C Difficile

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Missing Narrative: Examining the Impact of Disability on Post-Operative Infectious Complications - PubMed
Missing Narrative: Examining the Impact of Disability on Post-Operative Infectious Complications - PubMed
Background: More than 20% of the population in the United States suffers from a disability, yet the impact of disability on post-operative outcomes remains understudied. This analysis aims to characterize post-operative infectious complications in patients with disability. Patien …
·pubmed.ncbi.nlm.nih.gov·
Missing Narrative: Examining the Impact of Disability on Post-Operative Infectious Complications - PubMed
Comparative analyses of the faecal resistome against β-lactam and quinolone antibiotics in humans and livestock using metagenomic sequencing - PubMed
Comparative analyses of the faecal resistome against β-lactam and quinolone antibiotics in humans and livestock using metagenomic sequencing - PubMed
To assess the prevalence and abundance of antibiotic resistance genes in human and livestock gut microbiomes, 87 humans (healthy individuals and patients with Clostridioides difficile infection (CDI)) and 108 livestock (swine, cattle, and chickens) were enrolled. Gut microbiomes and fluoroquinolone- …
·pubmed.ncbi.nlm.nih.gov·
Comparative analyses of the faecal resistome against β-lactam and quinolone antibiotics in humans and livestock using metagenomic sequencing - PubMed
Repurposing dried blood spot (DBS) device technology to examine bile acid profiles in human dried fecal spot (DFS) samples - PubMed
Repurposing dried blood spot (DBS) device technology to examine bile acid profiles in human dried fecal spot (DFS) samples - PubMed
Dried blood spot (DBS) analysis has existed for 50 years, but application of this technique to fecal analysis remains limited. To address whether dried fecal spots (DFS) could be used to measure fecal bile acids, we collected feces from five subjects for each of the following cohorts: i) healthy …
·pubmed.ncbi.nlm.nih.gov·
Repurposing dried blood spot (DBS) device technology to examine bile acid profiles in human dried fecal spot (DFS) samples - PubMed
Axin1's mystique in manipulating microbiome amidst colitis - PubMed
Axin1's mystique in manipulating microbiome amidst colitis - PubMed
Classically, Axin1 is considered a regulator of Wnt/β-catenin signaling. However, Axin1's roles in host-microbial interactions have been unknown. Our recent study has demonstrated that deletion of intestinal epithelial Axin1 in epithelial cells and Paneth cells protects the host against colitis by e …
·pubmed.ncbi.nlm.nih.gov·
Axin1's mystique in manipulating microbiome amidst colitis - PubMed
Role of Baseline Gut Microbiota on Response to Fiber Intervention in Individuals with Irritable Bowel Syndrome - PubMed
Role of Baseline Gut Microbiota on Response to Fiber Intervention in Individuals with Irritable Bowel Syndrome - PubMed
Irritable bowel syndrome (IBS) is one of the most prevalent functional gut disorders in the world. Partially hydrolyzed guar gum, a low-viscosity soluble fiber, has shown promise in the management of IBS-related symptoms. In this study, we aimed to determine if an individual's baseline gut microbiot …
·pubmed.ncbi.nlm.nih.gov·
Role of Baseline Gut Microbiota on Response to Fiber Intervention in Individuals with Irritable Bowel Syndrome - PubMed
Engraftment of aging-related human gut microbiota and the effect of a seven-species consortium in a pre-clinical model - PubMed
Engraftment of aging-related human gut microbiota and the effect of a seven-species consortium in a pre-clinical model - PubMed
Human aging is characterized by gut microbiome alteration and differential loss of gut commensal species associated with the onset of frailty. The administration of cultured commensal strains to replenish lost taxa could potentially promote healthy aging. To investigate the interaction of whole micr …
·pubmed.ncbi.nlm.nih.gov·
Engraftment of aging-related human gut microbiota and the effect of a seven-species consortium in a pre-clinical model - PubMed
Former Paige CEO betting big on AI in microbiome medicine with new startup Jona
Former Paige CEO betting big on AI in microbiome medicine with new startup Jona
Health tech veteran Leo Grady believes the microbiome is going to revolutionize healthcare. | Leo Grady, the former CEO of Paige, saw an opportunity to leverage his work in healthcare AI to unlock the microbiome for health. He launched Jona, a company that provides an at-home microbiome profiling kit and then uses AI to analyze an individual's gut microbiome to deliver actionable, personalized insights.
·news.google.com·
Former Paige CEO betting big on AI in microbiome medicine with new startup Jona
Identification of an anti-CRISPR protein that inhibits the CRISPR-Cas type I-B system in Clostridioides difficile - PubMed
Identification of an anti-CRISPR protein that inhibits the CRISPR-Cas type I-B system in Clostridioides difficile - PubMed
Clostridioides difficile is the widespread anaerobic spore-forming bacterium that is a major cause of potentially lethal nosocomial infections associated with antibiotic therapy worldwide. Due to the increase in severe forms associated with a strong inflammatory response and higher recurrence …
·pubmed.ncbi.nlm.nih.gov·
Identification of an anti-CRISPR protein that inhibits the CRISPR-Cas type I-B system in Clostridioides difficile - PubMed
Efficacy of fecal microbiota transplantation in type 2 diabetes mellitus: a systematic review and meta-analysis - PubMed
Efficacy of fecal microbiota transplantation in type 2 diabetes mellitus: a systematic review and meta-analysis - PubMed
In patients with type 2 diabetes mellitus, FMT treatment can reduce the levels of PBG, TG, HOMA-IR, TC, ALT, and DBP, especially in the combined treatment regimen. In addition, FMT can reshape the intestinal flora and establish the balance of dominant flora.
·pubmed.ncbi.nlm.nih.gov·
Efficacy of fecal microbiota transplantation in type 2 diabetes mellitus: a systematic review and meta-analysis - PubMed
Fecal Microbiota Transplantation in Liver Cirrhosis - PubMed
Fecal Microbiota Transplantation in Liver Cirrhosis - PubMed
The human gastrointestinal tract houses a diverse array of probiotic and pathogenic bacteria and any alterations in this microbial composition can exert a significant influence on an individual's well-being. It is well-established that imbalances in the gut microbiota play a pivotal role in the deve …
·pubmed.ncbi.nlm.nih.gov·
Fecal Microbiota Transplantation in Liver Cirrhosis - PubMed
The Effect of Sodium Benzoate on Host Health: Insight into Physiological Indexes and Gut Microbiota - PubMed
The Effect of Sodium Benzoate on Host Health: Insight into Physiological Indexes and Gut Microbiota - PubMed
Sodium benzoate (SB) is a common food preservative widely used in the food industry. However, the effects of SB intake on host health at different stages were still unclear. Hence, we investigated the impact of SB with three concentrations (150 mg/kg, 500 mg/kg and 1000 mg/kg) and at three stages (i …
·pubmed.ncbi.nlm.nih.gov·
The Effect of Sodium Benzoate on Host Health: Insight into Physiological Indexes and Gut Microbiota - PubMed
Gut Microbiome-Based Therapeutics in Critically Ill Adult Patients-A Narrative Review - PubMed
Gut Microbiome-Based Therapeutics in Critically Ill Adult Patients-A Narrative Review - PubMed
The gut microbiota plays a crucial role in the human microenvironment. Dysbiosis of the gut microbiota is a common pathophysiological phenomenon in critically ill patients. Therefore, utilizing intestinal microbiota to prevent complications and improve the prognosis of critically ill patients is a p …
·pubmed.ncbi.nlm.nih.gov·
Gut Microbiome-Based Therapeutics in Critically Ill Adult Patients-A Narrative Review - PubMed
Unraveling Intestinal Microbial Shifts in ESRD and Kidney Transplantation: Implications for Disease-Related Dysbiosis - PubMed
Unraveling Intestinal Microbial Shifts in ESRD and Kidney Transplantation: Implications for Disease-Related Dysbiosis - PubMed
The composition of the gut microbiome is profoundly influenced by the accumulation of toxins in end-stage renal disease (ESRD) and specific medical treatments during kidney transplantation (KT). However, variations in results may arise due to factors such as genetics, dietary habits, and the strateg …
·pubmed.ncbi.nlm.nih.gov·
Unraveling Intestinal Microbial Shifts in ESRD and Kidney Transplantation: Implications for Disease-Related Dysbiosis - PubMed
A Simple In Vitro Test to Select Stools for Fecal Microbiota Transplantation to Limit Intestinal Carriage of Extensively Drug-Resistant Bacteria - PubMed
A Simple In Vitro Test to Select Stools for Fecal Microbiota Transplantation to Limit Intestinal Carriage of Extensively Drug-Resistant Bacteria - PubMed
Treatment options for multidrug-resistant bacterial infections are limited and often ineffective. Fecal microbiota transplantation (FMT) has emerged as a promising therapy for intestinal multidrug-resistant bacterial decolonization. However, clinical results are discrepant. The aim of our pilot stud …
·pubmed.ncbi.nlm.nih.gov·
A Simple In Vitro Test to Select Stools for Fecal Microbiota Transplantation to Limit Intestinal Carriage of Extensively Drug-Resistant Bacteria - PubMed
Efficacy, Safety, and Concerns on Microbiota Modulation, Antibiotics, Probiotics, and Fecal Microbial Transplant for Inflammatory Bowel Disease and Other Gastrointestinal Conditions: Results from an International Survey - PubMed
Efficacy, Safety, and Concerns on Microbiota Modulation, Antibiotics, Probiotics, and Fecal Microbial Transplant for Inflammatory Bowel Disease and Other Gastrointestinal Conditions: Results from an International Survey - PubMed
The gut microbiota play a pivotal role in human health. Dysbiosis, alterations in microbiota composition and function, is associated with gastrointestinal disorders, including inflammatory bowel disease (IBD). This international survey aimed to assess physicians' experiences, perceptions, and practi …
·pubmed.ncbi.nlm.nih.gov·
Efficacy, Safety, and Concerns on Microbiota Modulation, Antibiotics, Probiotics, and Fecal Microbial Transplant for Inflammatory Bowel Disease and Other Gastrointestinal Conditions: Results from an International Survey - PubMed
Multi-omics analysis of hospital-acquired diarrhoeal patients reveals biomarkers of enterococcal proliferation and Clostridioides difficile infection
Multi-omics analysis of hospital-acquired diarrhoeal patients reveals biomarkers of enterococcal proliferation and Clostridioides difficile infection
Nature Communications - Antibiotics can cause hospital-acquired diarrhoea, resulting in gut microbiota and metabolome changes. Here, the authors study the faecal microbiota and metabolome of 169...
·news.google.com·
Multi-omics analysis of hospital-acquired diarrhoeal patients reveals biomarkers of enterococcal proliferation and Clostridioides difficile infection
A Pharmacovigilance Study Regarding the Risk of Antibiotic-Associated Clostridioides difficile Infection Based on Reports from the EudraVigilance Database: Analysis of Some of the Most Used Antibiotics in Intensive Care Units - PubMed
A Pharmacovigilance Study Regarding the Risk of Antibiotic-Associated Clostridioides difficile Infection Based on Reports from the EudraVigilance Database: Analysis of Some of the Most Used Antibiotics in Intensive Care Units - PubMed
The Gram-positive anaerobic bacterium Clostridioides difficile (CD) can produce intense exotoxins, contributing to nosocomial infections, and it is the most common cause of health-care-associated infectious diarrhea. Based on spontaneous Individual Case Safety Reports from EudraVigilance (EV) …
·pubmed.ncbi.nlm.nih.gov·
A Pharmacovigilance Study Regarding the Risk of Antibiotic-Associated Clostridioides difficile Infection Based on Reports from the EudraVigilance Database: Analysis of Some of the Most Used Antibiotics in Intensive Care Units - PubMed
Therapies from Thiopeptides - PubMed
Therapies from Thiopeptides - PubMed
The first part of this contribution describes solutions that were developed to achieve progressively more efficient syntheses of the thiopeptide natural products, micrococcins P1 and P2 (MP1-MP2), with an eye toward exploring their potential as a source of new antibiotics. Such efforts enabled inves …
·pubmed.ncbi.nlm.nih.gov·
Therapies from Thiopeptides - PubMed
The Importance of a Healthy Microbiome in Pregnancy and Infancy and Microbiota Treatment to Reverse Dysbiosis for Improved Health - PubMed
The Importance of a Healthy Microbiome in Pregnancy and Infancy and Microbiota Treatment to Reverse Dysbiosis for Improved Health - PubMed
The most critical phase of human microbiome development is in the first 2-3 years of life. Preventing and treating dysbiosis during pregnancy and early life can have a profound effect on an infant's later health.
·pubmed.ncbi.nlm.nih.gov·
The Importance of a Healthy Microbiome in Pregnancy and Infancy and Microbiota Treatment to Reverse Dysbiosis for Improved Health - PubMed
The Gut Microbiome from a Biomarker to a Novel Therapeutic Strategy for Immunotherapy Response in Patients with Lung Cancer - PubMed
The Gut Microbiome from a Biomarker to a Novel Therapeutic Strategy for Immunotherapy Response in Patients with Lung Cancer - PubMed
The gastrointestinal microbiome has been shown to play a key role in determining the responses to cancer immunotherapy, including immune checkpoint inhibitor (ICI) therapy and CAR-T. In patients with non-small cell lung cancer (NSCLC), increasing evidence suggests that a microbiome composition signa …
·pubmed.ncbi.nlm.nih.gov·
The Gut Microbiome from a Biomarker to a Novel Therapeutic Strategy for Immunotherapy Response in Patients with Lung Cancer - PubMed
Trauma-toxicology: concepts, causes, complications - PubMed
Trauma-toxicology: concepts, causes, complications - PubMed
Trauma and toxic substances are connected in several aspects. On the one hand, toxic substances can be the reason for traumatic injuries in the context of accidental or violent and criminal circumstances. Examples for the first scenario is the release of toxic gases, chemicals, and particles during …
·pubmed.ncbi.nlm.nih.gov·
Trauma-toxicology: concepts, causes, complications - PubMed
A Colonic Organoid Model Challenged with the Large Toxins of Clostridioides difficile TcdA and TcdB Exhibit Deregulated Tight Junction Proteins - PubMed
A Colonic Organoid Model Challenged with the Large Toxins of Clostridioides difficile TcdA and TcdB Exhibit Deregulated Tight Junction Proteins - PubMed
Adult stem cell-derived human colonic organoid monolayers were applicable as a colon infection model for electrophysiological measurements. The TJ changes noted can explain the epithelial barrier dysfunction and diarrhea in patients, as well as increased entry of luminal antigens triggering inflamma …
·pubmed.ncbi.nlm.nih.gov·
A Colonic Organoid Model Challenged with the Large Toxins of Clostridioides difficile TcdA and TcdB Exhibit Deregulated Tight Junction Proteins - PubMed
Impact of functional status on development of Clostridioides difficile infection and increase in in-hospital mortality among antibiotic users - PubMed
Impact of functional status on development of Clostridioides difficile infection and increase in in-hospital mortality among antibiotic users - PubMed
Assessment of functional status, especially combined with comorbidities, was significantly associated with developing CDI and may also be useful in predicting in-hospital mortality.
·pubmed.ncbi.nlm.nih.gov·
Impact of functional status on development of Clostridioides difficile infection and increase in in-hospital mortality among antibiotic users - PubMed
Role of microbiota in radiation-induced small-bowel damage - PubMed
Role of microbiota in radiation-induced small-bowel damage - PubMed
Radiation-induced gastrointestinal damage is a common acute radiation syndrome. Previous studies have highlighted that Galectin-1 and Interleukin-6 (IL-6) are associated with flaking of small intestinal villi and intestinal radioresistance. Therefore, our goal is to study whether gut bacteria regula …
·pubmed.ncbi.nlm.nih.gov·
Role of microbiota in radiation-induced small-bowel damage - PubMed
Novel C. diff structures are required for infection, offer new therapeutic targets
Novel C. diff structures are required for infection, offer new therapeutic targets
Newly discovered iron storage 'ferrosomes' inside the bacterium C. diff -- the leading cause of hospital-acquired infections -- are important for infection in an animal model and could offer new targets for antibacterial drugs. They also represent a rare demonstration of a membrane-bound structure inside a pathogenic bacterium, upsetting the biological dogma that bacteria do not contain organelles.
·news.google.com·
Novel C. diff structures are required for infection, offer new therapeutic targets
Controlling infections in hospitalized pretransplant candidates - PubMed
Controlling infections in hospitalized pretransplant candidates - PubMed
Ideally, antimicrobial therapy should be complete prior to transplantation. In situations in which completion of therapy prior to transplant is not feasible, therapy may need to be prolonged or modified. In most situations, infections can be managed similarly to the general population, although some …
·pubmed.ncbi.nlm.nih.gov·
Controlling infections in hospitalized pretransplant candidates - PubMed