2016

Is Israel’s war with Hamas part of a deeper spiritual battle? JNS CEO and Jerusalem bureau chief Alex Traiman sits down with Tim Ballard, former CIA analyst,...

The monstrous lie of transgender medicine reveals that most of the establishment has little brains, soul, or character.

For daily episodes, insight, and analysis like this, SUBSCRIBE to The Charlie Kirk Show TODAY: https://apple.co/2VCxGshAnd for EVEN MORE—tune in to The Charl...

The world has undergone some shocking changes over the past five years. And many recognize that this could mean that the return of Jesus Christ is drawing ne...

7 Biblical prophecies are converging RIGHT NOW! Are we in the Tribulation?? Seven prophetic signs happening at the same time. Does this CONFIRM the Covenant ...

Tucker Carlson put out an interview with a middle eastern nun attacking Israel, Christian supporters of Israel, the Rapture, the Second Coming, the Millenniu...

In this week’s episode of The Dr. Ardis Show, Dr. Bryan Ardis reveals the shocking truth about stevia, the so-called "natural" sweetener hiding in your drinks, snacks, and supplements. You’ve been tol

Men’s testosterone has been declining for over 50 years. Among 28 compounds tested, 7 yielded a measurable increase in testosterone in humans.

Epigenetic modifications act as crucial regulators of gene activity and are influenced by both internal and external environmental factors, with diet being the most impactful external factor. On the other hand, cellular metabolism encompasses a complex network of biochemical reactions essential for maintaining cellular function, and it impacts every cellular process. Many metabolic cofactors are critical for the activity of chromatin-modifying enzymes, influencing methylation and the global acetylation status of the epigenome. For instance, dietary nutrients, particularly those involved in one-carbon metabolism (e.g., folate, vitamins B12 and B6, riboflavin, methionine, choline, and betaine), take part in the generation of S-adenosylmethionine (SAM), which represents the main methyl donor for DNA and histone methylation; α-ketoglutarate and ascorbic acid (vitamin C) act, respectively, as a co-substrate and cofactor for Ten-eleven Translocation (TET), which is responsible for DNA demethylation; and metabolites such as Acetyl-CoA directly impact histone acetylation, linking metabolism of the TCA cycle to epigenetic regulation. Further, bioactive compounds, such as polyphenols, modulate epigenetic patterns by affecting methylation processes or targeting epigenetic enzymes. Since diet and nutrition play a critical role in shaping epigenome functions and supporting human health, this review offers a comprehensive update on recent advancements in metabolism, epigenetics, and nutrition, providing insights into how nutrients contribute to metabolic balance, epigenome integrity maintenance and, consequently, disease prevention.

Pfizer’s 107 documented penalties span fraud, false marketing, bribery — and $11 billion in fines. Now it’s rewarded with an agreement to “cure” cancers its own mRNA shots helped unleash.

Why did the FDA relentlessly suppress all evidence of vaccine injuries?

The Alliance of Indigenous Nations International Tribunal — recognized by Canada on a Nation-to-Nation basis — has issued a historic global Order intended to take immediate worldwide effect.

A possible marketing stunt to boost collapsing mRNA shot uptake after inking a $70 billion deal with Pfizer.

South Korea study of 8.4 million adults finds higher risks of overall, lung, prostate, thyroid, gastric, colorectal, and breast cancers — across both mRNA and viral-vector platforms.

Analysis of Florida health data reveals Pfizer’s mRNA shot alone may have caused more U.S. deaths than any war in modern history.

Landmark preclinical study shows intranasal ivermectin nanocapsules safely shrink glioblastoma in animal models at doses lower than the approved human antiparasitic dose.

Discover a natural cardiology protocol to unclog arteries, reverse heart disease, and restore vascular health without invasive procedures.

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The mainstream media could EASILY do a quick survey like I did to independently confirm the link. But they won't because they don't want to know the truth that they've been misleading you.

Exploring how suppressing acute but manageable symptoms can transform them into significantly more severe illnesses.

How Environmental Toxins, Diagnostic Manipulation, and Vaccine-Derived Paralysis Challenge the Conventional Narrative of History's Most Celebrated Public Health Victory

Dying of Liver Failure While Making a Political Statement

Forgotten news segments show how widely acknowledged vaccine injuries were before the media was bought out by the pharmaceutical industry

The renowned security expert and investigator reveals the "Forbidden Facts" the U.S. government has concealed for decades.

Parkinson's disease is exploding, with cases rising an astonishing 60% faster than Alzheimer's when adjusted for age. But what if it's not an inevitable part...

Decades of neglect in understanding the actual causes of dementia have transformed it into one of the most costly diseases in existence.

Background: Aging is associated with chronic diseases and increased oxidative stress, particularly affecting liver function. Aging is linked to chronic diseases and heightened oxidative stress, particularly impacting liver function. Recent research has demonstrated that oral administration of trehalose offers multiple benefits for various tissues and organs.Methods: This study investigated the effects of oral trehalose (2% in water) on the gene expression of key markers linked to liver oxidative stress and inflammation in 4-month-old adult and 24-month-old Wistar rats. Thirty-two male Wistar rats (n = 8) were randomly assigned into four groups: adult control, aged control, adult trehalose (2% in water), and aged trehalose, over a treatment period of one month. Following treatment, liver tissues were analyzed using real-time PCR for genes related to oxidative stress (PGC-1α, NRF2, and SOD) and inflammation (NF-κB, IL-1β, TNF-α, and TGF-β).Results: Our findings revealed a significant up-regulation of PGC-1α, NRF2, and SOD in aged trehalose group compared to the aged control (P < 0.001); however, SOD expression increased by trehalose administration in aged rats compared to other 3 groups. Inflammatory markers (NF-κB, IL-1β, TNF-α) were significantly reduced by trehalose, and TGF-β expression, involved in fibrosis, was attenuated exclusively in aged rats compared with controls (P < 0.05).Conclusion: These results suggest that trehalose has a protective effect on hepatic function, particularly in the aging population, and highlight its potential therapeutic role in age-associated liver dysfunction.

This review explores the pharmacological potential of chondroitin sulfate and fucoidan as immunomodulatory agents targeting N-acetylgalactosaminidase (nagalase) to normalize immune responses. Nagalase, an enzyme produced by tumor and virus-infected cells, contributes to immune suppression by deactivating macrophage-activating factor. Both chondroitin sulfate and fucoidan, as representatives of glycosaminoglycans and heteropolysaccharides, exhibit significant potential in inhibiting nagalase activity, thereby restoring immune functionality. Chondroitin sulfate, a key component of the extracellular matrix, demonstrates anti-inflammatory and tissue-regenerative properties by modulating nuclear factor (NF)-κB pathways and cytokine expression. Fucoidan, a sulfated polysaccharide derived from brown seaweed, enhances immune responses through macrophage and natural killer cell activation, while also exhibiting antiviral and anticancer activities. This dual action positions these compounds as promising agents for therapeutic interventions in chronic inflammatory conditions, cancer, and infectious diseases. The synergistic effects of chondroitin sulfate and fucoidan highlight their potential to address the root causes of immune dysregulation. This review aims to elucidate the underlying mechanisms of action and explore the clinical applications of these compounds within the framework of innovative immunotherapeutic strategies. However, current evidence is limited by the predominance of preclinical studies and variability in experimental models. Well-designed clinical trials are needed to validate their efficacy for therapeutic use.

This review explores the pharmacological potential of chondroitin sulfate and fucoidan as immunomodulatory agents targeting N-acetylgalactosaminidase (nagalase) to normalize immune responses. Nagalase, an enzyme produced by tumor and virus-infected cells, contributes to immune suppression by deactivating macrophage-activating factor. Both chondroitin sulfate and fucoidan, as representatives of glycosaminoglycans and heteropolysaccharides, exhibit significant potential in inhibiting nagalase activity, thereby restoring immune functionality. Chondroitin sulfate, a key component of the extracellular matrix, demonstrates anti-inflammatory and tissue-regenerative properties by modulating nuclear factor (NF)-κB pathways and cytokine expression. Fucoidan, a sulfated polysaccharide derived from brown seaweed, enhances immune responses through macrophage and natural killer cell activation, while also exhibiting antiviral and anticancer activities. This dual action positions these compounds as promising agents for therapeutic interventions in chronic inflammatory conditions, cancer, and infectious diseases. The synergistic effects of chondroitin sulfate and fucoidan highlight their potential to address the root causes of immune dysregulation. This review aims to elucidate the underlying mechanisms of action and explore the clinical applications of these compounds within the framework of innovative immunotherapeutic strategies. However, current evidence is limited by the predominance of preclinical studies and variability in experimental models. Well-designed clinical trials are needed to validate their efficacy for therapeutic use.

This study investigated the anti-obesity and anti-inflammatory effects of D-Allulose compared to erythritol in high-fat diet (HFD)-fed mice, focusing …