The pretreatment of aqueous extract of Aloe vera leaf in rats proved to act as a potential antioxidant which could be implicated toward protection of the integrity of liver of rat against pesticide i...

Aloe vera has been used as folk medicine for a host of therapeutic indications of which the inner gel is the component extensively used and studied. Proponents of the use of this plant suggest that it is easily available, economical, and have fewer side effects compared to commercial drug compounds. However, the active constituents and their exact mechanisms have yet to be fully elucidated. This review focuses on the identification of the active constituents and their functional mechanism in the areas of anti-diabetic, anti-inflammatory, wound healing, and antibacterial. Preliminary evidence was found to support the antidiabetic effect which extended to the early stages of the disease with no adverse effects at the dosages used. Although topical application for its anti-inflammatory effect may be delayed and minute, oral administration has shown a significant response. However, too high a dose has been linked with an initial inflammatory reaction. Favorable response to the gel has also been demonstrated to support the use of A. vera in wound-healing and as an antibacterial agent, although limited to simple, uncomplicated wounds. Different active constituents such as acemannan and aloin have been suggested for the effects of the plant and this may be interpreted as synergism among different compounds rather than the action of a single compound. Until robust evidence is available, the plant should only be used as an adjunct to other well-established evidence-based treatment modalities.

The medicinal and other claimed uses of Aloe vera, the “wonder plant”, are endless. The extract for phytochemical analysis was collected in three different solvents, diethyl ether, ethanol and distilled water. The anti-fungal activities of the leaf extract were investigated on selected fungi organisms; Trycophytum rubrum, Penicillum notatum, Trycophytum vericophytum, Trycophytum soundanense, Claudosporium and Trycophytum mentagrophytis collected from Mycology Laboratory, University of Nigeria Teaching Hospital, Enugu, Nigeria. The plant extract was collected crude without solvent and agar-well diffusion method employed for the determination of antifungal activities on the test organisms using 200 mg ketoconazole drug as standard. The phytochemical constituents of aloe vera leaf include alkaloids, flavonoids, saponin, phenol, glycosides and tannins. Both undiluted and half diluted crude extract showed different zones of inhibition on the test organisms. The undiluted crude extract of Aloe vera had larger zone of inhibition on Trycophytum rubrum and Trycophytum mentagrophytis than the diluted crude extract while the diluted crude extract showed larger zone of inhibition on Trycophytum vericopytum than the undiluted crude extract.Keywords: Aloe vera, Phytochemicals, Constituents, Antifungal properties

The present study was premeditated to examine the radioprotective effects of aqueous Aloe vera gel extract against whole-body X-ray irradiation–induced hematolo...

An allergic reaction occurs when the immune system overreacts to harmless substance called allergen that gains access to the body. Food allergy is a hypersensitive immune reaction to food proteins and the number of patients with food allergy has recently increased. Aloe Vera is used for wellness and …

Our health span is to a great extent epigenetically determined by diets, gut environment, lifestyle, and various other environmental factors. Health benefits of long-term ingestion of aloe vera gel with immune modulation of the intestinal microbiota were discussed on congenital heart disease and heart failure. In this review, we demonstrated prophylaxes roles of successive ingestion of aloe vera juice on heart failure. Furthermore we presented three case reports on heart failure patients with aloe vera juice adjuvant.

While this plant is fairly common and well-known for its role in sunburn recovery, Aloe Vera is not content taking care of only one or two issues. This plant is a wonderful healing substance with plenty of uses.

Scar preventive dextran based bionanocomposite dressings containing aloe vera (AV) and manuka honey (MH) were developed as wound care devices. This wo…

The processed Aloe vera gel (PAG) contains immunomodulatory polysaccharides, which consists of a mixture of polymer chains of b-(1,4)-linked acetylated galactomannan with different lengths. PAG was shown to inhibit azoxymethane(AOM)-initiated and dextran sodium sulfate(DSS)-promoted colon carcinogenesis model in mice. In the present study, we examined the molecular mechanisms for the inhibition of colitis-associated colon carcinogenesis by PAG. PAG administration significantly inhibited the production of pro-inflammatory cytokines and mediators in the colon. Western blot analysis using the colon extracts showed that PAG administration reduced the activation of NF-kB resulting in the inhibition of iNOS and COX-2 expression. PAG appeared to inhibit NF-kB activation through the PPARγ activation. PAG administration also inhibited the expression and phosphorylation of STAT3, which was known to connect inflammation and cancer. PAG administration also inhibited cell cycle progression-related transcription factors such as the proliferating cell nuclear antigen (PCNA), ERK, cyclin-dependent kinase (CDK) 4 and cyclin D1. In contrast, PAG administration increased the expression of CDX2, which was known to be a tumor suppressor in colorectal cancers. These findings show that PAG suppresses colitis-related colon carcinogenesis by inhibiting both chronic inflammation and cell cycle progression in the colon.

The aloe vera plant has become increasingly popular in recent years. This study aimed to research the effect of aloe vera to prevent renal and lung tissue damage in an experimental ischemia–reperfusion (I/R) injury model. The study included 21 male Wistar Albino rats, which were categorized into control group, n = 7 (no procedures), Sham group n = 7 (I/R); and aloe vera therapy group, n = 7 (aloe vera and I/R). Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and malondialdehyde (MDA) were evaluated from lung and kidney tissues for biochemical investigations. As histopathological, hematoxylin and eosin and anti-iNOS were also examined. In biochemical investigations, SOD, CAT, and GPx levels of the Sham group were found to be lower compared with the other groups (P < 0.05). The aloe vera therapy group was not statistically different from control groups but significantly different compared with the Sham group. In the same way, the MDA levels of kidney and lung tissues were statistically significant in the aloe vera therapy group, compared to the Sham group. In the Sham group, the peribronchial and perialveolar edema were observed in lung parenchyma. Also, excess interstitial hemorrhage, leukocyte infiltration, and alveolar wall thickening were identified in ischemic groups. The histopathological changes were much lighter than in the aloe vera therapy group. In renal tissues, excess epithelial cell deterioration, tubular desqumination, and glomerular atrophy were observed in the Sham group. The histopathological changes were markedly reduced in the aloe vera therapy  group. In the kidney and lung tissue, the level of iNOS activity in the Sham group was significantly higher than in the control and aloe vera therapy group. This study indicated that aloe vera is protective against oxidative damage formed by I/R in distant organs like the lungs and kidneys.

Metabolic syndrome (MS) is a highly prevalent health problem worldwide and is associated with different risk factors, including hyperglycemia, dyslipidemia, hypertension, and obesity. This condition ...

SARS-CoV-2 is the pathogen agent of the new corona virus disease that appeared at the end of 2019 in China. There is, currently, no effective treatmen…

Aim Candida albicans can cause two major types of infections: superficial infections (such as oral or vaginal candidiasis) as well as life-threatening systemic infections, and Aloe vera extract is one of the potentially useful therapeutic options. The aim of this study was to determine …

The efficacy of Aloe vera has been known for various health and disease-related conditions. Butyrate, a well-known epigenetic histone deacetylase inhibitor, is causally implicated in tumorigenesis and tumor angiogenesis. Butyrate was shown to induce cell cycle arrest, differentiation, and apoptosis in a variety of cancer cells. Dietary factors, microbiota composition, and microbiota metabolism are intimately intertwined in a complex network, highlighting the importance of intestinal functions for health maintenance. In the present review, we discuss aloe vera fermentation as a tumor-suppressive process generating microbial-derived butyrate.

Based on activation of macrophages and vaccine adjuvant activity by aloe polysaccharide or acemannan, we showed that the importance of butyrate and host-micRNA-microbiota interaction in regulation of gut immunity, and butyrate is a chemical factor capable of facilitating induced pluripotent stem cell generation, an important step for the establishment of pluripotency. Furthermore we exhibited three case reports on the beneficial roles of aloe vera juice-successive ingestion as nutritional and medicinal uses to influenza virus and norovirus.

Aloe vera plant extracts are ubiquitous in foods, cosmetics, and medicine. Like all plants, these extracts contain an array of potential bioactives or glycans, ...

Pre-diabetes is a disturbing trend in the population, who are at risk of developing type-two diabetes. The aim of this study was to determine the effects use of Aloe vera in different doses on glucose and lipid profile in pre-diabetic subjects.This study ...