C Difficile

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L-valine derived from the gut microbiota protects sepsis-induced intestinal injury and negatively correlates with the severity of sepsis - PubMed
L-valine derived from the gut microbiota protects sepsis-induced intestinal injury and negatively correlates with the severity of sepsis - PubMed
Alterations in microbial and metabolic features in the gut can affect the severity of sepsis. Furthermore, L-valine can protect against sepsis-induced intestinal injury.
·pubmed.ncbi.nlm.nih.gov·
L-valine derived from the gut microbiota protects sepsis-induced intestinal injury and negatively correlates with the severity of sepsis - PubMed
Commensal-pathogen dynamics structure disease outcomes during Clostridioides difficile colonization - PubMed
Commensal-pathogen dynamics structure disease outcomes during Clostridioides difficile colonization - PubMed
Gastrointestinal colonization by Clostridioides difficile is common in healthcare settings and ranges in clinical presentation from asymptomatic carriage to lethal C. difficile infection (CDI). We used a systems biology approach to investigate why patients colonized with C. difficil …
·pubmed.ncbi.nlm.nih.gov·
Commensal-pathogen dynamics structure disease outcomes during Clostridioides difficile colonization - PubMed
The state of play of rodent models for the study of Clostridioides difficile infection - PubMed
The state of play of rodent models for the study of Clostridioides difficile infection - PubMed
Clostridioides difficile is the most common cause of nosocomial antibiotic-associated diarrhoea and is responsible for a spectrum of diseases characterized by high levels of recurrence and morbidity. In some cases, complications can lead to death. Currently, several types of animal models hav …
·pubmed.ncbi.nlm.nih.gov·
The state of play of rodent models for the study of Clostridioides difficile infection - PubMed
RelQ-mediated alarmone signalling regulates growth, stress-induced biofilm formation and spore accumulation in Clostridioides difficile - PubMed
RelQ-mediated alarmone signalling regulates growth, stress-induced biofilm formation and spore accumulation in Clostridioides difficile - PubMed
The bacterial stringent response (SR) is a conserved transcriptional reprogramming pathway mediated by the nucleotide signalling alarmones, (pp)pGpp. The SR has been implicated in antibiotic survival in Clostridioides difficile, a biofilm- and spore-forming pathogen that causes resilient, hig …
·pubmed.ncbi.nlm.nih.gov·
RelQ-mediated alarmone signalling regulates growth, stress-induced biofilm formation and spore accumulation in Clostridioides difficile - PubMed
Clinical characteristics of community-onset Clostridioides difficile infections at a tertiary hospital in mainland China: A fourteen-year (2010-2023) retrospective study - PubMed
Clinical characteristics of community-onset Clostridioides difficile infections at a tertiary hospital in mainland China: A fourteen-year (2010-2023) retrospective study - PubMed
Outpatients with CDI were common among patients having diarrhea during this period in our hospital. Elderly patients and patients went to emergency department may be susceptible to CDI. Based on MLST, the result revealed that the C. difficile isolates had high genetic diversity and maintained stabil …
·pubmed.ncbi.nlm.nih.gov·
Clinical characteristics of community-onset Clostridioides difficile infections at a tertiary hospital in mainland China: A fourteen-year (2010-2023) retrospective study - PubMed
Fecal Microbiota Transplantation (FMT) Market Projected to Reach $1.83 Billion by 2030, Driven by Rising Acceptance and Clinical Success
Fecal Microbiota Transplantation (FMT) Market Projected to Reach $1.83 Billion by 2030, Driven by Rising Acceptance and Clinical Success
Fecal microbiota transplantation involves transferring gut microbial communities from a healthy donor to a patient s intestinal tract to restore healthy microbiota and cure diseases The process has gained substantial traction over the past decade particularly for its efficacy in ...
·openpr.com·
Fecal Microbiota Transplantation (FMT) Market Projected to Reach $1.83 Billion by 2030, Driven by Rising Acceptance and Clinical Success
“Alarming Development” – First-Line Treatment for Deadly Superbug Is Weakening
“Alarming Development” – First-Line Treatment for Deadly Superbug Is Weakening
As vancomycin becomes more popular, its effectiveness diminishes. New research from the University of Houston College of Pharmacy suggests that vancomycin, commonly prescribed as the first-line treatment for C. difficile infections, may not be as effective as previously thought. C. diff infectio
·scitechdaily.com·
“Alarming Development” – First-Line Treatment for Deadly Superbug Is Weakening
Oral and gut microbiome alterations in oral chronic graft-versus-host disease: results from Close Assessment and Testing for Chronic GVHD (CATCH study) - PubMed
Oral and gut microbiome alterations in oral chronic graft-versus-host disease: results from Close Assessment and Testing for Chronic GVHD (CATCH study) - PubMed
The unusual coalescence of two distant niches in these patients may have short- or long-term consequences for the host, a novel avenue for future research. In addition, this study suggests a contribution of the oral microbiome to oral cGVHD pathogenesis.
·pubmed.ncbi.nlm.nih.gov·
Oral and gut microbiome alterations in oral chronic graft-versus-host disease: results from Close Assessment and Testing for Chronic GVHD (CATCH study) - PubMed
USPTO Grants Acurx Pharmaceuticals New Patent for Ibezapolstat to Treat CDI While Reducing Recurrence of Infection and Improving Health of the Gut Microbiome | ACXP Stock News
USPTO Grants Acurx Pharmaceuticals New Patent for Ibezapolstat to Treat CDI While Reducing Recurrence of Infection and Improving Health of the Gut Microbiome | ACXP Stock News
Acurx Pharmaceuticals secures patent for ibezapolstat, a promising C. difficile treatment. Learn how this breakthrough could revolutionize CDI therapy, reduce recurrence, and improve gut health as Phase 3 trials approach.
·stocktitan.net·
USPTO Grants Acurx Pharmaceuticals New Patent for Ibezapolstat to Treat CDI While Reducing Recurrence of Infection and Improving Health of the Gut Microbiome | ACXP Stock News
Therapeutic effects and mechanisms of fecal microbiota transplantation on EAE partly through HPA axis-mediated neuroendocrine regulation - PubMed
Therapeutic effects and mechanisms of fecal microbiota transplantation on EAE partly through HPA axis-mediated neuroendocrine regulation - PubMed
FMT showed a neuroprotective effect on EAE by increasing the abundance of the beneficial flora, rebuilding intestinal homeostasis, reducing IL-17 and cortisol serum levels, and promoting serum TLR-2; the therapeutic effect of FMT on EAE is partly dependent on the HPA axis.
·pubmed.ncbi.nlm.nih.gov·
Therapeutic effects and mechanisms of fecal microbiota transplantation on EAE partly through HPA axis-mediated neuroendocrine regulation - PubMed
Campylobacter Infection Introduced Following Fecal Microbiota Transplantation - PubMed
Campylobacter Infection Introduced Following Fecal Microbiota Transplantation - PubMed
Fecal microbiota transplantation is an evidence-based therapeutic option for recurrent Clostridium difficile infection, involving the transfer of healthy donor fecal material to restore gut microbial balance. Despite meticulous donor screening, Campylobacter jejuni, a prevalent cause o …
·pubmed.ncbi.nlm.nih.gov·
Campylobacter Infection Introduced Following Fecal Microbiota Transplantation - PubMed
Healthcare-associated Diarrhea due to Clostridioides difficile in Patients Attending a Tertiary Care Teaching Hospital of North India - PubMed
Healthcare-associated Diarrhea due to Clostridioides difficile in Patients Attending a Tertiary Care Teaching Hospital of North India - PubMed
Raj N, Agarwal J, Singh V, et al. Healthcare-associated Diarrhea due to Clostridioides difficile in Patients Attending a Tertiary Care Teaching Hospital of North India. Euroasian J Hepato-Gastroenterol 2024;14(1):60-64.
·pubmed.ncbi.nlm.nih.gov·
Healthcare-associated Diarrhea due to Clostridioides difficile in Patients Attending a Tertiary Care Teaching Hospital of North India - PubMed
Duration from start of antibiotic exposure to onset of Clostridioides difficile infection for different antibiotics in a non-outbreak setting - PubMed
Duration from start of antibiotic exposure to onset of Clostridioides difficile infection for different antibiotics in a non-outbreak setting - PubMed
The time gap between antibiotic exposure and onset of CDI is markedly different between different antibiotics. Decreased cephalosporin use could delay onset of healthcare facility-associated CDI and limit infections with onset within the hospital. This might decrease costs for inpatient care, need o …
·pubmed.ncbi.nlm.nih.gov·
Duration from start of antibiotic exposure to onset of Clostridioides difficile infection for different antibiotics in a non-outbreak setting - PubMed
Gut virome-wide association analysis identifies cross-population viral signatures for inflammatory bowel disease - PubMed
Gut virome-wide association analysis identifies cross-population viral signatures for inflammatory bowel disease - PubMed
Building upon these insights into the IBD gut virome, we identified potential biomarkers for prognosis and therapy in IBD patients, laying the foundation for further exploration of viromes in related conditions. Video Abstract.
·pubmed.ncbi.nlm.nih.gov·
Gut virome-wide association analysis identifies cross-population viral signatures for inflammatory bowel disease - PubMed
Clinical characteristics of community-onset Clostridioides difficile infections at a tertiary hospital in mainland China: A fourteen-year (2010-2023) retrospective study - PubMed
Clinical characteristics of community-onset Clostridioides difficile infections at a tertiary hospital in mainland China: A fourteen-year (2010-2023) retrospective study - PubMed
Outpatients with CDI were common among patients having diarrhea during this period in our hospital. Elderly patients and patients went to emergency department may be susceptible to CDI. Based on MLST, the result revealed that the C. difficile isolates had high genetic diversity and maintained stabil …
·pubmed.ncbi.nlm.nih.gov·
Clinical characteristics of community-onset Clostridioides difficile infections at a tertiary hospital in mainland China: A fourteen-year (2010-2023) retrospective study - PubMed
Fecal Microbiota Transfer from Young Mice Reverts Vascular Aging Hallmarks and Metabolic Impairments in Aged Mice - PubMed
Fecal Microbiota Transfer from Young Mice Reverts Vascular Aging Hallmarks and Metabolic Impairments in Aged Mice - PubMed
As a major risk factor for cardiometabolic diseases, aging refers to a gradual decline in physiological function, characterized with 12 conspicuous hallmarks, like telomere attrition, chronic inflammation, and dysbiosis. Common vascular aging hallmarks include endothelial dysfunction, telomere dysfu …
·pubmed.ncbi.nlm.nih.gov·
Fecal Microbiota Transfer from Young Mice Reverts Vascular Aging Hallmarks and Metabolic Impairments in Aged Mice - PubMed
Gut microbiota promotes macrophage M1 polarization in hepatic sinusoidal obstruction syndrome via regulating intestinal barrier function mediated by butyrate - PubMed
Gut microbiota promotes macrophage M1 polarization in hepatic sinusoidal obstruction syndrome via regulating intestinal barrier function mediated by butyrate - PubMed
These results suggested that the gut microbiota exacerbated HSOS progression by regulating macrophage M1 polarization via altered intestinal barrier function mediated by butyrate. Our study has identified new strategies for the clinical treatment of HSOS.
·pubmed.ncbi.nlm.nih.gov·
Gut microbiota promotes macrophage M1 polarization in hepatic sinusoidal obstruction syndrome via regulating intestinal barrier function mediated by butyrate - PubMed
Research Progress on the Correlation of Atopic Dermatitis with Gut Microbiota - PubMed
Research Progress on the Correlation of Atopic Dermatitis with Gut Microbiota - PubMed
Atopic dermatitis (AD) is a common skin disease, the pathogenesis of which has not been fully elucidated. The gut microbiota is the largest micro-ecosystem in the human body that affects the immune system and skin barrier function. Recent studies have shown that in addition to the environmental fact …
·pubmed.ncbi.nlm.nih.gov·
Research Progress on the Correlation of Atopic Dermatitis with Gut Microbiota - PubMed
Gut Bifidobacterium longum is associated with better native liver survival in patients with biliary atresia - PubMed
Gut Bifidobacterium longum is associated with better native liver survival in patients with biliary atresia - PubMed
Bifidobacterium longum (B. longum) is a beneficial bacterium commonly found in the human gut. It has been studied for its potential impacts on various health conditions. In patients with biliary atresia, we found that a greater abundance of B. longum in the fecal microbiome is a …
·pubmed.ncbi.nlm.nih.gov·
Gut Bifidobacterium longum is associated with better native liver survival in patients with biliary atresia - PubMed
Management of Clostridioides difficile infection: an Italian Delphi consensus - PubMed
Management of Clostridioides difficile infection: an Italian Delphi consensus - PubMed
Delphi methodology was used to achieve consensus on the management of CDI, on the identification of patients at risk of recurrences or severe infection, and on the most appropriate use of fidaxomicin, with the final aim of fostering clinical practice application of treatment algorithms proposed by p …
·pubmed.ncbi.nlm.nih.gov·
Management of Clostridioides difficile infection: an Italian Delphi consensus - PubMed
Microbiome's Universe: Impact on health, disease and cancer treatment - PubMed
Microbiome's Universe: Impact on health, disease and cancer treatment - PubMed
The human microbiome is a diverse ecosystem of microorganisms that reside in the body and influence various aspects of health and well-being. Recent advances in sequencing technology have brought to light microbial communities in organs and tissues that were previously considered sterile. The gut mi …
·pubmed.ncbi.nlm.nih.gov·
Microbiome's Universe: Impact on health, disease and cancer treatment - PubMed
[The Role of Gut Microbiota in Lung Carcinogenesis and Cancer Immunotherapy] - PubMed
[The Role of Gut Microbiota in Lung Carcinogenesis and Cancer Immunotherapy] - PubMed
In recent years, the human microbiota, especially the gut microbiota, has been attracting attention in various fields, and it is one of the topics in the field of oncology. The human microbiota is known to act directly or indirectly on host immunity, and the gut and lung microbiota influence each ot …
·pubmed.ncbi.nlm.nih.gov·
[The Role of Gut Microbiota in Lung Carcinogenesis and Cancer Immunotherapy] - PubMed
Uses of Fecal Microbiota Transplantation in Neurodegenerative Disease: A Scoping Review - PubMed
Uses of Fecal Microbiota Transplantation in Neurodegenerative Disease: A Scoping Review - PubMed
Fecal microbiota transplantation (FMT) is the administration of fecal bacteria from a healthy donor into the intestinal tract of a recipient in order to directly change the recipient's gut microbial composition and confer a health benefit. The relationship between the gut microbiome and the central …
·pubmed.ncbi.nlm.nih.gov·
Uses of Fecal Microbiota Transplantation in Neurodegenerative Disease: A Scoping Review - PubMed
Sotagliflozin attenuates cardiac dysfunction and depression-like behaviors in mice with myocardial infarction through the gut-heart-brain axis - PubMed
Sotagliflozin attenuates cardiac dysfunction and depression-like behaviors in mice with myocardial infarction through the gut-heart-brain axis - PubMed
Myocardial infarction (MI) and depression are leading causes of mortality and morbidity globally, and these conditions are increasing recognized as being fundamentally interconnected. The recently recognized gut-heart-brain axis offers insights into depression following MI, but effective treatments …
·pubmed.ncbi.nlm.nih.gov·
Sotagliflozin attenuates cardiac dysfunction and depression-like behaviors in mice with myocardial infarction through the gut-heart-brain axis - PubMed