0 Glyconutrients

A poloxamer-pluronic-mastic gum-gum acacia wound dressing

Aloe vera plant extracts are ubiquitous in foods, cosmetics, and medicine. Like all plants, these extracts contain an array of potential bioactives or glycans, ...

Aloe vera attenuated IMN-induced gastropathy in rats by the reduction of oxidative stress, inflammation, and improvement of gastric histopathology.

The common cold is a viral infection with important economic burdens in Western countries. The research and development of nutritional solutions to reduce the incidence and severity of colds today is a major focus of interest, and larch arabinogalactan ...

Background: Applying a cooling treatment from outside the body is one way to lower fever in children. Midwives commonly perform a warm water compress in their care, but it is considered less effective. Thus, compress with Aloe Vera Barbadensis Miller is proposed in this study as an alternative treatment. Objective: To examine the effect of Aloe Vera Barbadensis Miller compress in reducing body temperature in children with fever. Methods: This was a quasi-experimental study with pretest and posttest with control group design. Forty children were recruited, with twenty of them assigned in each group. Purposive sampling was performed to select the sample. A digital rectal thermometer was used to measure the temperature. Independent t- test and paired test were used for data analysis. Results: Findings showed that the Aloe Vera compress group showed a higher decrease of body temperature compared to the warm water compress group. The difference of body temperature after 20 minutes in the experiment group was 1.435 while in the control group was only 1.085. There were statistically significant differences in body temperature between the experiment and control group (p=0.013). Conclusion: Aloe Vera Barbadensis Miller compress is an effective alternative therapy in reducing body temperature in children with fever.  It is recommended for midwives to apply this intervention to reduce body temperature significantly.

Background: Fucoidan is a natural sulfated polysaccharide which exists mainly in the cell wall matrix of various species of brown seaweed. Various forms of fucoidan have also been recognized in some marine invertebrates such as sea urchins and sea cucumbers. Fucoidan inhibits the spread of cancerous cells by preventing the adhesion of tumor cells to the extracellular matrix in addition to inducing apoptosis, or programmed self-destruction, in human T-cells infected by T-cells leukemia virus type I (HTLV-1) which causes adult T-cell leukemia. The polysaccharide has also been shown to stimulate the phagocytic action of macrophages and synthesis of several immune cell types, which increases protection against infection. Fucoidan gives the immune system a big boost by enhancing phagocytosis. Additionally, it increases the number of mature white blood cells which are circulating in the body, thereby bolstering the first line of defense against infections and diseases. Moreover, fucoidan has anti-coagulant, anti-thrombotic, anti-inflammatory, antioxidant, anti-allergic, anti-tumor properties and also many others. Methods and Results: In this study, we investigated whether fucoidan is able to alleviate the vascular remodeling process triggered by immunological stimuli in rat allogenic aorta transplantation model, in addition to the evaluated potential mechanisms responsible for the observed effects. Our rat aorta transplantation model was subjected to intraperitoneal or oral treatment with fucoidan or placebo. The results of our study demonstrated that fucoidan inhibits endointimal hyperplasia formation and vascular modulation. In particular, intraperitoneal and oral administration of fucoidan reduced neointima formation in allografts retrieved 8 weeks after transplantation. Moreover, both treatments with fucoidan reduced the number of smooth muscle (SM) a-actin positive cells in intima and adventitia, decreased percentage of macrophages in intima and media, and increased the number of leukocytes in media of the allografts. Fucoidan treatments have also caused reduction in apoptosis in allograft intima and media. Conclusion: Through our study, we demonstrated the inhibitory effect of fucoidan on vascular remodeling in transplant vasculopathy within rats. Our study is the first report of the beneficial effects of fucoidan oral administration on this process, which may have important clinical implications and result in a better understanding of vascular remodeling.  Keywords : fucoidan, transplant vasculopathy, vascular remodeling

Studies have been focused on natural products with antibacterial and anti-inflammatory activities, such as fucoidan. Many in vivo studies have evaluat…

Background: Intensive care units (ICUs) admissions due to sepsis represent 2 to 11%. Although there are well stablished  therapeutic available, it still is the major cause of death in most ICUs and the leading cause of acute kidney injury. The objective of this work was to evaluate the role of Aloe vera extract on survival rates and kidney histopathology of mice submitted to sepsis induced by cecal ligation and puncture. Methods and Findings: Twenty six mice were distributed into four groups: Sham - surgery simulation (N=5); Control - Cecal ligation and puncture was performed (N=7); Aloe - Surgery simulation and treatment with Aloe vera extract (N=7); and Sepsis + Aloe - Cecal ligation and puncture was performed followed by treatment with Aloe vera extract (N=7). The animals were observed until death. Kidneys were analysed by histopathology. Kruskall-Wallis test was used to compare the histopathological results. Survival analysis was assessed by Kaplan-Meier statistics and compared using log rank test. A significance level of 5% was adopted. The survival time ranged from 19 hours for the Control group up to 24 hours for the animals of Sepsis + Aloe group, corresponding to a survival time of 1.26 times greater (p0.05). Conclusions: Aloe vera extracts delays mortality but does not attenuate kidney injury in sepsis induced by cecal ligation and puncture in mice.

Gum Arabic (GA), a nutrient from dried exudate of Acacia senegal, is widely used as emulsifier and stabilizer. It stimulates sodium and water absorption in diarrhea. This study explored the effects of GA in colonic tissue. Mice were treated with GA (10% wt/vol) in drinking water and gene array was p …

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Aloe vera contains multiple pharmacologically active substances which are capable of modulating cellular phenotypes and functions. Aloe vera ethanol and ethyl acetate extracts may be used in eye drops to treat inflammations and other ailments of external parts of the eye such as the cornea.

Objective: Lately, gum Arabic (GA) is traditionally used in Middle East countries to ameliorate renal function of patients with chronic renal failure (CRF). This action is controversial and it is still experimentally under evaluation. We aimed to shed more light on the potential effects of GA against γ-rays-induced nephrotoxicity in irradiated rats. Forty-eight male albino Sprague–Dawley rats were divided into four groups: control group(C), irradiated groups (R) 5Gy, gum Arabic groups (GA) 25 mg/kg orally administrated for 3 weeks, and  GA+R groups, rats were treated orally with 25 mg /kg GA for one week before and three weeks after irradiation (GA+R). The experimental rats were sacrificed after 7 and 21 days of irradiation. Histochemical examination of kidney cortex tissue of R groups showed significantly decreased PAS-positive materials, total protein content, and total DNA content, but it significantly increased amyloid β–protein content relative to the control group. While treatment with GA before and after irradiation showed a non-significant change in PAS-positive materials and the content of total protein, total DNA, and amyloid β–protein throughout the examined kidney cortex. According to the results obtained in the current study using GA as a natural agent showed a strong cytoprotective effect against the histochemical changes due to its radioprotective effect.

ZnO nanoparticles (ZnONPs) were synthesised through a simple and efficient biogenic synthesis approach, exploiting the reducing and capping potential …

Cervical cancer is a public health problem and is well-known as the fourth most common cancer and the fourth major cause of cancer-associated death in women in the developing countries [1].

Fucoidan, a sulfated polysaccharide extracted from brown seaweed, has been used in traditional Chinese herbal medicine to treat thyroid tumors for many years. Although a number of its cellular effects have been investigated, the role of fucoidan in molecular signaling, particularly in Ca2+ signaling …

Objectives Inflammation is ongoing process among sickle cell anemia even during steady state. C reactive protein (CRP) is cardinal marker that utilized widely as inflammatory indicator. Gum Arabic (GA) is gummy exudates from Acacia senegal tree. Fermentation by colonic bacteria increases serum butyrate concentrations, so considered as prebiotic agent. Gum Arabic (GA) has anti-inflammatory activity through butyrate. Earlier we proved that regular intake of GA increased fetal hemoglobin and anti-oxidant capacity most likely through raised level of butyrate, which would ameliorate symptoms of sickle cell anemia. Best of our knowledge this is the first study conducted to investigate GA intake on inflammatory markers among sickle patients. Results This was a retrospective study conducted on stored samples from trial of Gum Arabic and sickle cell anemia. Quantitative CRP was measured by Mindray BS 200 before and after Gum Arabic consumption for 12 weeks. Daily intake of GA significantly decreased C reactive protein level (P.V = 001) (95% CI 0.943–3.098). No correlation between CRP and age, fetal hemoglobin, hemolysis markers and white blood cells. Our findings revealed novel effect of GA as anti-inflammatory agent could be consumed as natural dietary supplement to modulate disease severity and downregulate inflammatory process. Trial registration: ClinicalTrials.gov Identifier: NCT02467257. Registered 3rd June 2015

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Current Oncology, an international, peer-reviewed Open Access journal.

Background There is a strong association between cardiometabolic risk and adipose tissue dysfunction with great consequences on type 2 diabetic patients. Visceral Adiposity Index (VAI) is an indirect clinical marker of adipose tissue dysfunction. Gum Arabic (GA) is a safe dietary fiber, an exudate of Acacia Senegal. Gum Arabic had shown lipid lowering effect in both humans and animals. The aim of this trial was to determine the effect of GA supplementation on anthropometric obesity marker, Visceral Adiposity Index (VAI) and blood pressure in patients with type 2 diabetes mellitus. Methods This randomized, double blinded, placebo controlled trial recruited a total of 91 type 2 diabetic patients (73 females, 18 males), age (mean ± SD) 50.09 ± 9.3 years on hypoglycemic agents and were randomly assigned into two groups, either to consume 30 g of GA or 5 g of placebo daily for 3 months. Anthropometric obesity markers were measured and indices were calculated. Blood pressure was measured and high density lipoprotein (HDL) and triglycerides (TG) were determined in fasting blood samples at the start and end of the study period. Results After intervention, Gum Arabic decreased BMI and VAI significantly (P

Oxidative stress has a major role in progression of diabetes-related behavioral deficits. It has been suggested that Aloe vera has anti-diabetic, anti…

50 ml/day of Aloe vera juice restored normal thyroid function in the participating subjects and decreased their elevated serum TPOAb levels after just 3 months.

In tumor microenvironment, macrophages as a polarized M2 population promote tumor progression via releasing multiple cytokines and chemokines. A brown seaweed fucose-rich polysaccharide, fucoidan has antitumor activity and immune modulation through affecting tumor cells and lymphocytes. Here, we focused on the effect of fucoidan on macrophages especially M2 subtype. Our results demonstrated that fucoidan down-regulated partial cytokines and chemokines, especially a M2-type chemokine CCL22. Furthermore, fucoidan inhibited tumor cells migration and CD4+ T lymphocytes, especially Treg cells, recruitment induced by M2 macrophages conditioned medium through suppression of CCL22. Mechanismly, fucoidan inhibited CCL22 via suppressing p65-NF-κB phosphorylation and nuclear translocation. In addition, p38-MAPK and PI3K-AKT also affected the expression of CCL22 through differential modulation of NF-κB transcriptional activity. Taken together, we reveal an interesting result that fucoidan can inhibit tumor cell migration and lymphocytes recruitment by suppressing CCL22 in M2 macrophages via NF-κB-dependent transcription, which may be a novel and promising mechanism for tumor immunotherapy.

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