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Mucopolysaccharidosis (MPS) consists of a group of 11 enzymatic defects which result in accumulation of undegraded glycosaminoglycans (GAG) in lysosomes. MPS is a severe metabolic disease for which only bone marrow/hematopoietic stem cell transplantation ...

Today was not the first time Sen. Rand Paul (R-KY) and Dr. Anthony Fauci clashed in a Senate hearing. READ MORE: https://www.forbes.com/sites/joewalsh/2021/07/20/fauci-and-rand-paul-accuse-each-other-of-lying-in-tense-testimony-over-covid-origins/?sh=623da6e64c73 Stay Connected Forbes on Facebook: http://fb.com/forbes Forbes Video on Twitter: http://www.twitter.com/forbes Forbes Video on Instagram: http://instagram.com/forbes More From Forbes: http://forbes.com

The lead author of a now retracted research note that claimed children's masks trapped dangerously high concentrations of carbon dioxide has said that JAMA Pediatrics' decision to pull the paper was politically motivated.

America’s Frontline Doctors filed a motion on July 19, seeking immediate injunctive relief to stop the emergency use authorization (EUA) for COVID-19 vaccines.

Trehalose is a disaccharide of two D-glucose molecules linked by a glycosidic linkage, which plays both structural and functional roles in bacteria. Trehalose can be synthesized and degraded by several pathways, and induction of trehalose biosynthesis ...

Spinal cord injury (SCI) is a major cause of irreversible nerve injury and leads to serious tissue loss and neurological dysfunction. Thorough investigation of cellular mechanisms, such as autophagy, is crucial for developing novel and effective therapeutics. We administered trehalose, an mTOR-independent autophagy agonist, in SCI rats suffering from moderate compression injury to elucidate the relationship between autophagy and SCI and evaluate trehalose’s therapeutic potential. 60 rats were divided into 4 groups and were treated with either control vehicle, trehalose, chloroquine, or trehalose + chloroquine 2 weeks prior to administration of moderate spinal cord crush injury. 20 additional sham rats were treated with control vehicle. H&E staining, Nissl staining, western blot, and immunofluorescence studies were conducted to examine nerve morphology and quantify autophagy and mitochondrial-dependent apoptosis at various time points after surgery. Functional recovery was assessed over a period of 4 weeks after surgery. Trehalose promotes autophagosome recruitment via an mTOR-independent pathway, enhances autophagy flux in neurons, inhibits apoptosis via the intrinsic mitochondria-dependent pathway, reduces lesion cavity expansion, decreases neuron loss, and ultimately improves functional recovery following SCI (all ). Furthermore, these effects were diminished upon administration of chloroquine, an autophagy flux inhibitor, indicating that trehalose’s beneficial effects were due largely to activation of autophagy. This study presents new evidence that autophagy plays a critical neuroprotective and neuroregenerative role in SCI, and that mTOR-independent activation of autophagy with trehalose leads to improved outcomes. Thus, trehalose has great translational potential as a novel therapeutic agent after SCI.

Aloe vera (L.) Burm. f. is a typical traditional Chinese medicine (TCM) collected in the Pharmacopoeia of the People's Republic of China (version 2015…

Do you know your vitamin D level? If not, getting your blood tested—and optimizing your levels—is one of ...

The $1 Billion Whistleblower Search; International Vaccine Mandates Start; W.H.O. Insider Exposes Pandemic Response; The Ultimate Proof Masks Don’t Work! Guest: Astrid Stuckelberger, PhD #TheCovidCartel #WHO #Tedros #UnMaskUs #CovidVaccineWhistleblower ORIGINAL AIR-DATE: July 15, 2021

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ICAN wrote to the Chief of California’s OSHA to request that, to the extent that CAL OSHA’S recommendations will allow less stringent mask rules for fully vaccinated individuals, those less […]

Compared with a usual diet supplemented with low-fat healthy-eating guidelines, patients on the ketogenic diet improved in daily function and quality of...

A new theory for the causes of dementia and other neurodegenerative diseases has been developed, involving an out-of-control immune system.

Contrary to mainstream medical belief, safe, natural, and nontoxic treatments can alleviate the symptoms of senile dementia. Research has demonstrated how these remedies can aid in preventing the onset of senile dementia.

More than 40% of dementia diagnoses have been shown to be wrong. Here's what may really be going on.

Contrary to mainstream medical belief, safe, natural, and nontoxic treatments can alleviate the symptoms of senile dementia. Research has demonstrated how these remedies can aid in preventing the onset of senile dementia.