C Difficile

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A team of investigators from Mass General Brigham’s founding members, Brigham and Women’s Hospital and Massachusetts General Hospital, has identified metabolic strategies used by Clostridioides difficile to rapidly colonize the gut and new treatments for it.

Off-target effects of NSAIDs enhance damage done by the important nosocomial pathogen, C. difficile.

Scientific Reports - Clostridioides difficile infection in thoroughbred horses in Japan from 2010 to 2021

Scientific Reports - Modulation of colonic immunometabolic responses during Clostridioides difficile infection ameliorates disease severity and inflammation

Clostridioides difficile infection (CDI) induces intense acute inflammatory responses through toxin release. A combination of antibiotic and anti-infl…

Clostridioides difficile is an anaerobic, Gram-positive, spore-forming gastrointestinal pathogen that causes severe diarrheal disease which can lead to death (1). To cause disease, C. difficile spores must be ingested and germinate in the intestine upon exposure to bile salts and glycine (2). Upon the outgrowth of spores into vegetative cells, C. difficile colonizes the colon, using the available nutrients to replicate within the host. As the population increases and nutrients become scarce, C. difficile produces toxins (TcdA and TcdB), releasing additional nutrients and further altering the metabolic environment (3). In turn, host inflammation is induced, resulting in the release of immune effectors and the characteristic pathologies associated with C. difficile infections (4).

Scientific Reports - An integrated pipeline for prediction of Clostridioides difficile infection

Leveraging systems biology approaches, we illustrate how metabolically distinct species of Clostridia protect against or worsen Clostridioides diffici…

The overuse of antibiotics has resulted in Clostridium difficile infection (CDI) as a significant global public health concern. Studies have shown tha…

A study of more than 25,000 hospitals encounters found that staying in a hospital bed that previously had a patient with C diff was associated with an increased risk of hospital-onset CDI.

Feldman details her experience with C. diff, how the COVID-19 pandemic slowed the timeline of care, and how her surgical history and the use of antibiotics played into the disease’s onset.

Feldman, who previously had C. diff, urges individuals to begin having conversations to help remove the stigma of the disease and raise awareness of its prevalence.

The Business Research Company's Difficile-Associated Diarrhea Treatment Global Market Report 2024 – Market Size, Trends, And Global Forecast 2024-2033

A study finds pathogen spores remain on surgical scrubs and patient gowns even after sodium hypochlorite disinfectant application. This finding presents an infection prevention challenge.

The effect of the microbiota-gut-brain axis on cognitive development in infancy is increasingly being scrutinized. In this issue of Cell Host & Microbe, Cerdó, Ruiz, and colleagues skillfully combine clinical and preclinical analyses, including a fecal transplantation experiment, to reveal assoc …

The microbiome plays a vital function in maintaining human health and homeostasis. Each microbiota has unique characteristics, including those of the gastrointestinal and female reproductive tract. Dysbiosis, or alterations to the composition of the microbial communities, impacts the microbiota-host …

The present findings demonstrate that the host gut microbiota is closely associated with the severity of T. gondii infection. We provide the first evidence that ALA can alleviate T. gondii-induced colitis by improving the dysregulation of the host gut microbiota and suppressing the production of pro …

Although some articles reported the beneficial effects of FMT on metabolic parameters, we failed to find a clinically significant alteration. Also, information regarding proper donors and the best method to induce FMT have not yet been sufficiently investigated, which should be considered along with …

The gut microbiota changes greatly at the onset of disease, and the importance of intestinal bacteria has been highlighted. The gut microbiota also changes greatly with aging. Aging causes skin dryness, but it is not known how changes in the gut microbiota with aging affects the expression of genes …

The origins of Alzheimer's disease (AD) and Parkinson's disease (PD) involve genetic mutations, epigenetic changes, neurotoxin exposure and gut microbiota dysregulation. The gut microbiota's dynamic composition and its metabolites influence intestinal and blood-brain barrier integrity, contributing …

Many research studies focus on intestinal microbiota-related depression induced by the usage of antibiotics, but the use of antibiotics is fairly different. To construct an effective antibiotic-induced depression mice model and explore the effect of intestinal microbiota in antibiotic-induced depres …

Eggerthella may potentially serve as a distinctive genus associated with chronic insomnia. FMT maybe a novel treatment option for adults with chronic insomnia and provide an alternative to traditional treatments for insomnia. The effects were positive correlated with the augmentation of probi …

These findings highlight the effect of the altered gut microbiota in the AH pathogenesis.

These findings highlight that deficiency of GABA-producing gut microbes plays an essential role in the pathogenesis of ET and that L5 is a promising candidate for treating ET.

The gut microbiota is a diverse ecosystem consisting of 100 trillion microbiomes. The interaction between the host's gut and distal organs profoundly impacts various functions such as metabolism, immunity, neurology, and nutrition within the human body. The liver, as the primary immune organ, plays …

Circadian rhythms influence various aspects of the biology and physiology of the host, such as food intake and sleep/wake cycles. In recent years, an increasing amount of genetic and epidemiological data has shown that the light/dark cycle is the main cue that regulates circadian rhythms. Other fact …

Residing in a hospital bed or room that previously had a patient with C. difficile increases the risk of HO-CDI. Increased attention to cleaning and disinfecting the healthcare environment may reduce hospital transmission of C. difficile.

Level III.

Surveillance findings from a national network of Canadian acute care hospitals indicate that rates of MRSA and VRE bloodstream infections, CPE infections and colonizations have increased substantially between 2016 and 2020 while rates of CDI have decreased. The collection of detailed, standardized s …