2016

(NaturalHealth365) Discover how extra virgin olive oil can help reduce the risk of heart attack and stroke. Learn about its benefits.

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Background/Objectives: Fucoidan, a sulfated polysaccharide derived from marine algae, is known for its antioxidant and immunomodulatory properties. Galectin-3 (Gal-3), a protein associated with cardiovascular fibrosis, has been identified as a potential therapeutic target in cardiac remodeling. This study aimed to evaluate whether fucoidan could inhibit Gal-3 activity and mitigate cardiac remodeling in a mouse model of pressure overload-induced cardiac hypertrophy. Methods: To test this hypothesis, we used transverse aortic constriction (TAC) surgery to induce pressure overload in normotensive mice, replicating the pathological features of cardiac hypertrophy. Mice were treated with fucoidan at a dose of 1.5 or 7.5 mg/kg/day. In vivo assessments of cardiac function, fibrosis, inflammation, and Gal-3 expression were performed. Results: Pressure overload led to significant upregulation of serum Gal-3 levels, increased cardiac collagen deposition, and elevated markers of fibrosis and inflammation. In mice treated with fucoidan, these effects were significantly attenuated. Fucoidan treatment prevented the upregulation of Gal-3, reduced collagen deposition, and decreased inflammatory cell infiltration, suggesting an inhibition of both fibrosis and inflammation. Conclusions: Fucoidan effectively mitigated the adverse effects of pressure overload in this mouse model, including reduced Gal-3 expression, fibrosis, and inflammation. These findings suggest that fucoidan holds promise as a therapeutic agent for preventing or delaying cardiac remodeling and associated complications, such as fibrosis and inflammation, in pressure overload-induced cardiac hypertrophy. Further research is needed to explore the underlying mechanisms and clinical applicability of fucoidan in cardiac disease.

Nonalcoholic fatty liver disease (NAFLD), characterized by hepatic lipid deposition, is one of the most prevalent chronic metabolic disorders globally, and its pharmaceutical treatments are still limited. Excessive lipid accumulation triggers endoplasmic reticulum (ER) stress and autophagy flux dysfunction, which are important mechanisms for NAFLD. Trehalose (Tre), a natural disaccharide, has been identified to reduce hepatic steatosis and glucose intolerance. However, its underlying mechanisms for NAFLD remain unclear. In this study, a high-fat-diet (HFD)-induced mouse NAFLD model and a saturated fatty acid palmitic acid (PA)-stimulated cell model were constructed. The results indicated that Tre supplementation ameliorated hepatocyte lipid deposition in vitro, as well as hepatic steatosis and hyperlipidemia in vivo. Mechanistically, Tre alleviated both autophagy flux dysfunction and endoplasmic reticulum (ER) stress. Under the stimulation of HFD or PA, Tre remarkably increased the expression and nucleic translocation of the lysosomal master protein transcription factor EB (TFEB), while decreasing the accumulation of p62 and also decreasing the ER stress markers (inositol-requiring enzyme 1 (IRE1α), XBP-1, CHOP, and BIP). Similar results were observed in an ER stressor tunicamycin (TM)-induced in vivo and in vitro models. In addition, the transcriptomic analysis of NAFLD patients revealed significant differences in ER stress-related and autophagy-related biomarkers, including TFEB, ATG7, IRE1α, and CHOP. Molecular docking results demonstrated a strong affinity between Tre and both IRE1α and TFEB. Overall, Tre protected hepatocytes from lipotoxicity-related ER stress and autophagy dysfunction, and its regulatory effect on the IRE1α–TFEB signaling pathway may be a critical mechanism. These findings suggest that Tre, as a bioactive substance with significant medicinal potential, holds considerable promise for drug development and clinical application in treating NAFLD.

What was the world like as it recovered from the worldwide Flood of Noah's day? Geologist Dr. John Whitmore and our host Dr. Del Tackett visit an ancient lakebed in Wyoming that just may reveal the answer! While a barren wasteland today, fossils left behind show that this region was lush, tropical, and very wet, and home to far more plants and animals than are present in modern-day Wyoming! "Beyond Is Genesis History? Vol 4. Mountains After the Flood" is the fourth installment in the popular series of short films that go deeper into the science and scholarship behind the Biblical book of Genesis. These fascinating extended interviews include many new things that have never been discussed before on film. Watch the full film "Is Genesis History? Mountains After the Flood": https://youtu.be/hqIWhyEIxmc "Is Genesis History?" is a documentary series that reveals how science intersects with the Bible. In over a hundred videos, scientists and scholars explore the evidence for creation in six normal days, a real Adam and Eve, a global Flood, a tower of Babel, a young earth, and hundreds of other fascinating aspects of God’s creation. Dr. Del Tackett serves as your guide in this amazing series that has impacted millions of people worldwide. Start with the feature film, then go where your interests lead you. Learn more at https://isgenesishistory.com Watch the original film "Is Genesis History?": https://youtu.be/UM82qxxskZE Watch the other "Beyond Is Genesis History?" series: - Vol 1 - Rocks & Fossils: https://www.youtube.com/playlist?list=PLEVsU6O-XMpGHKna3DpTkYPkn5kZ0MVy5 - Vol 2 - Life & Design: https://www.youtube.com/playlist?list=PLEVsU6O-XMpG_bxzfI68CZhPy9f4TqN2y - Vol 3 - Bible & Stars: https://www.youtube.com/playlist?list=PLEVsU6O-XMpGp3x9qnWu7Ndt4i9psZYMA

(NaturalHealth365) Rates of nonalcoholic fatty liver disease are surging worldwide. A review shows the potential of berberine against NAFLD.

With G Band, you can review your health data and manage smart wearable device.

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Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

As a sixth grader, Vogel participated in a hearing test. The only problem – she never heard the proverbial beeps. Vogel was hearing impaired and without the means or insurance to secure hearing aids. Fast forward to her mid-20s, and Vogel finally experienced the power of sound. Vogel shares her journey and the impact of the high costs of hearing aids on adolescent addiction and suicidal ideation. It’s time to listen. Christy Vogel is passionate about her mission to ignite joy in everyone she meets. She's been leaving her mark in the industry by providing her clients with expert marketing talent and results-oriented programs to help them reach their goals. With over 25 years of marketing experience, Christy understands how vital marketing leadership can be to the success of any corporation. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx

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Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

(NaturalHealth365) Green leafy vegetables can slow down cognitive decline by more than a decade. Learn which ones are the best.

(NaturalHealth365) VOCs are highly toxic substances that contaminate the air you breathe, especially at night if you're not careful.

Hyperbaric oxygen (HBO2) treatment is used across a range of medical specialties for a variety of applications, particularly where hypoxia and inflammation are important contributors. Because of its hypoxia-relieving and anti-inflammatory effects ...

The Healing Hut Clinic offers multiple treatments and protocols in for Hyperbaric oxygen treatment. This treatment has been used in cellular healing since the 1800s. It helps with repairing the tissue within the body by saturation the cells with oxygen. Definition: Hyperbaric Oxygen Chamber Therapy (HBOT) is a treatment that involves a patient breathing oxygen […]

Hyperbaric oxygen therapy could help improve functioning and symptoms in some children with cerebral palsy.

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OPENING SUMMER of 2024 Located in Boise, Idaho at THE IDAHO OUTDOOR FIELDHOUSE Steven N. Wyman MD, FACEP MEDICAL DIRECTOR Davin Strang HSD, MSOL, PMP DIRECTOR OF HYPERBARICS & SAFETY We are changing the face of well-being for our military veterans, challenged athletes, and first responders. Summit Hyperbarics & Wellness is bringing state-of-the-art hyperbaric chambers […]

Heal, recover & rejuvenate faster with our Hyperbaric Oxygen Chambers. Breath ambient oxygen at our Eagle Idaho clinic. 208-926-6613

How Hyperbaric Oxygen Works Most illnesses and injuries occur, and often linger, at the cellular or tissue level. In many cases, such as circulatory problems, non-healing wounds, and strokes, adequate oxygen cannot reach the damaged area and the body’s natural healing ability is unable to function properly. The delivery of 100% oxygen under pressure during […]

Alpine Wellness Clinic offers Mild Hyperbaric Chamber therapy, a treatment designed to enhance oxygen delivery to the body's tissues. This therapy is beneficial for a wide range of health conditions.

Learn about Hyperbaric Oxygen Therapy (HBOT) and how it can enhance healing and boost your immune system. Book your session now!

Kubota Vision is committed to translating innovation into a diverse portfolio of drugs and devices to preserve and restore vision for millions of people worldwide.

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