C Difficile

Proton pump inhibitors (PPIs) are commonly prescribed for various conditions, but their long-term use without evaluation can lead to dependence and associated risks, emphasizing the importance of appropriate monitoring and deprescribing.

Kidney transplantation is an effective method to improve the condition of patients with end-stage renal disease. The gut microbiota significantly affects the immune system and can be used as an influencing factor to change the prognoses of patients who have undergone kidney transplantation. Recipien …

We found insufficient evidence to support or refute the use of FMT for IBS. Larger trials are needed.

Acurx develops antibiotic candidates targeting the DNA polymerase IIIC enzyme such as Ibezapolstat, which has received FDA Fast track and QIDP designations to treat #CDiff. The Company also has early stage antibiotics targeting #MRSA, VRE and PRSP. https://t.co/9AArq59ckp $ACXP— Antimicrobials Working Group (@AWG_News) June 22, 2023

“🎙️ Alaina DeKerlegand, PharmD, BCIDP discusses why we would expect fidaxomicin to have a benefit over vancomycin. 🎧 Get valuable insights on this topic from an expert in the field. Available now on all major podcasting platforms! #Cdiff #fidaxomicin”

ISRCTN15475780.

FMT is an evolving therapy. There are several considerations for its use in UC but its use and role should be directed by further clinical trials.

Younger age, disease extent E2, and endoscopic mayo score 2 significantly predict achievement of clinical remission with FMT in active UC. The prediction model can help in selecting individuals for FMT. Validation in larger cohorts is needed.

Quadram Institute microbiologists have collaborated with clinicians at the Norfolk and Norwich University Hospital (NNUH) to develop and implement a successful new…

Maintenance FMT in patients who are in clinical remission may help sustain clinical, endoscopic and histological remission in patients with UC.

Although infections caused by Clostridioides difficile have historically been attributed to hospital acquisition, growing evidence supports the role of community acquisition in C. difficile infection (CDI). Symptoms of CDI can range from mild, self-resolving diarrhoea to toxic megacolo …

This case report discusses a nine-year-old female that presented with abdominal pain, diarrhea, and weight loss, suggestive of inflammatory bowel disease (IBD). She had an older brother previous...

Clostridioides difficile infection (CDI) is the most lethal of the five CDC urgent public health treats, resulting in 12,800 annual deaths in the U...

For many people, going to the hospital can make for an uneasy experience.

Your gut is a lively place. Bacteria of all kinds live in your intestines and, for the most part, help you to thrive. "The gut microbiome is a very complex ecosystem," says Dr. Geoffrey Preidis…

Anaerobic microorganisms are often associated with chronic mucosal infections including periodontal disease, inflammatory bowel diseases, and recurrent colitis caused by iClostridioides difficile/i. Management of these diseases requires a long term strategy, but available antibiotics (e.g., metr …

The Food and Drug Administration has approved a live fecal microbiota product (Rebyota) to prevent recurrence of Clostridioides difficile in adults.The product is approved for use following antibiotic treatment for recurrent episodes of C. difficile.

Practical use of fecal microbiota spores, live-brpk (formerly SER-109): an oral therapeutic for the prevention of recurrent Clostridioides difficile infection

Clostridioides difficile bacteria can cause excessive diarrhoea in patients, leading to further complications, such as severe dehydration and sepsis. Although C.difficile bacteria tend to reside harmlessly in many people's bowels, prolonged antibiotic use can alter the bacterial balanc …

Researchers wondered if a fecal transplant from a patient who had responded well to immunotherapy might improve the cure rate of those who did not.

The UK is conducting a large-scale trial into the use of faecal transplants to treat liver disease after a successful pilot of the “crapsules” suggested they mi

A pill filled with poo dubbed a 'crapsule' to boost gut health and prevent serious infections is starting a major trial of 300 people in 16 centres across the UK.

These findings suggested that imbalanced Th17/Treg cells decreased chicken growth performance, while FMT-reshaped gut microbiota, i.e., higher Lactobacilli, increased chicken growth performance by balancing Th17/Treg cells. Video Abstract.

Multisystem inflammatory syndrome (MIS) following COVID-19, a condition primarily diagnosed in children, has also been observed less frequently in adults. It usually presents with a multitude of symptoms, mimicking a shock-like state characterized by multiple organ failure. Diagnosis often involves ruling out other conditions and timely management to mitigate morbidity and mortality. In this case, a 39-year-old unvaccinated Caucasian male patient reported symptoms of fever, chills, night sweats, diarrhea, headache, nasal congestion, and facial pain. Despite treatment with antipyretics, the fever persisted. The patient had tested positive for COVID-19 via polymerase chain reaction (PCR) six weeks prior. Clinical findings included low oxygen saturation, sinus tachycardia, abnormal liver function, elevated inflammatory markers, a negative respiratory viral panel, a negative immunologic workup, and a positive Clostridium difficile (C. difficile) PCR. Following complaints of chest pain which quickly escalated to cardiac arrest, he was diagnosed with myopericarditis. These manifestations met the multisystem inflammatory syndrome in adults (MIS-A) diagnostic criteria as stipulated by the Centers for Disease Control and Prevention. The diagnosis of MIS-A was reached through exclusion. Notably, the patient responded well to symptomatic management. Given the infrequent occurrence of MIS-A cases, even in 2023, it remains a challenging diagnosis. Despite existing guidelines for management, the recovery of this patient solely through symptomatic treatment prior to the consideration of conventional treatment is striking. The patient had concurrent infections, including a C. difficile infection, but these did not account for the overall clinical presentation, particularly the myopericarditis and positive laboratory findings.

Kim-Lewis-PhD-the-University-Distinguished-Professor-of-Biology-at-Northeastern-University-in-Boston-was-awarded-the-American-Society-for-Microbiology-ASM-

Competition among species has therapeutic implications, the authors found.

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FMT treats immune-mediated colitis in patients by altering baseline microbial diversity and composition.

Our findings suggest that metronidazole and vancomycin are equally effective for the treatment of mild CDAD, but vancomycin is superior for treating patients with severe CDAD.