2016

These are the first reported cases of SIRS in which dapagliflozin, an SGLT-2 inhibitor, was used. The substantial reduction in the IM insulin dose following the addition of dapagliflozin in our reported cases of SIRS suggests a possible novel mechanism for dapagliflozin beyond its glucosuric effects …

The oral sodium-glucose cotransporter 2 inhibitor, dapagliflozin, is used to treat kidney disease, heart failure, and diabetes in adults, but has not been well studied in pediatrics, and does not have a recognized place in therapy in current practice guidelines. The purpose of this review is to summ …

The prevalence of type 1 diabetes (T1D) is increasing worldwide. T1D reduces life expectancy due to complications including cardiovascular disease. Sodium-glucose co-transporter (SGLT) inhibitors are a new class of drugs developed to treat type 2 diabetes (T2D), and now they can be used as an adjunc …

Dapagliflozin as adjunctive therapy to basal-bolus regime insulin in individuals with T1DM was well tolerated and improved glycemic control with no increase in hypoglycemia. We provide further evidence of the value of this intervention.

AstraZeneca.

Eight weeks of treatment with dapagliflozin did not restore hypoglycaemic awareness in people with T1DM and impaired awareness of hypoglycaemia, but ameliorated some clinical aspects.

Sodium glucose cotransporter-2 (SGLT2) is a sodium-dependent glucose transporter responsible for renal absorption of glucose. Dapagliflozin is an SGLT2 inhibitor used in patients with type 1 diabetes to promote urinary glucose excretion, but to date, randomized controlled trials (RCTs) to evaluate t …

Objective Young people with type 1 diabetes are likely to gain body weight and not achieve optimal glycemic control with only high doses of insulin. This study examined the efficacy of the sodium-glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin as an adjunct-to-insulin therapy in young Japane …

To clarify the frequency of hypoglycemia in patients with type 1 diabetes mellitus receiving dapagliflozin combination therapy to reduce their basal insulin dose. Sixty subjects were assigned to two groups according to their basal insulin-to-total daily dose (TDD) ratio: group A (basal insulin/TDD & …

Efficacy and safety results from the Japanese subpopulation of the DEPICT-2 study were generally consistent with those from the overall population, indicating that long-term dapagliflozin adjunct to insulin therapy improves glycaemic control without an increased risk of hypoglycaemia but with a risk …

Over 52 weeks, dapagliflozin provided glycaemic and weight benefits, with no increased frequency of severe hypoglycaemia compared with placebo. More DKA events were reported with dapagliflozin than placebo, highlighting the importance of appropriate patient selection, education and risk-mitigation s …

Diabetic kidney disease is a worldwide epidemic, and therapies are incomplete. Clinical data suggest that improved renal outcomes by Na+-glucose cotransporter 2 inhibitor (SGLT2i) are partly beyond their antihyperglycemic effects; however, the mechanisms are still elusive. Here, we invest …

Dapagliflozin treatment benefits to reduce HbA1c and FPG for type 1 diabetes.

Dapagliflozin has been used to treat patients with type 1 diabetes mellitus; however, the actual drug efficacy of dapagliflozin on glycated hemoglobin (HbA1c) and whether there is a rebound from dapagliflozin efficacy on HbA1c remain unknown. The present study aimed to explore the actual therapeutic …

Currently, there are insufficient or conflicting data regarding interventions evaluated in clinical trials for mitigation of vascular calcification in people with CKD. Therapy involving magnesium or sodium thiosulfate appears most promising, but evaluable studies were small and of short duration.

CKD animals exhibited depletion of the key protein constituents of the colonic epithelial TJ which was associated with systemic inflammation, oxidative stress and endotoxemia. Administration of AST-120 attenuated uremia-induced disruption of colonic epithelial TJ and the associated endotoxemia, oxid …

Itching along with other problems can be one of the factors exacerbating the sufferings and disturbing the comfort of patients with chronic renal failure. The present research aimed to study the effects of omega-3 on the treatment of uremic pruritus in hemodialysis (HD) patients. In this crossover r …

Hyperuricemia is a common metabolic disease with prominent morbidity, it can lead to many adverse effects and complications, such as chronic nephrosis…

Chronic kidney disease (CKD) exhibits progressive kidney dysfunction and leads to disturbed homeostasis, including accumulation of uremic toxins, activated renin-angiotensin system, and increased oxidative stress and proinflammatory cytokines. Patients ...

In this week's episode of The Dr. Ardis Show, Dr. Bryan Ardis presents a groundbreaking topic titled "The Venom Industrial Complex." Dr. Ardis is excited to share this comprehensive presentation, whic

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How Strength Training Boosts the Brain Get my Free Guide: 11 Science-Backed Steps to Help Boost Memory and Prevent Dementia https://www.austinperlmutter.com/memoryguide Full blog: https://www.austinperlmutter.com/post/how-weightlifting-boosts-your-brain Regular exercise lowers the risk of brain issues like depression and Alzheimer’s disease. Resistance training should also be considered for its brain health benefits. Benefits of Strength Training for Brain Health: 1. Better brain health in those who engage in resistance training. 2. Improved brain function, particularly in the elderly, from starting weightlifting. 3. Cognitive improvements in people with cognitive decline after resistance training. 4. Decreased depressive symptoms observed through resistance training. 5. Regulation of Metabolic Balance and Immunity seem to be key Tips for Effective Resistance Training: Start light and gradually increase weight. Consider working with a trainer for guidance. Group classes can boost motivation and provide social benefits. Resistance bands offer a versatile and effective alternative. Pay attention to your body to avoid injuries. Include leg exercises for maximum benefit. Ensure adequate protein intake and consider creatine supplementation for muscle and brain health. Check out my newsletter! https://www.austinperlmutter.com/newsletter This content is not intended to diagnose, treat, cure, or prevent disease. The information provided by this video should not be used as individual medical advice. You should always consult your healthcare provider for individual recommendations and treatment. #exercise #weightlifting #neuroscience

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(NaturalHealth365) A recent study uncovers surprising effects of dehydration on cognitive performance. Here is what you need to know.

Are the 10 Horns on the Beast, the 10 Lost Tribes of Israel? How could anyone say this? Well there are 10 horns on the beast and 10 tribes from Israel's northern kingdom. And there are 2 horns on the second beast or false prophet and 2 tribes from Israel's southern kingdom. Coincidence? If this theory is true, see how it revolutionizes many Bible prophecies such as the toes of iron and clay mixed, and the theory the Antichrist is from the tribe of Dan. Click here to watch this jaw-dropping theory and discover what the implications are of a Beast Empire made up of both Gentiles and Israelites This video contains AI images from our AI Artist team including Christian Vichi, Robert Forsbach, Jonathan Merrill, Jason Lawrence, Nelson, and FreethroughChrist

One of the most downloaded songs in America is about the book of Revelation. John Rich says he channeled the entire thing from God.Watch more here: https://w...