2016

9993 bookmarks
Newest
! 1 THE APPROACHING ‘TIDAL WAVE’ OF CANCER - The HighWire
! 1 THE APPROACHING ‘TIDAL WAVE’ OF CANCER - The HighWire
Many have abandoned the media’s desperate attempt to ignore why cancer rates are spiking. Now, the American Cancer Society is sounding the alarm, predicting an 80% increase in tumors by 2050. Meanwhile, independent researchers have stepped up and honed in on credible sources pointing to the mass COVID vaccine rollout in 2021 as the prime […]
·thehighwire.com·
! 1 THE APPROACHING ‘TIDAL WAVE’ OF CANCER - The HighWire
Glucosamine Enhancement of Learning and Memory Functions by Promoting Fibroblast Growth Factor 21 Production
Glucosamine Enhancement of Learning and Memory Functions by Promoting Fibroblast Growth Factor 21 Production
Fibroblast growth factor 21 (FGF21) plays a crucial role in metabolism and brain function. Glucosamine (GLN) has been recognized for its diverse beneficial effects. This study aimed to elucidate the modulation of FGF21 production by GLN and its impact on learning and memory functions. Using both in vivo and in vitro models, we investigated the effects of GLN on mice fed with a normal diet or high-fat diet and on mouse HT22 hippocampal cells, STHdhQ7/Q7 striatal cells, and rat primary cortical neurons challenged with GLN. Our results indicated that GLN promotes learning and memory functions in mice and upregulates FGF21 expression in the hippocampus, cortex, and striatum, as well as in HT22 cells, STHdhQ7/Q7 cells, and cortical neurons. In animals receiving GLN together with an FGF21 receptor FGFR1 inhibitor (PD173074), the GLN-enhanced learning and memory functions and induction of FGF21 production in the hippocampus were significantly attenuated. While exploring the underlying molecular mechanisms, the potential involvement of NF-κB, Akt, p38, JNK, PKA, and PPARα in HT22 and NF-κB, Akt, p38, and PPARα in STHdhQ7/Q7 were noted; GLN was able to mediate the activation of p65, Akt, p38, and CREB in HT22 and p65, Akt, and p38 in STHdhQ7/Q7 cells. Our accumulated findings suggest that GLN may increase learning and memory functions by inducing FGF21 production in the brain. This induction appears to be mediated, at least in part, through GLN’s activation of the NF-κB, Akt, p38, and PKA/CREB pathways.
·mdpi.com·
Glucosamine Enhancement of Learning and Memory Functions by Promoting Fibroblast Growth Factor 21 Production
Nicotine - The Other "N" Word
Nicotine - The Other "N" Word
In this podcast episode, Dr. Ardis explores the controversial topic of nicotine, challenging commonly held beliefs about its addictiveness and highlighting its potential benefits for health. He discus
·rumble.com·
Nicotine - The Other "N" Word
Sean Hashmi MD - YouTube
Sean Hashmi MD - YouTube
Hello, dear friends! I'm Dr. Sean Hashmi, founder of SELF Principle, a community focused on the latest research in nutrition, longevity, health, wellness, and kidney disease. As a father, husband, and kidney disease specialist, my journey in medicine began with personal loss and my family's health struggles. These experiences ignited my passion to explore the healing power of nutrition and wellness. Here, we'll delve into scientific insights, engaging expert interviews, and real stories. More than just learning, this channel is about connecting, growing, and supporting one another on the path to better health. Your thoughts, challenges, and triumphs matter to me, so please SUBSCRIBE and join our VIP list by hitting the bell. Together, we'll embark on a journey toward understanding, compassion, and wellness. With heartfelt gratitude, Sean Hashmi, MD, MS, FASN
·youtube.com·
Sean Hashmi MD - YouTube
Plant Based Kidney Health - YouTube
Plant Based Kidney Health - YouTube
Learn about your kidneys, how to protect them, and what to eat when you have kidney disease! Dr. Sean Hashmi is a Board Certified Nephrologist and Michele Crosmer is a Registered Dietitian and Certified Specialist in Renal Nutrition. We hope to educate and empower you to take control of your health and make proactive lifestyle choices to protect kidney health! Thanks so much for subscribing to our channel! Sean Hashmi, MD, MS, FASN and Michele Crosmer, RD, CSR
·youtube.com·
Plant Based Kidney Health - YouTube
Allulose Reduces Hypertrophy and Endoplasmic Reticulum Stress Induced by Palmitic Acid in Murine 3T3-L1 Adipocytes
Allulose Reduces Hypertrophy and Endoplasmic Reticulum Stress Induced by Palmitic Acid in Murine 3T3-L1 Adipocytes
Natural rare sugars are an alternative category of sweeteners with positive physiologic and metabolic effects both in in vitro and animal models. D-allulose is a D-fructose epimer that combines 70% sucrose sweetness with the advantage of an extremely low energy content. However, there are no data about the effect of D-allulose against adipose dysfunction; thus, it remains to be confirmed whether D-allulose is useful in the prevention and in treatment of adipose tissue alterations. With this aim, we evaluated D-allulose’s preventive effects on lipid accumulation in 3T3-L1 murine adipocytes exposed to palmitic acid (PA), a trigger for hypertrophic adipocytes. D-allulose in place of glucose prevented adipocyte hypertrophy and the activation of adipogenic markers C/EBP-β and PPARγ induced by high PA concentrations. Additionally, D-allulose pretreatment inhibited the NF-κB pathway and endoplasmic reticulum stress caused by PA, through activation of the Nrf2 pathway. Interestingly, these effects were also observed as D-allulose post PA treatment. Although our data need to be confirmed through in vivo models, our findings suggest that incorporating D-allulose as a glucose substitute in the diet might have a protective role in adipocyte function and support a unique mechanism of action in this sugar as a preventive or therapeutic compound against PA lipotoxicity through the modulation of pathways connected to lipid transport and metabolism.
·mdpi.com·
Allulose Reduces Hypertrophy and Endoplasmic Reticulum Stress Induced by Palmitic Acid in Murine 3T3-L1 Adipocytes
Is the April 8 Eclipse a Symbol of Divine Judgment or Not - The Ultimate Analysis - YouTube
Is the April 8 Eclipse a Symbol of Divine Judgment or Not - The Ultimate Analysis - YouTube
Is the April 8 Eclipse a Symbol of God's Judgment or not? It IS the most anticipated eclipse in history with the National Guard already called out to control the crowds. But how can we decide if it's a sign from God or that judgment is coming? Click here to watch this Nelson Walters video to discover how to decide if it's a warning of God's judgment on the USA and when that might happen. This video contains AI images from our AI Artist team including Christian Vichi, Robert Forsbach, Jonathan Merrill, Jason Lawrence, and FreethroughChrist
·youtube.com·
Is the April 8 Eclipse a Symbol of Divine Judgment or Not - The Ultimate Analysis - YouTube
Testifying to the Resurrection - with Dr. Fred Baltz - YouTube
Testifying to the Resurrection - with Dr. Fred Baltz - YouTube
AUDIO ONLY: Timothy Mahoney concludes his discussion with Dr. Fred Baltz about the Sudarium of Oviedo, believed by many to be the burial face cloth of Jesus referenced in the Gospel of John, Chapter 20. What kind of scientific analysis was used to study the Sudarium and what did the team conducting the analysis find? What additional connections have been made between the Sudarium and the Shroud of Turin? What does it mean for us today if these cloths are authentic? NOTE: This episode (Episode 2) is available on YouTube as audio only, please consider joining our Patterns+ platform to see the video version. In doing so you will receive special weekly content on Bible affirming evidence from the realms of archaeology and science, as well as theological subjects. Your subscription will also support us in the production of new Patterns of Evidence films. Help us continue to share and preserve the historical credibility of the Bible and evidence. JOIN NOW: https://digitalpatternsofevidence.vhx.tv/checkout/subscribe/purchase ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ -- Patterns of Evidence Quick Links -- ► SHOP ONLINE - https://store.patternsofevidence.com/ ► BECOME A MEMBER - https://digitalpatternsofevidence.vhx.tv/historical-faith-society ► DONATE - https://patternsofevidence.com/donations/ ► THINKER UPDATES - https://patternsofevidence.com/sign-up/ ► PRESS INQUIRIES - https://patternsofevidence.com/press/ ► PATTERNS+ - https://digitalpatternsofevidence.vhx.tv/checkout/subscribe/purchase -- Find us on Social Media -- ► Facebook - https://www.facebook.com/PatternsofEvidence ► Twitter - https://twitter.com/pattofevidence ► Instagram - https://www.instagram.com/patternsofevidence/ ► YouTube - https://www.youtube.com/patternsofevidence ► LinkedIn - https://www.linkedin.com/company/patterns-of-evidence
·youtube.com·
Testifying to the Resurrection - with Dr. Fred Baltz - YouTube
Two Main MTHFR Variants Explained: MTHFR C677T and MTHFR A1298C - YouTube
Two Main MTHFR Variants Explained: MTHFR C677T and MTHFR A1298C - YouTube
Discussing the two main MTHFR variations and our personal experiences with them in my recent podcast with Karalynne Call @just.ingredients.podcast The two main MTHFR variants are MTHFR C677T and A1298C. These MTHFR variants are also called MTHFR mutations, MTHFR polymorphisms, MTHFR SNPs. Want to learn more about the MTHFR gene and 7 other really important ones? Read Dr. Lynch's book, Dirty Genes: https://amzn.to/3TQh1yI StrateGene Report: Interpret over 100 genetic variations over 9 different pathways using your 23andme, Ancestry or SelfDecode raw data https://www.seekinghealth.com/products/strategene-report SHEI Membership: Monthly live calls with Dr. Lynch along with 100+ hours of Dr. Lynch’s conferences on genetics and epigenetics https://www.seekinghealth.com/products/membership Instagram: @DrBenLynch
·youtube.com·
Two Main MTHFR Variants Explained: MTHFR C677T and MTHFR A1298C - YouTube
Anti-tumor activity of fucoidan is mediated by nitric oxide released from macrophages - PubMed
Anti-tumor activity of fucoidan is mediated by nitric oxide released from macrophages - PubMed
Fucoidan, a sulfated polysaccharide, has significant cytotoxic activity against tumor cells; however, the mechanism(s) of this action remains poorly understood. The present study was designed to determine the in vitro and in vivo effects of fucoidan and their molecular mechanisms. Fucoidan from Clad …
·pubmed.ncbi.nlm.nih.gov·
Anti-tumor activity of fucoidan is mediated by nitric oxide released from macrophages - PubMed
Low molecular-weight fucoidan protects against hindlimb ischemic injury in type 2 diabetic mice through enhancing endothelial nitric oxide synthase phosphorylation - PubMed
Low molecular-weight fucoidan protects against hindlimb ischemic injury in type 2 diabetic mice through enhancing endothelial nitric oxide synthase phosphorylation - PubMed
This study demonstrates that LMWF alleviates hindlimb ischemic damage, at least in part by promoting eNOS phosphorylation, nitric oxide production, and VEGF expression, resulting in enhanced angiogenesis in the ischemic region.
·pubmed.ncbi.nlm.nih.gov·
Low molecular-weight fucoidan protects against hindlimb ischemic injury in type 2 diabetic mice through enhancing endothelial nitric oxide synthase phosphorylation - PubMed
Immunomodulatory and Anti-Inflammatory Effects of Fucoidan: A Review - PMC
Immunomodulatory and Anti-Inflammatory Effects of Fucoidan: A Review - PMC
Inflammation is the initial response of the immune system to potentially harmful stimuli (e.g., injury, stress, and infections). The process involves activation of macrophages and neutrophils, which produce mediators, such as nitric oxide (NO), prostaglandin ...
·ncbi.nlm.nih.gov·
Immunomodulatory and Anti-Inflammatory Effects of Fucoidan: A Review - PMC
Up-and-coming anti-epileptic effect of aloesone in Aloe vera: Evidenced by integrating network pharmacological analysis, in vitro, and in vivo models - PubMed
Up-and-coming anti-epileptic effect of aloesone in Aloe vera: Evidenced by integrating network pharmacological analysis, in vitro, and in vivo models - PubMed
Background: Aloe vera is a medically valuable plant with anti-epileptic activity; however, its mechanism of action remains unknown. In this study, network pharmacological, in vitro, and in vivo experiments were carried out to explore the potential anti-epileptic component …
·pubmed.ncbi.nlm.nih.gov·
Up-and-coming anti-epileptic effect of aloesone in Aloe vera: Evidenced by integrating network pharmacological analysis, in vitro, and in vivo models - PubMed