C Difficile

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AGA Clinical Practice Guideline on Fecal Microbiota-Based Therapies for Select Gastrointestinal Diseases - PubMed
AGA Clinical Practice Guideline on Fecal Microbiota-Based Therapies for Select Gastrointestinal Diseases - PubMed
Fecal microbiota-based therapies are effective therapy to prevent recurrent C difficile in select patients. Conventional fecal microbiota transplant is an adjuvant treatment for select adults hospitalized with severe or fulminant C difficile infection not responding to standard of care antibiotics. …
·pubmed.ncbi.nlm.nih.gov·
AGA Clinical Practice Guideline on Fecal Microbiota-Based Therapies for Select Gastrointestinal Diseases - PubMed
Clostridioides difficile Infection: Diagnosis and Treatment Challenges - PubMed
Clostridioides difficile Infection: Diagnosis and Treatment Challenges - PubMed
Clostridioides difficile is the most important cause of healthcare-associated diarrhea in the United States. The high incidence and recurrence rates of C. difficile infection (CDI), associated with high morbidity and mortality, pose a public health challenge. Although antibiotics targe …
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Clostridioides difficile Infection: Diagnosis and Treatment Challenges - PubMed
Clostridioides difficile Infection in Kidney Transplant Recipients - PubMed
Clostridioides difficile Infection in Kidney Transplant Recipients - PubMed
Clostridioides difficile (C. difficile) is a bacterial organism that typically infects the colon, which has had its homeostasis of healthy gut microbiota disrupted by antibiotics or other interventions. Patients with kidney transplantation are a group that are susceptible to C. diff …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile Infection in Kidney Transplant Recipients - PubMed
Anionic liposome formulation for oral delivery of thuricin CD, a potential antimicrobial peptide therapeutic - PubMed
Anionic liposome formulation for oral delivery of thuricin CD, a potential antimicrobial peptide therapeutic - PubMed
Thuricin CD is a two-peptide antimicrobial produced by Bacillus thuringiensis. Unlike previous antibiotics, it has shown narrow spectrum activity against Clostridioides difficile, a bacterium capable of causing infectious disease in the colon. However, peptide antibiotics have stability, solubility, …
·pubmed.ncbi.nlm.nih.gov·
Anionic liposome formulation for oral delivery of thuricin CD, a potential antimicrobial peptide therapeutic - PubMed
Clostridioides difficile Flagella - PubMed
Clostridioides difficile Flagella - PubMed
Clostridioides difficile is an important pathogen for humans with a lead in nosocomial infection, but it is also more and more common in communities. Our knowledge of the pathology has historically been focused on the toxins produced by the bacteria that remain its major virulence factors. Bu …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile Flagella - PubMed
Reviewing the Clostridioides difficile Mouse Model: Insights into Infection Mechanisms - PubMed
Reviewing the Clostridioides difficile Mouse Model: Insights into Infection Mechanisms - PubMed
Clostridioides difficile is an anaerobic, spore-forming bacterium associated with intestinal infection, manifesting a broad spectrum of gastrointestinal symptoms, ranging from mild diarrhea to severe colitis. A primary risk factor for the development of C. difficile infection (CDI) is …
·pubmed.ncbi.nlm.nih.gov·
Reviewing the Clostridioides difficile Mouse Model: Insights into Infection Mechanisms - PubMed
From Microbes to Memories: Challenges and Future Perspectives Regarding the Gut-Brain Axis for Improved Cognitive Health in Alzheimer's - PubMed
From Microbes to Memories: Challenges and Future Perspectives Regarding the Gut-Brain Axis for Improved Cognitive Health in Alzheimer's - PubMed
The gut-brain axis, a bidirectional communication network between the gastrointestinal tract and the central nervous system, regulates various physiological processes crucial for health, including immune response, metabolism, and neurotransmitter production. In the context of neurodegenerative disea …
·pubmed.ncbi.nlm.nih.gov·
From Microbes to Memories: Challenges and Future Perspectives Regarding the Gut-Brain Axis for Improved Cognitive Health in Alzheimer's - PubMed
Anaerobic antibiotic coverage in aspiration pneumonia and the associated benefits and harms: A retrospective cohort study - PubMed
Anaerobic antibiotic coverage in aspiration pneumonia and the associated benefits and harms: A retrospective cohort study - PubMed
Extended anaerobic coverage is likely unnecessary in aspiration pneumonia because it is associated with no additional mortality benefit, only an increased risk of C. difficile colitis.
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Anaerobic antibiotic coverage in aspiration pneumonia and the associated benefits and harms: A retrospective cohort study - PubMed
Investigating the impact of antibiotic-induced dysbiosis on protection from Clostridium difficile colitis by mouse colonic innate lymphoid cells - PubMed
Investigating the impact of antibiotic-induced dysbiosis on protection from Clostridium difficile colitis by mouse colonic innate lymphoid cells - PubMed
Innate lymphoid cells (ILCs) play a critical role in maintaining intestinal health in homeostatic and diseased conditions. During Clostridium difficile infection (CDI), IL-33 activates ILC2 to protect from colonic damage and mortality. The function of IL-33 and ILC is tightly regulated by the …
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Investigating the impact of antibiotic-induced dysbiosis on protection from Clostridium difficile colitis by mouse colonic innate lymphoid cells - PubMed
Using whole genome sequencing to characterize Clostridioides difficile isolates at a tertiary center in Melbourne, Australia - PubMed
Using whole genome sequencing to characterize Clostridioides difficile isolates at a tertiary center in Melbourne, Australia - PubMed
In both study periods, most C. difficile isolates were not closely related, suggesting varied sources of acquisition and that spread of C. difficile within the hospital was unlikely. Current infection control precautions may therefore warrant review. Underlying risk factors for CDI wer …
·pubmed.ncbi.nlm.nih.gov·
Using whole genome sequencing to characterize Clostridioides difficile isolates at a tertiary center in Melbourne, Australia - PubMed
Core-genome-mediated promising alternative drug and multi-epitope vaccine targets prioritization against infectious Clostridium difficile - PubMed
Core-genome-mediated promising alternative drug and multi-epitope vaccine targets prioritization against infectious Clostridium difficile - PubMed
Prevention of Clostridium difficile infection is challenging worldwide owing to its high morbidity and mortality rates. C. difficile is currently being classified as an urgent threat by the CDC. Devising a new therapeutic strategy become indispensable against C. difficile infection due to its high r …
·pubmed.ncbi.nlm.nih.gov·
Core-genome-mediated promising alternative drug and multi-epitope vaccine targets prioritization against infectious Clostridium difficile - PubMed
A monoclonal antibody collection for C. difficile typing ? - PubMed
A monoclonal antibody collection for C. difficile typing ? - PubMed
Clostridioides difficile is the leading cause of antibiotic-associated diarrhea and pseudomembranous colitis in adults. Various C. difficile strains circulate currently, associated with different outcomes and antibiotic resistance profiles. However, most studies still focus on the reference strain 6 …
·pubmed.ncbi.nlm.nih.gov·
A monoclonal antibody collection for C. difficile typing ? - PubMed
Rosin as a Natural Alternative for the effective disinfection of ESKAPE Pathogens and Clostridioides difficile spores - PubMed
Rosin as a Natural Alternative for the effective disinfection of ESKAPE Pathogens and Clostridioides difficile spores - PubMed
The findings from this study highlight the potential of Rosin and Rosetax-21 as both bactericidal and sporicidal disinfectants, with their efficacy varying based on the conditions and the pathogens tested. This presents an avenue for the development of novel healthcare disinfection strategies, espec …
·pubmed.ncbi.nlm.nih.gov·
Rosin as a Natural Alternative for the effective disinfection of ESKAPE Pathogens and Clostridioides difficile spores - PubMed
Improving Clostridioides difficile Infectious Disease Treatment Response via Adherence to Clinical Practice Guidelines - PubMed
Improving Clostridioides difficile Infectious Disease Treatment Response via Adherence to Clinical Practice Guidelines - PubMed
Clostridioides difficile (C. difficile) is a predominant nosocomial infection, and guidelines for improving diagnosis and treatment were published in 2017. We conducted a single-center, retrospective 10-year cohort study of patients with primary C. difficile infectious disease ( …
·pubmed.ncbi.nlm.nih.gov·
Improving Clostridioides difficile Infectious Disease Treatment Response via Adherence to Clinical Practice Guidelines - PubMed
Platelets promote human macrophages-mediated macropinocytosis of Clostridioides difficile - PubMed
Platelets promote human macrophages-mediated macropinocytosis of Clostridioides difficile - PubMed
Clostridioides difficile is the main causative agent of hospital-acquired diarrhea and the potentially lethal disease, C. difficile infection. The cornerstone of the current therapy is the use of antibiotics, which is not fully effective. The molecular mechanisms, inflammatory conditio …
·pubmed.ncbi.nlm.nih.gov·
Platelets promote human macrophages-mediated macropinocytosis of Clostridioides difficile - PubMed
A Streamlined Method to Obtain Biologically Active TcdA and TcdB Toxins from Clostridioides difficile - PubMed
A Streamlined Method to Obtain Biologically Active TcdA and TcdB Toxins from Clostridioides difficile - PubMed
The major virulence factors of Clostridioides difficile (C. difficile) are enterotoxins A (TcdA) and B (TcdB). The study of toxins is a crucial step in exploring the virulence of this pathogen. Currently, the toxin purification process is either laborious and time-consuming in C. di …
·pubmed.ncbi.nlm.nih.gov·
A Streamlined Method to Obtain Biologically Active TcdA and TcdB Toxins from Clostridioides difficile - PubMed
Host-defense piscidin peptides as antibiotic adjuvants against Clostridioides difficile - PubMed
Host-defense piscidin peptides as antibiotic adjuvants against Clostridioides difficile - PubMed
The spore-forming intestinal pathogen Clostridioides difficile causes multidrug resistant infection with a high rate of recurrence after treatment. Piscidins 1 (p1) and 3 (p3), cationic host defense peptides with micromolar cytotoxicity against C. difficile, sensitize C. difficile to clinically rele …
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Host-defense piscidin peptides as antibiotic adjuvants against Clostridioides difficile - PubMed
Pro-Inflammatory Cytokines Enhanced In Vitro Cytotoxic Activity of Clostridioides difficile Toxin B in Enteric Glial Cells: The Achilles Heel of Clostridioides difficile Infection? - PubMed
Pro-Inflammatory Cytokines Enhanced In Vitro Cytotoxic Activity of Clostridioides difficile Toxin B in Enteric Glial Cells: The Achilles Heel of Clostridioides difficile Infection? - PubMed
Bacterial infections are characterized by an inflammatory response, which is essential for infection containment but is also responsible for negative effects on the host. The pathogen itself may have evolved molecular mechanisms to antagonize the antimicrobial effects of an inflammatory response and …
·pubmed.ncbi.nlm.nih.gov·
Pro-Inflammatory Cytokines Enhanced In Vitro Cytotoxic Activity of Clostridioides difficile Toxin B in Enteric Glial Cells: The Achilles Heel of Clostridioides difficile Infection? - PubMed
Approaching pathogenic Clostridia from a One Health perspective - PubMed
Approaching pathogenic Clostridia from a One Health perspective - PubMed
Spore-forming pathogens have a unique capacity to thrive in diverse environments, and with temporal persistence afforded through their ability to sporulate. These behaviors require a One Health approach to identify critical reservoirs and outbreak-associated transmission chains, given their capacity …
·pubmed.ncbi.nlm.nih.gov·
Approaching pathogenic Clostridia from a One Health perspective - PubMed
Use of electronic health record data to identify hospital-associated Clostridioides difficile infections: a validation study - PubMed
Use of electronic health record data to identify hospital-associated Clostridioides difficile infections: a validation study - PubMed
Our algorithm accurately detected true HA-CDI cases from EHR data in our patient population. A multi-component algorithm performs better than any isolated component. Requiring a positive laboratory test for C. difficile strengthens diagnostic performance even further. Accurate detection could …
·pubmed.ncbi.nlm.nih.gov·
Use of electronic health record data to identify hospital-associated Clostridioides difficile infections: a validation study - PubMed
In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy - PubMed
In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy - PubMed
Clostridioides difficile infection (CDI) is a leading cause of hospital-acquired diarrhea, which often stems from disruption of the gut microbiota by broad-spectrum antibiotics. The increasing prevalence of antibiotic-resistant C. difficile strains, combined with disappointing clinical …
·pubmed.ncbi.nlm.nih.gov·
In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy - PubMed
Gut Microbiota-Gut Metabolites and Clostridioides difficile Infection: Approaching Sustainable Solutions for Therapy - PubMed
Gut Microbiota-Gut Metabolites and Clostridioides difficile Infection: Approaching Sustainable Solutions for Therapy - PubMed
Clostridioides difficile (C. difficile) infection (CDI) is the most common hospital-acquired infection. With the combination of a high rate of antibiotic resistance and recurrence, it has proven to be a debilitating public health threat. Current treatments for CDI include antibiotics a …
·pubmed.ncbi.nlm.nih.gov·
Gut Microbiota-Gut Metabolites and Clostridioides difficile Infection: Approaching Sustainable Solutions for Therapy - PubMed
Phase Variation of Flagella and Toxins in Clostridioides difficile is Mediated by Selective Rho-dependent Termination - PubMed
Phase Variation of Flagella and Toxins in Clostridioides difficile is Mediated by Selective Rho-dependent Termination - PubMed
Clostridioides difficile is an intestinal pathogen that exhibits phase variation of flagella and toxins through inversion of the flagellar (flg) switch controlling flagellar and toxin gene expression. The transcription termination factor Rho preferentially inhibits swimming motility of bacteria with …
·pubmed.ncbi.nlm.nih.gov·
Phase Variation of Flagella and Toxins in Clostridioides difficile is Mediated by Selective Rho-dependent Termination - PubMed
A Randomized, Double-Blind, Phase 3 Safety and Efficacy Study of Ridinilazole Versus Vancomycin for Treatment of Clostridioides difficile Infection: Clinical Outcomes With Microbiome and Metabolome Correlates of Response - PubMed
A Randomized, Double-Blind, Phase 3 Safety and Efficacy Study of Ridinilazole Versus Vancomycin for Treatment of Clostridioides difficile Infection: Clinical Outcomes With Microbiome and Metabolome Correlates of Response - PubMed
Although ridinilazole did not meet superiority in SCR, ridinilazole greatly reduced rCDI and preserved microbiome diversity and SBAs compared with vancomycin. These findings suggest that treatment of CDI with ridinilazole results in an earlier recovery of gut microbiome health. Clinical Trials Regis …
·pubmed.ncbi.nlm.nih.gov·
A Randomized, Double-Blind, Phase 3 Safety and Efficacy Study of Ridinilazole Versus Vancomycin for Treatment of Clostridioides difficile Infection: Clinical Outcomes With Microbiome and Metabolome Correlates of Response - PubMed
Concomitant Lymphocytic Colitis With Recurrent Clostridium difficile Infection - PubMed
Concomitant Lymphocytic Colitis With Recurrent Clostridium difficile Infection - PubMed
Microscopic colitis is a clinicopathological diagnosis that is characterized by chronic microscopic inflammation of the colon and presents with chronic watery diarrhea. There are following two subtypes of microscopic colitis: lymphocytic colitis and collagenous colitis. This is a case of a 70-year-o …
·pubmed.ncbi.nlm.nih.gov·
Concomitant Lymphocytic Colitis With Recurrent Clostridium difficile Infection - PubMed
Synthesis and antimicrobial activity of thiophene-based heterocycles derived from thiophene-2-carbohydrazide - PubMed
Synthesis and antimicrobial activity of thiophene-based heterocycles derived from thiophene-2-carbohydrazide - PubMed
Aim: Thiophene-based heterocycles were synthesized and evaluated for their antimicrobial activity against methicillin-resistant Staphylococcus aureus, Escherichia coli, Clostridium difficile and Candida albicans strains. Methods: Antimicrobial activity was determined usin …
·pubmed.ncbi.nlm.nih.gov·
Synthesis and antimicrobial activity of thiophene-based heterocycles derived from thiophene-2-carbohydrazide - PubMed
Antimicrobial Guanidinylate Polycarbonates Show Oral In Vivo Efficacy Against Clostridioides Difficile - PubMed
Antimicrobial Guanidinylate Polycarbonates Show Oral In Vivo Efficacy Against Clostridioides Difficile - PubMed
The emerging antibiotic resistance has been named by the World Health Organization (WHO) as one of the top 10 threats to public health. Notably, methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VREF) are designated as serious threats, whereas Clostri …
·pubmed.ncbi.nlm.nih.gov·
Antimicrobial Guanidinylate Polycarbonates Show Oral In Vivo Efficacy Against Clostridioides Difficile - PubMed