C Difficile

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Molecular docking, dynamics and in vitro analysis of multi-target inhibitors for Clostridioides difficile - PubMed
Molecular docking, dynamics and in vitro analysis of multi-target inhibitors for Clostridioides difficile - PubMed
The opportunistic pathogen, Clostridioides difficile owes its extreme pathogenicity for its ability to develop antibiotic resistance and recurrent infections. The current antibiotics used for the treatment are showing declining sensitivity and rising antibiotic resistance. Therefore, it is of …
·pubmed.ncbi.nlm.nih.gov·
Molecular docking, dynamics and in vitro analysis of multi-target inhibitors for Clostridioides difficile - PubMed
Epidemiology and outcomes of infections during extracorporeal membrane oxygenation in adult patients with COVID-19 ARDS- A single center study - PubMed
Epidemiology and outcomes of infections during extracorporeal membrane oxygenation in adult patients with COVID-19 ARDS- A single center study - PubMed
The most common infections in our patients were bloodstream infections followed by pneumonia. High rates of gram negative infections, including those caused by carbapenem resistant bacteria, reflect the Indian critical care unit epidemiology in general. Despite these high infection rates with antimi …
·pubmed.ncbi.nlm.nih.gov·
Epidemiology and outcomes of infections during extracorporeal membrane oxygenation in adult patients with COVID-19 ARDS- A single center study - PubMed
Impact of infectious diseases consultation for hospitalized patients with Clostridioides difficile infection - PubMed
Impact of infectious diseases consultation for hospitalized patients with Clostridioides difficile infection - PubMed
Clostridioides difficile infection (CDI) is associated with substantial morbidity and mortality. This study described outcomes associated with mandatory infectious diseases (ID) consultation in hospitalized patients with CDI. ID consultation was associated with increased appropriate concomita …
·pubmed.ncbi.nlm.nih.gov·
Impact of infectious diseases consultation for hospitalized patients with Clostridioides difficile infection - PubMed
Rapid Isothermal Detection of Pathogenic Clostridioides difficile Using Recombinase Polymerase Amplification - PubMed
Rapid Isothermal Detection of Pathogenic Clostridioides difficile Using Recombinase Polymerase Amplification - PubMed
Nosocomial-associated diarrhea due to Clostridioides difficile infection (CDI) is diagnosed after sample precultivation by the detection of the toxins in enzyme immunoassays or via toxin gene nucleic acid amplification. Rapid and direct diagnosis is important for targeted treatment to prevent …
·pubmed.ncbi.nlm.nih.gov·
Rapid Isothermal Detection of Pathogenic Clostridioides difficile Using Recombinase Polymerase Amplification - PubMed
Faecal microbiota transplantation for multidrug-resistant organism decolonization in spinal cord injury patients: a case series - PubMed
Faecal microbiota transplantation for multidrug-resistant organism decolonization in spinal cord injury patients: a case series - PubMed
FMT is a safe and effective strategy to eradicate MDR bacteria, even in spinal cord injured patients. FMT can allow relaxation of isolation facilitates, the participation of patients in a complete rehabilitation program, their social integration, and transfer to follow-up rehabilitation centres.
·pubmed.ncbi.nlm.nih.gov·
Faecal microbiota transplantation for multidrug-resistant organism decolonization in spinal cord injury patients: a case series - PubMed
Fecal bacteria-free filtrate transplantation is proved as an effective way for the recovery of radiation-induced individuals in mice - PubMed
Fecal bacteria-free filtrate transplantation is proved as an effective way for the recovery of radiation-induced individuals in mice - PubMed
FFT improves radiation-induced intestinal microecological dysbiosis by reshaping intestinal mucosal barrier function, gut microbiota configurations, and host metabolic profiles, highlighting FFT regimen as a promising safe alternative therapy for FMT is effective in the treatment of radiation intest …
·pubmed.ncbi.nlm.nih.gov·
Fecal bacteria-free filtrate transplantation is proved as an effective way for the recovery of radiation-induced individuals in mice - PubMed
Lactiplantibacillus plantarum and faecal microbiota transplantation can improve colitis in mice by affecting gut microbiota and metabolomics - PubMed
Lactiplantibacillus plantarum and faecal microbiota transplantation can improve colitis in mice by affecting gut microbiota and metabolomics - PubMed
Gut microbiota may have therapeutic effects on inflammatory bowel disease (IBD). Regulating intestinal microbiota through Lactiplantibacillus plantarum (L. plantarum) and faecal microbiota transplantation (FMT) is a novel approach to treating IBD. This study aimed to explore the effect of L. plantar …
·pubmed.ncbi.nlm.nih.gov·
Lactiplantibacillus plantarum and faecal microbiota transplantation can improve colitis in mice by affecting gut microbiota and metabolomics - PubMed
A Systematic Literature Review on Risk Factors for and Timing of Clostridioides difficile Infection in the United States - PubMed
A Systematic Literature Review on Risk Factors for and Timing of Clostridioides difficile Infection in the United States - PubMed
This SLR uses recent evidence to define the most important factors associated with CDI, confirming those that are well established and highlighting new ones that could help to identify patient populations at high risk.
·pubmed.ncbi.nlm.nih.gov·
A Systematic Literature Review on Risk Factors for and Timing of Clostridioides difficile Infection in the United States - PubMed
From popcorn to peril: a C. difficile survivor's tale [PODCAST]
From popcorn to peril: a C. difficile survivor's tale [PODCAST]
We sit down with Carol Raye, a patient advocate who shares her personal journey with a life-threatening C. difficile infection. Join us as Carol sheds light on the challenges she faced, the importance of responsible antibiotic use, and her mission to raise awareness about this growing health care issue. Discover how her experience has shaped her advocacy work and the urgent need for better treatment options.
·kevinmd.com·
From popcorn to peril: a C. difficile survivor's tale [PODCAST]
Fecal Microbiota Transplantation: A Prospective Treatment for Type 2 Diabetes Mellitus - PubMed
Fecal Microbiota Transplantation: A Prospective Treatment for Type 2 Diabetes Mellitus - PubMed
Dysregulation of GM is closely related to the development of T2DM. Promoting the conversion of GM in T2DM patients to normal population through FMT can reduce insulin resistance and lower their blood glucose level, which is an optional treatment for T2DM patients in the future. At present, the feasi …
·pubmed.ncbi.nlm.nih.gov·
Fecal Microbiota Transplantation: A Prospective Treatment for Type 2 Diabetes Mellitus - PubMed
The pH-responsive SmrR-SmrT system modulates C. difficile antimicrobial resistance, spore formation, and toxin production - PubMed
The pH-responsive SmrR-SmrT system modulates C. difficile antimicrobial resistance, spore formation, and toxin production - PubMed
Clostridioides difficile is an anaerobic gastrointestinal pathogen that spreads through the environment as dormant spores. To survive, replicate, and sporulate in the host intestine, C. difficile must adapt to a variety of conditions in its environment, including changes in pH, the ava …
·pubmed.ncbi.nlm.nih.gov·
The pH-responsive SmrR-SmrT system modulates C. difficile antimicrobial resistance, spore formation, and toxin production - PubMed
Prevalence and antimicrobial resistance of bacterial enteropathogens in Crete, Greece, during 2011-2022 - PubMed
Prevalence and antimicrobial resistance of bacterial enteropathogens in Crete, Greece, during 2011-2022 - PubMed
Diarrheal diseases are of great concern worldwide and are responsible for considerable morbidity and mortality. This study investigated the epidemiology and the antibiotic susceptibility of bacterial enteropathogens among diarrheal patients of all ages in Crete, Greece during 2011-2022. Stool specim …
·pubmed.ncbi.nlm.nih.gov·
Prevalence and antimicrobial resistance of bacterial enteropathogens in Crete, Greece, during 2011-2022 - PubMed
Role of the intestinal microbiome and its therapeutic intervention in cardiovascular disorder - PubMed
Role of the intestinal microbiome and its therapeutic intervention in cardiovascular disorder - PubMed
The gut microbiome is a heterogeneous population of microbes comprising viruses, bacteria, fungi, and protozoa. Such a microbiome is essential for sustaining host equilibrium, and its impact on human health can be altered by a variety of factors such as external variables, social behavior, age, nutr …
·pubmed.ncbi.nlm.nih.gov·
Role of the intestinal microbiome and its therapeutic intervention in cardiovascular disorder - PubMed
The interplay between microbiota and brain-gut axis in epilepsy treatment - PubMed
The interplay between microbiota and brain-gut axis in epilepsy treatment - PubMed
The brain-gut axis plays a vital role in connecting the cognitive and emotional centers of the brain with the intricate workings of the intestines. An imbalance in the microbiota-mediated brain-gut axis extends far beyond conditions like Irritable Bowel Syndrome (IBS) and obesity, playing a critical …
·pubmed.ncbi.nlm.nih.gov·
The interplay between microbiota and brain-gut axis in epilepsy treatment - PubMed
The management of Clostridioides difficile infection: from empirism to evidence - PubMed
The management of Clostridioides difficile infection: from empirism to evidence - PubMed
Clostridioides difficile infection (CDI) in clinical practice represents a challenge for its management and also prevention of recurrence. Even though there are updated guidelines for infection prevention, control and treatment, CDI remains a leading cause of healthcare acquired diarrhea with …
·pubmed.ncbi.nlm.nih.gov·
The management of Clostridioides difficile infection: from empirism to evidence - PubMed
Correction: Dynamics of inflammation-associated plasma proteins following faecal microbiota transplantation in patients with psoriatic arthritis and healthy controls: exploratory findings from the FLORA trial - PubMed
Correction: Dynamics of inflammation-associated plasma proteins following faecal microbiota transplantation in patients with psoriatic arthritis and healthy controls: exploratory findings from the FLORA trial - PubMed
Correction: Dynamics of inflammation-associated plasma proteins following faecal microbiota transplantation in patients with psoriatic arthritis and healthy controls: exploratory findings from the FLORA trial
·pubmed.ncbi.nlm.nih.gov·
Correction: Dynamics of inflammation-associated plasma proteins following faecal microbiota transplantation in patients with psoriatic arthritis and healthy controls: exploratory findings from the FLORA trial - PubMed
Horizontal gene transfer after faecal microbiota transplantation in adolescents with obesity - PubMed
Horizontal gene transfer after faecal microbiota transplantation in adolescents with obesity - PubMed
Our study suggests that novel microorganisms introduced into the recipient gut following FMT have no impact on the basal rate of HGT within the human gut microbiome. Analyses of further FMT studies are required to assess the generalisability of this conclusion across different FMT study designs and …
·pubmed.ncbi.nlm.nih.gov·
Horizontal gene transfer after faecal microbiota transplantation in adolescents with obesity - PubMed
Heterogeneity in practices to reduce the risk of transmission of Clostridioides difficile in healthcare settings: a survey of ESCMID Study Group for Clostridioides difficile (ESGCD) members - PubMed
Heterogeneity in practices to reduce the risk of transmission of Clostridioides difficile in healthcare settings: a survey of ESCMID Study Group for Clostridioides difficile (ESGCD) members - PubMed
Clostridioides difficile is a leading cause of healthcare-associated infections. The main objective was to assess the current landscape of CDI infection prevention and control (IPC) practices. An anonymous survey of IPC practices for CDI was conducted between July 25 and October 31, 2022. Precaution …
·pubmed.ncbi.nlm.nih.gov·
Heterogeneity in practices to reduce the risk of transmission of Clostridioides difficile in healthcare settings: a survey of ESCMID Study Group for Clostridioides difficile (ESGCD) members - PubMed
Watery Diarrhea Is Not Always Clostridioides difficile: A Case Report of Aeromonas hydrophila Gastroenteritis - PubMed
Watery Diarrhea Is Not Always Clostridioides difficile: A Case Report of Aeromonas hydrophila Gastroenteritis - PubMed
Aeromonas species can cause acute gastroenteritis but are much less commonly observed in the hospital setting than other bacteria. Most cases of Aeromonas hydrophila gastroenteritis reported in the literature have occurred in pediatric, elderly, and/or immunocompromised patients. We pr …
·pubmed.ncbi.nlm.nih.gov·
Watery Diarrhea Is Not Always Clostridioides difficile: A Case Report of Aeromonas hydrophila Gastroenteritis - PubMed
Rethinking Clostridioides difficile infection (CDI) surveillance definitions based on changing healthcare utilisation and a more realistic incubation period: reviewing data from a tertiary-referral hospital, Ireland, 2012 to 2021 - PubMed
Rethinking Clostridioides difficile infection (CDI) surveillance definitions based on changing healthcare utilisation and a more realistic incubation period: reviewing data from a tertiary-referral hospital, Ireland, 2012 to 2021 - PubMed
BackgroundCommunity-associated Clostridioides difficile infections (CA-CDI) have increased worldwide. Patients with CDI-related symptoms occurring 48 hours after hospitalisation and no inpatient stay 12 weeks prior are classified as CA-CDI, regardless of hospital day attendances 3 months …
·pubmed.ncbi.nlm.nih.gov·
Rethinking Clostridioides difficile infection (CDI) surveillance definitions based on changing healthcare utilisation and a more realistic incubation period: reviewing data from a tertiary-referral hospital, Ireland, 2012 to 2021 - PubMed
Isofagomine Inhibits Multiple TcdB Variants and Protects Mice from Clostridioides difficile-Induced Mortality - PubMed
Isofagomine Inhibits Multiple TcdB Variants and Protects Mice from Clostridioides difficile-Induced Mortality - PubMed
Clostridioides difficile causes life-threatening diarrhea and is one of the leading causes of nosocomial infections. During infection, C. difficile releases two gut-damaging toxins, TcdA and TcdB, which are the primary determinants of disease pathogenesis and are important therapeutic …
·pubmed.ncbi.nlm.nih.gov·
Isofagomine Inhibits Multiple TcdB Variants and Protects Mice from Clostridioides difficile-Induced Mortality - PubMed
Culture-independent detection of low-abundant Clostridioides difficile in environmental DNA via PCR - PubMed
Culture-independent detection of low-abundant Clostridioides difficile in environmental DNA via PCR - PubMed
Clostridioides difficile represents a major burden to public health. As a well-known nosocomial pathogen whose occurrence is highly associated with antibiotic treatment, most examined C. difficile strains originated from clinical specimen and were isolated under selective conditions em …
·pubmed.ncbi.nlm.nih.gov·
Culture-independent detection of low-abundant Clostridioides difficile in environmental DNA via PCR - PubMed
Primary clostridium difficile infection in patients with ulcerative colitis: Case report and literature review - PubMed
Primary clostridium difficile infection in patients with ulcerative colitis: Case report and literature review - PubMed
We illustrate the potential effectiveness of this medication by presenting an in-depth case report of a patient with early-stage UC. The report outlines the patient inclusion of infliximab to better manage UC inflammation alongside an adjunct vancomycin regimen, given the ineffectiveness of mesalazi …
·pubmed.ncbi.nlm.nih.gov·
Primary clostridium difficile infection in patients with ulcerative colitis: Case report and literature review - PubMed
The burden of Clostridioides difficile infections in South-East Asia and the Western Pacific: A narrative review - PubMed
The burden of Clostridioides difficile infections in South-East Asia and the Western Pacific: A narrative review - PubMed
The regional CDI burden in Asia is still incompletely documented, seemingly due to low awareness and limited laboratory testing. Despite this apparent under recognition, the current CDI burden highlights the need for broader surveillance and for application of preventative measures against CDI in As …
·pubmed.ncbi.nlm.nih.gov·
The burden of Clostridioides difficile infections in South-East Asia and the Western Pacific: A narrative review - PubMed
Immunogenicity and safety in rabbits of a Clostridioides difficile vaccine combining novel toxoids and a novel adjuvant - PubMed
Immunogenicity and safety in rabbits of a Clostridioides difficile vaccine combining novel toxoids and a novel adjuvant - PubMed
Clostridioides difficile infection (CDI) is a serious healthcare-associated disease, causing symptoms such as diarrhea and pseudomembranous colitis. The major virulence factors responsible for the disease symptoms are two secreted cytotoxic proteins, TcdA and TcdB. A parenteral vaccine based on form …
·pubmed.ncbi.nlm.nih.gov·
Immunogenicity and safety in rabbits of a Clostridioides difficile vaccine combining novel toxoids and a novel adjuvant - PubMed
Many Hands, Light Work: A Partnership Approach to Reducing Clostridioides difficile Burden on an Oncology Unit - PubMed
Many Hands, Light Work: A Partnership Approach to Reducing Clostridioides difficile Burden on an Oncology Unit - PubMed
An increase in hospital-onset Clostridioides difficile (HO-CDI) prompted an interprofessional team to implement enhanced environmental service cleaning practices and adopt a routine cleaning program undertaken by clinical staff. These interventions resulted in a reduction of HO-CDI from 7.27 cases p …
·pubmed.ncbi.nlm.nih.gov·
Many Hands, Light Work: A Partnership Approach to Reducing Clostridioides difficile Burden on an Oncology Unit - PubMed