human Diet (1981–2019): Systematic Review and Meta-Analysis of 21886 Samples Reveal Sources of Heterogeneity, High-Risk Foods, and Unexpected Higher Prevalence Toward the Tropic
Clostridioides difficile (CD) is a spore-forming bacterium that causes life-threatening intestinal infections in humans. Although formerly regarded as exclus...