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Integrated Multimodal Omics and Dietary Approaches for the Management of Neurodegeneration
Integrated Multimodal Omics and Dietary Approaches for the Management of Neurodegeneration
Neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease, are caused by a combination of multiple events that damage neuronal function. A well-characterized biomarker of neurodegeneration is the accumulation of proteinaceous aggregates in the brain. However, the gradually worsening symptoms of neurodegenerative diseases are unlikely to be solely due to the result of a mutation in a single gene, but rather a multi-step process involving epigenetic changes. Recently, it has been suggested that a fraction of epigenetic alternations may be correlated to neurodegeneration in the brain. Unlike DNA mutations, epigenetic alterations are reversible, and therefore raise the possibilities for therapeutic intervention, including dietary modifications. Additionally, reactive oxygen species may contribute to the pathogenesis of Alzheimer’s disease and Parkinson’s disease through epigenetic alternation. Given that the antioxidant properties of plant-derived phytochemicals are likely to exhibit pleiotropic effects against ROS-mediated epigenetic alternation, dietary intervention may be promising for the management of neurodegeneration in these diseases. In this review, the state-of-the-art applications using single-cell multimodal omics approaches, including epigenetics, and dietary approaches for the identification of novel biomarkers and therapeutic approaches for the treatment of neurodegenerative diseases are discussed.
·mdpi.com·
Integrated Multimodal Omics and Dietary Approaches for the Management of Neurodegeneration
Lisa Mosconi: How menopause affects the brain | TED Talk
Lisa Mosconi: How menopause affects the brain | TED Talk
Many of the symptoms of menopause -- hot flashes, night sweats, insomnia, memory lapses, depression and anxiety -- start in the brain. How exactly does menopause impact cognitive health? Sharing groundbreaking findings from her research, neuroscientist Lisa Mosconi reveals how decreasing hormonal levels affect brain aging -- and shares simple lifestyle changes you can make to support lifelong brain health.
·ted.com·
Lisa Mosconi: How menopause affects the brain | TED Talk
The XX Brain, by Lisa Mosconi, PhD
The XX Brain, by Lisa Mosconi, PhD
New Book on the Groundbreaking Science Empowering Women to Maximize Cognitive Health and Prevent Alzheimer's Disease. Intro by Maria Shriver. Includes chapters on Alzheimer's Disease, dementia, brain aging, menopause, perimenopause, women's health, HRT, neuroscience, and other related topics.
·thexxbrain.com·
The XX Brain, by Lisa Mosconi, PhD
The Alzheimer’s Solution
The Alzheimer’s Solution
Our Bestselling Books The 30-Day Alzheimer’s Solution Together, we can positively affect the most important organ in the body for billions of people with effective tools and methodologies. Our personalized, comprehensive programs for brain healthy living are programs that people can follow for the rest of their lives. BUY NOW: The action plan that you […]
·thebraindocs.com·
The Alzheimer’s Solution
Natural Remedies for ALS
Natural Remedies for ALS
Natural treatments for ALS, or Lou Gehrig's Disease, include supplements including Vitamins C and E, and B Complex.
·earthclinic.com·
Natural Remedies for ALS
How to Fix Your Leaky Brain - David Perlmutter M.D.
How to Fix Your Leaky Brain - David Perlmutter M.D.
A relatively new player in the discussion of factors leading to Alzheimer’s is the breakdown of the so-called blood-brain barrier (BBB). The blood-brain barrier is essentially a checkpoint within the …
·drperlmutter.com·
How to Fix Your Leaky Brain - David Perlmutter M.D.
Vitamin D and Dementia Risk - David Perlmutter M.D.
Vitamin D and Dementia Risk - David Perlmutter M.D.
For years I’ve been writing about the important role of vitamin D as it relates to general health and brain health in specific. And with good reason. The medical research …
·drperlmutter.com·
Vitamin D and Dementia Risk - David Perlmutter M.D.
Treating Alzheimer's with Fecal Material - David Perlmutter M.D.
Treating Alzheimer's with Fecal Material - David Perlmutter M.D.
In 2015, I published Brain Maker, a book that explored the remarkable, but generally overlooked relationship between the gut and the brain. These days, this relationship gets a lot of …
·drperlmutter.com·
Treating Alzheimer's with Fecal Material - David Perlmutter M.D.