Doxycycline tied to lower risk of C diff in pneumonia patients | CIDRAP
C Difficile
Efficacy and safety of fecal microbiota transplantation for the treatment of irritable bowel syndrome: an overview of overlapping systematic reviews - PubMed
Aim: Evidence from overlapping systematic reviews (SRs) and meta-analyses (MAs) has yielded conflicting results on the treatment of irritable bowel syndrome (IBS) with fecal microbiota transplantation (FMT). To thoroughly gather, assess, and synthesize evidence on FMT for IBS, we carried out …
A Comprehensive Review on Biotransformation, Interaction, and Health of Gut Microbiota and Bioactive Components - PubMed
To sum up, the importance of human gut microbiota in the research of bioactive components metabolism and transformation has attracted the attention of scholars all over the world. It is believed that with the deepening of research, human gut microbiota will be more widely used in the pharmacodynamic …
[Microbiome: from pathophysiology to clinical application?] - PubMed
The "microbiome" or the intestinal microbiota is currently in the focus of scientific interest. The number of publications on the topic of the microbiome is increasing every year. In particular, the role of the microbiome in the pathophysiology of various diseases has been studied. Currently it is i …
Fecal microbiota transplantation promotes reduction of antimicrobial resistance by strain replacement - PubMed
Multidrug-resistant organism (MDRO) colonization is a fundamental challenge in antimicrobial resistance. Limited studies have shown that fecal microbiota transplantation (FMT) can reduce MDRO colonization, but its mechanisms are poorly understood. We conducted a randomized, controlled trial of FMT f …
The Next Generation Fecal Microbiota Transplantation: To Transplant Bacteria or Virome - PubMed
Fecal microbiota transplantation (FMT) has emerged as a promising therapeutic approach for dysbiosis-related diseases. However, the clinical practice of crude fecal transplants presents limitations in terms of acceptability and reproductivity. Consequently, two alternative solutions to FMT are devel …
How I approach diarrhea in hematological transplant patients: A practical tool - PubMed
Diarrhea in hematopoietic stem-cell transplantation (HSCT) remains a multifactorial challenge that demands a nuanced diagnostic approach. The causes of infectious diarrhea in HSCT recipients are diverse and influenced by patient-specific risk factors, the post-transplant timeline, and local epidemio …
Study: Doxycycline can reduce recurrent C. diff infections in people with pneumonia
People with pneumonia who have experienced Clostridioides difficile (C. diff) infections may be able to reduce recurrences if they take doxycycline instead of the standard treatment. The study comes as the US Centers for Disease Control kicked off C. diff awareness month Wednesday.
Fecal microbiota transplantation promotes reduction of antimicrobial resistance by strain replacement
After FMT, antibiotic susceptible Enterobacterales strains that were not detected in the transplanted microbiota replaced highly resistant strains.
Long-lasting C. diff infections: A threat to the gut - Harvard Health
Virtually everyone carries the bacteria Clostridioides difficile, or C. diff. But half a million Americans a year develop a serious C. diff infection due to a gut microbiome imbalance. It di...
Exploring the Recently Approved and Upcoming Clostridioides difficile Therapeutics
This market has seen a flurry of activity, as shown by a review of the latest agents.
Complete genome sequence of a Clostridioides difficile cryptic C-III strain isolated from horse feces - PubMed
We provide the complete genome of a non-toxigenic Clostridioides difficile strain isolated from horse feces. The strain represents a sub-cluster in the cryptic clade C-III. The genome consists of one chromosome (4,144,784 bp) and one plasmid (10,144 bp) and encodes 3,798 putative genes.
Asymptomatic Carriers of C diff Have 24-times Greater Risk for Developing C diff Compared to Noncarriers
Routine screenings for C diff on admission to the hospital could possibly prevent C diff transmission in the hospital setting.
VIDEO: Patients ‘might fall through the cracks’ between FMT, live microbiota therapies
In a Healio video exclusive, Edward V. Loftus Jr., MD, highlighted benefits of newly available live biotherapeutics for Clostridioides difficile infection but noted concern for patients who don’t qualify and “might fall through the cracks.”In the arms race against C. difficile, clinicians have turned to fecal microbiota transplantation (FMT) to restore an infected
Alternative antibiotic selection can reduce the risk of health care-associated infections for patients with pneumonia
A new study published today in the American Journal of Infection Control (AJIC) reveals that the use of doxycycline may help protect against Clostridioides difficile (C. diff) infection for some patients ...
Biochemical Characterizations of the Putative Amidase Endolysin Ecd18980 Catalytic Domain from Clostridioides difficile - PubMed
Clostridioides difficile is the major causative pathogen of pseudomembranous colitis, and novel antimicrobial agents are required for treatment. Phage-derived endolysins exhibiting species-specific lytic activity have potential as novel antimicrobial agents. We surveyed the genome of C. difficile st …
Fecal Microbiota Transplantation Reduces Campylobacter jejuni Colonization in Young Broiler Chickens Challenged by Oral Gavage but Not by Seeder Birds - PubMed
Campylobacter spp., particularly C. jejuni and C. coli, are major food safety concerns, transmitted to humans mainly via contaminated poultry meat. In a previous study, we found that some commercial broiler farms consistently produced Campylobacter-free flocks while other …
Microbial Dysbiosis and Male Infertility: Understanding the Impact and Exploring Therapeutic Interventions - PubMed
The human microbiota in the genital tract is pivotal for maintaining fertility, but its disruption can lead to male infertility. This study examines the relationship between microbial dysbiosis and male infertility, underscoring the promise of precision medicine in this field. Through a comprehensiv …
Gut Dysbiosis in Irritable Bowel Syndrome: A Narrative Review on Correlation with Disease Subtypes and Novel Therapeutic Implications - PubMed
Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder characterized by chronic abdominal pain and altered bowel habits. It can be subclassified in different subtypes according to the main clinical manifestation: constipation, diarrhea, mixed, and unclassified. Over the p …
Microbiota Transplant and Gynecological Disorders: The Bridge between Present and Future Treatments - PubMed
Fecal microbiota transplantation (FMT) is a procedure that involves transferring fecal bacteria from a healthy donor to a patients' intestines to restore gut-immunity homeostasis. While FMT was primarily supposed to treat gastrointestinal disorders such as inflammatory bowel disease and irritable bo …
Letter: A step forward towards a standard FMT protocol for IBS - PubMed
Letter: A step forward towards a standard FMT protocol for IBS
Gut microbiota absence and transplantation affect diarrhea: an investigation in the germ-free piglet model - PubMed
This experiment was conducted to explore the effects of gut microbiota on neonatal diarrhea in a germ-free (GF) pig model. Twelve hysterectomy-derived GF piglets were housed in six sterile isolators. Among them, six piglets were treated as the GF group, and the other six piglets were orally introduc …
Study Data Suggest That Cancer, Irritable Bowel Disease Are Associated With Risk of C Diff Infection
Patients who are immunocompromised generally had worse risk and severity of CDI.
Genetic variation in the human leukocyte antigen region confers susceptibility to Clostridioides difficile infection - PubMed
Clostridioides difficile (C. diff.) infection (CDI) is a leading cause of hospital acquired diarrhea in North America and Europe and a major cause of morbidity and mortality. Known risk factors do not fully explain CDI susceptibility, and genetic susceptibility is suggested by the fact that some pat …
Vancomycin in the treatment of inflammatory bowel disease: there is a role beyond Clostridioides difficile infection - PubMed
The development of new biological agents and small molecules has revolutionized the treatment of Inflammatory Bowel Disease (IBD). However, many patients do not respond or gradually lose their response, necessitating the search for other therapeutic strategies (1). In this clinical case, we describe …
Identification of Micrococcin P2-Derivatives as Antibiotic Candidates against Two Gram-Positive Pathogens - PubMed
Thiopeptides exhibit potent antimicrobial activity against Gram-positive pathogens by inhibiting bacterial protein synthesis. Micrococcins are among the structurally simpler thiopeptides, but they have not been exploited in detail. This research involved a computational simulation of micrococcin P2 …
Understanding clinical implementation coordinators' experiences in deploying evidence-based interventions - PubMed
When implementing healthcare innovations, clinical implementation coordinators facilitated the implementation process through their roles and responsibilities and acted as strategic partners in improving the adoption and sustainability of a fluoroquinolone preauthorization protocol.
Empowering patients to prevent healthcare-associated infections - PubMed
In recent years there has been increasing interest in the empowerment of patients to serve as partners in efforts to prevent healthcare-associated infections. However, patients often have limited awareness of the risk for acquisition and dissemination of healthcare-associated pathogens and have rece …
Effects of Hyperbaric Oxygen Therapy for Clostridioides difficile-associated Colitis: A Retrospective Study - PubMed
HBO may have beneficial effect on CDI by shortening the symptomatic period and preventing recurrence.
With C Diff Month Set to Begin, the Peggy Lillis Foundation Will Host its 14th Annual Gala
The patient advocacy organization has events in place and is ready to launch its annual C diff awareness campaign.