C Difficile

New technology and innovation may help turn the corner on antibiotic resistance.

Identifying the underlying causes of prolonged lung inflammation associated with radiographic abnormalities could be key understanding long COVID and other lung conditions, researchers say.

Rapid diagnostics enhance patient outcomes by enabling prompt, targeted treatments, reducing inappropriate antibiotic use, and combating antimicrobial resistance through informed clinical decisions and stewardship programs.

Fidaxomicin (FDX), an RNA polymerase (RNAP) inhibitor antibiotic, is a guideline-recommended therapy for Clostridioides difficile infection. Mutations associated with reduced FDX minimum inhibitory concentrations (MICs) have been identified. However, the molecular characterization of these mu …

SCFAs not only mitigate damage to intestinal structure and function but also alleviate various lesions in the central nervous system, such as neuroinflammation, and reduce anxiety and depression-like behaviors, which were triggered by transplantation with fecal microbiota that had been affected by c …

FMT-induced microbiota restoration demonstrated a protective effect against sepsis. This study uniquely validates the effectiveness of FMT in a juvenile mouse sepsis model, offering potential implications for clinical research in critically ill children.

Faecal/intestinal microbiota transplant (FMT/IMT) is an efficacious treatment option for recurrent Clostridioides difficile infection, which has prompted substantial interest in FMT's potential role in the management of a much broader range of diseases associated with the gut microbiome. Desp …

Alcohol-associated liver disease (ALD) is a significant global health challenge, encompassing a spectrum from steatotic liver disease to cirrhosis and alcohol-associated hepatitis, and contributed to 25% of global cirrhosis deaths in 2019. The identification of both modifiable (e.g. heavy drinking, …

Scientists have developed a novel method to cultivate beneficial viruses from human feces, potentially revolutionizing how we treat gastrointestinal disorders.

Jeanie Bach, MSN, RN, CCRN, is a Disease Area Partner for Infectious Disease at Roche Diagnostics. Based in Arizona, she has nearly 20 years of experience in intensive care and emergency settings. She leads infectious disease initiatives and specializes in respiratory conditions, sepsis, and antimicrobial stewardship.

Fulminant Clostridium difficile colitis is a severe and potentially life-threatening form of Clostridium difficile-associated bacterial disease leading to inflammation and damage to the colon. C...

A new Johns Hopkins study made some new findings about the relatively new procedure of fecal transplants - which use feces from healthy people to help patients with a serious bowel disease.

In a novel study that identified male chromosome genetic material in the intestines of female patients undergoing fecal transplants, researchers at Johns Hopkins Medicine say they have significantly expanded ...

The new horizon of Clostridioides difficile infection treatment

This is the first report on the perspectives of potential participants in donating samples towards a stool microbiome biobank in South Africa, a necessity for faecal microbiota transplantation (FMT).

Led by Shruti K. Gohil, MD, MPH, the trials examined how computerized physician order entry prompts can reduce the use of extended-spectrum antibiotics in hospitalized patients while maintaining patient safety.

In a new study, researchers at the University of Copenhagen have been cultivating 'good viruses' from feces. The goal is to replace fecal capsules now

Faecal microbiota transplant will now be available to patients outside clinical trials.

Cell Discovery - Bacterial toxins induce non-canonical migracytosis to aggravate acute inflammation

The use of OVP significantly reduced the incidence of CDI during the in-hospital ASCT course without increasing CDI post-OVP use. These encouraging results should promote further research into the use of OVP in ASCT.

Oral Vancomycin to Prevent Clostridioides difficile in Stem Cell Transplant Recipients: The Last Frontier in Antimicrobial Prophylaxis

This rare but severe condition can result from antibiotic use.

As of Nov. 1, OpenBiome suspended its distribution of investigational fecal microbiota transplantation, which may put certain patients with recurrent, refractory or fulminant Clostridioides difficile infection at risk, according to the AGA. “It is important to understand that the suspension is a voluntary action on the part of OpenBiome, which is the result of some communications they have

Cachexia affects approximately 50-80% of advanced cancer patients, particularly those with gastric cancer (GC). Therefore, early detection of cachexia is essential to prevent its progression. Targeting the gut microbiota may be a promising approach for preventing and treating cachexia in patients wi …

Intermountain Health researchers have received a grant to address the problem of antibiotic overuse and resistance in urgent care and outpatient clinics. The $356,000 grant from Merck will launch the Intermountain ReSCORE-UC project, which will be a two-year study to better understand how to maintain proper antibiotic prescribing in outpatient settings. The goal is to […]

Clostridioides difficile strains of sequence type (ST) 37, primarily including PCR ribotype (RT) 017, are prevalent in mainland China. Our study aimed to compare the major virulence factors of an epidemic C. difficile isolate of ST37 type (Xy06) from China with the well-characterized …

Background: Systematic surveillance of Clostridioides difficile infection (CDI) in our institution showed a reduction in the incidence of healthcare associated CDI (HA-CDI) during COVID-19 pandemic. Aim: Our objective was to search for factors related to this reduction. Metho …

Fluoride, an environmental toxicant, not only arouses intestinal microbiota dysbiosis, but also causes neuronal apoptosis and a decline in learning and memory ability. The purpose of this study was to explore whether fecal microbiota transplantation (FMT) from healthy mice and bacteria-derived metab …