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Researchers in Sweden have discovered a new function for vitamin C. Treatment with vitamin C can dissolve the toxic protein aggregates that build up in the brain in Alzheimer's disease.

This study assessed the therapeutic utility of the autophagy enhancing stable disaccharide trehalose in the Tg2576 transgenic mouse model of Alzheimer's disease (AD) via an oral gavage of a 2% trehalose solution for 31 days. Furthermore, as AD is a neurodegenerative condition in which the transition …

Turmeric has been used in India for over 5,000 years, which is likely why still today both rural and urban populations have some of the lowest prevalence rates of Alzheimer's disease (AD) in the world. A study on patients with AD found that less than a gram of turmeric daily, taken for three months, resulted in 'remarkable improvements'

Researchers at UCLA say they've developed a program that shows for the first time Alzheimer's memory loss being reversed in some patients.

An aging specialist discusses 10 main signs of Alzheimer's disease and the importance of obtaining an early diagnosis. More than 5 million people in the United States have Alzheimer's disease, according to the Alzheimer's Association. Not only is Alzheimer's disease the sixth leading cause of death in the country, but it also currently cannot be prevented, cured or slowed.

A new study is helping to explain why the long-term use of common anticholinergic drugs used to treat conditions like allergies and overactive bladder lead to an increased risk of developing dementia later in life. The study used mouse models to show that long-term suppression of the neurotransmitter acetylcholine -- a target for anticholinergic drugs -- results in dementia-like changes in the brain.

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Inhibition of platelets in Alzheimer's disease patients may become important in therapy in future, say researchers whose findings could be of great importance for the treatment of Alzheimer's disease patients.

2019 RYB ALZ Risk - Main Opt-In.

Abundant clinical, epidemiological, imaging, genetic, molecular, and pathophysiological data together indicate that there occur an unusual inflammatory reaction and a disruption of the innate-immune signaling system in Alzheimer’s disease (AD) brain. Despite many years of intense study, the origin and molecular mechanics of these AD-relevant pathogenic signals are still not well understood. Here, we provide evidence that an intensely pro-inflammatory bacterial lipopolysaccharide (LPS), part of a complex mixture of pro-inflammatory neurotoxins arising from abundant Gram-negative bacilli of the human gastrointestinal (GI) tract, are abundant in AD-affected brain neocortex and hippocampus. For the first time, we provide evidence that LPS immunohistochemical signals appear to aggregate in clumps in the parenchyma in control brains, and in AD, about 75% of anti-LPS signals were clustered around the periphery of DAPI-stained nuclei. As LPS is an abundant secretory product of Gram-negative bacilli resident in the human GI-tract, these observations suggest (i) that a major source of pro-inflammatory signals in AD brain may originate from internally derived noxious exudates of the GI-tract microbiome; (ii) that due to aging, vascular deficits or degenerative disease these neurotoxic molecules may “leak” into the systemic circulation, cerebral vasculature, and on into the brain; and (iii) that this internal source of microbiome-derived neurotoxins may play a particularly strong role...

This is the first time a randomized, double-blind, clinical trial has shown that a nutritional intervention can help to conserve the ability of prodromal AD patients to carry out everyday tasks, such as paying bills, or finding your way around, as measured by the Clinical Dementia Rating-Sum of Boxes (CDR-SB) -- a combined measure for the ability to think and perform everyday tasks. This is important because those with prodromal AD currently have no approved, available pharmacological options.

The disaccharide trehalose is commonly considered to stimulate autophagy. Cell treatment with trehalose could decrease cytosolic aggregates of potentially pathogenic proteins, including mutant huntingtin, α-synuclein, and phosphorylated tau that are associated with neurodegenerative diseases. Here, …

Drugs being used to treat Alzheimer’s disease are actually associated with a more aggressive decline in cognitive function.

Exercise, which has a positive impact on brain health, needs to be front and center in terms of our Alzheimer’s messaging and outreach.

A new study highlights the role lifestyle factors, like sleep, exercise, stress, and weight gain can have on your risk of developing Alzheimer's disease.

Do you ever worry about you or a loved one getting Alzheimer’s disease? It’s heartbreaking to watch someone you love not remember who you are or have difficulties with everyday tasks. The sacred plant is effective in preventing these symptoms of cognitive decline by reducing brain inflammation due to aging and by restoring a process called neurogenesis. Watch as Dr. Daniel Stein, a cannabis Neurologist, shares what he refers to as a “type 3” preventative protocol. *** This limited clip is a preview from our Healing Brain Masterclass. Get full access to our entire 3 masterclass library, complete season 1 docuseries, and over 37 bonuses on a portable 100+ GB flash drive... Go here for all the details 👉 http://bit.ly/2rl3F33

Transgenic APPswe/PS1dE9 mice modeling Alzheimer’s disease demonstrate ongoing accumulation of β-amyloid fragments resulting in formation of amy...

New research has found a way to partially restore brain cell communication around areas damaged by plaques associated with Alzheimer's disease.

Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 …

Health Benefits of Lithium Orotate.