C Difficile

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Identification of a family of peptidoglycan transpeptidases reveals that Clostridioides difficile requires noncanonical cross-links for viability - PubMed
Identification of a family of peptidoglycan transpeptidases reveals that Clostridioides difficile requires noncanonical cross-links for viability - PubMed
Most bacteria are surrounded by a cell wall that contains peptidoglycan (PG), a large polymer composed of glycan strands held together by short peptide cross-links. There are two major types of cross-links, termed 4-3 and 3-3 based on the amino acids involved. 4-3 cross-links are created by penicill …
C Diff MolecularC Diff Molecular
·pubmed.ncbi.nlm.nih.gov·
Identification of a family of peptidoglycan transpeptidases reveals that Clostridioides difficile requires noncanonical cross-links for viability - PubMed
Finch wins US jury trial against Ferring over fecal-transplant patents
Finch wins US jury trial against Ferring over fecal-transplant patents
A federal jury in Delaware said on Friday that Swiss biopharmaceutical company Ferring Pharmaceuticals infringed patents for fecal transplant technology belonging to Finch Therapeutics and the University of Minnesota and should pay $25 million in damages and future royalties.
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·reuters.com·
Finch wins US jury trial against Ferring over fecal-transplant patents
Neutralization of Clostridium difficile Toxin B Mediated by Engineered Lactobacilli That Produce Single-Domain Antibodies | Infection and Immunity
Neutralization of Clostridium difficile Toxin B Mediated by Engineered Lactobacilli That Produce Single-Domain Antibodies | Infection and Immunity
ABSTRACT Clostridium difficile is the primary cause of nosocomial antibiotic-associated diarrhea in the Western world. The major virulence factors of C. difficile are two exotoxins, toxin A (TcdA) and toxin B (TcdB), which cause extensive colonic ...
C Diff Drug DevelopmentC Diff Drug Development
·journals.asm.org·
Neutralization of Clostridium difficile Toxin B Mediated by Engineered Lactobacilli That Produce Single-Domain Antibodies | Infection and Immunity
The Genesis of C diff Advocacy
The Genesis of C diff Advocacy
Peggy Lillis Foundation CEO Christian Lillis talks about how he became involved in advocacy around C diff and his motivation in helping to bring a bill to Congress to make the healthcare-associated infection a nationally notifiable infectious disease and condition.
C Diff PreventionC Diff Prevention
·contagionlive.com·
The Genesis of C diff Advocacy
Healthcare-associated infections and antimicrobial resistance in Canadian acute care hospitals, 2018-2022 - PubMed
Healthcare-associated infections and antimicrobial resistance in Canadian acute care hospitals, 2018-2022 - PubMed
From 2018 to 2022, the incidence of MRSA BSIs and CDIs decreased and VRE BSI and CPE infections increased in the Canadian acute care hospitals participating in a national sentinel network (CNISP). Few C. auris isolates were identified from 2012 to 2022. Reporting standardized surveillance dat …
C Diff TransmissionC Diff Transmission
·pubmed.ncbi.nlm.nih.gov·
Healthcare-associated infections and antimicrobial resistance in Canadian acute care hospitals, 2018-2022 - PubMed
Pantothenate kinase: A promising therapeutic target against pathogenic Clostridium species - PubMed
Pantothenate kinase: A promising therapeutic target against pathogenic Clostridium species - PubMed
Current treatment of clostridial infections includes broad-spectrum antibiotics and antitoxins, yet antitoxins are ineffective against all Clostridiumspecies. Moreover, rising antimicrobial resistance (AMR) threatens treatment effectiveness and public health. This study therefore aimed to dis …
C Diff Drug DevelopmentC Diff Drug Development
·pubmed.ncbi.nlm.nih.gov·
Pantothenate kinase: A promising therapeutic target against pathogenic Clostridium species - PubMed
Symbiotic biofilms formed by Clostridioides difficile and bacteroides thetaiotaomicron in the presence of vancomycin - PubMed
Symbiotic biofilms formed by Clostridioides difficile and bacteroides thetaiotaomicron in the presence of vancomycin - PubMed
Vancomycin (VAN) treatment in Clostridioides difficile infection (CDI) suffers from a relatively high rate of recurrence, with a variety of reasons behind this, including biofilm-induced recurrent infections. C. difficile can form monophyletic or symbiotic biofilms with other microbes …
C Diff TreatmentC Diff Treatment
·pubmed.ncbi.nlm.nih.gov·
Symbiotic biofilms formed by Clostridioides difficile and bacteroides thetaiotaomicron in the presence of vancomycin - PubMed
Family Stool Donation Predicts Failure of Fecal Microbiota Transplant for Clostridioides difficile Infection - PubMed
Family Stool Donation Predicts Failure of Fecal Microbiota Transplant for Clostridioides difficile Infection - PubMed
Colonoscopy-based FMT was highly effective for CDI, even in a population where immunosuppression and proton pump inhibitor use were common. Family stool donation was associated with FMT failure, compared with the use of a stool bank. The study suggests that the use of a stool bank may not only impro …
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·pubmed.ncbi.nlm.nih.gov·
Family Stool Donation Predicts Failure of Fecal Microbiota Transplant for Clostridioides difficile Infection - PubMed
Healthcare-associated infections and antimicrobial resistance in Canadian acute care hospitals, 2018-2022 - PubMed
Healthcare-associated infections and antimicrobial resistance in Canadian acute care hospitals, 2018-2022 - PubMed
From 2018 to 2022, the incidence of MRSA BSIs and CDIs decreased and VRE BSI and CPE infections increased in the Canadian acute care hospitals participating in a national sentinel network (CNISP). Few C. auris isolates were identified from 2012 to 2022. Reporting standardized surveillance dat …
C Diff TransmissionC Diff Transmission
·pubmed.ncbi.nlm.nih.gov·
Healthcare-associated infections and antimicrobial resistance in Canadian acute care hospitals, 2018-2022 - PubMed
Symbiotic biofilms formed by Clostridioides difficile and bacteroides thetaiotaomicron in the presence of vancomycin - PubMed
Symbiotic biofilms formed by Clostridioides difficile and bacteroides thetaiotaomicron in the presence of vancomycin - PubMed
Vancomycin (VAN) treatment in Clostridioides difficile infection (CDI) suffers from a relatively high rate of recurrence, with a variety of reasons behind this, including biofilm-induced recurrent infections. C. difficile can form monophyletic or symbiotic biofilms with other microbes …
C Diff MolecularC Diff Molecular
·pubmed.ncbi.nlm.nih.gov·
Symbiotic biofilms formed by Clostridioides difficile and bacteroides thetaiotaomicron in the presence of vancomycin - PubMed
Healing from Within: How Gut Microbiota Predicts IBD Treatment Success-A Systematic Review - PubMed
Healing from Within: How Gut Microbiota Predicts IBD Treatment Success-A Systematic Review - PubMed
Recent research indicates that the microbiome has a significant impact on the progression of inflammatory bowel disease (IBD) and that creating therapies that change its composition could positively impact the outcomes of IBD treatment. This review summarizes the results of extensive studies that ex …
C Diff MolecularC Diff Molecular
·pubmed.ncbi.nlm.nih.gov·
Healing from Within: How Gut Microbiota Predicts IBD Treatment Success-A Systematic Review - PubMed
MicroRNA miR-27a-5p reduces intestinal inflammation induced by Clostridioides difficile flagella by regulating the NF-κB signaling pathway - PubMed
MicroRNA miR-27a-5p reduces intestinal inflammation induced by Clostridioides difficile flagella by regulating the NF-κB signaling pathway - PubMed
miR-27a-5p plays a crucial role in regulating C. difficile-induced inflammation, suggesting its potential as a therapeutic target for controlling severe infection. These findings offer valuable insights into potential therapeutic strategies for managing C. difficile infection and associated inflamma …
C Diff MolecularC Diff Molecular
·pubmed.ncbi.nlm.nih.gov·
MicroRNA miR-27a-5p reduces intestinal inflammation induced by Clostridioides difficile flagella by regulating the NF-κB signaling pathway - PubMed
Development of two recombinant vaccines against Clostridioides difficile infection and immunogenicity in pregnant sows and neonatal piglets - PubMed
Development of two recombinant vaccines against Clostridioides difficile infection and immunogenicity in pregnant sows and neonatal piglets - PubMed
The synthesized recombinant proteins were capable of inducing antibody titers against C. difficile toxins A and B in sows, and were passively transferred to piglets through colostrum.
C Diff Drug DevelopmentC Diff Drug Development
·pubmed.ncbi.nlm.nih.gov·
Development of two recombinant vaccines against Clostridioides difficile infection and immunogenicity in pregnant sows and neonatal piglets - PubMed
Use of extracorporeal hemoperfusion therapy in an adult horse with Clostridioides difficile colitis and severe systemic inflammatory response syndrome - PubMed
Use of extracorporeal hemoperfusion therapy in an adult horse with Clostridioides difficile colitis and severe systemic inflammatory response syndrome - PubMed
An 8-year-old American Quarter Horse gelding was treated with extracorporeal hemoperfusion (HP) therapy for treatment of Clostridioides difficile (C. difficile) colitis-induced systemic inflammatory response syndrome (SIRS). The gelding developed C. difficile associated peracute colitis and severe S …
C Diff TreatmentC Diff Treatment
·pubmed.ncbi.nlm.nih.gov·
Use of extracorporeal hemoperfusion therapy in an adult horse with Clostridioides difficile colitis and severe systemic inflammatory response syndrome - PubMed
The impact of 30-day antecedent antibiotic exposure on C. difficile ribotype patterns and the relationship with clinical outcomes: A single center study - PubMed
The impact of 30-day antecedent antibiotic exposure on C. difficile ribotype patterns and the relationship with clinical outcomes: A single center study - PubMed
These findings suggest that fluoroquinolone and macrolide exposure were significantly associated with isolating a resistant strain, but we did not find significant differences in clinical outcomes based on the presence of antimicrobial resistance.
C Diff Drug StewardshipC Diff Drug Stewardship
·pubmed.ncbi.nlm.nih.gov·
The impact of 30-day antecedent antibiotic exposure on C. difficile ribotype patterns and the relationship with clinical outcomes: A single center study - PubMed
#VisualAbstract: Ridinilazole reduces recurrent Clostridioides difficile infection and preserves gut microbi-ome diversity versus vancomycin | 2 Minute Medicine
#VisualAbstract: Ridinilazole reduces recurrent Clostridioides difficile infection and preserves gut microbi-ome diversity versus vancomycin | 2 Minute Medicine
Click here to read this study in CID. ©2024 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.
C Diff TreatmentC Diff Treatment
·2minutemedicine.com·
#VisualAbstract: Ridinilazole reduces recurrent Clostridioides difficile infection and preserves gut microbi-ome diversity versus vancomycin | 2 Minute Medicine
Efficacy of fidaxomicin versus vancomycin in the treatment of Clostridium difficile infection: A systematic meta-analysis - PubMed
Efficacy of fidaxomicin versus vancomycin in the treatment of Clostridium difficile infection: A systematic meta-analysis - PubMed
There were no significant differences between fidaxomicin and vancomycin in the treatment of CDI in therapeutic effectiveness and adverse reactions, while fidaxomicin was superior to vancomycin in terms of recurrence rate and long-term mortality, and vancomycin is more effective in treating severe C …
C Diff TreatmentC Diff Treatment
·pubmed.ncbi.nlm.nih.gov·
Efficacy of fidaxomicin versus vancomycin in the treatment of Clostridium difficile infection: A systematic meta-analysis - PubMed
Vaccines and monoclonal antibodies to prevent healthcare-associated bacterial infections - PubMed
Vaccines and monoclonal antibodies to prevent healthcare-associated bacterial infections - PubMed
SUMMARYHealthcare-associated infections (HAIs) represent a burden for public health with a high prevalence and high death rates associated with them. Pathogens with a high potential for antimicrobial resistance, such as ESKAPE pathogens (Enterococcus faecium, S …
C Diff PreventionC Diff Prevention
·pubmed.ncbi.nlm.nih.gov·
Vaccines and monoclonal antibodies to prevent healthcare-associated bacterial infections - PubMed
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Importance of underlying mechanisms for interpreting relative risk of Clostridioides difficile infection among antibiotic-exposed patients in healthcare facilities - PubMed
Importance of underlying mechanisms for interpreting relative risk of Clostridioides difficile infection among antibiotic-exposed patients in healthcare facilities - PubMed
Clostridioides difficile infection (CDI) is a significant public health threat, associated with antibiotic-induced disruption of the normally protective gastrointestinal microbiota. CDI is thought to occur in two stages: acquisition of asymptomatic colonization from ingesting C. difficile bacteria f …
C Diff Drug StewardshipC Diff Drug Stewardship
·pubmed.ncbi.nlm.nih.gov·
Importance of underlying mechanisms for interpreting relative risk of Clostridioides difficile infection among antibiotic-exposed patients in healthcare facilities - PubMed
Importance of underlying mechanisms for interpreting relative risk of Clostridioides difficile infection among antibiotic-exposed patients in healthcare facilities - PubMed
Importance of underlying mechanisms for interpreting relative risk of Clostridioides difficile infection among antibiotic-exposed patients in healthcare facilities - PubMed
Clostridioides difficile infection (CDI) is a significant public health threat, associated with antibiotic-induced disruption of the normally protective gastrointestinal microbiota. CDI is thought to occur in two stages: acquisition of asymptomatic colonization from ingesting C. difficile bacteria f …
C Diff Drug StewardshipC Diff Drug Stewardship
·pubmed.ncbi.nlm.nih.gov·
Importance of underlying mechanisms for interpreting relative risk of Clostridioides difficile infection among antibiotic-exposed patients in healthcare facilities - PubMed
Disturbances of the gut microbiota-derived tryptophan metabolites as key actors in vagotomy-induced mastitis in mice - PubMed
Disturbances of the gut microbiota-derived tryptophan metabolites as key actors in vagotomy-induced mastitis in mice - PubMed
Previous studies have demonstrated that gut microbiota dysbiosis promotes the development of mastitis. The interaction of the vagus nerve and gut microbiota endows host homeostasis and regulates disease development, but whether the vagus nerve participates in the pathogenesis of mastitis is unclear. …
FMTFMT
·pubmed.ncbi.nlm.nih.gov·
Disturbances of the gut microbiota-derived tryptophan metabolites as key actors in vagotomy-induced mastitis in mice - PubMed