0 Glyconutrients

Gum Arabic is a natural gummy exudate gained from the trees of Acacia species (Acacia senegal and Acacia seyal), Family: Fabaceae. Gum Arabic considers as a dietary fiber with a high percentage of carbohydrates and low protein content. Sugars arabinose and ribose were originally discovered and isolated from gum Arabic and it is representing the original source of these sugars. A gum emanation from trees occurs under stress conditions such as heat, poor soil fertility, drought, and injury. Mainly gum is produced in belt region of Africa, mainly Sudan, Chad, and Nigeria. In the food industry, it is used in confectionery; in the pharmaceutical industry, it is used as emulsifier, film coating and others. Traditionally the gum used for chronic renal failure, digestive discomfort, and others. Although gum Arabic considered as an inert substance, recent information demonstrated multiple pharmacological and medical effects, such as weight reduction, antihypertensive, antihyperlipidemic, anticoagulant, antibacterial, antidiabetic, anti-inflammatory, nephroprotective and other effects.

Dr. Jennifer Kohler, Associate Professor at the University of Texas Southwestern Medical Center, speaks about her research in intestinal fucose. The Joint Webinar Series is a collaborative effort by GlycoNet and American Chemical Society's Carbohydrate Chemistry Division. The series is sponsored by New England Biolabs. To learn more, visit http://bit.ly/glycowebinar

The key difference between fucoidan and fucoxanthin is that fucoidan is a fucose-containing sulfated polysaccharide present in different species of brown a

Metabolic syndrome (MS) is a highly prevalent health problem worldwide and is associated with different risk factors, including hyperglycemia, dyslipidemia, hypertension, and obesity. This condition ...

Aloe vera plant extracts are ubiquitous in foods, cosmetics, and medicine. Like all plants, these extracts contain an array of potential bioactives or glycans, ...

Aloe vera attenuated IMN-induced gastropathy in rats by the reduction of oxidative stress, inflammation, and improvement of gastric histopathology.

Background: Applying a cooling treatment from outside the body is one way to lower fever in children. Midwives commonly perform a warm water compress in their care, but it is considered less effective. Thus, compress with Aloe Vera Barbadensis Miller is proposed in this study as an alternative treatment. Objective: To examine the effect of Aloe Vera Barbadensis Miller compress in reducing body temperature in children with fever. Methods: This was a quasi-experimental study with pretest and posttest with control group design. Forty children were recruited, with twenty of them assigned in each group. Purposive sampling was performed to select the sample. A digital rectal thermometer was used to measure the temperature. Independent t- test and paired test were used for data analysis. Results: Findings showed that the Aloe Vera compress group showed a higher decrease of body temperature compared to the warm water compress group. The difference of body temperature after 20 minutes in the experiment group was 1.435 while in the control group was only 1.085. There were statistically significant differences in body temperature between the experiment and control group (p=0.013). Conclusion: Aloe Vera Barbadensis Miller compress is an effective alternative therapy in reducing body temperature in children with fever.  It is recommended for midwives to apply this intervention to reduce body temperature significantly.

Recently, fucoidan has been proposed as a potential prebiotic agent for functional food and pharmaceutical development. However, while previous studies illustrated favorable modulations of gut microbiota by fucoidan, changes in the overall microbial structure remain elusive. In the present study, modulations

A poloxamer-pluronic-mastic gum-gum acacia wound dressing

Background: Intensive care units (ICUs) admissions due to sepsis represent 2 to 11%. Although there are well stablished  therapeutic available, it still is the major cause of death in most ICUs and the leading cause of acute kidney injury. The objective of this work was to evaluate the role of Aloe vera extract on survival rates and kidney histopathology of mice submitted to sepsis induced by cecal ligation and puncture. Methods and Findings: Twenty six mice were distributed into four groups: Sham - surgery simulation (N=5); Control - Cecal ligation and puncture was performed (N=7); Aloe - Surgery simulation and treatment with Aloe vera extract (N=7); and Sepsis + Aloe - Cecal ligation and puncture was performed followed by treatment with Aloe vera extract (N=7). The animals were observed until death. Kidneys were analysed by histopathology. Kruskall-Wallis test was used to compare the histopathological results. Survival analysis was assessed by Kaplan-Meier statistics and compared using log rank test. A significance level of 5% was adopted. The survival time ranged from 19 hours for the Control group up to 24 hours for the animals of Sepsis + Aloe group, corresponding to a survival time of 1.26 times greater (p0.05). Conclusions: Aloe vera extracts delays mortality but does not attenuate kidney injury in sepsis induced by cecal ligation and puncture in mice.

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The common cold is a viral infection with important economic burdens in Western countries. The research and development of nutritional solutions to reduce the incidence and severity of colds today is a major focus of interest, and larch arabinogalactan ...

Aloe vera contains multiple pharmacologically active substances which are capable of modulating cellular phenotypes and functions. Aloe vera ethanol and ethyl acetate extracts may be used in eye drops to treat inflammations and other ailments of external parts of the eye such as the cornea.

Cyclophosphamide (cy) is a widely used cancer drug. Many researchers have focused on the prevention and alleviation of its side effects, particularly damage to the intestinal mucosal barrier. In this study, we examined the effects of fucoidan, isolated from Acaudina molpadioides, on mice with intestinal muco

ZnO nanoparticles (ZnONPs) were synthesised through a simple and efficient biogenic synthesis approach, exploiting the reducing and capping potential …

Gum Arabic (GA), a nutrient from dried exudate of Acacia senegal, is widely used as emulsifier and stabilizer. It stimulates sodium and water absorption in diarrhea. This study explored the effects of GA in colonic tissue. Mice were treated with GA (10% wt/vol) in drinking water and gene array was p …

Cervical cancer is a public health problem and is well-known as the fourth most common cancer and the fourth major cause of cancer-associated death in women in the developing countries [1].

Europe PMC is an archive of life sciences journal literature.

Objective: Lately, gum Arabic (GA) is traditionally used in Middle East countries to ameliorate renal function of patients with chronic renal failure (CRF). This action is controversial and it is still experimentally under evaluation. We aimed to shed more light on the potential effects of GA against γ-rays-induced nephrotoxicity in irradiated rats. Forty-eight male albino Sprague–Dawley rats were divided into four groups: control group(C), irradiated groups (R) 5Gy, gum Arabic groups (GA) 25 mg/kg orally administrated for 3 weeks, and  GA+R groups, rats were treated orally with 25 mg /kg GA for one week before and three weeks after irradiation (GA+R). The experimental rats were sacrificed after 7 and 21 days of irradiation. Histochemical examination of kidney cortex tissue of R groups showed significantly decreased PAS-positive materials, total protein content, and total DNA content, but it significantly increased amyloid β–protein content relative to the control group. While treatment with GA before and after irradiation showed a non-significant change in PAS-positive materials and the content of total protein, total DNA, and amyloid β–protein throughout the examined kidney cortex. According to the results obtained in the current study using GA as a natural agent showed a strong cytoprotective effect against the histochemical changes due to its radioprotective effect.

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Oxidative stress has a major role in progression of diabetes-related behavioral deficits. It has been suggested that Aloe vera has anti-diabetic, anti…

The marine origin polysaccharide fucoidan combines multiple biological activities. As demonstrated by various studies in vitro and in vivo, fucoidans show anti-viral, anti-tumor, anti-oxidant, anti-inflammatory and anti-coagulant properties, although the detailed molecular action remains to be eluci …

Objectives Inflammation is ongoing process among sickle cell anemia even during steady state. C reactive protein (CRP) is cardinal marker that utilized widely as inflammatory indicator. Gum Arabic (GA) is gummy exudates from Acacia senegal tree. Fermentation by colonic bacteria increases serum butyrate concentrations, so considered as prebiotic agent. Gum Arabic (GA) has anti-inflammatory activity through butyrate. Earlier we proved that regular intake of GA increased fetal hemoglobin and anti-oxidant capacity most likely through raised level of butyrate, which would ameliorate symptoms of sickle cell anemia. Best of our knowledge this is the first study conducted to investigate GA intake on inflammatory markers among sickle patients. Results This was a retrospective study conducted on stored samples from trial of Gum Arabic and sickle cell anemia. Quantitative CRP was measured by Mindray BS 200 before and after Gum Arabic consumption for 12 weeks. Daily intake of GA significantly decreased C reactive protein level (P.V = 001) (95% CI 0.943–3.098). No correlation between CRP and age, fetal hemoglobin, hemolysis markers and white blood cells. Our findings revealed novel effect of GA as anti-inflammatory agent could be consumed as natural dietary supplement to modulate disease severity and downregulate inflammatory process. Trial registration: ClinicalTrials.gov Identifier: NCT02467257. Registered 3rd June 2015

50 ml/day of Aloe vera juice restored normal thyroid function in the participating subjects and decreased their elevated serum TPOAb levels after just 3 months.