Effect of dapagliflozin as an adjunct to insulin over 52 weeks in individuals with type 1 diabetes: post-hoc renal analysis of the DEPICT randomised controlled trials - PubMed
Long-term efficacy and safety of dapagliflozin in patients with inadequately controlled type 1 diabetes: pooled 52-week outcomes from the DEPICT-1 and -2 studies - PubMed
Over 52 weeks, dapagliflozin provided glycaemic and weight benefits, with no increased frequency of severe hypoglycaemia compared with placebo. More DKA events were reported with dapagliflozin than placebo, highlighting the importance of appropriate patient selection, education and risk-mitigation s …
Does Bible Give Us Clues Who PLANNED Trump Conspiracy? NOT WHO YOU THINK! - YouTube
Does the Bible give us clue who planned the Trump shooting? Yes, and it's not who you think? What evidence do we have that Thomas Michael Crooks had help? Where was the second shooter located? Click here to watch this extraordinary Nelson Walters video to help make sense of recent events in the USA AND what to overcome the events in our near future.
Long-term (52-week) efficacy and safety of dapagliflozin as an adjunct to insulin therapy in Japanese patients with type 1 diabetes: Subgroup analysis of the DEPICT-2 study - PubMed
Efficacy and safety results from the Japanese subpopulation of the DEPICT-2 study were generally consistent with those from the overall population, indicating that long-term dapagliflozin adjunct to insulin therapy improves glycaemic control without an increased risk of hypoglycaemia but with a risk …
Efficacy and safety of the SGLT2 inhibitor dapagliflozin in type 1 diabetes: A meta-analysis of randomized controlled trials - PubMed
Sodium glucose cotransporter-2 (SGLT2) is a sodium-dependent glucose transporter responsible for renal absorption of glucose. Dapagliflozin is an SGLT2 inhibitor used in patients with type 1 diabetes to promote urinary glucose excretion, but to date, randomized controlled trials (RCTs) to evaluate t …
Dapagliflozin: an effective adjunctive treatment in type 1 diabetes - PubMed
Dapagliflozin as adjunctive therapy to basal-bolus regime insulin in individuals with T1DM was well tolerated and improved glycemic control with no increase in hypoglycemia. We provide further evidence of the value of this intervention.
Effect of short-term use of dapagliflozin on impaired awareness of hypoglycaemia in people with type 1 diabetes - PubMed
Eight weeks of treatment with dapagliflozin did not restore hypoglycaemic awareness in people with T1DM and impaired awareness of hypoglycaemia, but ameliorated some clinical aspects.
Dapagliflozin as an Adjunct Therapy to Insulin in Patients with Type 1 Diabetes Mellitus: Efficacy and Safety of this Combination - PubMed
The prevalence of type 1 diabetes (T1D) is increasing worldwide. T1D reduces life expectancy due to complications including cardiovascular disease. Sodium-glucose co-transporter (SGLT) inhibitors are a new class of drugs developed to treat type 2 diabetes (T2D), and now they can be used as an adjunc …
Dr. Ben Carson: The Left’s Worship of Kamala Harris, and God’s Mission for Donald Trump - YouTube
How was Kamala Harris transformed from an embarrassing incompetent to the coolest, most inspirational leader in the world in a single day? Dr. Ben Carson on America’s North Korean media landscape.
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Bible Identifies the 10 NATIONS of the ANTICHRIST KINGDOM (Revelation and Psalms) - YouTube
Who are the 10 horns of the Beast, the 10 nations that make up the core of the Antichrist Kingdom? Looking at Revelation and Psalms TOGETHER, the answer beco...
Fucoidan from Laminaria japonica protects renal tubular epithelial cells from uric acid induced NLRP3-mediated pyroptosis through inhibition of NF-κB pathway - ScienceDirect
Hyperuricemia is a common metabolic disease with prominent morbidity, it can lead to many adverse effects and complications, such as chronic nephrosis…
Sean Hannity: President Biden and Vice President Kamala Harris have blood on their hands - YouTube
Fox News host Sean Hannity unpacks Vice President Kamala Harris' record as she seeks the presidency on 'Hannity.'
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The Mystery of the Essenes | Ken Johnson & Josh Peck - YouTube
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Interview with Chief Joseph RiverWind (Genesis Apologetics) - YouTube
To kickoff our new movie--"Out of Babel" (www.outofbabel.com), we wanted to interview our Native American consultants for the movie and friends, Chief Joseph RiverWind—a descendant of the Arawak Taino Tribe—and his wife, Dr. Laralyn of the Cherokee and Muskogee Creek. They tell a story about their special Journey to Israel were some meaningful things happened. Chief Joseph and Laralyn can be supported by visiting Firekeepers International (https://www.firekeepersinternational.org/)
! 1 Dapagliflozin Pharmacokinetics Is Similar in Adults With Type 1 and Type 2 Diabetes Mellitus - PubMed
Dapagliflozin improves glycemic control in patients with type 2 diabetes mellitus (T2DM) and is approved in Japanese patients with type 1 diabetes mellitus (T1DM) with inadequate glycemic control. The objectives of this work were to characterize the dapagliflozin pharmacokinetics (PK) in patients wi …
A Network Meta-Analysis of the Dose-Response Effects of Dapagliflozin on Efficacy and Safety in Adults With Type 1 Diabetes - PubMed
Dapagliflozin 10 mg could achieve a better outcome in efficacy and could not increase the risk of hypoglycemia. Although it may induce a higher risk of DKA and genital infection, there was no significant difference between dapagliflozin 10 mg and 5 mg. Our outcomes indicate that dapagliflozin 10mg h …
Insulin dose reduction in dapagliflozin combination therapy for type 1 diabetes mellitus: the RISING-STAR study - PubMed
To clarify the frequency of hypoglycemia in patients with type 1 diabetes mellitus receiving dapagliflozin combination therapy to reduce their basal insulin dose. Sixty subjects were assigned to two groups according to their basal insulin-to-total daily dose (TDD) ratio: group A (basal insulin/TDD & …
A Possible Novel Effect for Dapagliflozin in the Management of Subcutaneous Insulin Resistance Syndrome: A Report of Two Cases - PubMed
These are the first reported cases of SIRS in which dapagliflozin, an SGLT-2 inhibitor, was used. The substantial reduction in the IM insulin dose following the addition of dapagliflozin in our reported cases of SIRS suggests a possible novel mechanism for dapagliflozin beyond its glucosuric effects …
Clinical studies of dapagliflozin in pediatric patients: a rapid review - PubMed
The oral sodium-glucose cotransporter 2 inhibitor, dapagliflozin, is used to treat kidney disease, heart failure, and diabetes in adults, but has not been well studied in pediatrics, and does not have a recognized place in therapy in current practice guidelines. The purpose of this review is to summ …
Efficacy of Low-dose Dapagliflozin in Young People with Type 1 Diabetes - PubMed
Objective Young people with type 1 diabetes are likely to gain body weight and not achieve optimal glycemic control with only high doses of insulin. This study examined the efficacy of the sodium-glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin as an adjunct-to-insulin therapy in young Japane …
Therapeutic effect and rebound evaluation of dapagliflozin on glycated hemoglobin (HbA1c) in type 1 diabetes mellitus patients - PubMed
Dapagliflozin has been used to treat patients with type 1 diabetes mellitus; however, the actual drug efficacy of dapagliflozin on glycated hemoglobin (HbA1c) and whether there is a rebound from dapagliflozin efficacy on HbA1c remain unknown. The present study aimed to explore the actual therapeutic …
The prophetic implications of Iran & Proxies vs. Israel - YouTube
This 15 minute video is filled with prophetic morsels and topped off with Marsalus sauce. LA Marzulli connects with Bill Salus at the Prophecy Watchers Colorado Conference in June 2024. Although a short visit, they covered several topics including, the destruction of Damascus in Isaiah 17, Iran and its potential nuclear capabilities, Ezekiel 38 and also the Rapture.
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! 1 Benefit or Risk in Patient with Type 1 Diabetes Based on Appropriated Dosage of Dapagliflozin: A Case Report - PubMed
Purpose: Dapagliflozin has been used extensively in patients with type 2 diabetes mellitus (T2DM). However, due to the potential diabetic ketoacidosis (DKA) risk of dapagliflozin, its use in type 1 diabetes mellitus (T1DM) is limited. Here, we reported an obese patient with T1DM and inadequat …
! 1 Effects of dapagliflozin on renal function in type 1 diabetes patients in the real world: A retrospective multicenter study of the KAMOGAWA-A cohort - PubMed
At 24 months, the decline in eGFR was significantly lower in the dapagliflozin group than in the non-use group without increasing diabetic ketoacidosis and hypoglycemia.