2016

(NaturalHealth365) Research shows a chemical found in a popular artificial sweetener causes DNA damage. Discover the study findings.

Angiogenesis and metastasis represent two challenging targets to combat cancer development in the later stages of its progression. Numerous studies have indicated the important role of natural products in blocking tumor angiogenesis signaling pathways in several advanced tumors. In recent years, the marine polysaccharides fucoidans emerged as promising anticancer compounds showing potent antitumor activity in both in vitro and in vivo models of different types of cancers. The objective of this review is to focus on the antiangiogenic and antimetastatic activities of fucoidans with special emphasis on preclinical studies. Independently from their source, fucoidans inhibit several angiogenic regulators, primarily vascular endothelial growth factor (VEGF). A glance towards fucoidans’ ongoing clinical trials and pharmacokinetic profile is provided to present the main challenges that still need to be addressed for their bench-to-bedside translation.

Background: Humans with hypertensive heart disease are more likely to experience heart failure, arrhythmia, myocardial infarction, and sudden death, and it is crucial to treat this condition. Fucoidan (FO) is a natural substance derived from marine algae that has antioxidant and immunomodulatory activities. FO has also been shown to regulate apoptosis. However, whether FO can protect against cardiac hypertrophy is unknown.Methods: We investigated the effect of FO in hypertrophic models in vivo and in vitro. C57BL/6 mice were given an oral gavage of FO (300 mg/kg/day) or PBS (internal control) the day before surgery, followed by a 14-day infusion of Ang II or saline. AC-16 cells were treated with si-USP22 for 4 h and then treated with Ang II (100 nM) for 24 h. Systolic blood pressure (SBP) was recorded, echocardiography was used to assess cardiac function, and pathological changes in heart tissues were assessed by histological staining. Apoptosis levels were detected by TUNEL assays. The mRNA level of genes was assessed by qPCR. Protein expression was detected by immunoblotting.Results: Our data showed that USP22 expression was lowered in Ang II-infused animals and cells, which could promote cardiac dysfunction and remodeling. However, treatment with FO significantly upregulated the expression of USP22 and reduced the incidence of cardiac hypertrophy, fibrosis, inflammation, and oxidative responses. Additionally, FO treatment lowered p53 expression and apoptosis while incre...

Aloe vera is a perennial, succulent cacti with cosmopolitan distribution. This plant holds a long history of usages in recovering different

Pesticide exposure can pose a serious risk to nontarget animals. Cartap is being broadly used in agricultural fields. The toxic effects of cartap on the levels of hepatotoxicity and neurotoxicity have not been properly studied in mammalian systems. Therefore, the present work focused on the effect of cartap on the liver and brain of Wistar rats and made an assessment of the ameliorating potential of A. vera. The experimental animals were divided into 4 groups, comprising six rats in each: Group 1—Control; Group 2—A. vera; Group 3—Cartap; and Group 4—A. vera + Cartap. The animals orally given cartap and A. vera were sacrificed after 24 h of the final treatment and histological and biochemical investigations were conducted in liver and brain of Wistar rats. Cartap at sublethal concentrations caused substantial decreases in CAT, SOD, and GST levels in the experimental rats. The activity levels of transaminases and phosphatases in cartap group were also found to be substantially altered. The AChE activity was recorded as decreasing in RBC membrane and brain of the cartap-treated animals. The TNF-α and IL-6 level in serum were increased expressively in the cartap challenged groups. Histological investigation of liver showed disorganized hepatic cords and severely congested central veins due to cartap. However, the A. vera extract was observed to significantly protect against the effects of cartap toxicity. The protective impact of A. vera against cartap toxicity may be due to the existence of antioxidants in it. These findings suggest that A. vera may be developed as a potential supplement to the appropriate medication in the treatment of cartap toxicity.

Learn why eating a Paleo-ish diet is backed by cutting edge nutritional research, and how the immune system affects weight and health.

Kickstart your Keto journey now; learn the steps to Keto success, test and track your glucose & ketones to measure ketosis, and get fantastic Keto recipes.

2018 Interview Dorian Greenow, also known as Mister Mojo, is the cofounder of Keto-Mojo, viewed by many experts as the best strategy to measure your ketone levels. While ketones can be measured by blood, breath or urine testing, blood testing is th…

Dr Buttar Info Home Page

It is with sadness, yet great appreciation, that we pay tribute to my friend and colleague Dr. Rashid Buttar, who passed away on May 18th.

Today I talked to the Co-Hosts of Talk Truth, Allan Hunsperger and Corri Hunsperger about my interview with the late Dr. Rashid Buttar. Talk Truth: www.talktruth.ca ☆ We no longer can trust our mainst

On May 1st the Centers for Medicare & Medicaid Services announced it will “soon end” its COVID vaccination mandate for healthcare workers.

(NaturalHealth365) Pfizer and BioNTech were recently exposed as fraudulent enterprises willing to bend the truth for financial gain.

(NaturalHealth365) FDA advisory panel green lights highly controversial shot for pregnant women. Learn the details here.

(NaturalHealth365) Professor of Oncology issues dire warning about mRNA COVID boosters, insisting risks far outweigh benefits.

(NaturalHealth365) A group of health experts is set to investigate the extent of COVID jab injuries. But how objective will they be?

(NaturalHealth365) Concerns over COVID shot safety mount as the number of post-jab adverse events increase.

(NaturalHealth365) FDA’s leaked presentation shows agency expected many COVID jab-related adverse events and failed to disclose them.

(NaturalHealth365) An MIT professor is speaking out against the mRNA COVID jabs, publicly calling for a halt to the jab program.

So-called "long Covid" is turning out to be a devastating condition for an incredibly large number of individuals around the world. It's been estimated that ...

Rue plant extract may treat COVID-19, according to new clinical research.

The “Pandemic” hasn’t ended… It’s JUST begun. The New Global Pandemic Treaty poses a major threat to our freedom and health… New VIRUSES. New TRACKING SYSTEMS. New DIGITAL CURRENCIES. But…There is “NEW HOPE” and New Freedom Register now for a limited time, FREE viewing of this breakthrough 9-episode docuseries. Enter your email address to access […]

The “Pandemic” hasn’t ended… It’s JUST begun. The New Global Pandemic Treaty poses a major threat to our freedom and health… New VIRUSES. New TRACKING SYSTEMS. New DIGITAL CURRENCIES. But…There is “NEW HOPE” and New Freedom Register now for a limited time, FREE viewing of this breakthrough 9-episode docuseries. Enter your email address to access […]

Dr. Sabine Hazan, MD, a gastroenterologist and world leading expert in the microbiome discusses her research on the relationship between {ov!d and the GI tra...