C Difficile

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Is shorter also better in the treatment of Clostridioides difficile infection? - PubMed
Is shorter also better in the treatment of Clostridioides difficile infection? - PubMed
Shortened treatment regimens for CDI with vancomycin and fidaxomicin were shown to be effective in our cohort of patients compared with 10 days of treatment. The recurrence rate was lower in the study group. A larger, prospective, double-blind, randomized, multicentre study is needed to support our …
·pubmed.ncbi.nlm.nih.gov·
Is shorter also better in the treatment of Clostridioides difficile infection? - PubMed
Clinical outcomes and treatment necessity in patients with toxin-negative Clostridioides difficile stool samples - PubMed
Clinical outcomes and treatment necessity in patients with toxin-negative Clostridioides difficile stool samples - PubMed
Our study demonstrates that toxin EIA-negative patients had milder laboratory findings and no complications, despite not receiving treatment. Prolonged hospitalisation and exposure to high-risk antibiotics could potentially serve as markers for the development of toxin EIA-positive CDI.
·pubmed.ncbi.nlm.nih.gov·
Clinical outcomes and treatment necessity in patients with toxin-negative Clostridioides difficile stool samples - PubMed
Bazedoxifene attenuates dextran sodium sulfate-induced colitis in mice through gut microbiota modulation and inhibition of STAT3 and NF-κB pathways - PubMed
Bazedoxifene attenuates dextran sodium sulfate-induced colitis in mice through gut microbiota modulation and inhibition of STAT3 and NF-κB pathways - PubMed
Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disorder of the gastrointestinal tract for which treatment options remain limited. In this study, we used a dual-luciferase-based screening of an FDA-approved drug library, identifying Bazedoxifene (BZA) as an inhibitor of the …
·pubmed.ncbi.nlm.nih.gov·
Bazedoxifene attenuates dextran sodium sulfate-induced colitis in mice through gut microbiota modulation and inhibition of STAT3 and NF-κB pathways - PubMed
Fecal Microbiota Transplantation Improves Clinical Symptoms of Fibromyalgia: An open-label, Randomized, Nonplacebo-Controlled Study - PubMed
Fecal Microbiota Transplantation Improves Clinical Symptoms of Fibromyalgia: An open-label, Randomized, Nonplacebo-Controlled Study - PubMed
Fibromyalgia (FM) is a complex and poorly understood disorder characterized by chronic and widespread musculoskeletal pain, of which the etiology remains unknown. Now, the disorder of the gut microbiome is considered as one of the main causes of FM. This study was aimed to investigate the potential …
·pubmed.ncbi.nlm.nih.gov·
Fecal Microbiota Transplantation Improves Clinical Symptoms of Fibromyalgia: An open-label, Randomized, Nonplacebo-Controlled Study - PubMed
Effects of microbiome-based interventions on neurodegenerative diseases: a systematic review and meta-analysis - PubMed
Effects of microbiome-based interventions on neurodegenerative diseases: a systematic review and meta-analysis - PubMed
Neurodegenerative diseases (NDDs) are characterized by neuronal damage and progressive loss of neuron function. Microbiome-based interventions, such as dietary interventions, biotics, and fecal microbiome transplant, have been proposed as a novel approach to managing symptoms and modulating disease …
·pubmed.ncbi.nlm.nih.gov·
Effects of microbiome-based interventions on neurodegenerative diseases: a systematic review and meta-analysis - PubMed
The incidence of Clostridium difficile infection in children with and without inflammatory bowel diseases: A single-center study in Taiwan from 2006 to 2019 - PubMed
The incidence of Clostridium difficile infection in children with and without inflammatory bowel diseases: A single-center study in Taiwan from 2006 to 2019 - PubMed
Both CA-CDI and healthcare facility-onset CDI (HO-CDI) were increasing substantially in the pediatric population over the past decade in Taiwan. Compared to the general pediatric population, pediatric IBD patients had a much higher incidence of CDI.
·pubmed.ncbi.nlm.nih.gov·
The incidence of Clostridium difficile infection in children with and without inflammatory bowel diseases: A single-center study in Taiwan from 2006 to 2019 - PubMed
Navigating Clostridioides difficile Testing Guidelines: Addressing Adherence Challenges in Health Care Settings
Navigating Clostridioides difficile Testing Guidelines: Addressing Adherence Challenges in Health Care Settings
A study presented at the Society for Healthcare Epidemiology of America (SHEA) conference evaluated adherence to laxative administration guidelines before CDI testing in Veteran Affairs (VA) hospitals and explored associated demographic and contextual factors.
·news.google.com·
Navigating Clostridioides difficile Testing Guidelines: Addressing Adherence Challenges in Health Care Settings
New C. difficile treatment guidelines advise fidaxomicin over vancomycin
New C. difficile treatment guidelines advise fidaxomicin over vancomycin
Fidaxomicin should be the antibiotic of choice when treating adults with Clostridioides difficile infection, according to new guidance from U.S. infectious disease experts. And monoclonal antibodies can be added to the regimen for certain recurrent infections, the authors say.
·news.google.com·
New C. difficile treatment guidelines advise fidaxomicin over vancomycin
Gut microbiota in MAFLD: therapeutic and diagnostic implications - PubMed
Gut microbiota in MAFLD: therapeutic and diagnostic implications - PubMed
Metabolic dysfunction-associated fatty liver disease (MAFLD), formerly known as nonalcoholic fatty liver disease, is becoming a significant contributor to chronic liver disease globally, surpassing other etiologies, such as viral hepatitis. Prevention and early treatment strategies to curb its growi …
·pubmed.ncbi.nlm.nih.gov·
Gut microbiota in MAFLD: therapeutic and diagnostic implications - PubMed
A Case of Clostridioides difficile Infection of a Pregnant Woman Treated with Colectomy - PubMed
A Case of Clostridioides difficile Infection of a Pregnant Woman Treated with Colectomy - PubMed
Clostridioides difficile-associated pseudomembranous colitis (PMC) is a life-threatening inflammatory bowel disease. Here, we aimed to present a 40-year-old woman at 25 weeks of gestation whose pregnancy was terminated earlier than expected. Unfortunately, despite fidaxomicin and oral vancomy …
·pubmed.ncbi.nlm.nih.gov·
A Case of Clostridioides difficile Infection of a Pregnant Woman Treated with Colectomy - PubMed
C. diff linked to contaminated hospital beds, study finds
C. diff linked to contaminated hospital beds, study finds
Make sure to disinfect beds properly after they are used by someone with Clostridioides difficile, or C. diff. According to a new study, staying in a bed previously used by a person with C. diff raises the risk that they’ll get the infection.
·news.google.com·
C. diff linked to contaminated hospital beds, study finds
The gut microbe pair of Oribacterium sp. GMB0313 and Ruminococcus sp. GMB0270 confers complete protection against SARS-CoV-2 infection by activating CD8+ T cell-mediated immunity - PubMed
The gut microbe pair of Oribacterium sp. GMB0313 and Ruminococcus sp. GMB0270 confers complete protection against SARS-CoV-2 infection by activating CD8+ T cell-mediated immunity - PubMed
Despite the potential protective role of the gut microbiome against COVID-19, specific microbes conferring resistance to COVID-19 have not yet been identified. In this work, we aimed to identify and validate gut microbes at the species level that provide protection against SARS-CoV-2 infection. To i …
·pubmed.ncbi.nlm.nih.gov·
The gut microbe pair of Oribacterium sp. GMB0313 and Ruminococcus sp. GMB0270 confers complete protection against SARS-CoV-2 infection by activating CD8+ T cell-mediated immunity - PubMed
Tryptophan metabolites relieve intestinal Candida albicans infection by altering the gut microbiota to reduce IL-22 release from group 3 innate lymphoid cells of the colon lamina propria - PubMed
Tryptophan metabolites relieve intestinal Candida albicans infection by altering the gut microbiota to reduce IL-22 release from group 3 innate lymphoid cells of the colon lamina propria - PubMed
Invasive candidiasis may be caused by Candida albicans (C. albicans) colonization of the intestinal tract. Preventing intestinal damage caused by Candida albicans infection and protecting intestinal barrier function have become a critical issue. Integrated analyses of the microb …
·pubmed.ncbi.nlm.nih.gov·
Tryptophan metabolites relieve intestinal Candida albicans infection by altering the gut microbiota to reduce IL-22 release from group 3 innate lymphoid cells of the colon lamina propria - PubMed
Gut microbiome changes in mouse, Mongolian gerbil, and hamster models following Clostridioides difficile challenge - PubMed
Gut microbiome changes in mouse, Mongolian gerbil, and hamster models following Clostridioides difficile challenge - PubMed
Based on the observed responses to C. difficile challenge, we concluded for the first time that the Mongolian gerbil could be used as an animal model for CDI. Additionally, the taxa identified in this study may be used as biomarkers for further studies on CDI and to improve understanding rega …
·pubmed.ncbi.nlm.nih.gov·
Gut microbiome changes in mouse, Mongolian gerbil, and hamster models following Clostridioides difficile challenge - PubMed
Updates and Opinions in Diagnosis and Treatment of Clostridiodes difficile in Pediatrics - PubMed
Updates and Opinions in Diagnosis and Treatment of Clostridiodes difficile in Pediatrics - PubMed
The diagnosis and treatment of C. difficile infection in pediatrics remain challenging and recommendations lag behind advances made in the adult field. Recent data suggests that use of fidaxomicin both as treatment of first episode or recurrences may be beneficial in pediatrics just as in adu …
·pubmed.ncbi.nlm.nih.gov·
Updates and Opinions in Diagnosis and Treatment of Clostridiodes difficile in Pediatrics - PubMed
Understanding the influence of the microbiome on childhood infections - PubMed
Understanding the influence of the microbiome on childhood infections - PubMed
Recent advances in sequencing technologies have led to an explosion of studies associating the human microbiome with the risk and severity of infectious diseases. As our knowledge of the extent to which the microbiome influences childhood infections continues to grow, microbiome-based diagnostics an …
·pubmed.ncbi.nlm.nih.gov·
Understanding the influence of the microbiome on childhood infections - PubMed
A digital twin of the infant microbiome to predict neurodevelopmental deficits - PubMed
A digital twin of the infant microbiome to predict neurodevelopmental deficits - PubMed
Despite the recognized gut-brain axis link, natural variations in microbial profiles between patients hinder definition of normal abundance ranges, confounding the impact of dysbiosis on infant neurodevelopment. We infer a digital twin of the infant microbiome, forecasting ecosystem trajectories fro …
·pubmed.ncbi.nlm.nih.gov·
A digital twin of the infant microbiome to predict neurodevelopmental deficits - PubMed
Just a gut feeling: Faecal microbiota transplant for treatment of depression - A mini-review - PubMed
Just a gut feeling: Faecal microbiota transplant for treatment of depression - A mini-review - PubMed
The GM plays an integral role in human health and disease through its communication with the rest of the body via the MGBA. FMT may provide a means to transfer the healthy phenotype into the recipient and this concept in humans is attracting enormous attention as a prospective treatment for psychopa …
·pubmed.ncbi.nlm.nih.gov·
Just a gut feeling: Faecal microbiota transplant for treatment of depression - A mini-review - PubMed
New treatment approaches for Clostridioides difficile infections: alternatives to antibiotics and fecal microbiota transplantation - PubMed
New treatment approaches for Clostridioides difficile infections: alternatives to antibiotics and fecal microbiota transplantation - PubMed
Clostridioides difficile causes a range of debilitating intestinal symptoms that may be fatal. It is particularly problematic as a hospital-acquired infection, causing significant costs to the health care system. Antibiotics, such as vancomycin and fidaxomicin, are still the drugs of choice f …
·pubmed.ncbi.nlm.nih.gov·
New treatment approaches for Clostridioides difficile infections: alternatives to antibiotics and fecal microbiota transplantation - PubMed
Advances in Therapeutic Strategies for the Management of Clostridioides difficile Infection - PubMed
Advances in Therapeutic Strategies for the Management of Clostridioides difficile Infection - PubMed
The infection caused by Clostridioides difficile represents one of the bacterial infections with the greatest increase in incidence among nosocomial infections in recent years. C. difficile is a Gram-positive bacterium able to produce toxins and spores. In some cases, infection results …
·pubmed.ncbi.nlm.nih.gov·
Advances in Therapeutic Strategies for the Management of Clostridioides difficile Infection - PubMed
Genetic determinants of resistance to antimicrobial therapeutics are rare in publicly available Clostridioides difficile genome sequences - PubMed
Genetic determinants of resistance to antimicrobial therapeutics are rare in publicly available Clostridioides difficile genome sequences - PubMed
Genomic data suggested that resistance to therapeutic antimicrobial drugs is rare in C. difficile. Public antimicrobial resistance marker databases were not equipped to detect most of the genetic determinants relevant to antibiotic therapy of CDI.
·pubmed.ncbi.nlm.nih.gov·
Genetic determinants of resistance to antimicrobial therapeutics are rare in publicly available Clostridioides difficile genome sequences - PubMed
Kai-Xin-San improves cognitive impairment in D-gal and Aβ25-35 induced AD rats by regulating gut microbiota and reducing neuronal damage - PubMed
Kai-Xin-San improves cognitive impairment in D-gal and Aβ25-35 induced AD rats by regulating gut microbiota and reducing neuronal damage - PubMed
KXS can maintain the ecological balance of intestinal microbiota and exert its anti-AD effect by regulating the composition and proportion of gut microbiota in AD rats through the microbiota-gut-brain axis.
·pubmed.ncbi.nlm.nih.gov·
Kai-Xin-San improves cognitive impairment in D-gal and Aβ25-35 induced AD rats by regulating gut microbiota and reducing neuronal damage - PubMed
Gut microbiota dysbiosis contributes to depression-like behaviors via hippocampal NLRP3-mediated neuroinflammation in a postpartum depression mouse model - PubMed
Gut microbiota dysbiosis contributes to depression-like behaviors via hippocampal NLRP3-mediated neuroinflammation in a postpartum depression mouse model - PubMed
Postpartum depression (PPD) is a severe mental disorder that affects approximately 10---20% of women after childbirth. The precise mechanism underlying PPD pathogenesis remains elusive, thus limiting the development of therapeutics. Gut microbiota dysbiosis is considered to contribute to major depre …
·pubmed.ncbi.nlm.nih.gov·
Gut microbiota dysbiosis contributes to depression-like behaviors via hippocampal NLRP3-mediated neuroinflammation in a postpartum depression mouse model - PubMed
Fine-tuning the gut ecosystem: the current landscape and outlook of artificial microbiome therapeutics - PubMed
Fine-tuning the gut ecosystem: the current landscape and outlook of artificial microbiome therapeutics - PubMed
The gut microbiome is acknowledged as a key determinant of human health, and technological progress in the past two decades has enabled the deciphering of its composition and functions and its role in human disorders. Therefore, manipulation of the gut microbiome has emerged as a promising therapeut …
·pubmed.ncbi.nlm.nih.gov·
Fine-tuning the gut ecosystem: the current landscape and outlook of artificial microbiome therapeutics - PubMed
Dermal injury drives a skin to gut axis that disrupts the intestinal microbiome and intestinal immune homeostasis in mice - PubMed
Dermal injury drives a skin to gut axis that disrupts the intestinal microbiome and intestinal immune homeostasis in mice - PubMed
The composition of the microbial community in the intestine may influence the functions of distant organs such as the brain, lung, and skin. These microbes can promote disease or have beneficial functions, leading to the hypothesis that microbes in the gut explain the co-occurrence of intestinal and …
·pubmed.ncbi.nlm.nih.gov·
Dermal injury drives a skin to gut axis that disrupts the intestinal microbiome and intestinal immune homeostasis in mice - PubMed
Fecal microbiota transplantation in autoimmune diseases - An extensive paper on a pathogenetic therapy - PubMed
Fecal microbiota transplantation in autoimmune diseases - An extensive paper on a pathogenetic therapy - PubMed
The role of infections in the pathogenesis of autoimmune diseases has long been recognized and reported. In addition to infectious agents, the internal composition of the "friendly" living bacteria, (microbiome) and its correlation to immune balance and dysregulation have drawn the attention of rese …
·pubmed.ncbi.nlm.nih.gov·
Fecal microbiota transplantation in autoimmune diseases - An extensive paper on a pathogenetic therapy - PubMed
Advances in Therapeutic Strategies for the Management of Clostridioides difficile Infection - PubMed
Advances in Therapeutic Strategies for the Management of Clostridioides difficile Infection - PubMed
The infection caused by Clostridioides difficile represents one of the bacterial infections with the greatest increase in incidence among nosocomial infections in recent years. C. difficile is a Gram-positive bacterium able to produce toxins and spores. In some cases, infection results …
·pubmed.ncbi.nlm.nih.gov·
Advances in Therapeutic Strategies for the Management of Clostridioides difficile Infection - PubMed