The anti-cancer effects of Aloe vera barbadensis extract C (AVBEC) have been demonstrated in a previous study. However, the specific functional ingred…

Revista Brasileira de Farmacognosia - Diabetes mellitus is defined as prolonged hyperglycemia, which can harm the eyes, kidneys, and cardiovascular and neurological systems. Herbal agents and their...

Protective agent for hepatotoxicity is still a great challenge in the management of liver diseases. Aloe vera is a beneficial plant that has been studied for food supplements, cosmetic and herbal medicine. Aloe vera contains many compounds which have a role in body health including polysaccharides, phenolic, flavonoid, terpenoid, amino acid, and several minerals. There have been compelling evidences that natural phytochemicals and their derivatives have hepatoprotective activities. Information of the aloe vera and its mechanism of action for possible hepatoprotective activities, including in silico, in vitro, and in vivo studies were obtained from Pubmed, Science Direct, Scopus, and Google scholar search engines. This current review was focusing on the possible contribution of compounds inside aloe vera gel and the suggestion of its mechanism on protective effect, especially for liver. The complexity of monosaccharides composition, backbone structures, acetyl group, and molecular weight of aloe polysaccharides have possible correlations with its hepatoprotective effect. Most of the hepatoprotective mechanisms of aloe compounds are related to their protective effect against inflammation and oxidative stress. Several compounds may have combination effects or several targets lead to synergistic effects. Keywords: Aloe vera, food supplement, hepatoprotective, liver disease, mechanism of action.

Aloe vera products, both in food and cosmetics, are becoming increasingly popular due to their claimed beneficial effects, which are mainly attributed to the active compound acemannan. Usually, these end products are based on powdered starting materials. High temperatures during the drying process to obtain the starting materials have several advantages, like shortening the drying time, eliminating toxic aloin and reducing bacterial contamination. Nevertheless, there are two major drawbacks: first, at temperatures of 80 °C or higher, structural changes in acemannan, especially its deacetylation (>46%), are triggered, which does not happen at lower temperatures (14% at 60 °C); secondly, a toxic principle is formed at higher temperatures, resulting in a higher cytotoxicity. Thus, two temperature-dependent but opposing effects cause with a median cytotoxic concentration of CC50 = 0.4× a peak of cytotoxicity at 80 °C; at 60 °C this cytotoxic substance is not formed and at 100 °C aloin is more readily eliminated, resulting in a CC50 = 1.1× and CC50 = 1.4×, respectively. The cytotoxic substance generated by dry heat at 80 °C is not a modified polysaccharide because its polysaccharide-enriched alcohol-insoluble fraction is with CC50 = 0.9× less cytotoxic. Moreover, this substance is polar enough to be washed away with ethanol. Additionally, when Aloe gel is heated at 80 °C under humid conditions (pasteurization), the cytotoxicity does not increase (CC50 = 1.6×). Finally, to produce powdered starting materials from Aloe gel, it is recommended to use temperatures of around 60 °C in order to preserve the acemannan structure (and thus biological activity) and the low cytotoxicity.

Objective: To compared efficacy of alpha lipoic acid (antioxidant medication) and aloe vera gel together versus intralesional steroids (hydrocortisone) in management of oral submucous fibrosis by evaluating post treatment clinical features of mouth opening and burning sensation. Study Design: A prospective comparative study. Place and Duration of Study: Department of ENT, Combined Military Hospital, Malir Karachi, from Jul 2018 to Mar 2020. Methodology: Twenty-eight patients were involved in the research and were distributed into two groups, I and II. Alpha lipoid acid with aloe vera gel was given in group I and hydrocortisone was given in group II. Burning sensation and mouth opening were recorded both at start and at monthly interval later on for three consecutive months. The data collected were statistically analyzed by using SPSS-22. Results: A significant lessening in burning sensation (p

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The purpose of this study was to determine the effectiveness of aloe vera juice against stomach acid. Aloe vera also contains key elements such as resin, aloin, tannins, aloin-emodin, polysaccharides, 19 amino acids, 12 vitamins and 20 minerals that are important for health. Aloe vera is a natural ingredient that is good for detoxifying heavy metals in the body, and is able to maximize the performance of the digestive system. consuming aloe vera juice in a certain dose, is very effective for healing wounds in the stomach, as well as being a natural remedy for stomach ulcers which is quite effective. Aloe vera has the ability to stimulate the release of pepsin, which is an enzyme in the stomach that works to support the digestive system

Background: Rheumatoid arthritis is a chronic inflammatory disease of autoimmune etiology. Current treatment includes non-steroidal anti-inflammatory drugs, selective cyclooxygenase-2 inhibitors, glucocorticoids, and disease-modifying antirheumatoid drugs, newer agents such as tumor necrosis factor-α inhibitors, and monoclonal antibodies have adverse effects such as peptic ulcer, renal toxicity, and hematological toxicity. Moreover, they are expensive when used on a long-term basis. Hence, it is necessary to find out the new cost effective as well as less toxic drug as alternative. Aim and Objective: The present study was taken up to evaluate antiarthritic activity of Aloe vera aqueous extract (AVE) in Wistar albino rats when used orally. Materials and Methods: A total 36 no. of healthy Wistar albino rats of weight 100–200 mg were used and divided into six different groups containing six rats in each. Into subplantar region of hind paw of all rats except normal control, 0.1 mL of complete Freund’s adjuvant (6 mg Mycobacterium butyricum suspended in heavy paraffin oil) was injected for induction of arthritis. The rats were treated with vehicle (gum acacia), standard drugs (indomethacin and dexamethasone) and test drug, that is, AVE 125 mg/kg, 250 mg/kg for 12 days. The rats were evaluated by measuring the % increase in paw edema volume and paw thickness (joint diameter), assessing the biophysical parameters (arthritic score), hematological parameters erythrocyte sedimentation rate, rheumatoid factor, and histopathological study of joints (arthritic index) for testing the antiarthritic potential. Results: AVE 250 mg/kg showed significant antiarthritic property as that of standard indomethacin and dexamethasone in terms of reduction in inflammation and arthritic scores. Conclusion: AVE at 250 mg/kg offered significant protection against arthritis and inflammation and can be a safer alternative for long term use.

Background. Aloe vera has long been considered an anticancer herb in different parts of the world. Objective. To explore the potential mechanism of aloe vera in the treatment of cancer using network pharmacology and molecule docking approaches. Methods. The active ingredients and corresponding protein targets of aloe vera were identified from the TCMSP database. Targets related to cancer were obtained from GeneCards and OMIM databases. The anticancer targets of aloe vera were obtained by intersecting the drug targets with the disease targets, and the process was presented in the form of a Venn plot. These targets were uploaded to the String database for protein-protein interaction (PPI) analysis, and the result was visualized by Cytoscape software. Go and KEGG enrichment were used to analyze the biological process of the target proteins. Molecular docking was used to verify the relationship between the active ingredients of aloe vera and predicted targets. Results. By screening and analyzing, 8 active ingredients and 174 anticancer targets of aloe vera were obtained. The active ingredient-anticancer target network constructed by Cytoscape software indicated that quercetin, arachidonic acid, aloe-emodin, and beta-carotene, which have more than 4 gene targets, may play crucial roles. In the PPI network, AKT1, TP53, and VEGFA have the top 3 highest values. The anticancer targets of aloe vera were mainly involved in pathways in cancer, prostate cancer, bladder cancer, pancreatic cancer, and non-small-cell lung cancer and the TNF signaling pathway. The results of molecular docking suggested that the binding ability between TP53 and quercetin was the strongest. Conclusion. This study revealed the active ingredients of aloe vera and the potential mechanism underlying its anticancer effect based on network pharmacology and provided ideas for further research.

Aloe vera extract and its bioactive compounds possess anti-proliferative properties against cancer cells. However, no detailed molecular mechanism of …

Mukesh Kumar Sharma1,2*, Jagat Chauhan1, Mohan Kumar1, Chetan Kumar Joshi3, Sandeep Sharma4 and Chhagan Lal5 Article: 7205 Full Text

One of the simplest and safest ways to treat diabetes is exercise regularly and Consumption of herbal medicines that have few side effects. The aim of this study was to evaluate the effect of high-intensity interval training with aloe vera supplementation on some selected adipokines in type 2 diabetic men. In this quasi-experimental study, 44 men with type 2 diabetes (mean age 25-40 years) were randomly divided into four groups (n=11) of control, aloe vera, exercise and exercise- aloe vera groups. High-intensity interval training were performed 3 sessions per week for 12 weeks. Subjects received an aloe vera capsule containing 100 mg of aloe vera gel powder in the morning immediately after waking up and one capsule after dinner. Blood samples and anthropometric characteristics were obtained before and after the intervention. Data were analyzed using two-way ANOVA with repeated measures, t-test and Tukey post hoc test at P

Introduction: Anti-inflammatory compounds are effective in improving the symptoms of inflammatory bowel diseases such as ulcerative colitis. The aim of this study was to evaluate the effect of aloe vera extract on the inflammatory factors affecting acetic acid-induced ulcerative colitis. Materials and Methods: 32 male Wistar rats are divided in ...

ABSTRACTBackground: Acrylamide, an industrial chemical found in many industrial applications as well as for chemical and environmental purposes. The Aloe vera plant Known for many years and was known and used for its health, beauty, medicinal and skin care properties. The name Aloe vera derives from the Arabic word “Alloeh” meaning “shining bitter substance,” while “vera” in Latin means “true.” 2000 years ago.Objective: The aim of the study was to evaluate the role of the Aloe vera extract and its influence on experimental lesions in the jujenal mucosa caused by Acrylamide.Materials and Method: Thirty adult female albino rats were used and divided equally into three groups (10 rat/eachgroup): (I)control group. (II)Acrylamide treated group (5 mg/kg/day). (III) Acrylamide&Aloe vera treatedgroup (0.4 ml/100g).The experiment extended for 3 weeks, thejejunum samples were collected, prepared and studded by light microscope and scanning electron microscope.Results: This study revealed that acrylamide administration to rats induces pathological changes in the jejunum in the form of the fused villi;irregular mucosal folds; cellular infiltration and thickened discontinued muscularis externa, with electron microscopic study there were areas of erosion and ulceration of the villi with loss of the normal picture . Administration of Aloe vera gel restored the normal architecture of the villi and crypts with normal appearance of most layers, scanning electron microscopy showed intact epithelium withgoblet cells openings discharging mucus.Conclusion:Acrylamide markedly affect the jujenal mucosa as seen by light and electron microscope, Aloe vera gel administration can protect the mucosa from this harmful effect.Keywords: Acrylamide, Aloe vera, jejunum, Rats.

Decontamination of air, soil, and water polluted with dangerous mercury, cadmium, arsenic, and chromium by plants is called phytoremediation. As a living plant, Aloe vera was used to clean up the soil, water and air contaminated with dangerous heavy metals and gas. Aloe vera plant and the waste powder occurred from aloe vera gel processing, were applied for phytoremediation in which Aloe vera was proposed as a cost-effective plant-based approach of environmental remediation. Bioleaching is a process of extracting metals from their ores through the use of living microorganisms. Endophytic bacteria in Aloe vera gel could be used as bioleaching of heavy metals. Furthermore the detoxification of heavy metals and hepato-therapeutic effects by Aloe vera was focused specially on hepatic fibrosis and chronic kidney diseases. Case reports showed the suppression of gall bladder hypertrophy and ureteral stone by aloe vera supplements.

Cardiovascular diseases (CVDs) comprise the most prevalent causes of morbidity and mortality in both men and women worldwide. CVDs are associated with several risk factors such as hyperlipidemia, dia...

Aloe vera is a functional food with various pharmacological functions, including an immune-modulating effect. Until now, A. vera has never been studie…

Aloe barbadensis Miller, commonly known as Aloe vera has been used since time immemorial for treatment of various diseases such as cancer, inflammator…

Aloe vera (L.) Burm. f. is a typical traditional Chinese medicine (TCM) collected in the Pharmacopoeia of the People's Republic of China (version 2015…

This study aimed to investigate the interactive effect of aloe vera intake and eight weeks’ aerobic exercise on serum BDNF, glucose, and insulin levels in women with type 2 diabetes. In this experimental study, 32 women with type 2 diabetes were selected and randomly divided into four groups of control, supplement, exercise, exercise + supplement. The exercise program was performed 3 sessions per week for 8 weeks (40 min of exercise with 50-60% of heart rate reserve in the first four weeks and 60 min of exercise with 60-80% of heart rate reserve in the second four weeks). The supplement taking groups received 400 mg/kg of oral aloe Vera 3 days per week for 8 weeks. The data were analyzed using analysis of covariance (ANCOVA). A significant increase was observed in BDNF levels, insulin sensitivity of patients in the supplement, exercise, and exercise + supplement groups (p=0.001). The glucose and insulin levels, insulin resistance, BMI, and body fat percentage significantly decreased in the supplement, exercise, and exercise + supplement groups (p=0.001). It seems aloe Vera intake and aerobic exercise to have protective effects against development of type 2 diabetes complications in women.

ScholarWorks@Gachon: The Role of Processed Aloe vera Gel in Intestinal Tight Junction: An In Vivo and In Vitro Study