C Difficile

Health care facility floors and sink drains and other wastewater drainage sites are universally contaminated with potential pathogens and there are plausible mechanisms by which organisms can be disseminated from these sites. However, floors and sink drains are not addressed as potential sources of …

Clostridioides difficile (C. diff.) infection (CDI) is a leading cause of hospital acquired diarrhea in North America and Europe and a major cause of morbidity and mortality. Known risk factors do not fully explain CDI susceptibility, and genetic susceptibility is suggested by the fact that some pat …

The 31-year-old, from Houston, was diagnosed with C. diff, a highly contagious infection that throws the digestive system off balance and leads to painful inflammation in the colon.

Lab experiments support treating inflammation rather than bacteria

A chemical engineer at the University of Alberta has developed a disinfectant that is more effective than purely alcohol-based products, just by adding salt.

If you have UC, you’re more susceptible to this serious infection. Here’s what you need to know to protect yourself.

While inflammation is involved in both of these conditions, they have some important distinctions.

Clostridioides difficile (C. diff) intestinal infections can cause severe, debilitating diarrhea in patients who are hospitalized or on immunosuppressive therapies. The infections can be very hard to ...

New phase 1B data support further investigation into Adiso Therapeutic's prospective treatment.

The following is a summary of “Does clinician-initiated Clostridioides difficile testing improve outcomes of patients with Clostridioides Difficile infection?” published in the October 2023 issue of Infectious Control by Bartlett, et al. Clostridioides difficile (C. difficile) is a common illness that people get in hospitals. It can have serious effects on patients and our healthcare

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This form of stewardship can reduce unnecessary antibiotic prescribing, reduce costs, and optimize patient outcomes.

The effectiveness of fecal microbiota transplantation (FMT) in ulcerative colitis (UC) remains unclear. This study aimed to investigate the feasibility and effectiveness of serial fecal infusions via colonoscopy in patients with active UC. Subjects with mild-to-moderate UC received three consecutive …

These data suggest that IBD patients, potentially due to underlying intestinal dysbiosis, experience undiagnosed C. difficile infections that result in impaired toxin-specific immunity. This may contribute to the development of inflammatory T cell responses toward commensal bacteria and provide a ra …

Findings from this study demonstrate the importance of underlying chronic conditions in the development of recurrent C. difficile disease and the shortcomings of current treatment options for recurrent cases. Additionally, our findings indicate that initial treatment selection may impact the likelih …

VANCOUVER, British Columbia — In this Healio video exclusive, Paul Feuerstadt, MD, FACG, AGAF, discusses the evolution of treatment for Clostridioides difficile infection, from antimicrobials to recently FDA-approved live biotherapeutics. “It’s so important for us to understand that C. diff has a major impact on our society,” Feuerstadt, assistant clinical professor of

The results obtained from the present basic experiments could suggest that teicoplanin is a potential antibiotic for the treatment of severe CDI with recurrence-prevention activity.

C. diff infection can cause severe intestinal inflammation. A new approach blocks the inflammation triggered by C. diff’s toxin.

Feuerstadt reviews ACG 2023 data showing live microbiota therapy provides consistent protection against rCDI in one of the most vulnerable patient populations.

Discover how live bacterial therapeutics can be used to treat diseases, and what the future of microbiome-based treatments looks like.

These data suggest that IBD patients, potentially due to underlying intestinal dysbiosis, experience undiagnosed C. difficile infections that result in impaired toxin-specific immunity. This may contribute to the development of inflammatory T cell responses toward commensal bacteria and provide a ra …

Findings from this study demonstrate the importance of underlying chronic conditions in the development of recurrent C. difficile disease and the shortcomings of current treatment options for recurrent cases. Additionally, our findings indicate that initial treatment selection may impact the likelih …

Scientific Reports - Host fecal DNA specific methylation signatures mark gut dysbiosis and inflammation in children affected by autism spectrum disorder

Rates of CDI among hospitalized patients with IBD had initially increased, but have declined since 2015. Increased comorbidity, large hospital size, public insurance, and urban teaching hospitals were associated with higher rates of CDI. CDI was associated with increased mortality in hospitalized pa …

Linda Stein Gold, MD, discusses the notable transition in topical therapies for both psoriasis and atopic dermatitis, with the introduction of effective FDA-approved nonsteroidal treatments.

A U of A chemical engineer has developed a disinfectant that is more effective than purely alcohol-based products, just by adding salt.

Clostridioides difficile is a leading cause of antibiotic-associated diarrhea and nosocomial infection in the United States. The symptoms of C. difficile infection (CDI) are associated with the production of two homologous protein toxins, TcdA and TcdB. The toxins are considered bona fide targets fo …

Gut microbiota serves in the development and maintenance of phenotype. However, the underlying mechanisms are still in its infancy. The current study shows epigenetic remodelling in the brain as a causal mechanism in the gut microbiota-brain axis. Like in trauma patients, gut dysbiosis and anxiety w …

The study was retrospectively registered at ClinicalTrials.gov (NCT05121285) (16/11/2021).