C Difficile

Discover the top probiotics for optimal gut health. Learn about the best strains, benefits, and how to choose the right probiotic supplement. Boost…

Guidelines for microbiome analyses and FMT in pediatric patients and clinical studies investigating their benefits are absolutely necessary to improve the patient-centered care in pediatric gastroenterology. The long-term and successful establishment of pediatric FMT centers with standardized proced …

Objective: To investigate the clinical efficacy of fecal microbiota transplantation (FMT) for treating steroid-refractory gastrointestinal acute graft-versus-host disease (GI-aGVHD) . Methods: This analysis included 29 patients with hematology who developed steroid-refractory GI-aGVHD …

Despite significant advances in therapies, heart failure (HF) remains a progressive disease that, once advanced, is associated with significant death and disability. Cardiac replacement therapies with left ventricular assist device (LVAD) and heart transplantation (HT) are the only treatment options …

Targeting the microbiome to improve outcomes in stem cell transplant

Disruption of the intestinal bacterial microbiota is frequently observed in the context of allogeneic hematopoietic cell transplantation (HCT) and is particularly pronounced in patients who develop graft-versus-host disease (GVHD). Donor fecal microbiota transplantation (FMT) restores gut microbial …

Dysbiosis of the gut microbiome is thought to be the developmental origins of the host's health and disease through the microbiota-gut-brain (MGB) axis: such as immune-mediated, metabolic, neurodegenerative, and neurodevelopmental diseases. Autism spectrum disorder (ASD) and attention-deficit/hypera …

The human microbiota is a complex ecosystem that colonizes body surfaces and interacts with host organ systems, especially the immune system. Since the composition of this ecosystem depends on a variety of internal and external factors, each individual harbors a unique set of microbes. These differe …

Objective Inflammatory bowel disease (IBD) is a multifactorial immune-mediated inflammatory disease of the intestine, comprising Crohn’s disease and ulcerative colitis. By characterising metabolites in faeces, combined with faecal metagenomics, host genetics and clinical characteristics, we aimed to unravel metabolic alterations in IBD.Design We measured 1684 different faecal metabolites and 8 short-chain and branched-chain fatty acids in stool samples of 424 patients with IBD and 255 non-IBD controls. Regression analyses were used to compare concentrations of metabolites between cases and controls and determine the relationship between metabolites and each participant’s lifestyle, clinical characteristics and gut microbiota composition. Moreover, genome-wide association analysis was conducted on faecal metabolite levels.Results We identified over 300 molecules that were differentially abundant in the faeces of patients with IBD. The ratio between a sphingolipid and L-urobilin could discriminate between IBD and non-IBD samples (AUC=0.85). We found changes in the bile acid pool in patients with dysbiotic microbial communities and a strong association between faecal metabolome and gut microbiota. For example, the abundance of Ruminococcus gnavus was positively associated with tryptamine levels. In addition, we found 158 associations between metabolites and dietary patterns, and polymorphisms near NAT2 strongly associated with coffee metabolism.Conclusion In this large-scale analysis, we identified alterations in the metabolome of patients with IBD that are independent of commonly overlooked confounders such as diet and surgical history. Considering the influence of the microbiome on faecal metabolites, our results pave the way for future interventions targeting intestinal inflammation.Data are available on reasonable request. Tables containing the levels of faecal metabolites and bacterial taxa abundances are provided with the manuscript. The raw metagenomics, host genomics and phenotypic data used in this study are available from the European Genome–Phenome Archive data repository: 1000 Inflammatory bowel disease (IBD) cohort (https://www.ebi.ac.uk/ega/datasets/EGAD00001004194), Lifelines DEEP cohort (https://www.ebi.ac.uk/ega/datasets/EGAD00001001991). This includes submitting a letter of intent to the corresponding data access committees. Codes are publicly available at: [https://github.com/GRONINGEN-MICROBIOME-CENTRE/Fecal\_Metabolites\_IBD][1] [1]: https://github.com/GRONINGEN-MICROBIOME-CENTRE/Fecal_Metabolites_IBD

Clostridioides difficile infection (CDI) is one of the most common diseases associated with medical care, having a more significant impact on patients with inflammatory bowel disease (IBD). The latest studies have proposed a change in management for CDI in IBD patients. This study aims to perform a systematic review that explores the risk factors associated with the infection and the most optimal approach in management. Multiple databases were used for this research, including PubMed, Google Scholar, Science Direct, and Cochrane Library. Studies published in the last five years in the English language were selected based on pre-established criteria. The quality assessment used was the Assessment of Multiple Systematic Review, the Newcastle-Ottawa Scale, and the Scale for the Assessment of Narrative Review Articles. Twelve studies met the inclusion criteria in this systematic review, including literature reviews, a case and control study, and systematic reviews and meta-analyses. Based on the findings in this research, we conclude that the treatment for an initial episode of CDI in IBD patients is the use of antibiotics, vancomycin, or fidaxomicin. For episodes of recurrent CDI (rCDI), fetal microbiota transplantation should be considered. The most common risk factors associated are gut microbiota disturbances, the use of antibiotics, and hospitalization. Due to a wide range of risk factors mentioned in some studies but disregarded in others, further research is needed to determine the most prevalent risk factors.

Infection prevention in skilled nursing facilities is essential for the safety of residents, staff, and visitors to minimize the communal spread of healthcare-associated infections.

Structural-racism-and-systemic-injustices-inhibit-the-ability-to-have-equitable-healthcare-also-negatively-impacts-antimicrobial-stewardship-according-to-Jacinda

The bacterium commonly referred to as C. diff is sometimes called “C-difficult” because it is so hard to treat, said Mohamed Seleem, director of the Center

Three therapeutic regulatory approvals in less than a year signal that the promise of the human microbiome may finally be paying off. All of the approved therapies focus on treating recurrent Clostridium difficile infection, but what is next for the field? With promising oncology-related trial results from a number of researchers and companies such as […]

Paraneoplastic syndromes often cause endocrine, neurological, cutaneous, and hematologic pathologies, and cases with digestive symptoms as prominent are rare.

Mucosal-associated invariant T (MAIT) cells are innate-like T cells mainly found in the mucosa and peripheral blood. We have recently demonstrated that Clostridioides difficile activates MAIT cell in vitro. However, their role in the pathogenesis of C. difficile infection (CDI) in human patients rem …

Therapy for C. difficile infections includes the use of antibiotics, immunosuppressors, and fecal microbiota transplantation (FMT). However, these treatments have several drawbacks, including the loss of colonization resistance, promotion of autoimmune disorders, and the potential for unknown …

Antibiotics work by either killing the bacteria directly or by inhibiting the growth of bacteria.

It takes diligent and dedicated housekeeping staff using technology to keep on top of viruses and bacteria that linger on surfaces and potentially cause infection.

Fecal microbiota transplantation (FMT) has proven to be an effective treatment for recurrent Clostridioides difficile infection (rCDI) in both adult and pediatric patients. However, as microbiome development is a critical factor in children, it remains unclear whether adult fecal donors can provide …

Introduction. Environmental surveillance for Clostridioides difficile is challenging. There are no internationally agreed recommendations on which method should be used when environmental surveillance is undertaken. Aim. To compare the detection of C. difficile by RT-PCR to culture-based methods and to determine which is more sensitive and specific in the clinical environment. Methods. Forty-four near-patient areas of C. difficile -positive patients were sampled using contact plates and moistened flocked swabs. Results. Detection using moistened flocked swabs followed by RT-PCR or culture detected more C. difficile than contact plates. The sensitivity and specificity of a RT-PCR assay for tcdB compared to the culture methods was 76 and 91 %, respectively. Conclusion. Despite the lower sensitivity and specificity, RT-PCR could potentially offer a more rapid and practical alternative.

Attendees at the Society for Healthcare Epidemiology of America (SHEA) 2023 Spring Conference heard presentations about using electronic health records to identify cases of Clostridioides difficile earlier, as well as an update about infection control strategies.

In a new Annals "Beyond the Guidelines" feature, an infectious diseases specialist and a gastroenterologist discuss the benefits and risks of different treatment approaches for Clostridioides difficile ...

### What you need to know An older woman with moderate stage dementia living in a long term care home has new confusion and slurred speech. Her nurse notes an “unusual smell” while collecting a urine specimen and sends it for culture testing to the microbiology laboratory. The care home physician is notified that afternoon of the clinical finding and performs a focused examination, which is unremarkable, and then signs off the urine culture order. The urine culture returns with significant growth of Escherichia coli and the woman is prescribed a course of antibiotics. Five days later, she experiences an acute decline in her clinical status, including worsening dysarthria and right sided weakness, and is transferred to hospital, where a stroke is diagnosed. Focusing on a diagnosis of urinary tract infection (UTI), despite the absence of correlating symptoms, has resulted in delayed recognition of stroke symptoms and timely treatment. Overdiagnosis of UTI is one of the most common reasons for unnecessary use of antibiotics in long term care, including nursing and care homes.1 Most residents in these settings who have a positive result on urine culture testing do not actually have a UTI but rather asymptomatic bacteriuria (ASB), defined as the presence of significant levels of bacteria isolated in the urine (greater than 105 colony forming units/mL) in the absence of localising symptoms of UTI, …

There was no difference in the incidence rates of HA-CDI between COVID-19 and non-COVID-19 periods at our institution.

Molecular Psychiatry - A systematic review exploring the association between the human gut microbiota and brain connectivity in health and disease

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/PRNewswire/ -- Why do nonsteroidal anti-inflammatory drugs (NSAIDs) exacerbate gastrointestinal infections by Clostridioides difficile, the leading cause of...

A recent article in USA Today proclaimed that we are *this* far away from no longer having working antibiotics, a cataclysmic development that would pose "an existential threat for modern medicine."

This systematic review shows that the administration of probiotics has moderate preventive or mitigating effects on the occurrence of VAP in ICU patients, CDI, AAD, and nosocomial infections among children. Consequently, applying antibiotics along with the proper probiotic species can be advantageou …