0 Glyconutrients

Cornea acts as a structural barrier and protects the eye from environmental stresses. Inflammation in ocular surface causes discomfort and visual dist…

Oxidative stress has a major role in progression of diabetes-related behavioral deficits. It has been suggested that Aloe vera has anti-diabetic, anti…

The T-cell adjuvanticity of mycobacterial cord factor trehalose 6,6'-dimycolate (TDM) is well established. The identification of the C-type lectin Mincle on inn...

The marine acid polysaccharide fucoidan has attracted attention from both the food and pharmaceutical industries due to its promising therapeutic effects. Fucoidan is a polysaccharide that mainly consists of L-fucose and sulphate groups. Its excellent biological function is attributed to its unique …

Parkinson's disease is a debilitating neurodegenerative disorder that is pathologically characterized by intracellular inclusions comprised primarily of alpha-synuclein (αSyn) that can also be transmitted from neuron to neuron. Several lines of evidence suggest that these inclusions cause neurodegen …

Fucoidan is a sulfated polysaccharide based predominantly on l-fucose, and has several biologic functions. Reactive oxygen species-mediated apoptosis …

The present review explains therapeutic and pharmaceutical potential of Aloe vera a well-known plant grows in semi-arid climate of tropical and subtropical regions. This article emphasizes important uses of A. vera constituents as dietary nutraceutical, medicinal, and therapeutic potential. Plant is cultivated for agricultural and medicinal and decoration purposes for indoors as a potted plant. Plant is a good depository of chemical constituents which display a very wide array of biological activities such as anticancer, antiparasitic, antidiabetic, anti-inflammatory, anti-arthritic, antiparasitic, antitumor, antioxidant, chemopreventive, hepatoprotective, and gastroprotective. Plant is used to prepare skin protective/care gels mainly for soothing, moisturizing, and wound healing. Thick watery plant sap works are added as key ingredient in many beauty products. Plant leaves are used to generate aroma, beverages, skin lotion, cosmetics, or ointments for minor burns. Plant contains vitamins, enzymes, minerals, sugars, lignin, saponins, salicylic acids, and amino acids as main ingredients. Plant is a good source of Vitamins A, C, and E, which are antioxidants. It also contains Vitamin B12, folic acid, and choline watery juicy of A. vera leaf which contains important minerals such as calcium, chromium, copper, selenium, magnesium, manganese, and potassium. Plant ingredients were found active against gingivitis, psoriasis, and used for herbal therapy in inflammatory bowel disease. A. vera contains important fatty acids mainly steroids such as cholesterol, campesterol, β-sitosterol, and lupeol. Aloin and emodin act as analgesics, antibacterials, and antivirals while lupeol shows antiseptic and analgesic properties. It also contains auxins and gibberellin hormones that help in wound healing and have anti-inflammatory action. Saponins that are the soapy substances display cleansing and antiseptic properties.

Endometriosis is common in reproductive-age women and its pathology is to increase proliferation and migration to enhance epithelial-to-mesenchymal transition progression (EMT). However, treatments are currently limited, so it is important to explore new therapeutic drugs. Hence, in this study, we investigate the therapeutic effect of fucoidan (FC) on the progression and mechanisms of endometriosis. The cell viability of endometrial cell lines End1/E6E7 and Vk2/E6E7 treated with different concentrations of FC were assessed by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and cell counting. Cell migration was evaluated using wound-healing assay. In an in vivo experiment, female Balb/c mice received surgically induced endometriosis followed by different concentrations of fucoidan for 6 weeks. High-frequency ultrasound imaging was applied to detect subsequent lesion growth. The results demonstrated that fucoidan inhibited the viability and migration ability of End1/E6E7 and Vk2/E6E7 cells. Additionally, the administration of fucoidan reduced the volume and weight of endometriotic lesions, decreased inflammatory cytokines and vascular endothelial growth factor (VEGF) of serum and lesions, and improved EMT proliferation and apoptosis-related protein expression. For the first time, fucoidan indicated anti-proliferative and anti-inflammatory effects as well as inhibited EMT progression and induced apoptosis, improving endometriosis.

In recent decades, attention to cancer-preventive treatments and studies on the development of anticancer drugs have sharply increased owing to the in…

The aim of this study was to evaluate evidence for the efficacy of aloe vera on managing prediabetes and early non-treated diabetes mellitus. We performed a systematic search of PubMed, Embase, and Cochrane Central Register of Controlled Trials until 28 January 2016. A total of five randomized controlled trials (RCTs) involving 415 participants were included. Compared with the controls, aloe vera supplementation significantly reduced the concentrations of fasting blood glucose (FBG) (p = 0.02; weighed mean difference [WMD]: −30.05 mg/dL; 95% confidence interval [CI]: −54.87 to −5.23 mg/dL), glycosylated hemoglobin A1c (HbA1c) (p < 0.00001; WMD: −0.41%; 95% CI: −0.55% to −0.27%), triglyceride (p = 0.0001), total cholesterol (TC) (p < 0.00001), and low density lipoprotein-cholesterol (LDL-C) (p < 0.00001). Aloe vera was superior to placebo in increasing serum high density lipoprotein-cholesterol (HDL-C) levels (p = 0.04). Only one adverse event was reported. The evidence from RCTs showed that aloe vera might effectively reduce the levels of FBG, HbA1c, triglyceride, TC and LDL-C, and increase the levels of HDL-C on prediabetes and early non-treated diabetic patients. Limited evidence exists about the safety of aloe vera. Given the small number and poor quality of RCTs included in the meta-analysis, these results are inconclusive. A large-scale, well-designed RCT is needed to further address this issue.

Four antithrombotic fucoidan fractions F1, F2, LF1, and LF2 with different monosaccharide composition, molecular weight, and degree of sulfation and s…

Autophagy is a highly conserved recycling pathway that promotes cell survival during periods of stress. We previously reported that induction of autophagy through the inhibition of the mechanistic target of rapamycin (MTOR) inhibits HIV replication in human macrophages and CD4+ T lymphocy …

Summary. Background: Fucoidan, an antithrombotic polysaccharide, can induce endothelial colony-forming cells (ECFC) to adopt an angiogenic phenotype in vitro. Objectives: We evaluated the effect of...

Aloe vera healed wounds earlier than untreated rats with gradual improvement in wound areas and collagen content. Aloe vera also improved the expression of IGF-1 and VEGF in skin and bone marrow indicating improvement in angiogenesis. RT- PCR analysis showed increased expression of genes for chemota …

Fucoidans are a class of sulfated fucose-rich polysaccharides found in brown marine algae and echinoderms. Fucoidans have an attractive array of bioactivities and potential applications including immune modulation, cancer inhibition, and pathogen inhibition. ...

Dr. Rob Sinnott talks about a new study that demonstrates improved memory performance after taking Ambrotose Complex. Read the release here: http://ow.ly/tDtIn

On Nov. 1, 2018, GlycoNet held a panel discussion, Why Sugars Matter in Fighting Disease, at the Li Ka Shing Centre for Health Research Innovation in Edmonton, Alberta. The panel discussion was MC'd by author and former Daily Planet host Jay Ingram. Panel members included: Dr. Mona Nemer, Canada’s Chief Science Advisor; Dr. Todd Lowary, Scientific Director, GlycoNet; Dr. Lori West, Professor, University of Alberta and Director, Canadian Donation and Transplant Research Program (CNTRP); Dr. David Vocadlo, Professor, Simon Fraser University; Dr. Karla Williams, Assistant Professor, University of British Columbia and Co-founder of GlyCa BioSciences and; Ms. Erum Razvi, PhD candidate, The Hospital for Sick Children.

The powerful Glyconutrients in Ambrotose LIFE do more for your digestive and cognitive function and cell to cell communication than any other product.

Non-invasive GlycoCheck testing technology quantifies vessel density, red blood cell concentration, blood flow and glycocalyx function.

Hans Vink, PhD, PhD is one of the pioneers of glycocalyx research. He has been studying glycocalyx science and function since the 1980s.

Supplementation with the dietary plant-derived polysaccharides in AA resulted in significant changes in serum protein N-glycosylation in healthy individuals. How this occurs and whether it has biological significance remains to be evaluated.

Our Microvascular supplement improves Glycocalyx Health effectively. Endocalyx™ has been clinically shown to maintain blood flow circulation. Shop online now!

Learn about how GlycoNet is funding glycomics research to help bridge the gap between fundamental advances and therapeutic applications in cancer, inflammation and cardiovascular disease The Canadian Glycomics Network (GlycoNet) aims to use the study of carbohydrates to improve human health. Find more information at www.glyconet.ca.

Glycomics is the study of carbohydrates or sugars in biological systems. Learn how glycomics research at GlycoNet is helping to better understand rare genetic diseases which impacts more than 600 million people worldwide. Glycomics presents an opportunity to develop novel treatments for rare genetic diseases that arise from deficiencies in sugar metabolism, such as Gaucher’s disease and Fabry’s disease. Understanding the biochemical and molecular basis of single gene disorders has led to therapeutic strategies for rare diseases and a realization that the development of many common disorders involves altered glycosylation pathways. Developing therapies for rare diseases thus potentially impacts common disorders. The Canadian Glycomics Network (GlycoNet) aims to use the study of carbohydrates to improve human health. Find more information at www.glyconet.ca.