0 Glyconutrients

Abstract Biogenic synthesis of silver nanoparticles (AgNP) was performed at room temperature using Aloe vera plant extract in the presence of ammoniacal silver nitrate as a metal salt precursor. The formation of AgNP was monitored by UV-visible spectroscopy at different time intervals. The shape and size of the synthesized particle were visualized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM) observations. These results were confirmed by X-ray powder diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) analyses and further supported by surface-enhanced Raman spectroscopy/Raman scattering (SERS) study. UV-visible spectrum has shown a sharp peak at 420 nm and further evidenced by FTIR peak profile (at 1587.6, 1386.4, and 1076 cm−1 with corresponding compounds). The main band position with SERS was noticed at 1594 cm−1 (C–C stretching vibration). When samples were heated under microwave radiation, AgNP with octahedron shapes with 5–50 nm were found and this method can be one of the easier ways to synthesis anisotropic AgNP, in which the plant extract plays a vital role to regulate the size and shape of the nanoparticles. Enhanced antibacterial effects (two- to fourfold) were observed in the case of Aloe vera plant protected AgNP than the routinely synthesized antibiotic drugs. Graphical Abstract Shape and size-controlled synthesis of silver nanoparticles using Aloe vera plant extract

Background Dermatophytosis in calves is a major public and veterinary health concern worldwide because of its zoonotic potential and associated economic losses in cattle farms. However, this condition has lacked adequate attention; thus, to develop effective control measures, we determined ringworm prevalence, risk factors, and the direct-sample nested PCR diagnostic indices compared with the conventional methods of dermatophytes identification. Moreover, the phenolic composition of an Aloe vera gel extract (AGE) and its in vitro and in vivo antidermatophytic activity were evaluated and compared with those of antifungal drugs. Results Of the 760 calves examined, 55.79% (424/760) showed ringworm lesions; 84.91% (360/424) were positive for fungal elements in direct-microscopy, and 79.72% (338/424) were positive in culture. Trichophyton verrucosum was the most frequently identified dermatophyte (90.24%). The risk of dermatophytosis was higher in 4–6-month-old vs. 1-month-old calves (60% vs. 41%), and in summer and winter compared with spring and autumn seasons (66 and 54% vs. 48%). Poor hygienic conditions, intensive breeding systems, animal raising for meat production, parasitic infestation, crossbreeding, and newly purchased animals were statistically significant risk factors for dermatophytosis. One-step PCR targeting the conserved regions of the 18S and 28S genes achieved unequivocal identification of T. verrucosum and T. mentagrophytes in hair samples. Nested-PCR exhibited an excellent performance in all tested diagnostic indices and increased the species-specific detection of dermatophytes by 20% compared with culture. Terbinafine and miconazole were the most active antifungal agents for dermatophytes. Gallic acid, caffeic acid, chlorogenic acid, cinnamic acid, aloe-Emodin, quercetin, and rutin were the major phenolic compounds of AGE, as assessed using high-performance liquid chromatography (HPLC). These compounds increased and synergized the antidermatophytic activity of AGE. The treated groups showed significantly lower clinical scores vs. the control group (P

Background: Diabetes mellitus is a disorder in the metabolism of sugars, fats and proteins in the body, leading to hyperglycemia and hyperlipidemia. Resistin is an adipocytokine associated with diabetes. This study aimed at investigating the effect of high intensity interval training and Aloe Vera consumption on resistin and the insulin resistance index in diabetic rats. Materials and Methods: In this experimental study, 32 male Wistar streptozotocin-(STZ) diabetic rats were randomly divided into four groups including the control, training, supplementation and training + supplementation. The training program included 8 weeks, five sessions per week, and each session with 6-12 periods of two minutes activity at 90 maximum speed and one minute rest (10 m/min). The Aloe Vera gel (300 mg/kg) was given as gavage in the supplementation recipient groups, 5 days a week for 8 weeks. Results: The results showed that the insulin levels and insulin resistance index increased and resistin decreased significantly in the experimental groups (P0.05). Conclusion: It seems that combination of high intensity interval training and the use of Aloe Vera can have a positive effect on diabetes control by reducing resistin and glucose and increasing insulin levels.

There is a growing interest in butyrate because its impact on epigenetic mechanisms will lead to more specific and efficacious therapeutic strategies for the presentation and treatment of different disease ranging from genetic/metabolic conditions to neurological degeneration disorders. The dietary natural source of butyrate through a high fiber diet or butyrate produced by fermentation of non-digestive fiber, such as acemannan in Aloe Vera leaf gel, is a highly appealing approach to present a simple and relatively low risk method to potentially improve outcomes in aged people with brain troubles. In this review, we will discuss the pharmacological effects of butyrate as a histone deacetylase inhibitor to an insulin resistance and energy expenditure, and as pro-drugs to ulcerative colitis and cancer, and the gut-liver axis in pre-clinical treatment.

Introduction : Tuberculosis has become a serious health  problem in the world. Increased mortality in patients with tuberculosis infection is associated with MDR and hepatotoxic side effects of antituberculosis drugs. Therefore, it is necessary to find an alternative drug that can reduce the hepatotoxic side effects . Objective : This study aims to investigate the benefits of Aloe vera in preventing liver damage as a side effect of antituberculosis drug administration. Method: Twenty-five rats will be divided into five groups, namely the control group (without any treatment), the group of rats treated by anti-tuberculosis drugs, and a group of mice were given antituberculosis drugs and got Aloe vera extract at a dose of 40; 80; and 120 mg/kg body weight. Results: Antituberculosis drugs are isoniazid and rifampicyn a dose of 50 mg/kg body weight. Levels of TNF-a were significantly higher in the antituberculosis group compared with the control group (P < 0.05). All doses of Alovevera reduce levels of TNF-a compared with the antituberculosis group (P < 0.05), although it has not yet reached levels comparable to the control group (P > 0.05). Conclusion: It was concluded that administration of Aloe vera can suppress the production of TNF-a as a result of antituberculosis drug administration. Thus, Aloe vera can be a useful alternative to natural materials in the successful treatment of tuberculosis through the inhibition of hepatotoxid side effect.   Keywords: Aloe vera; TNF-a; antituberculosis drugs.

This study sought to improve the handling, stability to aqueous medium and healing properties of alginate-based three-dimensional structures to be app…

Nonsteroidal anti-inflammatory drugs (NSAIDs) are well-known for exerting numerous adverse effects on the gastrointestinal tract such as bleeding, ulceration, and perforation, thereby limiting their use. Most previous studies have focused on NSAID-induced gastropathy. However, improved diagnostic techniques

Background: Stomatitis is the most common complication of chemotherapy. This study aimed to assess the effect of aloe vera solution on stomatitis and its pain intensity in patients undergoing chemotherapeutic procedures.Methods: In this randomized controlled clinical trial, 64 patients with Acute Myeloid Leukemia and Acute Lymphocytic Leukemia undergoing chemotherapy were randomly divided into a control and an intervention group. The intervention group patients were asked to wash their mouths with 5 ml of aloe vera solution for two minutes three times a day for 14 days. The control group patients, however, used only the ordinary mouthwashes recommended in hematologic centers. The patients’ mouths were examined by two assistants on days 1, 3, 5, 7, and 14. The intensity of stomatitis was recorded according to WHO stomatitis intensity checklists and pain was evaluated using Visual Analog Scale. The data were analyzed by SPSS statistical software, version 18.Results: The results showed that aloe vera solution mouthwash significantly reduced the intensity of stomatitis and its pain in the intervention group compared to the control group. On the first day, no significant difference was found between the two groups regarding the mean intensity of stomatitis (P=0.178) and pain (P=0.154). However, a significant difference was observed between the two groups in this regard on other days (days 3-14: P=0.001 for stomatitis intensity, P=0.001 for pain).Conclusions: Aloe vera solution can improve the patients’ nutritional status, reduce stomatitis and its pain intensity, and increase the patients’ satisfaction.Trial Registration Number: IRCT2014092819318N1

Background and Objectives: Aloe Vera is native to tropical and subtropical regions and considering the combined assets of its active constituents, as a plant has long been used to treat various diseases. In this study the effect of different concentrations of Aloe Vera Gel on qualitative characteristics and viability of probiotic ...

Scar preventive dextran based bionanocomposite dressings containing aloe vera (AV) and manuka honey (MH) were developed as wound care devices. This wo…

Human norovirus (HuNoV) is the major cause of viral foodborne diseases, but no effective medication is currently available. This study reported the an…

• Aloe's prebiotic effects are fantastic due to the chemical structure of some of its components. Surprisingly the aloe vera gel is about 55% polysaccharides and contains a compound called acemannan.

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Air pollution has become a serious environmental issue and a threat to all over the world. SO2 is considered as the most poisonous and irritant gas as it penetrates deeper in the vitals hence alters the physiology, biochemistry and behavior of the living individuals. The present study has been designed to explore out the protective effect of Aloe vera against SO2 induced hepatotoxicity in albino rats. The twenty albino rats were grouped in four sets-control set (1) were kept in control conditions, while, experimental set (2) was exposed to 80ppm of SO2 gas 1h/d for 30 and 60 days, experimental set (3) were exposed to 80ppm of SO2 gas 1h/d with oral administration of Aloe vera fruits extracts (200mg/kg b.wt.) for 30 and 60 days respectively. The findings of the present investigation have indicated that SO2 causes significant increase in total bilirubin (p

The skin, being a cell-renewal system, is one of the first organs to be affected in total-body irradiation during radiotherapy. An attempt has been made in the present study to explore radiation-induced biochemical alterations caused by whole-body gamma irradiation and their modulation in Swiss albi …

AIM: Long-term dietary intake of non-caloric fiber, such as Aloe vera gel influences the structural and activity of micro-organisms in the human gut. The present investigation was executed with an innovative concept: symbiotic effect of probiotics that are used commercially as lactic acid bacteria i.e. Lactobacillus fermentum and Aloe vera juice as prebiotics for a prospective prophylaxis. MATERIALS AND METHODS: Fermentation of L. fermentum with Aloe vera juice certified by International Aloe Science Council was carried out and the quantification of short chain fatty acids (SCFAs) from the fermentation broth in large scale was determined by gas-chromatography-mass-spectrometry selective detection in the selective ion monitoring mode. RESULTS: The growth of L. fermentum and L. helveticus with Aloe vera juice (AVJ) individually on MRS broth was continued to keep at pH 3.5 and 3.6, while pH of the negative controls changed to 4.3 and 4.0, respectively, during 24 hr incubation. The growth rate and the viability of L. helveticus incubated with different concentrations (5-25%) of Aloe vera juice were strongly reduced. However, the growth rate of L. fermentum was enhanced in a concentration dependent manner with emphasis on the use of 15% AVJ that resulted in two times more growth than that of the negative control. Continuation of L. fermentum growth at pH 3.6 in combination with AVJ during incubation for 24 hr suggests the durability of prebiotic potential by AVJ in in vitro fermentation. Acetic, propionic and lactic acid as SCFAs in the ether extract were identified from the fermentation culture medium. CONCLUSION: The prebiotic activity of AVJ may be assessed by the participation of SCFAs during 24 hrs-incubation with L. fermentum. An innovative concept of symbiotics: a combination of AVJ and L. fermentum, is a perspective prophylaxis on future intestinal health claims. Due to tolerance to acid, L. fermentum may pass through the gastric barrier and colonize the intestine after oral administration.

Background Dental pulp stem cells (DPSCs) can play a prominent role in tissue regeneration. Aloe vera L. (Liliaceae) contains the polysaccharide of acemannan that was shown to be a trigger factor fo...

Introduction Pharmaceuticals are a large and diverse group of compounds designed to prevent, cure, and treat disease, and improve health [1-2].  Significant fractions of the parent compound are excreted in un-metabolized form or as metabolites (active or inactive) into raw sewage and wastewater

There is plenty of research that indicates that the unnaturally accelerated aging process associated with modern living and/or natural environmental exposures such as excessive ultraviolet radiation (photo-aging), can be slowed.

Aim Candida albicans can cause two major types of infections: superficial infections (such as oral or vaginal candidiasis) as well as life-threatening systemic infections, and Aloe vera extract is one of the potentially useful therapeutic options. The aim of this study was to determine …

The present study was undertaken to investigate the hepatoprotective effect of Aloe vera against side effect of antituberculosis drug.Twenty-five rats will be divided into five groups, namely the control group (without any treatment), the group of rats ...

Medisains adalah jurnal ilmiah ilmu-ilmu kesehatan diterbitkan 3 kali dalam 1 tahun (april, agustus dan desember) oleh Fakultas Ilmu Kesehatan Universitas Muhammadiyah Purwokerto