Aloe

Objective: Multiple sclerosis (MS) is a self-immune demyelinating disorder of the CNS, followed by neuropathic discomfort, especially in young people in reproductive age. So, This research was conducted with the aim of assessing the protective effect of Aloe vera gel (AVG) extract on histopathologic changes of the ovary and gonadotropin in an experimental MS model of rat. Methods: In this research, 30 pieces of rats of Wistar race were randomly divided into 6 groups of 5. 20 pieces, 14μl of ethidium bromide was injected in their lateral ventricles to induce MS. In 5 pieces as control group 2, 14μL of saline was injected into the lateral ventricles, and the remaining 5 rats were considered as control group 1. Treatment of three groups of rats with MS was performed with AVG extract at 50 mg/kg BW, 100 mg/kg BW 100 and 200 mg/ kg BW. At the end, blood sampling to measure serum FSH and LH, Their ovaries were isolated for microscopic examination. Results: The results of counting the number of ovarian follicles showed a significant decrease in the number of primary and secondary and graafian follicles in group 3, compared to the control group. There is a significant increase in the concentration of FSH and LH in group 3 in comparison to the control group. Conclusion: Finally, It can be said that by inducing MS, The number of ovarian follicles decreased, and the number of atretic follicles and the concentration of gonadotropin hormones increased, and treatment with AVG extract was effective in improving these factors. Bangladesh Journal of Medical Science Vol.19(3) 2020 p.444-452

The aloe vera plant has become increasingly popular in recent years. This study aimed to research the effect of aloe vera to prevent renal and lung tissue damage in an experimental ischemia–reperfusion (I/R) injury model. The study included 21 male Wistar Albino rats, which were categorized into control group, n = 7 (no procedures), Sham group n = 7 (I/R); and aloe vera therapy group, n = 7 (aloe vera and I/R). Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and malondialdehyde (MDA) were evaluated from lung and kidney tissues for biochemical investigations. As histopathological, hematoxylin and eosin and anti-iNOS were also examined. In biochemical investigations, SOD, CAT, and GPx levels of the Sham group were found to be lower compared with the other groups (P < 0.05). The aloe vera therapy group was not statistically different from control groups but significantly different compared with the Sham group. In the same way, the MDA levels of kidney and lung tissues were statistically significant in the aloe vera therapy group, compared to the Sham group. In the Sham group, the peribronchial and perialveolar edema were observed in lung parenchyma. Also, excess interstitial hemorrhage, leukocyte infiltration, and alveolar wall thickening were identified in ischemic groups. The histopathological changes were much lighter than in the aloe vera therapy group. In renal tissues, excess epithelial cell deterioration, tubular desqumination, and glomerular atrophy were observed in the Sham group. The histopathological changes were markedly reduced in the aloe vera therapy  group. In the kidney and lung tissue, the level of iNOS activity in the Sham group was significantly higher than in the control and aloe vera therapy group. This study indicated that aloe vera is protective against oxidative damage formed by I/R in distant organs like the lungs and kidneys.

CAB Direct platform is the most thorough and extensive source of reference in the applied life sciences, incorporating the leading bibliographic databases CAB Abstracts and Global Health

The present investigation was carried out to evaluate the possible radioprotective potential of an Aloe vera extract against whole-body X-ray irradiation-induced testicular alterations in mice. Male ...

The efficacy of Aloe vera has been known for various health and disease-related conditions. Butyrate, a well-known epigenetic histone deacetylase inhibitor, is causally implicated in tumorigenesis and tumor angiogenesis. Butyrate was shown to induce cell cycle arrest, differentiation, and apoptosis in a variety of cancer cells. Dietary factors, microbiota composition, and microbiota metabolism are intimately intertwined in a complex network, highlighting the importance of intestinal functions for health maintenance. In the present review, we discuss aloe vera fermentation as a tumor-suppressive process generating microbial-derived butyrate.

The skin, being a cell-renewal system, is one of the first organs to be affected in total-body irradiation during radiotherapy. An attempt has been made in the present study to explore radiation-induced biochemical alterations caused by whole-body gamma irradiation and their modulation in Swiss albi …

Objective: In the living organisms, deleterious effects produced by ionizing radiations. Human exposure to ionizing radiations increased enormously because of rapid technological advancements. There is a need to protect humans against such effects of ionizing radiation. Protection against the deleterious effects of ionizing radiations by radioprotectors was studied, which may be of great help for human application. Present study was conducted to evaluate the modulating efficacy of prolonged administration of Aloe vera extract against gamma irradiation-induced toxicity in mice. Methods: Animals were given Aloe vera leaf extract orally 1000 mg/kg body weight/d for 15 consecutive days before radiation exposure (0.5, 3 and 5.5 Gy gamma radiation). Results: Mice were autopsied at day ¼, 1, 3, 5, 10 and 20 after irradiation to evaluate the radio modulator effect in terms of the hepatosomatic index. Conclusion: Aloe vera extract has a beneficial protective effect against radiation-induced oxidative stress.

The Journal of Alternative and Complementary Medicine

Introduction Pharmaceuticals are a large and diverse group of compounds designed to prevent, cure, and treat disease, and improve health [1-2].  Significant fractions of the parent compound are excreted in un-metabolized form or as metabolites (active or inactive) into raw sewage and wastewater

There is plenty of research that indicates that the unnaturally accelerated aging process associated with modern living and/or natural environmental exposures such as excessive ultraviolet radiation (photo-aging), can be slowed.

Background Dermatophytosis in calves is a major public and veterinary health concern worldwide because of its zoonotic potential and associated economic losses in cattle farms. However, this condition has lacked adequate attention; thus, to develop effective control measures, we determined ringworm prevalence, risk factors, and the direct-sample nested PCR diagnostic indices compared with the conventional methods of dermatophytes identification. Moreover, the phenolic composition of an Aloe vera gel extract (AGE) and its in vitro and in vivo antidermatophytic activity were evaluated and compared with those of antifungal drugs. Results Of the 760 calves examined, 55.79% (424/760) showed ringworm lesions; 84.91% (360/424) were positive for fungal elements in direct-microscopy, and 79.72% (338/424) were positive in culture. Trichophyton verrucosum was the most frequently identified dermatophyte (90.24%). The risk of dermatophytosis was higher in 4–6-month-old vs. 1-month-old calves (60% vs. 41%), and in summer and winter compared with spring and autumn seasons (66 and 54% vs. 48%). Poor hygienic conditions, intensive breeding systems, animal raising for meat production, parasitic infestation, crossbreeding, and newly purchased animals were statistically significant risk factors for dermatophytosis. One-step PCR targeting the conserved regions of the 18S and 28S genes achieved unequivocal identification of T. verrucosum and T. mentagrophytes in hair samples. Nested-PCR exhibited an excellent performance in all tested diagnostic indices and increased the species-specific detection of dermatophytes by 20% compared with culture. Terbinafine and miconazole were the most active antifungal agents for dermatophytes. Gallic acid, caffeic acid, chlorogenic acid, cinnamic acid, aloe-Emodin, quercetin, and rutin were the major phenolic compounds of AGE, as assessed using high-performance liquid chromatography (HPLC). These compounds increased and synergized the antidermatophytic activity of AGE. The treated groups showed significantly lower clinical scores vs. the control group (P

Air pollution has become a serious environmental issue and a threat to all over the world. SO2 is considered as the most poisonous and irritant gas as it penetrates deeper in the vitals hence alters the physiology, biochemistry and behavior of the living individuals. The present study has been designed to explore out the protective effect of Aloe vera against SO2 induced hepatotoxicity in albino rats. The twenty albino rats were grouped in four sets-control set (1) were kept in control conditions, while, experimental set (2) was exposed to 80ppm of SO2 gas 1h/d for 30 and 60 days, experimental set (3) were exposed to 80ppm of SO2 gas 1h/d with oral administration of Aloe vera fruits extracts (200mg/kg b.wt.) for 30 and 60 days respectively. The findings of the present investigation have indicated that SO2 causes significant increase in total bilirubin (p

This study sought to improve the handling, stability to aqueous medium and healing properties of alginate-based three-dimensional structures to be app…

Scar preventive dextran based bionanocomposite dressings containing aloe vera (AV) and manuka honey (MH) were developed as wound care devices. This wo…

Abstract Biogenic synthesis of silver nanoparticles (AgNP) was performed at room temperature using Aloe vera plant extract in the presence of ammoniacal silver nitrate as a metal salt precursor. The formation of AgNP was monitored by UV-visible spectroscopy at different time intervals. The shape and size of the synthesized particle were visualized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM) observations. These results were confirmed by X-ray powder diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) analyses and further supported by surface-enhanced Raman spectroscopy/Raman scattering (SERS) study. UV-visible spectrum has shown a sharp peak at 420 nm and further evidenced by FTIR peak profile (at 1587.6, 1386.4, and 1076 cm−1 with corresponding compounds). The main band position with SERS was noticed at 1594 cm−1 (C–C stretching vibration). When samples were heated under microwave radiation, AgNP with octahedron shapes with 5–50 nm were found and this method can be one of the easier ways to synthesis anisotropic AgNP, in which the plant extract plays a vital role to regulate the size and shape of the nanoparticles. Enhanced antibacterial effects (two- to fourfold) were observed in the case of Aloe vera plant protected AgNP than the routinely synthesized antibiotic drugs. Graphical Abstract Shape and size-controlled synthesis of silver nanoparticles using Aloe vera plant extract

Abstract Biogenic synthesis of silver nanoparticles (AgNP) was performed at room temperature using Aloe vera plant extract in the presence of ammoniacal silver nitrate as a metal salt precursor. The formation of AgNP was monitored by UV-visible spectroscopy at different time intervals. The shape and size of the synthesized particle were visualized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM) observations. These results were confirmed by X-ray powder diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) analyses and further supported by surface-enhanced Raman spectroscopy/Raman scattering (SERS) study. UV-visible spectrum has shown a sharp peak at 420 nm and further evidenced by FTIR peak profile (at 1587.6, 1386.4, and 1076 cm−1 with corresponding compounds). The main band position with SERS was noticed at 1594 cm−1 (C–C stretching vibration). When samples were heated under microwave radiation, AgNP with octahedron shapes with 5–50 nm were found and this method can be one of the easier ways to synthesis anisotropic AgNP, in which the plant extract plays a vital role to regulate the size and shape of the nanoparticles. Enhanced antibacterial effects (two- to fourfold) were observed in the case of Aloe vera plant protected AgNP than the routinely synthesized antibiotic drugs. Graphical Abstract Shape and size-controlled synthesis of silver nanoparticles using Aloe vera plant extract

The Journal of Alternative and Complementary Medicine

Support Your Digestive System with Aloe Vera By Jamie Rutherford 2/3/2017 For Global Healing Center Support Your Digestive System with Aloe Vera A properly functioning digestive system is the found…

Human norovirus (HuNoV) is the major cause of viral foodborne diseases, but no effective medication is currently available. This study reported the an…

AIM: Long-term dietary intake of non-caloric fiber, such as Aloe vera gel influences the structural and activity of micro-organisms in the human gut. The present investigation was executed with an innovative concept: symbiotic effect of probiotics that are used commercially as lactic acid bacteria i.e. Lactobacillus fermentum and Aloe vera juice as prebiotics for a prospective prophylaxis. MATERIALS AND METHODS: Fermentation of L. fermentum with Aloe vera juice certified by International Aloe Science Council was carried out and the quantification of short chain fatty acids (SCFAs) from the fermentation broth in large scale was determined by gas-chromatography-mass-spectrometry selective detection in the selective ion monitoring mode. RESULTS: The growth of L. fermentum and L. helveticus with Aloe vera juice (AVJ) individually on MRS broth was continued to keep at pH 3.5 and 3.6, while pH of the negative controls changed to 4.3 and 4.0, respectively, during 24 hr incubation. The growth rate and the viability of L. helveticus incubated with different concentrations (5-25%) of Aloe vera juice were strongly reduced. However, the growth rate of L. fermentum was enhanced in a concentration dependent manner with emphasis on the use of 15% AVJ that resulted in two times more growth than that of the negative control. Continuation of L. fermentum growth at pH 3.6 in combination with AVJ during incubation for 24 hr suggests the durability of prebiotic potential by AVJ in in vitro fermentation. Acetic, propionic and lactic acid as SCFAs in the ether extract were identified from the fermentation culture medium. CONCLUSION: The prebiotic activity of AVJ may be assessed by the participation of SCFAs during 24 hrs-incubation with L. fermentum. An innovative concept of symbiotics: a combination of AVJ and L. fermentum, is a perspective prophylaxis on future intestinal health claims. Due to tolerance to acid, L. fermentum may pass through the gastric barrier and colonize the intestine after oral administration.