Role of probiotics in preventing Clostridioides difficile infection in older adults: an integrative review - PubMed
Clostridioides difficile infection (CDI) is the leading cause of healthcare-associated diarrhea. This infection can particularly affect older adults, the most susceptible to CDI. Currently, the standard therapeutic measure is antibiotic therapy, which in turn increases the risk of recurrence …
Your height may influence the diversity of your gut microbiome
Taller people may have longer gastrointestinal tracts that can house a broader array of microorganisms and could protect them against infections from bacteria such as Clostridium difficile
Is Dysbiotic Gut the Cause of Low Back Pain? - PubMed
Low back pain (LBP) is the foremost cause of disability that affects the day-to-day activities of millions of people worldwide. The putative trigger of LBP is linked to the gut microbiome (GM) and its dysbiotic environment. With the concept of GM, various disease pathogenesis has been revisited with …
Dual RNA-seq identifies genes and pathways modulated during Clostridioides difficile colonization - PubMed
The gastrointestinal pathogen Clostridioides difficile is the most common cause of hospital-acquired diarrhea. Bacterial interactions with the gut mucosa are crucial for the establishment of C. difficile infection; however, key infection events like bacterial attachment and gut penetra …
Editor's note: This story originally appeared in the fall 2023 issue of ASU Thrive magazine.A new treatment from ASU is helping people with autism and children with a rare disorder called
Mandatory MRSA, MSSA and Gram-negative bacteraemia and C. difficile infection: financial year April 2023 to March 2024
Mandatory surveillance of healthcare associated infections (HCAI); MRSA, MSSA and Gram-negative bacteraemia (Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa), Klebsiella species (Klebsiella. spp.), and Clostridioides difficile (C. difficile) infection. Annual data and epidemiological commentary for the financial year April 2023 to March 2024.
Surveillance of MRSA, MSSA and Gram-negative bacteraemia and C. difficile infection among Independent Sector providers: experimental statistics, April 2023 to March 2024
Counts and rates of MRSA, MSSA, E. coli, P. aeruginosa, Klebsiella spp. bacteraemia and C. difficile infection reported by independent sector healthcare organisations, with accompanying commentary.
Clostridioides difficile Infections among Pediatric Patients Hospitalized at an Oncology Department of a Tertiary Hospital in Poland - PubMed
Background and Objectives: Gastrointestinal tract infections caused by Clostridioides difficile bacteria are diagnosed in pediatric patients with increasing frequency. Children treated at pediatric units are a group of patients at high risk of this infection; therefore, appropriate dif …
A Case of Clostridioides difficile: Update on Practice Guidelines - PubMed
This report describes a case of recurrent Clostridioides difficile infection (CDI) and illustrates that pharmacist's role in selecting appropriate treatment. The report discusses CDI risk factors and reviews the guidelines for the pharmacological management of CDI.
Dual RNA-seq identifies genes and pathways modulated during Clostridioides difficile colonization - PubMed
The gastrointestinal pathogen Clostridioides difficile is the most common cause of hospital-acquired diarrhea. Bacterial interactions with the gut mucosa are crucial for the establishment of C. difficile infection; however, key infection events like bacterial attachment and gut penetra …
Linked mutations within the pathogenicity locus of Clostridioides difficile increase virulence - PubMed
Linked-mutation strains are associated with high virulence and PMC development. This result will help monitor the clinical prognosis of C. difficile infection and provide key insights for developing therapeutic targets and monoclonal antibodies.
A hidden community of billions is working to keep your body running smoothly. It’s affected by what you eat and drink, any medicines you take, how much you exercise, and how often you poo. It has also been linked to type 2 diabetes, heart disease, obesity, mental health, and dementia. Meet your gut microbiome: a community of around 4,500 different types of bacteria living in your bowels. You carry around as many microbial cells as human cells in your body. The community’s composition is different in all of us, but when it’s knocked out of balance, so are you. Cambridge scientists are trying to get a grasp on the basic rules these bacteria play by, in the hope of understanding not only what’s going on in there, but how we might be able to use our microbiome to our advantage.
Molecular characterization and genotyping of isolates from cancer patients with Clostridioides difficile infection or asymptomatic colonization - PubMed
Introduction. Cancer patients with Clostridioides difficile infection (CDI) are at a higher risk for adverse outcomes. In addition, a high prevalence of Clostridioides difficile asymptomatic colonization (CDAC) has been reported in this vulnerable population.Gap Statement. …
Antibiotic utilisation and resistance over the first decade of nationally funded antimicrobial stewardship programmes in Singapore acute-care hospitals - PubMed
In the five hospitals with complete data, decrease in broad-spectrum antibiotic utilisation rate was followed by decrease in incidence density of antibiotic-resistant organisms. ASP should continue to be nationally funded as a key measure to combat antimicrobial resistance in acute care hospitals.
Comparison of Different Antibiotics and the Risk for Community-Associated Clostridioides difficile Infection: A Case-Control Study - PubMed
We found wide variation in CDI risk within and between classes of antibiotics. These findings ordering the level of associated risk across antibiotics can help inform tradeoffs in antibiotic prescribing decisions and stewardship efforts.
Molecular characterization and genotyping of isolates from cancer patients with Clostridioides difficile infection or asymptomatic colonization - PubMed
Introduction. Cancer patients with Clostridioides difficile infection (CDI) are at a higher risk for adverse outcomes. In addition, a high prevalence of Clostridioides difficile asymptomatic colonization (CDAC) has been reported in this vulnerable population.Gap Statement. …
Clinical Efficacy of Fidaxomicin and Oral Metronidazole for Treating Clostridioides difficile Infection and the Associated Recurrence Rate: A Retrospective Cohort Study - PubMed
Clostridioides difficile infection (CDI) has significant implications for healthcare economics. Although clinical trials have compared fidaxomicin (FDX) and vancomycin, comparisons of FDX and oral metronidazole (MNZ) are limited. Therefore, we compared the therapeutic effects of FDX and oral …
Design of 8-mer peptides that block Clostridioides difficile toxin A in intestinal cells
Communications Biology - A computational design and experimental screening approach leads to the identification of peptide inhibitors that block Toxin A in colon epithelial cells.
Role of the Alteration in Calcium Homeostasis in Cell Death Induced by Clostridioides difficile Toxin A and Toxin B - PubMed
Clostridioides difficile (C. difficile), responsible for 15-25% of gastrointestinal infections, causes health problems mainly due to the toxic activity of toxins A and B (Tcds). These are responsible for its clinical manifestations, including diarrhea, pseudomembranous colitis, toxic m …
Microbiota in Irritable Bowel Syndrome and Endometriosis: Birds of a Feather Flock Together-A Review - PubMed
Endometriosis and irritable bowel syndrome (IBS) are chronic conditions affecting up to 10% of the global population, imposing significant burdens on healthcare systems and patient quality of life. Interestingly, around 20% of endometriosis patients also present with symptoms indicative of IBS. The …
Targeting nonalcoholic fatty liver disease via gut microbiome-centered therapies - PubMed
Humans possess abundant amounts of microorganisms, including bacteria, fungi, viruses, and archaea, in their gut. Patients with nonalcoholic fatty liver disease (NAFLD) exhibit alterations in their gut microbiome and an impaired gut barrier function. Preclinical studies emphasize the significance of …
Unveiling the complex relationship between gut microbiota and liver cancer: opportunities for novel therapeutic interventions - PubMed
Hepatocellular carcinoma (HCC) has been linked to the gut microbiota, with recent studies revealing the potential of gut-generated responses to influence several arms of the immune responses relevant to HCC formation. The pro- or anti-tumor effects of specific bacterial strains or gut microbiota-rel …
"Why don't you want my poop?" Willing stool donor's experiences of being ineligible to donate intestinal microbiota - PubMed
BCAs need strategies to mitigate the disappointment of ineligible donors, maintain satisfaction with BCAs, and preserve donor identity since many ineligible donors give multiple human substances. BCAs should provide more information about eligibility criteria during early screening stages to reduce …
The role of Fecal Microbiota Transplantation (FMT) in treating patients with multiple sclerosis - PubMed
Limited associative data do not provide an understanding of role of FMT in the treatment for MS. Until appropriately designed randomized comparative trials which are underway, are completed, we cannot recommend routine use of FMT in people with MS.
Gut Microbiota-Targeted Interventions in the Management of Chronic Kidney Disease - PubMed
Recent advances in microbiome research have informed the potential role of the gut microbiota in the regulation of metabolic, cardiovascular, and renal systems, and, when altered, in the pathogenesis of various cardiometabolic disorders, including chronic kidney disease (CKD). The improved understan …
Gut microbiota and eye diseases: a bibliometric study and visualization analysis - PubMed
In conclusion, the bibliometric analysis displays the research hotspots and developmental directions of the involvement of gut microbiota in the pathogenesis and treatment of some ocular diseases. It provides an overview of this field's dynamic evolution and structural relationships.
Exploring the complex role of gut microbiome in the development of precision medicine strategies for targeting microbial imbalance-induced colon cancer - PubMed
The gut microbiome has been increasingly recognized as a key player in the development and progression of colon cancer. Alterations in the gut microbiota, known as dysbiosis, can lead to a variety of medical issues. Microbial adaptation through signals and small molecules can enhance pathogen coloni …