C Difficile

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Buty and the beast: the complex role of butyrate in Parkinson's disease - PubMed
Buty and the beast: the complex role of butyrate in Parkinson's disease - PubMed
Parkinson's disease (PD) is a complex neurodegenerative disease which is often associated with gastrointestinal (GI) dysfunction. The GI tract is home to a wide range of microorganisms, among which bacteria, that can influence the host through various mechanisms. Products produced by these bacteria …
·pubmed.ncbi.nlm.nih.gov·
Buty and the beast: the complex role of butyrate in Parkinson's disease - PubMed
The Many Faces of Metabolic Dysfunction-Associated Fatty Liver Disease Treatment: From the Mediterranean Diet to Fecal Microbiota Transplantation - PubMed
The Many Faces of Metabolic Dysfunction-Associated Fatty Liver Disease Treatment: From the Mediterranean Diet to Fecal Microbiota Transplantation - PubMed
The gastrointestinal tract is inhabited by the gut microbiota. The main phyla are Firmicutes and Bacteroidetes. In non-alcoholic fatty liver disease, now renamed metabolic dysfunction-associated fatty liver disease (MAFLD), an alteration in Firmicutes and Bacteroidetes abundance promotes its pathoge …
·pubmed.ncbi.nlm.nih.gov·
The Many Faces of Metabolic Dysfunction-Associated Fatty Liver Disease Treatment: From the Mediterranean Diet to Fecal Microbiota Transplantation - PubMed
Dysbiosis in Inflammatory Bowel Disease and Spondyloarthritis: Still a Long Way to Go? - PubMed
Dysbiosis in Inflammatory Bowel Disease and Spondyloarthritis: Still a Long Way to Go? - PubMed
The association between Inflammatory Bowel Disease (IBD) and Spondyloarthritis (SpA) has been known for years, as has the concept that IBD is associated with an altered intestinal bacterial composition, a condition known as "dysbiosis". Recently, a state of intestinal dysbiosis has also been found i …
·pubmed.ncbi.nlm.nih.gov·
Dysbiosis in Inflammatory Bowel Disease and Spondyloarthritis: Still a Long Way to Go? - PubMed
Complementary Therapeutic Effect of Fecal Microbiota Transplantation in Ulcerative Colitis after the Response to Anti-Tumor Necrosis Factor Alpha Agent Was Lost: A Case Report - PubMed
Complementary Therapeutic Effect of Fecal Microbiota Transplantation in Ulcerative Colitis after the Response to Anti-Tumor Necrosis Factor Alpha Agent Was Lost: A Case Report - PubMed
In patients with ulcerative colitis (UC), the development of an antidrug antibody (ADA) to anti-tumor necrosis factor (TNF)α agent is a crucial problem which aggravates the clinical course of the disease, being cited as one of the most common causes for discontinuing anti-TNFα treatment. This is due …
·pubmed.ncbi.nlm.nih.gov·
Complementary Therapeutic Effect of Fecal Microbiota Transplantation in Ulcerative Colitis after the Response to Anti-Tumor Necrosis Factor Alpha Agent Was Lost: A Case Report - PubMed
Modulating gut microbiome in cancer immunotherapy: Harnessing microbes to enhance treatment efficacy - PubMed
Modulating gut microbiome in cancer immunotherapy: Harnessing microbes to enhance treatment efficacy - PubMed
Immunotherapy has emerged as a robust approach against cancer, yet its efficacy has varied among individuals, accompanied by the occurrence of immune-related adverse events. As a result, the efficacy of immunotherapy is far from satisfactory, and enormous efforts have been invested to develop strate …
·pubmed.ncbi.nlm.nih.gov·
Modulating gut microbiome in cancer immunotherapy: Harnessing microbes to enhance treatment efficacy - PubMed
Phlorizin Limits Bovine Viral Diarrhea Virus Infection in Mice via Regulating Gut Microbiota Composition - PubMed
Phlorizin Limits Bovine Viral Diarrhea Virus Infection in Mice via Regulating Gut Microbiota Composition - PubMed
Phlorizin (PHZ) is one of the main pharmacologically active ingredients in Lithocarpus polystachyus. We have previously shown that PHZ inhibits the replication of bovine viral diarrhea virus (BVDV), but the exact antiviral mechanism, especially in vivo, is still unknown. Here, we furth …
·pubmed.ncbi.nlm.nih.gov·
Phlorizin Limits Bovine Viral Diarrhea Virus Infection in Mice via Regulating Gut Microbiota Composition - PubMed
Microbial perspective on the skin-gut axis and atopic dermatitis - PubMed
Microbial perspective on the skin-gut axis and atopic dermatitis - PubMed
Atopic dermatitis (AD) is a relapsing inflammatory skin condition that has become a global health issue with complex etiology and mounting prevalence. The association of AD with skin and gut microbiota has been revealed by virtue of the continuous development of sequencing technology and genomics an …
·pubmed.ncbi.nlm.nih.gov·
Microbial perspective on the skin-gut axis and atopic dermatitis - PubMed
[Buzhong Yiqi Decoction ameliorates spleen deficiency syndrome by regulating gut microbiota] - PubMed
[Buzhong Yiqi Decoction ameliorates spleen deficiency syndrome by regulating gut microbiota] - PubMed
This study aims to decipher the mechanism of Buzhong Yiqi Decoction(BZYQD) in the treatment of spleen deficiency syndrome via gut microbiota. The mouse models of spleen deficiency syndrome were established by fecal microbiota transplantation(FMT, from patients with spleen deficiency syndrome) and ad …
·pubmed.ncbi.nlm.nih.gov·
[Buzhong Yiqi Decoction ameliorates spleen deficiency syndrome by regulating gut microbiota] - PubMed
Microbiota therapeutics for inflammatory bowel disease: the way forward - PubMed
Microbiota therapeutics for inflammatory bowel disease: the way forward - PubMed
Microbiota therapeutics that transplant faecal material from healthy donors to people with mild-to-moderate ulcerative colitis have shown the potential to induce remission in about 30% of participants in small, phase 2 clinical trials. Despite this substantial achievement, the field needs to leverag …
·pubmed.ncbi.nlm.nih.gov·
Microbiota therapeutics for inflammatory bowel disease: the way forward - PubMed
Safety profile and effects on the peripheral immune response of fecal microbiota transplantation in clinically healthy dogs - PubMed
Safety profile and effects on the peripheral immune response of fecal microbiota transplantation in clinically healthy dogs - PubMed
Fecal microbiota transplantation did not significantly alter the evaluated variables and recipients experienced minimal adverse events associated with FMT administration. Fecal microbiota transplantation was not associated with serious adverse events, changes in peripheral immunologic variables, or …
·pubmed.ncbi.nlm.nih.gov·
Safety profile and effects on the peripheral immune response of fecal microbiota transplantation in clinically healthy dogs - PubMed
Gut-Liver Axis Dysregulation in Portal Hypertension: Emerging Frontiers - PubMed
Gut-Liver Axis Dysregulation in Portal Hypertension: Emerging Frontiers - PubMed
Portal hypertension (PH) is a complex clinical challenge with severe complications, including variceal bleeding, ascites, hepatic encephalopathy, and hepatorenal syndrome. The gut microbiota (GM) and its interconnectedness with human health have emerged as a captivating field of research. This revie …
·pubmed.ncbi.nlm.nih.gov·
Gut-Liver Axis Dysregulation in Portal Hypertension: Emerging Frontiers - PubMed
Alterations in gut microbiota contribute to cognitive deficits induced by chronic infection of Toxoplasma gondii - PubMed
Alterations in gut microbiota contribute to cognitive deficits induced by chronic infection of Toxoplasma gondii - PubMed
Chronic infection with Toxoplasma gondii (T. gondii) emerges as a risk factor for neurodegenerative diseases in animals and humans. However, the underlying mechanisms are largely unknown. We aimed to investigate whether gut microbiota and its metabolites play a role in T. gondii-induced cognitive de …
·pubmed.ncbi.nlm.nih.gov·
Alterations in gut microbiota contribute to cognitive deficits induced by chronic infection of Toxoplasma gondii - PubMed
Comparison of rectal swabs and fecal samples for the detection of Clostridioides difficile infections with a new in-house PCR assay - PubMed
Comparison of rectal swabs and fecal samples for the detection of Clostridioides difficile infections with a new in-house PCR assay - PubMed
Clostridioides difficile infection (CDI) is the leading cause of healthcare-associated diarrhea, resulting in high morbidity, mortality, and economic burden. In clinical laboratories, CDI testing is currently performed on stool samples collected from patients with diarrhea. However, the diagn …
·pubmed.ncbi.nlm.nih.gov·
Comparison of rectal swabs and fecal samples for the detection of Clostridioides difficile infections with a new in-house PCR assay - PubMed
Effect of Leptin Receptor Q223R Polymorphism on Clostridioides difficile Infection-Induced Macrophage Migration Inhibitory Factor Production - PubMed
Effect of Leptin Receptor Q223R Polymorphism on Clostridioides difficile Infection-Induced Macrophage Migration Inhibitory Factor Production - PubMed
Proinflammatory cytokine levels and host genetic makeup are key determinants of Clostridioides difficile infection (CDI) outcomes. We previously reported that blocking the inflammatory cytokine macrophage migration inhibitory factor (MIF) ameliorates CDI. Here, we determined kinetics of MIF producti …
·pubmed.ncbi.nlm.nih.gov·
Effect of Leptin Receptor Q223R Polymorphism on Clostridioides difficile Infection-Induced Macrophage Migration Inhibitory Factor Production - PubMed
Deficiency of IL-22-binding protein enhances the ability of the gut microbiota to protect against enteric pathogens - PubMed
Deficiency of IL-22-binding protein enhances the ability of the gut microbiota to protect against enteric pathogens - PubMed
Interleukin 22 (IL-22) promotes intestinal barrier integrity, stimulating epithelial cells to enact defense mechanisms against enteric infections, including the production of antimicrobial peptides. IL-22 binding protein (IL-22BP) is a soluble decoy encoded by the Il22ra2 gene that decreases …
·pubmed.ncbi.nlm.nih.gov·
Deficiency of IL-22-binding protein enhances the ability of the gut microbiota to protect against enteric pathogens - PubMed
X-ray structure and mutagenesis analyses of Clostridioides difficile endolysin Ecd09610 glucosaminidase domain - PubMed
X-ray structure and mutagenesis analyses of Clostridioides difficile endolysin Ecd09610 glucosaminidase domain - PubMed
Clostridioides difficile endolysin (Ecd09610) consists of an unknown domain at its N terminus, followed by two catalytic domains, a glucosaminidase domain and endopeptidase domain. X-ray structure and mutagenesis analyses of the Ecd09610 catalytic domain with glucosaminidase activity (Ecd09610CD53) …
·pubmed.ncbi.nlm.nih.gov·
X-ray structure and mutagenesis analyses of Clostridioides difficile endolysin Ecd09610 glucosaminidase domain - PubMed
Fecal microbiota transplantation for irritable bowel syndrome: Current evidence and perspectives - PubMed
Fecal microbiota transplantation for irritable bowel syndrome: Current evidence and perspectives - PubMed
In this editorial we comment on the article published in the recent issue of the World journal of Gastroenterology. We focus specifically on the mechanisms un-derlying the effects of fecal microbiota transplantation (FMT) for irritable bowel syndrome (IBS), the factors which affect the outcom …
·pubmed.ncbi.nlm.nih.gov·
Fecal microbiota transplantation for irritable bowel syndrome: Current evidence and perspectives - PubMed
Histidine kinase-mediated cross-regulation of the vancomycin-resistance operon in Clostridioides difficile - PubMed
Histidine kinase-mediated cross-regulation of the vancomycin-resistance operon in Clostridioides difficile - PubMed
The dipeptide D-Ala-D-Ala is an essential component of peptidoglycan and the target of vancomycin. Most Clostridioides difficile strains possess the vanG operon responsible for the synthesis of D-Ala-D-Ser, which can replace D-Ala-D-Ala in peptidoglycan. The C. difficile vanG operon is regulated by …
·pubmed.ncbi.nlm.nih.gov·
Histidine kinase-mediated cross-regulation of the vancomycin-resistance operon in Clostridioides difficile - PubMed
Post-infectious ibs following Clostridioides difficile infection; role of microbiota and implications for treatment - PubMed
Post-infectious ibs following Clostridioides difficile infection; role of microbiota and implications for treatment - PubMed
Up to 25% of patients recovering from antibiotic-treated Clostridioides difficile infection (CDI) develop functional symptoms reminiscent of Post-Infectious Irritable Bowel Syndrome (PI-IBS). For patients with persistent symptoms following infection, a clinical dilemma arises as to whether to provid …
·pubmed.ncbi.nlm.nih.gov·
Post-infectious ibs following Clostridioides difficile infection; role of microbiota and implications for treatment - PubMed
Clostridiodes difficile infection in inflammatory bowel disease: a clinical review - PubMed
Clostridiodes difficile infection in inflammatory bowel disease: a clinical review - PubMed
Available studies show that the prevalence of CDI-IBD is not optimistic. Currently, potential treatment options for CDI-IBD include a number of probiotics and novel antibiotics. This review updates the knowledge on the management of CDI in IBD patients, which is timely and important for GI doctors a …
·pubmed.ncbi.nlm.nih.gov·
Clostridiodes difficile infection in inflammatory bowel disease: a clinical review - PubMed
Theophylline-based control of repA on a Clostridioides difficile plasmid for use in allelic exchange - PubMed
Theophylline-based control of repA on a Clostridioides difficile plasmid for use in allelic exchange - PubMed
Historically, mutagenesis in the non-model enteropathogenic bacterium Clostridioides difficile has been challenging. Developing a versatile and reliable method of generating targeted mutations in C. difficile is important to further our understanding of its pathogenesis. Some of the most common targ …
·pubmed.ncbi.nlm.nih.gov·
Theophylline-based control of repA on a Clostridioides difficile plasmid for use in allelic exchange - PubMed
Scutellaria baicalensis Georgi alleviates Clostridium difficile associated diarrhea and its modulatory effects on the gut microbiota - PubMed
Scutellaria baicalensis Georgi alleviates Clostridium difficile associated diarrhea and its modulatory effects on the gut microbiota - PubMed
The growing incidence of Clostridium difficile associated diarrhea (CDAD) underscores the urgency for potent treatments. This research delves into the therapeutic potential of Scutellaria baicalensis Georgi (Lamiaceae) root (SR) in addressing CDAD and its influence on gut microbiota. Using a CDAD mo …
·pubmed.ncbi.nlm.nih.gov·
Scutellaria baicalensis Georgi alleviates Clostridium difficile associated diarrhea and its modulatory effects on the gut microbiota - PubMed
Management and Outcomes of Patients at a Specialty Clinic for Clostridioides difficile Infection - PubMed
Management and Outcomes of Patients at a Specialty Clinic for Clostridioides difficile Infection - PubMed
Vancomycin and fidaxomicin taper regimens were the most common treatment strategies employed but nearly half of patients (40/83) referred to our Clostridioides difficile infection (CDI) clinic did not require further treatment. The overall 60-day CDI recurrence rate was 16.9% (11/65). CDI man …
·pubmed.ncbi.nlm.nih.gov·
Management and Outcomes of Patients at a Specialty Clinic for Clostridioides difficile Infection - PubMed
Deficiency of IL-22-binding protein enhances the ability of the gut microbiota to protect against enteric pathogens - PubMed
Deficiency of IL-22-binding protein enhances the ability of the gut microbiota to protect against enteric pathogens - PubMed
Interleukin 22 (IL-22) promotes intestinal barrier integrity, stimulating epithelial cells to enact defense mechanisms against enteric infections, including the production of antimicrobial peptides. IL-22 binding protein (IL-22BP) is a soluble decoy encoded by the Il22ra2 gene that decreases …
·pubmed.ncbi.nlm.nih.gov·
Deficiency of IL-22-binding protein enhances the ability of the gut microbiota to protect against enteric pathogens - PubMed
Impact of including productivity costs in economic analyses of vaccines for C. difficile infections and infant respiratory syncytial virus, in a UK setting - PubMed
Impact of including productivity costs in economic analyses of vaccines for C. difficile infections and infant respiratory syncytial virus, in a UK setting - PubMed
Considering productivity costs in future cost-effectiveness analyses of vaccines for C. difficile and RSV will contribute to better-informed reimbursement decisions from a societal perspective.
·pubmed.ncbi.nlm.nih.gov·
Impact of including productivity costs in economic analyses of vaccines for C. difficile infections and infant respiratory syncytial virus, in a UK setting - PubMed
Comparison of rectal swabs and fecal samples for the detection of Clostridioides difficile infections with a new in-house PCR assay - PubMed
Comparison of rectal swabs and fecal samples for the detection of Clostridioides difficile infections with a new in-house PCR assay - PubMed
Clostridioides difficile infection (CDI) is the leading cause of healthcare-associated diarrhea, resulting in high morbidity, mortality, and economic burden. In clinical laboratories, CDI testing is currently performed on stool samples collected from patients with diarrhea. However, the diagn …
·pubmed.ncbi.nlm.nih.gov·
Comparison of rectal swabs and fecal samples for the detection of Clostridioides difficile infections with a new in-house PCR assay - PubMed