Aloe vera (Aloe barbadensis) is a perennial, drought-resisting, succulent plant belonging to Liliaceae family.

Aloe vera gel is a potential material as raw material industry, this is because a very complex composition. However Aloe vera gel is very easily oxidized or unstable. Viscosity gel and the benefit are decreased at room temperature after 24-36 hours. This research aims to obtain information about the resistance to oxidation via nitogren gas treatment and antioxidants, as well as the influence of phase changes in an attempt to retain the characteristics of the physicochemical Aloe vera gel over time. This Study can be described a conclusion that the best storage conditions are sound-proofed temperature conditions (4 ± 1)oc. Environmental conditioning by administering nitrogen gas storage and antioxidant Buthylated Hydroxytoluene (BHT) 750 ppm for 4 weeks defending the nature physicochemical Aloe vera gel. Freeze drying process of Aloe vera gel that has filled gum Arabic 3 % generates a more homogenous powder and smaller and more.

The pretreatment of aqueous extract of Aloe vera leaf in rats proved to act as a potential antioxidant which could be implicated toward protection of the integrity of liver of rat against pesticide i...

Aloe vera leaf contains some bioactive compounds that have a strong binding affinity toward estrogen receptor as compared to standard drug tamoxifen. In this study, we have found that the IC50 of Aloe vera leaf extract against breast cancer cell line (MCF-7) is 23 µg/mL whic …

Aloe vera attenuated IMN-induced gastropathy in rats by the reduction of oxidative stress, inflammation, and improvement of gastric histopathology.

Food industries typically use Aloe vera as concentrated (100× to 200×) and dried powders in their final products. These powders are obtained by extrusion of Aloe inner leaf gel (ILG) or Aloe whole leaf (WLP); the juice is filtered through diatomaceous earth and activated carbon before spray drying at temperatures below 70 °C. In another process, Aloe inner leaf gel was dried at ~80 °C and mashed to a powder rich in high molecular weight fibres and soluble polysaccharides (ILF). In contrast to ILG and WLP, the ILF sample was cytotoxic for the human intestinal cell line Caco-2 (CC50 = 1 g/l), even at concentrations below the recommended dose for human consumption. At lower concentrations (250 mg/l) with LPS challenged macrophage-like THP-1 cells decreased by 40% the release of the anti-inflammatory cytokine IL-10, whereas the release of the proinflammatory cytokine IL-1β increased by 35% (compared to untreated but challenged macrophage-like THP-1 cells). Unexpectedly, under the same conditions, the less cytotoxic ILG and WLP, both samples with a lower fibre content, significantly increased (up to 2.4 times) the release of IL-10, while the concentration of IL-1β remained unaltered and of TNFα decreased by 35%. Even more interesting is that a treatment of the ILF sample with activated carbon reduced its cytotoxicity and increased the IL-10 release (3.1 times). Based on these results, we suggest applying an activated carbon treatment on Aloe-starting products, which have high fibre content and have received high temperature treatment, in order to reduce their cytotoxicity and improve their immunomodulatory properties.

Background: Intensive care units (ICUs) admissions due to sepsis represent 2 to 11%. Although there are well stablished  therapeutic available, it still is the major cause of death in most ICUs and the leading cause of acute kidney injury. The objective of this work was to evaluate the role of Aloe vera extract on survival rates and kidney histopathology of mice submitted to sepsis induced by cecal ligation and puncture. Methods and Findings: Twenty six mice were distributed into four groups: Sham - surgery simulation (N=5); Control - Cecal ligation and puncture was performed (N=7); Aloe - Surgery simulation and treatment with Aloe vera extract (N=7); and Sepsis + Aloe - Cecal ligation and puncture was performed followed by treatment with Aloe vera extract (N=7). The animals were observed until death. Kidneys were analysed by histopathology. Kruskall-Wallis test was used to compare the histopathological results. Survival analysis was assessed by Kaplan-Meier statistics and compared using log rank test. A significance level of 5% was adopted. The survival time ranged from 19 hours for the Control group up to 24 hours for the animals of Sepsis + Aloe group, corresponding to a survival time of 1.26 times greater (p0.05). Conclusions: Aloe vera extracts delays mortality but does not attenuate kidney injury in sepsis induced by cecal ligation and puncture in mice.

Aloe vera (Aloe barbadensis Miller) is a perennial succulent medicinal plant. It has been used as a traditional or folk medicine for thousands of year…

Aloe vera contains multiple pharmacologically active substances which are capable of modulating cellular phenotypes and functions. Aloe vera ethanol and ethyl acetate extracts may be used in eye drops to treat inflammations and other ailments of external parts of the eye such as the cornea.

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Metabolic syndrome (MS) is a highly prevalent health problem worldwide and is associated with different risk factors, including hyperglycemia, dyslipidemia, hypertension, and obesity. This condition ...

SARS-CoV-2 is the pathogen agent of the new corona virus disease that appeared at the end of 2019 in China. There is, currently, no effective treatmen…

Introduction Aloe Vera is a plant that belongs to the Aasphodelacea (Liliaceae) family has been used as an herbal medicine for centuries. It is native to Africa and many Mediterranean countries and is used for several healing purposes, like treating various skin disorders such as abcesses, burns and eczema. Its juice

Cervical cancer is a public health problem and is well-known as the fourth most common cancer and the fourth major cause of cancer-associated death in women in the developing countries [1].

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An allergic reaction occurs when the immune system overreacts to harmless substance called allergen that gains access to the body. Food allergy is a hypersensitive immune reaction to food proteins and the number of patients with food allergy has recently increased. Aloe Vera is used for wellness and …

Aloe vera has been traditionally used to treat skin injuries (burns, cuts, insect bites, and eczemas) and digestive problems because its anti-inflammatory, antimicrobial, and wound healing properties. Research on this medicinal plant has been aimed at validating traditional uses and deepening the mechanism of action, identifying the compounds responsible for these activities. The most investigated active compounds are aloe-emodin, aloin, aloesin, emodin, and acemannan. Likewise, new actions have been investigated for Aloe vera and its active compounds. This review provides an overview of current pharmacological studies (in vitro, in vivo, and clinical trials), written in English during the last six years (2014–2019). In particular, new pharmacological data research has shown that most studies refer to anti-cancer action, skin and digestive protective activity, and antimicrobial properties. Most recent works are in vitro and in vivo. Clinical trials have been conducted just with Aloe vera, but not with isolated compounds; therefore, it would be interesting to study the clinical effect of relevant metabolites in different human conditions and pathologies. The promising results of these studies in basic research encourage a greater number of clinical trials to test the clinical application of Aloe vera and its main compounds, particularly on bone protection, cancer, and diabetes.

Based on activation of macrophages and vaccine adjuvant activity by aloe polysaccharide or acemannan, we showed that the importance of butyrate and host-micRNA-microbiota interaction in regulation of gut immunity, and butyrate is a chemical factor capable of facilitating induced pluripotent stem cell generation, an important step for the establishment of pluripotency. Furthermore we exhibited three case reports on the beneficial roles of aloe vera juice-successive ingestion as nutritional and medicinal uses to influenza virus and norovirus.

Aloe vera plant extracts are ubiquitous in foods, cosmetics, and medicine. Like all plants, these extracts contain an array of potential bioactives or glycans, ...

Pre-diabetes is a disturbing trend in the population, who are at risk of developing type-two diabetes. The aim of this study was to determine the effects use of Aloe vera in different doses on glucose and lipid profile in pre-diabetic subjects.This study ...